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  1. Recurrence represents a well-known poor prognostic factor for colorectal cancer (CRC) patients. This study aimed to establish an effective prognostic prediction model based on noninvasive circulating tumor DNA...

    Authors: Xin Yang, Xiaofeng Wen, Qin Guo, Yunfeng Zhang, Zhenxing Liang, Qian Wu, Zhihao Li, Weimei Ruan, Zhujia Ye, Hong Wang, Zhiwei Chen, Jian-Bing Fan, Ping Lan, Huashan Liu and Xianrui Wu
    Citation: Clinical Epigenetics 2022 14:160
  2. The epigenetic regulation of the renin–angiotensin–aldosterone system (RAAS) potentially plays a role in the pathophysiology underlying the high burden of hypertension in sub-Saharan Africans (SSA). Here we re...

    Authors: Eva L. van der Linden, Adrienne Halley, Karlijn A. C. Meeks, Felix Chilunga, Charles Hayfron-Benjamin, Andrea Venema, Ingrid M. Garrelds, A. H. Jan Danser, Bert-Jan van den Born, Peter Henneman and Charles Agyemang
    Citation: Clinical Epigenetics 2022 14:159
  3. Epigenome-wide association studies (EWAS) have helped to define the associations between DNA methylation and many clinicopathologic and developmental traits. Since DNA methylation is affected by genetic variat...

    Authors: Shaobo Li, Nicholas Mancuso, Catherine Metayer, Xiaomei Ma, Adam J. de Smith and Joseph L. Wiemels
    Citation: Clinical Epigenetics 2022 14:158
  4. High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiv...

    Authors: Katarzyna Ewa Sokolowska, Dominika Maciejewska-Markiewicz, Jan Bińkowski, Joanna Palma, Olga Taryma-Leśniak, Katarzyna Kozlowska-Petriczko, Konrad Borowski, Magdalena Baśkiewicz-Hałasa, Viktoria Hawryłkowicz, Patrycja Załęcka, Marcin Ufnal, Dominik Strapagiel, Justyna Jarczak, Karolina Skonieczna-Żydecka, Karina Ryterska, Bogusław Machaliński…
    Citation: Clinical Epigenetics 2022 14:157
  5. The protocadherin proteins are cell adhesion molecules at the crossroad of signaling pathways playing a major role in neuronal development. It is now understood that their role as signaling hubs is not only im...

    Authors: Arnaud Carrier, Cécile Desjobert, Valérie Lobjois, Lise Rigal, Florence Busato, Jörg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo and Joëlle Riond
    Citation: Clinical Epigenetics 2022 14:156
  6. Smoking and alcohol consumption may compromise health by way of epigenetic modifications. Epigenetic signatures of alcohol and tobacco consumption could provide insights into the reversibility of phenotypic ch...

    Authors: Jonviea D. Chamberlain, Sébastien Nusslé, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E. Harris, Janie Corley, Simon R. Cox and Semira Gonseth Nusslé
    Citation: Clinical Epigenetics 2022 14:155
  7. DNA methylation is an important epigenetic mechanism that regulates gene expression. To date, most DNA methylation studies have focussed on CpG islands in the gene promoter region, and the mechanism of methyla...

    Authors: Qi Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Junsheng Chen, Bing Wang and Yongjun Chen
    Citation: Clinical Epigenetics 2022 14:154
  8. Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into p...

    Authors: Verônica Euclydes, Catarina Gomes, Gisele Gouveia, Vinicius Daguano Gastaldi, Arthur Sant’Anna Feltrin, Caroline Camilo, Rossana Pulcineli Vieira, Aloísio Felipe-Silva, Sandra Grisi, Günther Fink, Alexandra Brentani and Helena Brentani
    Citation: Clinical Epigenetics 2022 14:152
  9. Children born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined wh...

    Authors: Ellen Ø. Carlsen, Yunsung Lee, Per Magnus, Astanand Jugessur, Christian M. Page, Haakon E. Nustad, Siri E. Håberg, Rolv T. Lie and Maria C. Magnus
    Citation: Clinical Epigenetics 2022 14:151
  10. Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV te...

    Authors: Chiara Herzog, Karin Sundström, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner…
    Citation: Clinical Epigenetics 2022 14:150
  11. Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a lack of characteristic molecular or histomorphological hallmarks. A DNA ...

    Authors: Siyer Roohani, Felix Ehret, Eilís Perez, David Capper, Armin Jarosch, Anne Flörcken, Sven Märdian, Daniel Zips and David Kaul
    Citation: Clinical Epigenetics 2022 14:149
  12. The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly understo...

