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  1. Content type: Research

    5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of mo...

    Authors: Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li…

    Citation: Clinical Epigenetics 2018 10:94

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  2. Content type: Research

    Investigating how epigenetic information is transmitted through the mammalian germline is the key to understanding how this information impacts on health and disease susceptibility in offspring. EED is essenti...

    Authors: Lexie Prokopuk, Jessica M. Stringer, Craig R. White, Rolf H. A. M. Vossen, Stefan J. White, Ana S. A. Cohen, William T. Gibson and Patrick S. Western

    Citation: Clinical Epigenetics 2018 10:95

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  3. Content type: Short report

    Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in li...

    Authors: Glenn S. Gerhard, Ivana Malenica, Lorida Llaci, Xin Chu, Anthony T. Petrick, Christopher D. Still and Johanna K. DiStefano

    Citation: Clinical Epigenetics 2018 10:93

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  4. Content type: Research

    Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis...

    Authors: Jing-dong Zhou, Yu-xin Wang, Ting-juan Zhang, Xi-xi Li, Yu Gu, Wei Zhang, Ji-chun Ma, Jiang Lin and Jun Qian

    Citation: Clinical Epigenetics 2018 10:92

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  5. Content type: Research

    Early screening for prostate cancer (PCA) remains controversial because of overdiagnosis and overtreatment of clinically insignificant cancers. Even though a number of diagnostic tests have been developed to i...

    Authors: Igor Brikun, Deborah Nusskern, Andrew Decatus, Eric Harvey, Lin Li and Diha Freije

    Citation: Clinical Epigenetics 2018 10:91

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  6. Content type: Research

    This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for g...

    Authors: Sarah Gonzalez-Nahm, Michelle A. Mendez, Sara E. Benjamin-Neelon, Susan K. Murphy, Vijaya K. Hogan, Diane L. Rowley and Cathrine Hoyo

    Citation: Clinical Epigenetics 2018 10:90

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  7. Content type: Research

    Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition...

    Authors: Katharina Bomans, Judith Schenz, Sandra Tamulyte, Dominik Schaack, Markus Alexander Weigand and Florian Uhle

    Citation: Clinical Epigenetics 2018 10:89

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  8. Content type: Research

    Gestational age at delivery is associated with health and social outcomes. Recently, cord blood DNA methylation data has been used to predict gestational age. The discrepancy between gestational age predicted ...

    Authors: Jasmine N. Khouja, Andrew J. Simpkin, Linda M. O’Keeffe, Kaitlin H. Wade, Lotte C. Houtepen, Caroline L. Relton, Matthew Suderman and Laura D. Howe

    Citation: Clinical Epigenetics 2018 10:86

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  9. Content type: Research

    Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental ...

    Authors: Qihua Tan, Shuxia Li, Morten Frost, Marianne Nygaard, Mette Soerensen, Martin Larsen, Kaare Christensen and Lene Christiansen

    Citation: Clinical Epigenetics 2018 10:87

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  10. Content type: Review

    Triple-negative breast cancer (TNBC) has been clinically difficult to manage because of tumor aggressiveness, cellular and histological heterogeneity, and molecular mechanisms’ complexity. All this in turn lea...

    Authors: Rubén Rodríguez Bautista, Alette Ortega Gómez, Alfredo Hidalgo Miranda, Alejandro Zentella Dehesa, Cynthia Villarreal-Garza, Federico Ávila-Moreno and Oscar Arrieta

    Citation: Clinical Epigenetics 2018 10:88

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  11. Content type: Research

    Posttranslational modification of histone tails such as histone 3 lysine 27 acetylation (H3K27ac) is tightly coupled to epigenetic regulation of gene expression. To explore whether this is involved in placenta...

    Authors: N. D. Paauw, A. T. Lely, J. A. Joles, A. Franx, P. G. Nikkels, M. Mokry and B. B. van Rijn

    Citation: Clinical Epigenetics 2018 10:85

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  12. Content type: Research

    Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk ...

    Authors: Xu Gao, Yan Zhang, Ben Schöttker and Hermann Brenner

    Citation: Clinical Epigenetics 2018 10:84

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  13. Content type: Research

    Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 ...

    Authors: Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand and Sherita Hill Golden

    Citation: Clinical Epigenetics 2018 10:82

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  14. Content type: Research

    Malignant pleural mesothelioma (MPM) is a very rare and highly aggressive cancer of the pleura associated in most cases with asbestos exposure. To date, no really efficient treatments are available for this pa...

