Articles

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce gene...

Authors: Youssef Siblini, Céline Chéry, Pierre Rouyer, Jérémie Raso, Amélia Julien, Sébastien Hergalant, Aurélie François, Lina Bezdetnaya, Guillaume Vogin, Jean-Louis Guéant and Abderrahim Oussalah

Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature

Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated ...

Authors: U. Schagdarsurengin, C. Luo, H. Slanina, D. Sheridan, S. Füssel, N. Böğürcü-Seidel, S. Gattenloehner, G. B. Baretton, L. C. Hofbauer, F. Wagenlehner and T. Dansranjav

Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy

The thymic microenvironment is mainly comprised of thymic epithelial cells, the cytokines, exosomes, surface molecules, and hormones from the cells, and plays a vital role in the development, differentiation, ...

Authors: Cexun Hu, Keyu Zhang, Feng Jiang, Hui Wang and Qixiang Shao

Correction to: Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS‑CoV‑2 infectivity

Authors: Maria Laura Saiz, Marta L. DeDiego, Darío López-García, Viviana Corte-Iglesias, Aroa Baragaño-Raneros, Ivan Astola, Victor Asensi, Carlos López-Larrea and Beatriz Suarez-Alvarez

Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals

Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...

Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Brent A. Coull, Andrea A. Baccarelli, Robert O. Wright, Chitra Amarasiriwardena, Diane R. Gold, Emily Oken, Marie-France Hivert and Andres Cardenas

Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients

A shift in the proportions of blood immune cells is a hallmark of cancer development. Here, we investigated whether methylation-derived immune cell type ratios and methylation-derived neutrophil-to-lymphocyte ...

Authors: Mehdi Manoochehri, Thomas Hielscher, Nasim Borhani, Clarissa Gerhäuser, Olivia Fletcher, Anthony J. Swerdlow, Yon-Dschun Ko, Hiltrud Brauch, Thomas Brüning and Ute Hamann

Epigenetic modelling of former, current and never smokers

DNA methylation (DNAm) performs excellently in the discrimination of current and former smokers from never smokers, where AUCs > 0.9 are regularly reported using a single CpG site (cg05575921; AHRR). However, the...

Authors: Ryan J. Langdon, Paul Yousefi, Caroline L. Relton and Matthew J. Suderman

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study

Hypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of early-life exposures and the development of cardiovascular risk facto...

Authors: Giulietta S. Monasso, Vincent W. V. Jaddoe, Leanne K. Küpers and Janine F. Felix

Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing

GGC repeat expansions in NOTCH2NLC are associated with neuronal intranuclear inclusion disease. Very recently, asymptomatic carriers with NOTCH2NLC repeat expansions were reported. In these asymptomatic individua...

Authors: Hiromi Fukuda, Daisuke Yamaguchi, Kristofor Nyquist, Yasushi Yabuki, Satoko Miyatake, Yuri Uchiyama, Kohei Hamanaka, Ken Saida, Eriko Koshimizu, Naomi Tsuchida, Atsushi Fujita, Satomi Mitsuhashi, Kazuyuki Ohbo, Yuki Satake, Jun Sone, Hiroshi Doi…

Epigenetic adaptations of the masticatory mucosa to periodontal inflammation

In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammat...

Authors: Gesa M. Richter, Jochen Kruppa, H. Gencay Keceli, Emel Tuğba Ataman-Duruel, Christian Graetz, Nicole Pischon, Gunar Wagner, Carsten Rendenbach, Yvonne Jockel-Schneider, Orlando Martins, Corinna Bruckmann, Ingmar Staufenbiel, Andre Franke, Rahime M. Nohutcu, Søren Jepsen, Henrik Dommisch…

Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one of the main contributing factors. Various tissues display sex differences in DNA methylation; how...

Authors: Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez-Romero, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Voisin and Nir Eynon

Chromatin accessibility analysis identifies GSTM1 as a prognostic marker in human glioblastoma patients

Glioblastoma (GBM) is a malignant human brain tumor that has an extremely poor prognosis. Classic mutations such as IDH (isocitrate dehydrogenase) mutations, EGFR (epidermal growth factor receptor) alternations, ...

Authors: Yin-Cheng Huang, Joseph Chieh-Yu Lai, Pei-Hua Peng, Kuo-Chen Wei and Kou-Juey Wu

DNA methylation of the KLK8 gene in depression symptomatology

Depression is a common, complex, and debilitating mental disorder estimated to be under-diagnosed and insufficiently treated in society. Liability to depression is influenced by both genetic and environmental ...