    Authors: Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau…
    Citation: Clinical Epigenetics 2022 14:148
  13. Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-s...

    Authors: Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma and Ryuji Hamamoto
    Citation: Clinical Epigenetics 2022 14:147
  14. Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern depending on parental origin. In humans, congenital imprinting disruptions resulting from genetic or epigenetic mechanisms ...

    Authors: Yunqi Chao, Yifang Qin, Xinyi Zou, Xiangzhi Wang, Chenxi Hu, Fangling Xia and Chaochun Zou
    Citation: Clinical Epigenetics 2022 14:146
  15. Epigenetics includes a complex set of processes that alter gene activity without modifying the DNA sequence, which ultimately determines how the genetic information common to all the cells of an organism is us...

    Authors: Giulia Robusti, Alessandro Vai, Tiziana Bonaldi and Roberta Noberini
    Citation: Clinical Epigenetics 2022 14:145
  16. Imprinting disorders, which affect growth, development, metabolism and neoplasia risk, are caused by genetic or epigenetic changes to genes that are expressed from only one parental allele. Disease may result ...

    Authors: Deborah Mackay, Jet Bliek, Masayo Kagami, Jair Tenorio-Castano, Arrate Pereda, Frédéric Brioude, Irène Netchine, Dzhoy Papingi, Elisa de Franco, Margaret Lever, Julie Sillibourne, Paola Lombardi, Véronique Gaston, Maithé Tauber, Gwenaelle Diene, Eric Bieth…
    Citation: Clinical Epigenetics 2022 14:143
  17. Arterial hypertension represents a worldwide health burden and a major risk factor for cardiovascular morbidity and mortality. Hypertension can be primary (primary hypertension, PHT), or secondary to endocrine...

    Authors: Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo…
    Citation: Clinical Epigenetics 2022 14:142
  18. Cryopreservation has important application in assisted reproductive technology (ART). The vitrification technique has been widely used in the cryopreservation of oocytes and embryos, as a large number of clini...

    Authors: Huanhuan Chen, Lei Zhang, Li Meng, Linlin Liang and Cuilian Zhang
    Citation: Clinical Epigenetics 2022 14:141
  19. Epigenome-wide association studies (EWAS) assessing the link between DNA methylation (DNAm) and phenotypes related to structural brain measures, cognitive function, and neurodegenerative diseases are becoming ...

    Authors: Yasmine Sommerer, Olena Ohlei, Valerija Dobricic, Derek H. Oakley, Tanja Wesse, Sanaz Sedghpour Sabet, Ilja Demuth, Andre Franke, Bradley T. Hyman, Christina M. Lill and Lars Bertram
    Citation: Clinical Epigenetics 2022 14:139
  20. Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been increasingly identified to be associated with tumor...

    Authors: Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang and Liang Tao
    Citation: Clinical Epigenetics 2022 14:138
  21. Aberrant epigenetic modifications such as DNA methylation may contribute to the pathogenesis of DR. We aimed at elucidating the role of novel DNA methylation modifications in diabetic retinopathy (DR) in patie...

    Authors: Shaopeng Yang, Xiao Guo, Weijing Cheng, Ishith Seth, Gabriella Bulloch, Yifan Chen, Xianwen Shang, Zhuoting Zhu, Wenyong Huang and Wei Wang
    Citation: Clinical Epigenetics 2022 14:137
  22. Identifying blood-based DNA methylation patterns is a minimally invasive way to detect biomarkers in predicting age, characteristics of certain diseases and conditions, as well as responses to immunotherapies....

    Authors: Emily Tang, John K. Wiencke, Gayathri Warrier, Helen Hansen, Lucie McCoy, Terri Rice, Paige M. Bracci, Margaret Wrensch, Jennie W. Taylor, Jennifer L. Clarke, Devin C. Koestler, Lucas A. Salas, Brock C. Christensen, Karl T. Kelsey and Annette M. Molinaro
    Citation: Clinical Epigenetics 2022 14:136
  23. Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in brea...

    Authors: Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang and Ze-fang Ren
    Citation: Clinical Epigenetics 2022 14:135
  24. Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied ...

    Authors: Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs Jr., Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:134
  25. Penile cancer is one of the most aggressive male tumors. Although it is preventable, the main etiologic causes are lifestyle behaviors and viral infection, such as human papillomavirus (HPV). Long-term epigene...

    Authors: Renan da Silva Santos, Carlos Gustavo Hirth, Daniel Pascoalino Pinheiro, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Manoel Odorico de Moraes Filho, Arlindo de Alencar Araripe Moura, Marcos Venício Alves Lima, Claudia do Ó Pessoa and Cristiana Libardi Miranda Furtado
    Citation: Clinical Epigenetics 2022 14:133
  26. The associations between blood lipids and DNA methylation have been investigated in epigenome-wide association studies mainly among European ancestry populations. Several studies have explored the direction of...

