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  1. Research

    Cord blood DNA methylation and adiposity measures in early and mid-childhood

    Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...

    Jacob K. Kresovich, Yinan Zheng, Andres Cardenas, Brian T. Joyce, Sheryl L. Rifas-Shiman, Emily Oken, Matthew W. Gillman, Marie-France Hivert, Andrea A. Baccarelli and Lifang Hou

    Clinical Epigenetics 2017 9:86

    Published on: 15 August 2017

  2. Research

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel

    Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagno...

    Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli and Maria Pia Foschini

    Clinical Epigenetics 2017 9:85

    Published on: 15 August 2017

  3. Research

    Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variat...

    J. Guiot, I. Struman, V. Chavez, M. Henket, M. Herzog, K. Scoubeau, N. Hardat, B. Bondue, JL. Corhay, C. Moermans and R. Louis

    Clinical Epigenetics 2017 9:84

    Published on: 15 August 2017

  4. Research

    Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

    Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) du...

    Yin Li, Yan Wang, Yong Zhou, Jie Li, Kai Chen, Leisi Zhang, Manman Deng, Suqi Deng, Peng Li and Bing Xu

    Clinical Epigenetics 2017 9:83

    Published on: 14 August 2017

  5. Research

    LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

    Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin ...

    Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia and Barbara A. Foster

    Clinical Epigenetics 2017 9:82

    Published on: 11 August 2017

  6. Research

    Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer

    The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprog...

    Emilie Evanno, Julie Godet, Nathalie Piccirilli, Joëlle Guilhot, Serge Milin, Jean Marc Gombert, Benoit Fouchaq and Joëlle Roche

    Clinical Epigenetics 2017 9:80

    Published on: 8 August 2017

  7. Research

    Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer

    Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findi...

    Hitoshi Hiura, Hiromitsu Hattori, Norio Kobayashi, Hiroaki Okae, Hatsune Chiba, Naoko Miyauchi, Akane Kitamura, Hiroyuki Kikuchi, Hiroaki Yoshida and Takahiro Arima

    Clinical Epigenetics 2017 9:79

    Published on: 3 August 2017

  8. Review

    Translating epigenetics into clinic: focus on lupus

    Systemic lupus erythematosus (SLE) is a chronic relapsing–remitting autoimmune disease with highly heterogeneous phenotypes. Biomarkers with high sensitivity and specificity are useful for early diagnosis as w...

    Zijun Wang, Christopher Chang, Mou Peng and Qianjin Lu

    Clinical Epigenetics 2017 9:78

    Published on: 2 August 2017

  9. Research

    Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD

    Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate th...

    Kristina Gervin, Hedvig Nordeng, Eivind Ystrom, Ted Reichborn-Kjennerud and Robert Lyle

    Clinical Epigenetics 2017 9:77

    Published on: 2 August 2017

  10. Methodology

    Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs

    Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the ...

    Alexander M. Morin, Evan Gatev, Lisa M. McEwen, Julia L. MacIsaac, David T. S. Lin, Nastassja Koen, Darina Czamara, Katri Räikkönen, Heather J. Zar, Karestan Koenen, Dan J. Stein, Michael S. Kobor and Meaghan J. Jones

    Clinical Epigenetics 2017 9:75

    Published on: 25 July 2017

  11. Research

    High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

    Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12...

    Hugo Sanchez, Mohammad B. Hossain, Lydia Lera, Sandra Hirsch, Cecilia Albala, Ricardo Uauy, Karin Broberg and Ana M. Ronco

    Clinical Epigenetics 2017 9:74

    Published on: 24 July 2017

  12. Research

    A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients

    Most DNA cancer methylation markers are based on the transcriptional regulation of the promoter-gene relationship. Recently, the importance of long-range interactions between distal CpGs and target genes has b...

    Seong-Min Park, Eun-Young Choi, Mingyun Bae, Jung Kyoon Choi and Youn-Jae Kim

    Clinical Epigenetics 2017 9:73

    Published on: 24 July 2017

  13. Research

    MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers

    The aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopatholog...

    Wei-Tzu Cheng, Roseanne Rosario, Anita Muthukaruppan, Michelle K Wilson, Kathryn Payne, Peter C. Fong, Andrew N. Shelling and Cherie Blenkiron

    Clinical Epigenetics 2017 9:72

    Published on: 21 July 2017

  14. Research

    Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1

    Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA...

    Vicki E. Maltby, Rodney A. Lea, Katherine A. Sanders, Nicole White, Miles C. Benton, Rodney J. Scott and Jeannette Lechner-Scott

    Clinical Epigenetics 2017 9:71

    Published on: 18 July 2017

  15. Methodology

    Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers

    The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic ma...

    Noa Gilat, Tzlil Tabachnik, Amit Shwartz, Tamar Shahal, Dmitry Torchinsky, Yael Michaeli, Gil Nifker, Shahar Zirkin and Yuval Ebenstein

    Clinical Epigenetics 2017 9:70

    Published on: 14 July 2017

  16. Methodology

    PAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples

    Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could not only represent useful biomarkers but also suggest possible targetable ...

    Roberta Noberini, Rémi Longuespée, Cristina Richichi, Giancarlo Pruneri, Mark Kriegsmann, Giuliana Pelicci and Tiziana Bonaldi

    Clinical Epigenetics 2017 9:69

    Published on: 11 July 2017

  17. Research

    BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

    The BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critic...

    Darlene A. Kertes, Samarth S. Bhatt, Hayley S. Kamin, David A. Hughes, Nicole C. Rodney and Connie J. Mulligan

    Clinical Epigenetics 2017 9:68

    Published on: 30 June 2017

  18. Research

    Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

    Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...

    Bram G. Janssen, Hyang-Min Byun, Harry A. Roels, Wilfried Gyselaers, Joris Penders, Andrea A. Baccarelli and Tim S. Nawrot

    Clinical Epigenetics 2017 9:66

    Published on: 21 June 2017

  19. Research

    Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

    Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...

    Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R. Jezioro, David Z. Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P. Perera, Andrew G. Rundle, Matthew S. Perzanowski, Steven N. Chillrud and Rachel L. Miller

    Clinical Epigenetics 2017 9:65

    Published on: 13 June 2017

  20. Research

    Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer

    This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 ex...

    Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Yuki Misawa, Shiori Endo, Masato Mima, Hideya Kawasaki, Thomas E. Carey and Takeharu Kanazawa

    Clinical Epigenetics 2017 9:64

    Published on: 12 June 2017

  21. Research

    Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A

    Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, co...

    Andrea Halaburková, Rastislav Jendželovský, Ján Kovaľ, Zdenko Herceg, Peter Fedoročko and Akram Ghantous

    Clinical Epigenetics 2017 9:62

    Published on: 8 June 2017

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