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  1. DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradat...

    Authors: Stine H. Kresse, Sara Brandt-Winge, Heidi Pharo, Bjørnar T. B. Flatin, Marine Jeanmougin, Hege Marie Vedeld and Guro E. Lind
    Citation: Clinical Epigenetics 2023 15:151
  2. Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigene...

    Authors: Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun and Heather J. Lee
    Citation: Clinical Epigenetics 2023 15:150
  3. Aortic stenosis (AS) is one of the most common cardiac diseases and major cause of morbidity and mortality in the elderly. Transcatheter aortic valve implantation (TAVI) is performed in such patients with symp...

    Authors: Leon Kanwischer, Xingbo Xu, Afifa Binta Saifuddin, Sabine Maamari, Xiaoying Tan, Fouzi Alnour, Björn Tampe, Thomas Meyer, Michael Zeisberg, Gerd Hasenfuss, Miriam Puls and Elisabeth M. Zeisberg
    Citation: Clinical Epigenetics 2023 15:149
  4. Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec...

    Authors: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci…
    Citation: Clinical Epigenetics 2023 15:148
  5. Blood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often utilize samples which have been cryopreserved for years or even decad...

    Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Patricia T. Kin, Ngiap Chuan Tan, Hai-Yang Law and Ann S. G. Lee
    Citation: Clinical Epigenetics 2023 15:147
  6. Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, an...

    Authors: Bing Liang, Yanhong Wang, Jiazhen Xu, Yingchun Shao and Dongming Xing
    Citation: Clinical Epigenetics 2023 15:146
  7. Epigenetic mechanisms are informational cellular processes instructing normal and diseased phenotypes. They are associated with DNA but without altering the DNA sequence. Whereas chemical processes like DNA me...

    Authors: Reiner Siebert, Ole Ammerpohl, Mirko Rossini, Dennis Herb, Sven Rau, Martin B. Plenio, Fedor Jelezko and Joachim Ankerhold
    Citation: Clinical Epigenetics 2023 15:145
  8. First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormaliti...

    Authors: Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith and Francesco Beguinot
    Citation: Clinical Epigenetics 2023 15:144
  9. Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.

    Authors: Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden…
    Citation: Clinical Epigenetics 2023 15:142
  10. Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We...

    Authors: Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman…
    Citation: Clinical Epigenetics 2023 15:131
  11. Vitamin D might have anti-tumor effect, which is affected by the genes related to vitamin D metabolic pathway. Epigenetic mechanism may affect the expression level of vitamin D metabolic pathway related genes,...

    Authors: Yi-Fan Wang, Lei Li, Xue-Qing Deng, Yu-Jing Fang and Cai-Xia Zhang
    Citation: Clinical Epigenetics 2023 15:140
  12. Aberrant DNA methylation occurs commonly during pathogenesis of neuroimmunological diseases and is of clinical value in various encephalitis subtypes. However, knowledge of the impact of DNA methylation change...

    Authors: Shan Qiao, Quanye Sun, Haiyun Li, Jie Yin, Aihua Wang and Shanchao Zhang
    Citation: Clinical Epigenetics 2023 15:139
  13. The pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach for small amounts of DNA. Evaluation of the pooled sample method in epigenomic studies...

    Authors: Shota Nishitani, Takashi X. Fujisawa, Akiko Yao, Shinichiro Takiguchi and Akemi Tomoda
    Citation: Clinical Epigenetics 2023 15:138
  14. Gestational diabetes mellitus (GDM), characterized by hyperglycemia that develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and cardiometabolic disorders later in life. This p...

    Authors: Isma’il Kadam, Mudar Dalloul, Jeanette Hausser, Monique Huntley, Lori Hoepner, Lawrence Fordjour, Joan Hittelman, Anjana Saxena, Jia Liu, Itamar D. Futterman, Howard Minkoff and Xinyin Jiang
    Citation: Clinical Epigenetics 2023 15:137
  15. The onset of puberty is associated with a shift in the circadian timing of sleep, leading to delayed sleep initiation [i.e., later sleep onset time (SOT)] due to later bedtimes and/or longer sleep onset latenc...

    Authors: Michael Larsen, Fan He, Yuka Imamura Kawasawa, Arthur Berg, Alexandros N. Vgontzas, Duanping Liao, Edward O. Bixler and Julio Fernandez-Mendoza
    Citation: Clinical Epigenetics 2023 15:136
  16. Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence...

    Authors: Yunfeng Liu, Lucy Sinke, Thomas H. Jonkman, Roderick C. Slieker, Erik W. van Zwet, Lucia Daxinger and Bastiaan T. Heijmans
    Citation: Clinical Epigenetics 2023 15:135
  17. Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using current methods. We developed a highly sensitive 5-hydroxymet...

    Authors: Jianming Shao, Shilpan Shah, Siddhartha Ganguly, Youli Zu, Chuan He and Zejuan Li
    Citation: Clinical Epigenetics 2023 15:134
  18. Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or...

