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Research
Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigeneti...
Clinical Epigenetics 2017 9:87
Published on: 17 August 2017
Research
Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...
Clinical Epigenetics 2017 9:86
Published on: 15 August 2017
Research
Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagno...
Clinical Epigenetics 2017 9:85
Published on: 15 August 2017
Research
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variat...
Clinical Epigenetics 2017 9:84
Published on: 15 August 2017
Research
Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) du...
Clinical Epigenetics 2017 9:83
Published on: 14 August 2017
Research
Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin ...
Clinical Epigenetics 2017 9:82
Published on: 11 August 2017
Research
Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the role of smoking in the development and progress of periodont...
Clinical Epigenetics 2017 9:81
Published on: 10 August 2017
Research
The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprog...
Clinical Epigenetics 2017 9:80
Published on: 8 August 2017
Research
Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findi...
Clinical Epigenetics 2017 9:79
Published on: 3 August 2017
Review
Systemic lupus erythematosus (SLE) is a chronic relapsing–remitting autoimmune disease with highly heterogeneous phenotypes. Biomarkers with high sensitivity and specificity are useful for early diagnosis as w...
Clinical Epigenetics 2017 9:78
Published on: 2 August 2017
Research
Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate th...
Clinical Epigenetics 2017 9:77
Published on: 2 August 2017
Erratum
Clinical Epigenetics 2017 9:76
Published on: 27 July 2017
The original article was published in Clinical Epigenetics 2017 9:25
Methodology
Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the ...
Clinical Epigenetics 2017 9:75
Published on: 25 July 2017
Research
Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12...
Clinical Epigenetics 2017 9:74
Published on: 24 July 2017
Research
Most DNA cancer methylation markers are based on the transcriptional regulation of the promoter-gene relationship. Recently, the importance of long-range interactions between distal CpGs and target genes has b...
Clinical Epigenetics 2017 9:73
Published on: 24 July 2017
Research
The aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopatholog...
Clinical Epigenetics 2017 9:72
Published on: 21 July 2017
Research
Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA...
Clinical Epigenetics 2017 9:71
Published on: 18 July 2017
Methodology
The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic ma...
Clinical Epigenetics 2017 9:70
Published on: 14 July 2017
Methodology
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could not only represent useful biomarkers but also suggest possible targetable ...
Clinical Epigenetics 2017 9:69
Published on: 11 July 2017
Research
The BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critic...
Clinical Epigenetics 2017 9:68
Published on: 30 June 2017
Review
Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and ...
Clinical Epigenetics 2017 9:67
Published on: 29 June 2017
Research
Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...
Clinical Epigenetics 2017 9:66
Published on: 21 June 2017
Research
Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...
Clinical Epigenetics 2017 9:65
Published on: 13 June 2017
Research
This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 ex...
Clinical Epigenetics 2017 9:64
Published on: 12 June 2017
Research
Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, co...
Clinical Epigenetics 2017 9:62
Published on: 8 June 2017