Authors: Anna Starnawska, Lina Bukowski, Ana Chernomorchenko, Betina Elfving, Heidi Kaastrup Müller, Edwin van den Oord, Karolina Aberg, Jerry Guintivano, Jakob Grove, Ole Mors, Anders D. Børglum, Anders L. Nielsen, Per Qvist and Nicklas Heine Staunstrup

H3K36 trimethylation-mediated biological functions in cancer

Histone modification is an important form of epigenetic regulation. Thereinto, histone methylation is a critical determination of chromatin states, participating in multiple cellular processes. As a conserved ...

Authors: Chu Xiao, Tao Fan, He Tian, Yujia Zheng, Zheng Zhou, Shuofeng Li, Chunxiang Li and Jie He

Validating biomarkers and models for epigenetic inference of alcohol consumption from blood

Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. Recently, DNA methylation-based inference of alcohol consumption from blood wa...

Authors: Silvana C. E. Maas, Athina Vidaki, Alexander Teumer, Ricardo Costeira, Rory Wilson, Jenny van Dongen, Marian Beekman, Uwe Völker, Hans J. Grabe, Sonja Kunze, Karl-Heinz Ladwig, Joyce B. J. van Meurs, André G. Uitterlinden, Trudy Voortman, Dorret I. Boomsma, P. Eline Slagboom…

Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers

5-Hydroxymethylcytosine (5hmC) is a significant DNA epigenetic modification. However, the 5hmC modification alterations in genomic regions encoding long non-coding RNA (lncRNA) and their clinical significance ...

Authors: Meng Zhou, Ping Hou, Congcong Yan, Lu Chen, Ke Li, Yiran Wang, Jingting Zhao, Jianzhong Su and Jie Sun

High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments

DNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutat...

Authors: Teoman Deger, Ruben G. Boers, Vanja de Weerd, Lindsay Angus, Marjolijn M. J. van der Put, Joachim B. Boers, Z. Azmani, Wilfred F. J. van IJcken, Dirk J. Grünhagen, Lisanne F. van Dessel, Martijn P. J. K. Lolkema, Cornelis Verhoef, Stefan Sleijfer, John W. M. Martens, Joost Gribnau and Saskia M. Wilting

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals

The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation i...

Authors: Yuqing Chen, Irfahan Kassam, Suk Hiang Lau, Jaspal S. Kooner, Rory Wilson, Annette Peters, Juliane Winkelmann, John C. Chambers, Vincent T. Chow, Chiea Chuen Khor, Rob M. van Dam, Yik-Ying Teo, Marie Loh and Xueling Sim

Correction to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology

Authors: Borja Sesé, Miquel Ensenyat-Mendez, Sandra Iñiguez, Pere Llinàs-Arias and Diego M. Marzese

Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA

Methylation analysis of circulating cell-free DNA (cirDNA), as a liquid biopsy, has a significant potential to advance the detection, prognosis, and treatment of cancer, as well as many genetic disorders. The ...

Authors: Mohammad Amin Kerachian, Marjan Azghandi, Sina Mozaffari-Jovin and Alain R. Thierry

SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis

To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We foun...

Authors: Moonmoon Deb, Dipranjan Laha, Jyotirindra Maity and Hiranmoy Das

Association of peripheral blood DNA methylation level with Alzheimer’s disease progression

Identifying biomarkers associated with Alzheimer’s disease (AD) progression may enable patient enrichment and improve clinical trial designs. Epigenome-wide association studies have revealed correlations betwe...

Authors: Qingqin S. Li, Aparna Vasanthakumar, Justin W. Davis, Kenneth B. Idler, Kwangsik Nho, Jeffrey F. Waring and Andrew J. Saykin

DNA methylation-based profiling reveals distinct clusters with survival heterogeneity in high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is the most common type of epigenetically heterogeneous ovarian cancer. Methylation typing has previously been used in many tumour types but not in HGSOC. Methylation t...

Authors: Jieyu Wang, Jun Li, Ruifang Chen, Huiran Yue, Wenzhi Li, Beibei Wu, Yang Bai, Guohua Zhu and Xin Lu

Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity

Authors: Jairo A. Pinzon Cortes and Assam El-Osta

Race/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study

Racial/ethnic disparities in health reflect a combination of genetic and environmental causes, and DNA methylation may be an important mediator. We compared in an exploratory manner the blood DNA methylome of ...