    Authors: Zhiyu Wu, Lu Chen, Xuanming Hong, Jiahui Si, Weihua Cao, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Yu Guo…
    Citation: Clinical Epigenetics 2022 14:132
  27. Epigenetics exerts a vital role in the onset and development of renal cell carcinoma (RCC). Mounting evidence has shed light on the significance of human immune system in response to tumor infiltrating T cells...

    Authors: Shu-cheng Liu, Li-bo Chen, Ping-feng Chen, Meng-long Huang, Tian-pei Liu, Jun Peng and Xin-sheng Lu
    Citation: Clinical Epigenetics 2022 14:131
  28. Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA...

    Authors: Hannah R. Elliott, Kimberley Burrows, Josine L. Min, Therese Tillin, Dan Mason, John Wright, Gillian Santorelli, George Davey Smith, Deborah A. Lawlor, Alun D. Hughes, Nishi Chaturvedi and Caroline L. Relton
    Citation: Clinical Epigenetics 2022 14:130
  29. Alterations in the epigenome are a risk factor in multiple disease states. We have demonstrated in the past that disruption of the epigenome during early pregnancy or periconception, as demonstrated by altered...

    Authors: Andrey V. Dolinko, Bryant M. Schultz, Jayashri Ghosh, Charikleia Kalliora, Monica Mainigi, Christos Coutifaris, Carmen Sapienza and Suneeta Senapati
    Citation: Clinical Epigenetics 2022 14:129
  30. Cri du chat (also called 5p deletion, or monosomy 5p) syndrome is a genetic disease caused by deletions of various lengths in the short (p) arm of chromosome 5. Genetic analysis and phenotyping have been used ...

    Authors: Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl and Arne Søraas
    Citation: Clinical Epigenetics 2022 14:128
  31. Arteriovenous malformation (AVM) is a tangle of arteries and veins, rupture of which can result in catastrophic hemorrhage in vulnerable sites such as the brain. Cerebral AVM is associated with a high mortalit...

    Authors: Jaya Mary Thomas, Dhakshmi Sasankan, Mathew Abraham, Sumi Surendran, Chandrasekharan C. Kartha and Arumugam Rajavelu
    Citation: Clinical Epigenetics 2022 14:127
  32. 5-Hydroxymethylcytosine (5hmC), an important DNA epigenetic modification, plays a vital role in tumorigenesis, progression and prognosis in many cancers. Diffuse large B cell lymphoma (DLBCL) can involve almos...

    Authors: Ye Shen, Jinping Ou, Bo He, Jinmin Yang, Huihui Liu, Lihong Wang, Bingjie Wang, Liang Gao, Chengqi Yi, Jinying Peng and Xinan Cen
    Citation: Clinical Epigenetics 2022 14:126
  33. Phthalates and bisphenols are non-persistent endocrine disrupting chemicals that are ubiquitously present in our environment and may have long-lasting health effects following fetal exposure. A potential mecha...

    Authors: Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix and Leonardo Trasande
    Citation: Clinical Epigenetics 2022 14:125
  34. The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in ...

    Authors: Natalia Cullell, Carolina Soriano-Tárraga, Cristina Gallego-Fábrega, Jara Cárcel-Márquez, Elena Muiño, Laia Llucià-Carol, Miquel Lledós, Manel Esteller, Manuel Castro de Moura, Joan Montaner, Anna Rosell, Pilar Delgado, Joan Martí-Fábregas, Jerzy Krupinski, Jaume Roquer, Jordi Jiménez-Conde…
    Citation: Clinical Epigenetics 2022 14:124
  35. High-altitude (HA, 2500 m) hypoxic exposure evokes a multitude of physiological processes. The hypoxia-sensing genes though influence transcriptional output in disease susceptibility; the exact regulatory mech...

    Authors: Kavita Sharma, Aastha Mishra, Himanshu Singh, Tashi Thinlas and M. A. Qadar Pasha
    Citation: Clinical Epigenetics 2022 14:123
  36. DNA methylation-regulated genes have been demonstrated as the crucial participants in the occurrence of coronary heart disease (CHD). The machine learning based on DNA methylation-regulated genes has tremendou...

    Authors: Xiaokang Zhang, Chen Wang, Dingdong He, Yating Cheng, Li Yu, Daoxi Qi, Boyu Li and Fang Zheng
    Citation: Clinical Epigenetics 2022 14:122
  37. Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD). DNAm surrogate of exposures predict...

