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  1. Content type: Research

    Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of poor embryo development. Moving these initial fin...

    Authors: Mohammad Abbasi, Andrew D. Smith, Harish Swaminathan, Peer Sangngern, Amanda Douglas, Alan Horsager, Douglas T. Carrell and Philip J. Uren

    Citation: Clinical Epigenetics 2018 10:119

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  2. Content type: Research

    A variety of abnormalities in vitamin D metabolism have been reported in patients with active tuberculosis. However, intervention trials have produced inconsistent results. We hypothesized that genetic and epi...

    Authors: Min Wang, Weimin Kong, Biyu He, Zhongqi Li, Huan Song, Peiyi Shi and Jianming Wang

    Citation: Clinical Epigenetics 2018 10:118

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  3. Content type: Research

    Whole-exome sequencing has revealed a rare missense variant in PLD3 gene (rs145999145) to be associated with late onset Alzheimer’s disease (AD). Nevertheless, the association remains controversial and little is ...

    Authors: Idoia Blanco-Luquin, Miren Altuna, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, María Cámara, Victoria Zelaya, María Elena Erro, Carmen Echavarri and Maite Mendioroz

    Citation: Clinical Epigenetics 2018 10:116

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  4. Content type: Review

    Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extre...

    Authors: Qingsheng Kong, Yongnan Hao, Xin Li, Xin Wang, Bingyuan Ji and Yili Wu

    Citation: Clinical Epigenetics 2018 10:117

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  5. Content type: Review

    The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally cons...

    Authors: Yishui Lian, Lingjiao Meng, Pingan Ding and Meixiang Sang

    Citation: Clinical Epigenetics 2018 10:115

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  6. Content type: Research

    Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder with a population frequency of approximately 1 in 10,000. The most common epigenetic defect in BWS is a loss of methylation (LOM) at the 11p15.5 impr...

    Authors: Vinod Dagar, Wendy Hutchison, Andrea Muscat, Anita Krishnan, David Hoke, Ashley Buckle, Priscillia Siswara, David J. Amor, Jeffrey Mann, Jason Pinner, Alison Colley, Meredith Wilson, Rani Sachdev, George McGillivray, Matthew Edwards, Edwin Kirk…

    Citation: Clinical Epigenetics 2018 10:114

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  7. Content type: Research

    Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between genetic variants and free fatty...

    Authors: Zhen He, Rong Zhang, Feng Jiang, Hong Zhang, Aihua Zhao, Bo Xu, Li Jin, Tao Wang, Wei Jia, Weiping Jia and Cheng Hu

    Citation: Clinical Epigenetics 2018 10:113

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  8. Content type: Research

    Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying ...

    Authors: Erin W. Hofstatter, Steve Horvath, Disha Dalela, Piyush Gupta, Anees B. Chagpar, Vikram B. Wali, Veerle Bossuyt, Anna Maria Storniolo, Christos Hatzis, Gauri Patwardhan, Marie-Kristin Von Wahlde, Meghan Butler, Lianne Epstein, Karen Stavris, Tracy Sturrock, Alexander Au…

    Citation: Clinical Epigenetics 2018 10:112

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  9. Content type: Research

    Lung cancer is the leading cause of cancer-related death. While cigarette smoking is the primary cause of this malignancy, risk differs across racial/ethnic groups. For the same number of cigarettes smoked, Na...

    Authors: Sungshim L. Park, Yesha M. Patel, Lenora W. M. Loo, Daniel J. Mullen, Ite A. Offringa, Alika Maunakea, Daniel O. Stram, Kimberly Siegmund, Sharon E. Murphy, Maarit Tiirikainen and Loïc Le Marchand

    Citation: Clinical Epigenetics 2018 10:110

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  10. Content type: Research

    Inhibitor of differentiation protein 4 (ID4) is a dominant negative regulator of the basic helix-loop-helix (bHLH) family of transcription factors. During tumorigenesis, ID4 may act as a tumor suppressor or as...

    Authors: Daniela Nasif, Emanuel Campoy, Sergio Laurito, Richard Branham, Guillermo Urrutia, María Roqué and María T. Branham

    Citation: Clinical Epigenetics 2018 10:111

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  11. Content type: Research

    The importance of epigenetic alterations in psychiatric disorders is increasingly acknowledged and the use of DNA methylation patterns as markers of disease is a topic of ongoing investigation. Recent studies ...

    Authors: Mara Thomas, Nora Knoblich, Annalena Wallisch, Katarzyna Glowacz, Julia Becker-Sadzio, Friederike Gundel, Christof Brückmann and Vanessa Nieratschker

    Citation: Clinical Epigenetics 2018 10:109

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  12. Content type: Research

    Lung cancer is the leading cause of cancer death worldwide. Recently, epigenetic dysregulation has been known to promote tumor progression and therefore may be a therapeutic target for anticancer therapy. JARI...