    Authors: Douae Bensaid, Thibaut Blondy, Sophie Deshayes, Virginie Dehame, Philippe Bertrand, Marc Grégoire, Mohammed Errami and Christophe Blanquart

    Citation: Clinical Epigenetics 2018 10:79

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  15. Content type: Research

    Assisted reproductive technology (ART) has been associated with low birth weight of fresh embryo transfer (FRESH) derived and increased birth weight of frozen embryo transfer (FET)-derived newborns. Owing to t...

    Authors: Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen and Nina Kaminen-Ahola

    Citation: Clinical Epigenetics 2018 10:80

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  16. Content type: Research

    Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs,...

    Authors: Fleur S. Peters, Annemiek M. A. Peeters, Pooja R. Mandaviya, Joyce B. J. van Meurs, Leo J. Hofland, Jacqueline van de Wetering, Michiel G. H. Betjes, Carla C. Baan and Karin Boer

    Citation: Clinical Epigenetics 2018 10:81

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  17. Content type: Research

    High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modif...

    Authors: Varun Sasidharan Nair, Haytham El Salhat, Rowaida Z. Taha, Anne John, Bassam R. Ali and Eyad Elkord

    Citation: Clinical Epigenetics 2018 10:78

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  18. Content type: Research

    An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an alter...

    Authors: D. Gentilini, E. Somigliana, L. Pagliardini, E. Rabellotti, P. Garagnani, L. Bernardinelli, E. Papaleo, M. Candiani, A. M. Di Blasio and P. Viganò

    Citation: Clinical Epigenetics 2018 10:77

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  19. Content type: Research

    Primary testing for high-risk HPV (hrHPV) is increasingly implemented in cervical cancer screening programs. Many hrHPV-positive women, however, harbor clinically irrelevant infections, demanding additional di...

    Authors: Iris Babion, Barbara C. Snoek, Putri W. Novianti, Annelieke Jaspers, Nienke van Trommel, Daniëlle A. M. Heideman, Chris J. L. M. Meijer, Peter J. F. Snijders, Renske D. M. Steenbergen and Saskia M. Wilting

    Citation: Clinical Epigenetics 2018 10:76

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  20. Content type: Research

    Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations betwee...

    Authors: Marija Klasić, Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Ivan Biruš, Paula Dobrinić, Nicholas T. Ventham, Irena Trbojević-Akmačić, Mirna Šimurina, Jerko Štambuk, Genadij Razdorov, Nicholas A. Kennedy, Jack Satsangi, Ana M. Dias, Salome Pinho, Vito Annese…

    Citation: Clinical Epigenetics 2018 10:75

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  21. Content type: Correction

    After publication of the original article [1], it came to the publishers’ attention that the below author’s corrections provided at the proofing stage had been misinterpreted.

    Authors: Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2018 10:74

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    The original article was published in Clinical Epigenetics 2018 10:57

  22. Content type: Methodology

    Mislabeled, contaminated or poorly performing samples can threaten power in methylation microarray analyses or even result in spurious associations. We describe a set of quality checks for the popular Illumina...

    Authors: Jonathan A. Heiss and Allan C. Just

    Citation: Clinical Epigenetics 2018 10:73

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  23. Content type: Research

    Current standard methods used to detect and monitor bladder cancer (BC) are invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker classifier for BC monitoring and validate...

    Authors: Antoine G. van der Heijden, Lourdes Mengual, Mercedes Ingelmo-Torres, Juan J. Lozano, Cindy C. M. van Rijt-van de Westerlo, Montserrat Baixauli, Bogdan Geavlete, Cristian Moldoveanud, Cosmin Ene, Colin P. Dinney, Bogdan Czerniak, Jack A. Schalken, Lambertus A. L. M. Kiemeney, Maria J. Ribal, J. Alfred Witjes and Antonio Alcaraz

    Citation: Clinical Epigenetics 2018 10:71

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  24. Content type: Research

    Active demethylation of 5-methyl-2′-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2′-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2′-deoxycytidine (5-fdC) and 5-carboxy-2′-d...

    Authors: Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, Magdalena Bodnar, Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Anna Szpila, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski…

    Citation: Clinical Epigenetics 2018 10:72

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