Authors: Min-Ae Song, Anna Eames Seffernick, Kellie J. Archer, Kellie M. Mori, Song-Yi Park, Linda Chang, Thomas Ernst, Maarit Tiirikainen, Karolina Peplowska, Lynne R. Wilkens, Loïc Le Marchand and Unhee Lim

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity

SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the ...

Authors: Maria Laura Saiz, Marta L. DeDiego, Darío López-García, Viviana Corte-Iglesias, Aroa Baragaño Raneros, Ivan Astola, Victor Asensi, Carlos López-Larrea and Beatriz Suarez-Alvarez

DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide. Various predi...

Authors: Yujing Xia, Alison Brewer and Jordana T. Bell

Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids

Lung cancer is the leading cause of cancer-related mortality. The alteration of DNA methylation plays a major role in the development of lung cancer. Methylation biomarkers become a possible method for lung ca...

Authors: Lei Li, Zhujia Ye, Sai Yang, Hao Yang, Jing Jin, Yingying Zhu, Jinsheng Tao, Siyu Chen, Jiehan Xu, Yanying Liu, Weihe Liang, Bo Wang, Mengzhu Yang, Qiaoyun Huang, Zhiwei Chen, Weimin Li…

DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status

Current clinical guidelines suggest that breast cancers with low hormone receptor expression (LowHR) in 1–10% of tumor cells should be regarded as hormone receptor positive. However, clinical data show that th...

Authors: Philipp Jurmeister, Karsten Weber, Sonia Villegas, Thomas Karn, Michael Untch, Anne Thieme, Volkmar Müller, Eliane Taube, Peter Fasching, Wolfgang D. Schmitt, Frederik Marmé, Elmar Stickeler, Bruno V. Sinn, Paul Jank, Christian Schem, Frederick Klauschen…

Investigating the DNA methylation profile of e-cigarette use

Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation...

Authors: Rebecca C. Richmond, Carlos Sillero-Rejon, Jasmine N. Khouja, Claire Prince, Alexander Board, Gemma Sharp, Matthew Suderman, Caroline L. Relton, Marcus Munafò and Suzanne H. Gage

Histone H3 lysine 27 acetylation profile undergoes two global shifts in undernourished children and suggests altered one-carbon metabolism

Stunting is a condition in which a child does not reach their full growth potential due to chronic undernutrition. It arises during the first 2 years of a child’s life and is associated with developmental defi...

Authors: Kristyna Kupkova, Savera J. Shetty, Rashidul Haque, William A. Petri Jr. and David T. Auble

Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal wo...

Authors: Lulu Wang, Zhenxing Mao, Xiaotian Liu, Dandan Wei, Pengling Liu, Luting Nie, Keliang Fan, Ning Kang, Yu Song, Qingqing Xu, Juan Wang, Mian Wang, Wei Liao, Tao Jing, Wenjie Li, Chongjian Wang…

Prenatal and postnatal traffic pollution exposure, DNA methylation in Shank3 and MeCP2 promoter regions, H3K4me3 and H3K27me3 and sociability in rats’ offspring

Road traffic air pollution is linked with an increased risk of autistic spectrum disorder (ASD). The aim of this study is to assess the effect of exposure to prenatal or postnatal traffic-related air pollution...

Authors: Qinfeng Zhou, Yu Tian, Chenlu Xu, Juling Wang and Yongtang Jin

Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers

Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our o...

Authors: Patrice Gallet, Abderrahim Oussalah, Celso Pouget, Gunnar Dittmar, Celine Chery, Guillaume Gauchotte, Roger Jankowski, Jean Louis Gueant and Rémi Houlgatte

Correction to: Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction

Authors: Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio and Daniela Furlan

Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes

Maternal smoking during pregnancy (MSDP) affects development of multiple organ systems including the placenta, lung, brain, and vasculature. In particular, children exposed to MSDP show lifelong deficits in pu...

Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Shannon M. O’Sullivan, Kristin Milner, Brittany Vuylsteke, Robert S. Tepper, David M. Haas, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel

DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker

Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the brain, and alterations to 5hmC in adult CNS tumors have been re...

Authors: Nasim Azizgolshani, Curtis L. Petersen, Youdinghuan Chen, Joshua J. Levy, Lucas A. Salas, Laurent Perreard, Lananh N. Nguyen and Brock C. Christensen

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance

Organoids or spheroids have emerged as a physiologically relevant in vitro preclinical model to study patient-specific diseases. A recent study used spheroids of MCF10 cells to model breast cancer progression ...