    Authors: Kuang-Tai Kuo, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Wei-Hwa Lee, Chun-Hua Wang, M. Hsiao, Liang-Shun Wang and Chi-Tai Yeh

    Citation: Clinical Epigenetics 2018 10:107

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  13. Content type: Research

    Psoriasis is a chronic inflammatory autoimmune skin disorder. Several studies suggested psoriasis to be a complex multifactorial disease, but the exact triggering factor is yet to be determined. Evidences sugg...

    Authors: Aditi Chandra, Swapan Senapati, Sudipta Roy, Gobinda Chatterjee and Raghunath Chatterjee

    Citation: Clinical Epigenetics 2018 10:108

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  14. Content type: Correction

    Upon publication of the original article [1], the authors noticed that the Figs. 1, 2 and 3 were incorrectly given.

    Authors: Rubén Rodríguez Bautista, Alette Ortega Gómez, Alfredo Hidalgo Miranda, Alejandro Zentella Dehesa, Cynthia Villarreal-Garza, Federico Ávila-Moreno and Oscar Arrieta

    Citation: Clinical Epigenetics 2018 10:106

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    The original article was published in Clinical Epigenetics 2018 10:88

  15. Content type: Research

    Prognostic tools for prostate cancer (PC) are inadequate and new molecular biomarkers may improve risk stratification. The epigenetic mark 5-hydroxymethylcytosine (5hmC) has recently been proposed as a novel c...

    Authors: Tine Maj Storebjerg, Siri H. Strand, Søren Høyer, Anne-Sofie Lynnerup, Michael Borre, Torben F. Ørntoft and Karina D. Sørensen

    Citation: Clinical Epigenetics 2018 10:105

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  16. Content type: Research

    Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells...

    Authors: Varun Sasidharan Nair, Salman M. Toor, Rowaida Z. Taha, Hibah Shaath and Eyad Elkord

    Citation: Clinical Epigenetics 2018 10:104

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  17. Content type: Research

    Urinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, a...

    Authors: Emma Ahlén Bergman, Ciputra Adijaya Hartana, Markus Johansson, Ludvig B. Linton, Sofia Berglund, Martin Hyllienmark, Christian Lundgren, Benny Holmström, Karin Palmqvist, Johan Hansson, Farhood Alamdari, Ylva Huge, Firas Aljabery, Katrine Riklund, Malin E. Winerdal, David Krantz…

    Citation: Clinical Epigenetics 2018 10:102

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  18. Content type: Short report

    The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals.

    Authors: Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr and Ian J. Deary

    Citation: Clinical Epigenetics 2018 10:101

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  19. Content type: Research

    TET1 is a tumor suppressor gene (TSG) that codes for ten-eleven translocation methyl cytosine dioxygenase1 (TET1) catalyzing the conversion of 5-methylcytosine to 5-hydroxy methyl cytosine as a first step of T...

    Authors: Jiangxia Fan, Yan Zhang, Junhao Mu, Xiaoqian He, Bianfei Shao, Dishu Zhou, Weiyan Peng, Jun Tang, Yu Jiang, Guosheng Ren and Tingxiu Xiang

    Citation: Clinical Epigenetics 2018 10:103

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  20. Content type: Research

    Histone deacetylase inhibitors (HDACi) are promising anti-cancer drugs that could also be employed for urothelial carcinoma (UC) therapy. It is unclear, however, whether inhibition of all 11 zinc-dependent HDA...

    Authors: Aline Kaletsch, Maria Pinkerneil, Michèle J. Hoffmann, Ananda A. Jaguva Vasudevan, Chenyin Wang, Finn K. Hansen, Constanze Wiek, Helmut Hanenberg, Christoph Gertzen, Holger Gohlke, Matthias U. Kassack, Thomas Kurz, Wolfgang A. Schulz and Günter Niegisch

    Citation: Clinical Epigenetics 2018 10:100

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  21. Content type: Research

    Constitutive methylation of tumor suppressor genes are associated with increased cancer risk. However, to date, the question of epimutational transmission of these genes remains unresolved. Here, we studied th...

    Authors: Nisreen Al-Moghrabi, Maram Al-Showimi, Nujoud Al-Yousef, Bushra Al-Shahrani, Bedri Karakas, Lamyaa Alghofaili, Hannah Almubarak, Safia Madkhali and Hind Al Humaidan

    Citation: Clinical Epigenetics 2018 10:99

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  22. Content type: Research

    Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was p...

