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  1. Content type: Research

    The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking ce...

    Authors: Sang-Won Um, Yujin Kim, Bo Bin Lee, Dongho Kim, Kyung-Jong Lee, Hong Kwan Kim, Joungho Han, Hojoong Kim, Young Mog Shim and Duk-Hwan Kim

    Citation: Clinical Epigenetics 2018 10:65

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  2. Content type: Research

    To investigate the relationship between early-life stress and glucocorticoid receptor (GR) gene methylation, which may result in long-lasting neurodevelopmental impairment, we performed a longitudinal analysis...

    Authors: Masato Kantake, Natsuki Ohkawa, Tomohiro Iwasaki, Naho Ikeda, Atsuko Awaji, Nobutomo Saito, Hiromichi Shoji and Toshiaki Shimizu

    Citation: Clinical Epigenetics 2018 10:66

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  3. Content type: Research

    Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer (CRC). A prospective correlative biomarker study ...

    Authors: Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin and Graeme P. Young

    Citation: Clinical Epigenetics 2018 10:63

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  4. Content type: Research

    The changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic a...

    Authors: Emma E. Thompson, Jessie Nicodemus-Johnson, Kyung Won Kim, James E. Gern, Daniel J. Jackson, Robert F. Lemanske and Carole Ober

    Citation: Clinical Epigenetics 2018 10:62

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  5. Content type: Research

    Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. A...

    Authors: Daniel Castellano-Castillo, Sonsoles Morcillo, Mercedes Clemente-Postigo, Ana Belén Crujeiras, Jose Carlos Fernandez-García, Esperanza Torres, Francisco José Tinahones and Manuel Macias-Gonzalez

    Citation: Clinical Epigenetics 2018 10:60

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  6. Content type: Research

    Exposure to endocrine-disrupting chemicals can alter normal physiology and increase susceptibility to non-communicable diseases like obesity. Especially the prenatal and early postnatal period is highly vulner...

    Authors: Kristin M. Junge, Beate Leppert, Susanne Jahreis, Dirk K. Wissenbach, Ralph Feltens, Konrad Grützmann, Loreen Thürmann, Tobias Bauer, Naveed Ishaque, Matthias Schick, Melanie Bewerunge-Hudler, Stefan Röder, Mario Bauer, Angela Schulz, Michael Borte, Kathrin Landgraf…

    Citation: Clinical Epigenetics 2018 10:58

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  7. Content type: Research

    There are many reasons to think that epigenetics is a key determinant of fetal growth variability across the normal population. Since IGF1 and INS genes are major determinants of intrauterine growth, we examined ...

    Authors: Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2018 10:57

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  8. Content type: Research

    Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has n...

    Authors: Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher and Donna K. Arnett

    Citation: Clinical Epigenetics 2018 10:56

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  9. Content type: Research

    Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome o...

    Authors: Yan Cheng, Cátia Monteiro, Andreia Matos, Jiaying You, Avelino Fraga, Carina Pereira, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi, Gema Frühbeck, Ricardo Ribeiro and Pingzhao Hu

    Citation: Clinical Epigenetics 2018 10:54

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  10. Content type: Research

    IgE-mediated sensitization may be epigenetically programmed in utero, but early childhood environment may further alter complex traits and disease phenotypes through epigenetic plasticity. However, the epigeno...

    Authors: Cheng Peng, Andres Cardenas, Sheryl L. Rifas-Shiman, Marie-France Hivert, Diane R. Gold, Thomas A. Platts-Mills, Xihong Lin, Emily Oken, Andrea A. Baccarelli, Augusto A. Litonjua and Dawn L. DeMeo

    Citation: Clinical Epigenetics 2018 10:55

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  11. Content type: Research

    Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the ear...

    Authors: María Gallardo-Gómez, Sebastian Moran, María Páez de la Cadena, Vicenta Soledad Martínez-Zorzano, Francisco Javier Rodríguez-Berrocal, Mar Rodríguez-Girondo, Manel Esteller, Joaquín Cubiella, Luis Bujanda, Antoni Castells, Francesc Balaguer, Rodrigo Jover and Loretta De Chiara

    Citation: Clinical Epigenetics 2018 10:53

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  12. Content type: Research

    Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause de...

    Authors: Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Ryuji Ishikawa, Takeharu Kanazawa and Hiroyuki Mineta

    Citation: Clinical Epigenetics 2018 10:52

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  13. Content type: Research

    The prevalence of respiratory allergy in children is increasing. Epigenetic DNA methylation changes are plausible underlying molecular mechanisms.

