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Cardiovascular epigenetics

Section information

Section Editor : Ronan Murphy
Associate Editor: Gianluigi Condorelli

The impact of epigenetics in cardiovascular disease is now emerging as an important player at different levels from etiology to therapeutics. This section publishes original epigenetic research and reviews in all cardiovascular medical specialties from both animal model and human studies. Research that links epigenetic regulation with cardiovascular risk factors, biomarkers and subclinical cardiovascular diseases will also be included in this section.

  1. Platelet-endothelial aggregation receptor 1 (PEAR-1) is a transmembrane receptor involved in platelet activation and megakaryopoiesis whose expression is driven by DNA methylation. PEAR1 variants were associated ...

    Authors: Benedetta Izzi, Francesco Gianfagna, Wen-Yi Yang, Katrien Cludts, Amalia De Curtis, Peter Verhamme, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Jan A. Staessen, Marc F. Hoylaerts and Licia Iacoviello

    Citation: Clinical Epigenetics 2019 11:151

    Content type: Research

    Published on:

  2. Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associ...

    Authors: Kenneth Westerman, Paola Sebastiani, Paul Jacques, Simin Liu, Dawn DeMeo and José M. Ordovás

    Citation: Clinical Epigenetics 2019 11:142

    Content type: Research

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  3. Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (MACE) in patients with cardiovascular d...

    Authors: Laura M. Tsujikawa, Li Fu, Shovon Das, Christopher Halliday, Brooke D. Rakai, Stephanie C. Stotz, Christopher D. Sarsons, Dean Gilham, Emily Daze, Sylwia Wasiak, Deborah Studer, Kristina D. Rinker, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong and Ewelina Kulikowski

    Citation: Clinical Epigenetics 2019 11:102

    Content type: Research

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  4. Cardiac disease modelling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) requires thorough insight into cardiac cell type differentiation processes. However, current methods to dis...

    Authors: Kirstin Hoff, Marta Lemme, Anne-Karin Kahlert, Kerstin Runde, Enrique Audain, Dorit Schuster, Jens Scheewe, Tim Attmann, Thomas Pickardt, Almuth Caliebe, Reiner Siebert, Hans-Heiner Kramer, Hendrik Milting, Arne Hansen, Ole Ammerpohl and Marc-Phillip Hitz

    Citation: Clinical Epigenetics 2019 11:89

    Content type: Research

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  5. Hypertension is one of primary clinical presentations of pre-eclampsia. The occurrence and progress of hypertension are closely related to vascular dysfunction. However, information is limited regarding the pa...

    Authors: Qinqin Gao, Xiaorong Fan, Ting Xu, Huan Li, Yun He, Yuxian Yang, Jie Chen, Hongmei Ding, Jianying Tao and Zhice Xu

    Citation: Clinical Epigenetics 2019 11:84

    Content type: Research

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  6. Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a predicted transcription factor with potential role in hematopoietic development. Recent evidence linked low methylation level of ZBTB12 exon1 to myoc...

    Authors: Fabrizia Noro, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello and Benedetta Izzi

    Citation: Clinical Epigenetics 2019 11:74

    Content type: Research

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  7. Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory f...

    Authors: Pei Du, Keqin Gao, Yu Cao, Shuang Yang, Yang Wang, Ren Guo, Ming Zhao and Sujie Jia

    Citation: Clinical Epigenetics 2019 11:44

    Content type: Research

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  8. Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulabi...

    Authors: Xiao Wang, Kristina Sundquist, Peter J. Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A. Memon, Jan Sundquist and Bengt Zöller

    Citation: Clinical Epigenetics 2019 11:28

    Content type: Research

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  9. Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...

    Authors: Cavin K. Ward-Caviness, Golareh Agha, Brian H. Chen, Liliane Pfeiffer, Rory Wilson, Petra Wolf, Christian Gieger, Joel Schwartz, Pantel S. Vokonas, Lifang Hou, Allan C. Just, Stefania Bandinelli, Dena G. Hernandez, Andrew B. Singleton, Holger Prokisch, Thomas Meitinger…

    Citation: Clinical Epigenetics 2018 10:161

    Content type: Research

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  10. Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has n...