    Authors: Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raúl F. Pérez, Sara López-Tamargo, Ana Díez-Borge, Juan J. Alba-Linares, Nerea González-del-Rey, Rocío G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virginia López, Teresa Morales-Ruiz, Rafael R. Ariza, Teresa Roldán-Arjona…
    Citation: Clinical Epigenetics 2023 15:133
  19. Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the biological mechanisms that regulate acetaminophen in the developing offsprin...

    Authors: Yijun Li, Xiumei Hong, Liming Liang, Xiaobin Wang and Christine Ladd-Acosta
    Citation: Clinical Epigenetics 2023 15:132
  20. An accurate and reproducible next-generation sequencing platform is essential to identify malignancy-related abnormal DNA methylation changes and translate them into clinical applications including cancer dete...

    Authors: Jin Sun, Mingyang Su, Jianhua Ma, Minjie Xu, Chengcheng Ma, Wei Li, Rui Liu, Qiye He and Zhixi Su
    Citation: Clinical Epigenetics 2023 15:130
  21. Stunting is a global health problem affecting hundreds of millions of children worldwide and contributing to 45% of deaths in children under the age of five. Current therapeutic interventions have limited effi...

    Authors: Kristyna Kupkova, Savera J. Shetty, Marilyn G. Pray-Grant, Patrick A. Grant, Rashidul Haque, William A. Petri Jr. and David T. Auble
    Citation: Clinical Epigenetics 2023 15:129
  22. DNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic age prediction in diagnostics or routine forensic casework requires appropriate laborator...

    Authors: Ewelina Pośpiech, Aleksandra Pisarek, Joanna Rudnicka, Rezvan Noroozi, Michał Boroń, Aleksander Masny, Bożena Wysocka, Kamila Migacz-Gruszka, Dagmara Lisman, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Maria Szargut, Joanna Dowejko, Kamila Stanisz, Julia Zacharczuk, Piotr Zieliński…
    Citation: Clinical Epigenetics 2023 15:128
  23. As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact offspring. A...

    Authors: Guilherme de Sena Brandine, Kenneth I. Aston, Timothy G. Jenkins and Andrew D. Smith
    Citation: Clinical Epigenetics 2023 15:127
  24. Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type and level of metal exposure and epigenetic changes in subjects e...

    Authors: Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova and Arsen Arakelyan
    Citation: Clinical Epigenetics 2023 15:126

    The Correction to this article has been published in Clinical Epigenetics 2023 15:143

  25. Screening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontli...

    Authors: Sofia Salta, João Lobo, Bruno Magalhães, Rui Henrique and Carmen Jerónimo
    Citation: Clinical Epigenetics 2023 15:125
  26. Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy. Currently, several novel targeted ...

    Authors: Guang Lu, Shikai Jin, Suwen Lin, Yuping Gong, Liwen Zhang, Jingwen Yang, Weiwei Mou and Jun Du
    Citation: Clinical Epigenetics 2023 15:124
  27. PAX1 gene methylation plays an important role in the development of cervical cancer. However, its prognostic value after radiotherapy for locally advanced cervical cancer is unknown, so this study aimed to invest...

    Authors: Xuanxuan Li, Huan Liu, Xue Zhou, Yangying Zhou, Yu Zhang, Yu-Ligh Liou, Manting Zeng and Hong Zhu
    Citation: Clinical Epigenetics 2023 15:123
  28. The potential for DNA methylation (DNAm) as an early marker for cardiovascular disease (CVD) and how such an association might differ by glycemic exposure has not been examined in type 1 diabetes, a population...

    Authors: Rachel G. Miller, Josyf C. Mychaleckyj, Suna Onengut-Gumuscu, Eleanor Feingold, Trevor J. Orchard and Tina Costacou
    Citation: Clinical Epigenetics 2023 15:122
  29. Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) ha...

    Authors: Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, Jérôme Bertherat, Guillaume Assié and Valentina Boeva
    Citation: Clinical Epigenetics 2023 15:121
  30. Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention. Altered methylation of ATP-binding cassette subfamily G member...

    Authors: Jialie Jin, Xiaojing Zhao, Chao Zhu, Mengxia Li, Jinxin Wang, Yao Fan, Chunlan Liu, Chong Shen and Rongxi Yang
    Citation: Clinical Epigenetics 2023 15:120
  31. Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detect...

    Authors: Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang and Xishan Wang
    Citation: Clinical Epigenetics 2023 15:119
  32. Pancreatic cancer is the most lethal cancer with a dismal prognosis mainly due to diagnosis at advanced stage and ineffective treatments. CA19-9 levels and computed tomography (CT) imaging are the main standar...

