Research
Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and...
Clinical Epigenetics 2017 9:114
Published on: 17 October 2017
Research
Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences...
Clinical Epigenetics 2017 9:113
Published on: 16 October 2017
Research
Asthma heritability has only been partially explained by genetic variants and is known to be sensitive to environmental factors, implicating epigenetic modifications such as DNA methylation in its pathogenesis.
Clinical Epigenetics 2017 9:112
Published on: 13 October 2017
Research
Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adr...
Clinical Epigenetics 2017 9:110
Published on: 13 October 2017
Research
Uniparental disomy of certain chromosomes are associated with a group of well-known genetic syndromes referred to as imprinting disorders. However, the extreme form of uniparental disomy affecting the whole ge...
Clinical Epigenetics 2017 9:111
Published on: 13 October 2017
Research
KIBRA has been suggested as a key regulator of the Hippo signaling pathway, regulating organ size, cell contact inhibition, tissue regeneration as well as tumorigenesis and cystogenesis. We recently reported t...
Clinical Epigenetics 2017 9:109
Published on: 6 October 2017
Research
Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in childre...
Clinical Epigenetics 2017 9:108
Published on: 5 October 2017
Review
Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene tran...
Clinical Epigenetics 2017 9:105
Published on: 3 October 2017
Review
Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing t...
Clinical Epigenetics 2017 9:106
Published on: 3 October 2017
Research
There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregn...
Clinical Epigenetics 2017 9:107
Published on: 3 October 2017
Research
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by lymphocytic infiltration and overproduction of autoantibodies, leading to significant morbidity and mortality. However, the ...
Clinical Epigenetics 2017 9:104
Published on: 22 September 2017
Research
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among A...
Clinical Epigenetics 2017 9:103
Published on: 21 September 2017
Research
Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...
Clinical Epigenetics 2017 9:102
Published on: 21 September 2017
Research
Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatit...
Clinical Epigenetics 2017 9:101
Published on: 16 September 2017
Research
Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are un...
Clinical Epigenetics 2017 9:99
Published on: 15 September 2017
Letter to the Editor
In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implicati...
Clinical Epigenetics 2017 9:100
Published on: 15 September 2017
Review
Respiratory diseases hold several genome, epigenome, and transcriptional aberrations as a cause of the accumulated damage promoted by, among others, environmental risk factors. Such aberrations can also come a...
Clinical Epigenetics 2017 9:98
Published on: 8 September 2017
Research
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression o...
Clinical Epigenetics 2017 9:95
Published on: 6 September 2017
Research
Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marke...
Clinical Epigenetics 2017 9:97
Published on: 5 September 2017
Research
We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals. However, mechanisms related to this phenoty...
Clinical Epigenetics 2017 9:94
Published on: 2 September 2017
Short report
Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can i...
Clinical Epigenetics 2017 9:96
Published on: 2 September 2017
Research
Cellular senescence due to genomic instability is believed to be one of the mechanisms causing health problems in diabetes mellitus (DM). Low methylation levels of Alu elements or Alu hypomethylation, an epige...
Clinical Epigenetics 2017 9:93
Published on: 31 August 2017
Short report
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome,...
Clinical Epigenetics 2017 9:92
Published on: 30 August 2017
Research
Aberrant CpG island methylation has been increasingly recognized as a common event in myelodysplastic syndrome (MDS). To date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes ...
Clinical Epigenetics 2017 9:91
Published on: 30 August 2017
Research
Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIP...
Clinical Epigenetics 2017 9:89
Published on: 25 August 2017