Authors: Jingwei Li, Kun Fang, Lavanya Choppavarapu, Ke Yang, Yini Yang, Junbai Wang, Ruifeng Cao, Ismail Jatoi and Victor X. Jin

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The search for new therapeutic targets is therefore essential. In addition to a wide panel of genetic mutations, epigenetic...

Authors: Laurie Herviou, Sara Ovejero, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva De Smedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien and Jérôme Moreaux

METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors

Thymic epithelial tumors (TETs) are rare neoplasms, originating from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined, and a deeper molecular characterization...

Authors: Alessia Iaiza, Claudia Tito, Zaira Ianniello, Federica Ganci, Valentina Laquintana, Enzo Gallo, Andrea Sacconi, Silvia Masciarelli, Luciana De Angelis, Sara Aversa, Daniele Diso, Marco Anile, Vincenzo Petrozza, Francesco Facciolo, Enrico Melis, Edoardo Pescarmona…

Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy

Pancreatic cancer is one of the lethal cancers among solid malignancies. Pathological diagnosis of surgical margins is sometimes unreliable due to tissue shrinkage, invisible field cancerization and skipped le...

Authors: Yuki Sunagawa, Masamichi Hayashi, Suguru Yamada, Hiroshi Tanabe, Keisuke Kurimoto, Nobutake Tanaka, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike and Yasuhiro Kodera

Prenatal risk factors and neonatal DNA methylation in very preterm infants

Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative...

Authors: Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O’Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. DellaGrotta, Carmen J. Marsit and Barry M. Lester

Cellular reprogramming and epigenetic rejuvenation

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing th...

Authors: Daniel J. Simpson, Nelly N. Olova and Tamir Chandra

Dynamics of epigenetic regulator gene BCOR mutation and response predictive value for hypomethylating agents in patients with myelodysplastic syndrome

BCOR (BCL6 corepressor) is an epigenetic regulator gene involved in the specification of cell differentiation and body structure development. Recurrent somatic BCOR mutations have been identified in myelodyspl...

Authors: Xiao Li, Feng Xu, Zheng Zhang, Juan Guo, Qi He, Lu-Xi Song, Dong Wu, Li-Yu Zhou, Ji-Ying Su, Chao Xiao, Chun-Kang Chang and Ling-Yun Wu

Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer

Disease progression and therapeutic resistance are hallmarks of advanced stage prostate cancer (PCa), which remains a major cause of cancer-related mortality around the world. Longitudinal studies, coupled wit...

Authors: Romina Silva, Bruce Moran, Anne-Marie Baird, Colm J. O’Rourke, Stephen P. Finn, Ray McDermott, William Watson, William M. Gallagher, Donal J. Brennan and Antoinette S. Perry

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer

In an effort to contribute to overcoming the platinum resistance exhibited by most solid tumors, we performed an array of epigenetic approaches, integrating next-generation methodologies and public clinical da...

Authors: Javier Andrés Soto, Carlos Rodríguez-Antolín, Olga Vera, Olga Pernía, Isabel Esteban-Rodríguez, Maria Dolores Diestro, Javier Benitez, Fátima Sánchez-Cabo, Rafael Alvarez, Javier De Castro and Inmaculada Ibanez de Cáceres

DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity...

Authors: Chunhong Hu, Xiaohan Liu, Yue Zeng, Junqi Liu and Fang Wu

Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation

Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ...

Authors: Darina Czamara, Linda Dieckmann, Simone Röh, Sarah Kraemer, Rebecca C. Rancourt, Sara Sammallahti, Eero Kajantie, Hannele Laivuori, Johan G. Eriksson, Katri Räikkönen, Wolfgang Henrich, Andreas Plagemann, Elisabeth B. Binder, Thorsten Braun and Sonja Entringer

Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain

Prenatal alcohol exposure is recognized for altering DNA methylation profiles of brain cells during development, and to be part of the molecular basis underpinning Fetal Alcohol Spectrum Disorder (FASD) etiolo...

Authors: L. M. Legault, K. Doiron, M. Breton-Larrivée, A. Langford-Avelar, A. Lemieux, M. Caron, L. A. Jerome-Majewska, D. Sinnett and S. McGraw

Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

The trajectory of frailty in older adults is important to public health; therefore, markers that may help predict this and other important outcomes could be beneficial. Epigenetic clocks have been developed an...

Authors: Chris P. Verschoor, David T. S. Lin, Michael S. Kobor, Oxana Mian, Jinhui Ma, Guillaume Pare and Gustavo Ybazeta