    Authors: Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher and Donna K. Arnett

    Citation: Clinical Epigenetics 2018 10:56

    Content type: Research

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  11. The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constit...

    Authors: Tomi Akinyemiju, Anh N. Do, Amit Patki, Stella Aslibekyan, Degui Zhi, Bertha Hidalgo, Hemant K. Tiwari, Devin Absher, Xin Geng, Donna K. Arnett and Marguerite R. Irvin

    Citation: Clinical Epigenetics 2018 10:49

    Content type: Research

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  12. Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia (BPD).

    Authors: Cho-Ming Chao, Rhea van den Bruck, Samantha Lork, Janica Merkle, Laura Krampen, Patrick P Weil, Malik Aydin, Saverio Bellusci, Andreas C. Jenke and Jan Postberg

    Citation: Clinical Epigenetics 2018 10:37

    Content type: Research

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  13. Alterations in DNA methylation are demonstrated in atherosclerosis pathogenesis. However, changing rules of global DNA methylation and hydroxymethylation in peripheral blood leukocytes (PBLs) and different blo...

    Authors: Qianyun Deng, Wei Huang, Chunyan Peng, Jiajia Gao, Zuhua Li, Xueping Qiu, Na Yang, Bifeng Yuan and Fang Zheng

    Citation: Clinical Epigenetics 2018 10:9

    Content type: Research

    Published on:

  14. Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing t...

    Authors: Igor Gošev, Martina Zeljko, Željko Đurić, Ivana Nikolić, Milorad Gošev, Sanja Ivčević, Dino Bešić, Zoran Legčević and Frane Paić

    Citation: Clinical Epigenetics 2017 9:106

    Content type: Review

    Published on:

  15. Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...

    Authors: Jacob K. Kresovich, Yinan Zheng, Andres Cardenas, Brian T. Joyce, Sheryl L. Rifas-Shiman, Emily Oken, Matthew W. Gillman, Marie-France Hivert, Andrea A. Baccarelli and Lifang Hou

    Citation: Clinical Epigenetics 2017 9:86

    Content type: Research

    Published on:

  16. Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial ...

    Authors: Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Keiko Naruse, Shigeki Yokota, Hiroyuki Asano, Tatsuaki Matsubara and Mitsuhiro Yokota

    Citation: Clinical Epigenetics 2017 9:54

    Content type: Short report

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  17. DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of trig...

    Authors: Kim V. E. Braun, Klodian Dhana, Paul S. de Vries, Trudy Voortman, Joyce B. J. van Meurs, Andre G. Uitterlinden, Albert Hofman, Frank B. Hu, Oscar H. Franco and Abbas Dehghan

    Citation: Clinical Epigenetics 2017 9:15

    Content type: Research

    Published on:

  18. Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DN...

    Authors: Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J. Barton, Hazel Inskip, Nicholas C. Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson and Keith M. Godfrey

    Citation: Clinical Epigenetics 2016 8:90

    Content type: Short report

    Published on:

  19. Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methyl...

    Authors: Ting Li-Tempel, Mauro F. Larra, Estelle Sandt, Sophie B. Mériaux, Andrea B. Schote, Hartmut Schächinger, Claude P. Muller and Jonathan D. Turner

    Citation: Clinical Epigenetics 2016 8:12

    Content type: Research

    Published on:

  20. DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Ther...

    Authors: Simonetta Guarrera, Giovanni Fiorito, N. Charlotte Onland-Moret, Alessia Russo, Claudia Agnoli, Alessandra Allione, Cornelia Di Gaetano, Amalia Mattiello, Fulvio Ricceri, Paolo Chiodini, Silvia Polidoro, Graziella Frasca, Monique W. M. Verschuren, Jolanda M. A. Boer, Licia Iacoviello, Yvonne T. van der Schouw…

    Citation: Clinical Epigenetics 2015 7:133

    Content type: Research

    Published on:

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