    Authors: María Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, María Teresa Cano, Elizabeth Inga-Saavedra, Rosa María Rodríguez-Alonso, Silvia Guil-Luna, María Auxiliadora Gómez-España, Antonio Rodríguez-Ariza and Enrique Aranda
    Citation: Clinical Epigenetics 2023 15:118
  33. Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in he...

    Authors: Ilse Vanhorebeek, Grégoire Coppens, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe
    Citation: Clinical Epigenetics 2023 15:116
  34. Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association...

    Authors: Xian Shi, Minghan Qu, Yi Jiang, Ziwei Zhu, Chengguqiu Dai, Minghui Jiang, Lin Ding, Yu Yan, Chaolong Wang, Xiaomin Zhang, Shanshan Cheng and Xingjie Hao
    Citation: Clinical Epigenetics 2023 15:115
  35. DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that ca...

    Authors: Kristine L. Haftorn, Julia Romanowska, Yunsung Lee, Christian M. Page, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur and William R. P. Denault
    Citation: Clinical Epigenetics 2023 15:114
  36. To systematically evaluate the efficacy and safety of FDA-approved isocitrate dehydrogenase (IDH) inhibitors in the treatment of IDH-mutated acute myeloid leukemia (AML).

    Authors: Xiu Chen, Hongyun Xing, Xiaolu Xie, Liqiu Kou, Jun Li and Yaling Li
    Citation: Clinical Epigenetics 2023 15:113
  37. The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persisten...

    Authors: Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zsófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Brossart…
    Citation: Clinical Epigenetics 2023 15:112
  38. Biomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide stu...

    Authors: Katleen Janssens, Isabelle Neefs, Joe Ibrahim, Anne Schepers, Patrick Pauwels, Marc Peeters, Guy Van Camp and Ken Op de Beeck
    Citation: Clinical Epigenetics 2023 15:111
  39. An adverse intrauterine or periconceptional environment, such as hyperglycemia during pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this study, we explored the epige...

    Authors: Teresa Linares-Pineda, Nerea Peña-Montero, Nicolás Fragoso-Bargas, Carolina Gutiérrez-Repiso, Fuensanta Lima-Rubio, María Suarez-Arana, Antonio Sánchez-Pozo, Francisco J. Tinahones, María Molina-Vega, María José Picón-César, Christine Sommer and Sonsoles Morcillo
    Citation: Clinical Epigenetics 2023 15:110
  40. With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use in pregnancy is rapidly increasing. Howev...

    Authors: Lyndsey E. Shorey-Kendrick, Victoria H. J. Roberts, Rahul J. D’Mello, Elinor L. Sullivan, Susan K. Murphy, Owen J. T. Mccarty, Danny J. Schust, Jason C. Hedges, A. J. Mitchell, Jose Juanito D. Terrobias, Charles A. Easley IV, Eliot R. Spindel and Jamie O. Lo
    Citation: Clinical Epigenetics 2023 15:104
  41. Alterations in DNA methylation (DNAm) have been reported to be a mechanism by which bariatric surgeries resulted in considerable metabolic improvements. Previous studies have mostly focused on change in DNAm f...

    Authors: Xiaoxiao Wen, Helena Palma-Gudiel, Guanhong Miao, Mingjing Chen, Zhiguang Huo, Hao Peng, Stephen Anton, Gang Hu, Ricky Brock, Phillip J. Brantley and Jinying Zhao
    Citation: Clinical Epigenetics 2023 15:108
  42. In utero exposure to maternal hyperglycemia has been associated with an increased risk for the development of chronic diseases in later life. These predispositions may be programmed by fetal DNA methylation (D...

    Authors: Amélie Taschereau, Kathrine Thibeault, Catherine Allard, Diana Juvinao-Quintero, Patrice Perron, Sharon M. Lutz, Luigi Bouchard and Marie-France Hivert
    Citation: Clinical Epigenetics 2023 15:107
  43. DNA methylation has previously been associated with ischemic stroke, but the specific genes and their functional roles in ischemic stroke remain to be determined. Here we aimed to identify differentially methy...

    Authors: Hao Peng, Helena Palma-Gudiel, Carolina Soriano-Tarraga, Jordi Jimenez-Conde, Mingzhi Zhang, Yonghong Zhang and Jinying Zhao
    Citation: Clinical Epigenetics 2023 15:106
  44. Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylat...

    Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost and Wolfgang Wagner
    Citation: Clinical Epigenetics 2023 15:105

    The Correction to this article has been published in Clinical Epigenetics 2023 15:117

  45. The Dutch population-based cervical cancer screening programme (PBS) consists of primary high-risk human papilloma virus (hrHPV) testing with cytology as triage test. In addition to cervical scraping by a gene...

    Authors: J. de Waard, A. Bhattacharya, M. T. de Boer, B. M. van Hemel, M. D. Esajas, K. M. Vermeulen, G. H. de Bock, E. Schuuring and G. B. A. Wisman
    Citation: Clinical Epigenetics 2023 15:103