    Authors: Andrea Cappozzo, Cathal McCrory, Oliver Robinson, Anna Freni Sterrantino, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Licia Iacoviello, Fulvio Ricceri, Sabina Sieri, Paolo Chiodini, Gareth J. McKay, Amy Jayne McKnight, Frank Kee, Ian S. Young…
    Citation: Clinical Epigenetics 2022 14:121
  38. There has been extensive scrutiny of cancer driving mutations within the exome (especially amino acid altering mutations) as these are more likely to have a clear impact on protein functions, and thus on cell ...

    Authors: Michael Pudjihartono, Jo K. Perry, Cris Print, Justin M. O’Sullivan and William Schierding
    Citation: Clinical Epigenetics 2022 14:120
  39. Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi…
    Citation: Clinical Epigenetics 2022 14:119

    The original article was published in Clinical Epigenetics 2019 11:68

  40. Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed to...

    Authors: Peilong Li, Shibiao Liu, Lutao Du, Ghazal Mohseni, Yi Zhang and Chuanxin Wang
    Citation: Clinical Epigenetics 2022 14:118
  41. DNA 5-hydroxymethylcytosine (5hmC) is produced by dynamic 5mC oxidation process contributing to tissue specification, and loss of 5hmC has been reported in multiple cancers including genitourinary cancers. How...

    Authors: Jie Qi, Yue Shi, Yezhen Tan, Qi Zhang, Jianye Zhang, Jilu Wang, Cong Huang and Weimin Ci
    Citation: Clinical Epigenetics 2022 14:117
  42. Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identif...

    Authors: Cora Palanca-Ballester, David Hervas, Maria Villalba, Teresa Valdes-Sanchez, Diana Garcia, Maria Isabel Alcoriza-Balaguer, Marta Benet, Raquel Martinez-Tomas, Andres Briones-Gomez, Jose Galbis-Caravajal, Alfonso Calvo, Oscar Juan, Agustin Lahoz, Enrique Cases and Juan Sandoval
    Citation: Clinical Epigenetics 2022 14:116
  43. Cystoscopy is the gold standard for bladder cancer detection, but is costly, invasive and has imperfect diagnostic accuracy. We aimed to identify novel and accurate DNA methylation biomarkers for non-invasive ...

    Authors: Heidi Dietrichson Pharo, Marine Jeanmougin, Eirill Ager-Wick, Hege Marie Vedeld, Anne Klara Sørbø, Christina Dahl, Louise Katrine Larsen, Hilde Honne, Sara Brandt-Winge, May-Britt Five, Sara Monteiro-Reis, Rui Henrique, Carmen Jeronimo, Kenneth Steven, Rolf Wahlqvist, Per Guldberg…
    Citation: Clinical Epigenetics 2022 14:115
  44. DNA methylation (DNAm) is considered a plausible pathway through which genetic and environmental factors may influence the development of allergies. However, causality has yet to be determined as it is unknown...

    Authors: Anna Kilanowski, Simon Kebede Merid, Sarina Abrishamcar, Dakotah Feil, Elisabeth Thiering, Melanie Waldenberger, Erik Melén, Annette Peters, Marie Standl and Anke Hüls
    Citation: Clinical Epigenetics 2022 14:114
  45. Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place the important epigenetic mark 5-methyl-2’-deoxycytidine by methylating 2’-deoxycytidine (...

    Authors: Tina Aumer, Constanze B. Gremmelmaier, Leander S. Runtsch, Johannes C. Pforr, G. Nur Yeşiltaç, Stefanie Kaiser and Franziska R. Traube
    Citation: Clinical Epigenetics 2022 14:113
  46. Despite clinical relevance of immunological activation due to histone leakage into the serum following cardiac surgery, long-term data describing their longitudinal dynamic are lacking. Therefore, this study e...

    Authors: Krzysztof Laudanski, Da Liu, Jihane Hajj, Danyal Ghani and Wilson Y. Szeto
    Citation: Clinical Epigenetics 2022 14:112
  47. The novel long noncoding RNA MEF2C-AS1 has been identified to play suppressor roles during tumorigenesis. DNA methylation has a regulatory effect on gene expression in cancer initiation and progression. However, ...

    Authors: Sangni Qian, Shujuan Lin, Xin Xu, Hao Bai, Aibuta Yeerken, Xiaojiang Ying, Zhenjun Li, Xinglin Fei, Jinhua Yang, Mengling Tang, Jianbing Wang, Mingjuan Jin and Kun Chen
    Citation: Clinical Epigenetics 2022 14:111