    Authors: Sabine A. S. Langie, Matthieu Moisse, Katarzyna Szarc vel Szic, Ellen Van Der Plas, Gudrun Koppen, Sofie De Prins, Tijs Louwies, Vera Nelen, Guy Van Camp, Diether Lambrechts, Greet Schoeters, Wim Vanden Berghe and Patrick De Boever

    Citation: Clinical Epigenetics 2018 10:50

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  14. Content type: Research

    Breast cancer is the most frequent cancer among women worldwide. Biomarkers for early detection and prognosis of these patients are needed. We hypothesized that deafness, autosomal dominant 5 (DFNA5) may be a val...

    Authors: Lieselot Croes, Matthias Beyens, Erik Fransen, Joe Ibrahim, Wim Vanden Berghe, Arvid Suls, Marc Peeters, Patrick Pauwels, Guy Van Camp and Ken Op de Beeck

    Citation: Clinical Epigenetics 2018 10:51

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  15. Content type: Research

    The etiology and pathogenesis of pre-eclampsia (PE) is unclear, and there is no ideal early clinical biomarker for prediction of PE. The competing endogenous RNA (ceRNA) hypothesis is a new approach to uncover...

    Authors: Xiaopeng Hu, Junping Ao, Xinyue Li, Huijuan Zhang, Ji Wu and Weiwei Cheng

    Citation: Clinical Epigenetics 2018 10:48

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  16. Content type: Research

    The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential role of H19 and its clinical significance in acute myeloid leukemia (AML) remain largely elusive.

    Authors: Ting-juan Zhang, Jing-dong Zhou, Wei Zhang, Jiang Lin, Ji-chun Ma, Xiang-mei Wen, Qian Yuan, Xi-xi Li, Zi-jun Xu and Jun Qian

    Citation: Clinical Epigenetics 2018 10:47

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  17. Content type: Research

    The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constit...

    Authors: Tomi Akinyemiju, Anh N. Do, Amit Patki, Stella Aslibekyan, Degui Zhi, Bertha Hidalgo, Hemant K. Tiwari, Devin Absher, Xin Geng, Donna K. Arnett and Marguerite R. Irvin

    Citation: Clinical Epigenetics 2018 10:49

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  18. Content type: Review

    Monosomy of the X chromosome is the most frequent genetic abnormality in human as it is present in approximately 2% of all conceptions, although 99% of these embryos are spontaneously miscarried. In postnatal ...

    Authors: Francisco Álvarez-Nava and Roberto Lanes

    Citation: Clinical Epigenetics 2018 10:45

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  19. Content type: Research

    Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have be...

    Authors: Elaheh Rahbar, Charlotte Mae K. Waits, Edward H. Kirby Jr., Leslie R. Miller, Hannah C. Ainsworth, Tao Cui, Susan Sergeant, Timothy D. Howard, Carl D. Langefeld and Floyd H. Chilton

    Citation: Clinical Epigenetics 2018 10:46

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  20. Content type: Research

    Kidney cancer and clear cell renal carcinoma (ccRCC) are the 16th most common cause of death worldwide. ccRCC is often metastasized at diagnosis, and surgery remains the main treatment; therefore, early diagno...

    Authors: Elisa Cocco, Manuela Leo, Claudia Canzonetta, Serena Di Vito, Antonello Mai, Dante Rotili, Arianna Di Napoli, Andrea Vecchione, Cosimo De Nunzio, Patrizia Filetici and Antonella Stoppacciaro

    Citation: Clinical Epigenetics 2018 10:44

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  21. Content type: Research

    To identify aberrant promoter methylation of genomic loci encoding microRNA (mgmiR) in head and neck squamous cell carcinoma (HNSCC) and to evaluate a biomarker panel of mgmiRs to improve the diagnostic accura...

    Authors: Yu Cao, Katherine Green, Steve Quattlebaum, Ben Milam, Ling Lu, Dexiang Gao, Hui He, Ningning Li, Liwei Gao, Francis Hall, Matthew Whinery, Elyse Handley, Yi Ma, Tao Xu, Feng Jin, Jing Xiao…

    Citation: Clinical Epigenetics 2018 10:43

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  22. Content type: Research

    DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain contro...

    Authors: Ming-En Lin, Hsin-An Hou, Cheng-Hong Tsai, Shang-Ju Wu, Yuan-Yeh Kuo, Mei-Hsuan Tseng, Ming-Chih Liu, Chia-Wen Liu, Wen-Chien Chou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Chi-Cheng Li, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu…

    Citation: Clinical Epigenetics 2018 10:42

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