    Authors: Lu Gao, Xiaochen Liu, Joshua Millstein, Kimberly D. Siegmund, Louis Dubeau, Rachel L. Maguire, Junfeng (Jim) Zhang, Bernard F. Fuemmeler, Scott H. Kollins, Cathrine Hoyo, Susan K. Murphy and Carrie V. Breton

    Citation: Clinical Epigenetics 2018 10:98

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  23. Content type: Short report

    Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a...

    Authors: Rhian L. Clissold, Beth Ashfield, Joe Burrage, Eilis Hannon, Coralie Bingham, Jonathan Mill, Andrew Hattersley and Emma L. Dempster

    Citation: Clinical Epigenetics 2018 10:97

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  24. Content type: Research

    Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Ye...

    Authors: Anna Suarez, Jari Lahti, Darina Czamara, Marius Lahti-Pulkkinen, Polina Girchenko, Sture Andersson, Timo E. Strandberg, Rebecca M. Reynolds, Eero Kajantie, Elisabeth B. Binder and Katri Raikkonen

    Citation: Clinical Epigenetics 2018 10:96

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  25. Content type: Research

    5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of mo...

    Authors: Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li…

    Citation: Clinical Epigenetics 2018 10:94

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  26. Content type: Research

    Investigating how epigenetic information is transmitted through the mammalian germline is the key to understanding how this information impacts on health and disease susceptibility in offspring. EED is essenti...

    Authors: Lexie Prokopuk, Jessica M. Stringer, Craig R. White, Rolf H. A. M. Vossen, Stefan J. White, Ana S. A. Cohen, William T. Gibson and Patrick S. Western

    Citation: Clinical Epigenetics 2018 10:95

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  27. Content type: Short report

    Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in li...

    Authors: Glenn S. Gerhard, Ivana Malenica, Lorida Llaci, Xin Chu, Anthony T. Petrick, Christopher D. Still and Johanna K. DiStefano

    Citation: Clinical Epigenetics 2018 10:93

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  28. Content type: Research

    Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis...

    Authors: Jing-dong Zhou, Yu-xin Wang, Ting-juan Zhang, Xi-xi Li, Yu Gu, Wei Zhang, Ji-chun Ma, Jiang Lin and Jun Qian

    Citation: Clinical Epigenetics 2018 10:92

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  29. Content type: Research

    Early screening for prostate cancer (PCA) remains controversial because of overdiagnosis and overtreatment of clinically insignificant cancers. Even though a number of diagnostic tests have been developed to i...

    Authors: Igor Brikun, Deborah Nusskern, Andrew Decatus, Eric Harvey, Lin Li and Diha Freije

    Citation: Clinical Epigenetics 2018 10:91

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  30. Content type: Research

    This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for g...

    Authors: Sarah Gonzalez-Nahm, Michelle A. Mendez, Sara E. Benjamin-Neelon, Susan K. Murphy, Vijaya K. Hogan, Diane L. Rowley and Cathrine Hoyo

    Citation: Clinical Epigenetics 2018 10:90

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  31. Content type: Research

    Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition...

    Authors: Katharina Bomans, Judith Schenz, Sandra Tamulyte, Dominik Schaack, Markus Alexander Weigand and Florian Uhle

    Citation: Clinical Epigenetics 2018 10:89

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  32. Content type: Research

    Gestational age at delivery is associated with health and social outcomes. Recently, cord blood DNA methylation data has been used to predict gestational age. The discrepancy between gestational age predicted ...

    Authors: Jasmine N. Khouja, Andrew J. Simpkin, Linda M. O’Keeffe, Kaitlin H. Wade, Lotte C. Houtepen, Caroline L. Relton, Matthew Suderman and Laura D. Howe

    Citation: Clinical Epigenetics 2018 10:86

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  33. Content type: Research

    Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental ...

    Authors: Qihua Tan, Shuxia Li, Morten Frost, Marianne Nygaard, Mette Soerensen, Martin Larsen, Kaare Christensen and Lene Christiansen

    Citation: Clinical Epigenetics 2018 10:87

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  34. Content type: Review

    Triple-negative breast cancer (TNBC) has been clinically difficult to manage because of tumor aggressiveness, cellular and histological heterogeneity, and molecular mechanisms’ complexity. All this in turn lea...

    Authors: Rubén Rodríguez Bautista, Alette Ortega Gómez, Alfredo Hidalgo Miranda, Alejandro Zentella Dehesa, Cynthia Villarreal-Garza, Federico Ávila-Moreno and Oscar Arrieta

    Citation: Clinical Epigenetics 2018 10:88

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    The Correction to this article has been published in Clinical Epigenetics 2018 10:106

  35. Content type: Research

    Posttranslational modification of histone tails such as histone 3 lysine 27 acetylation (H3K27ac) is tightly coupled to epigenetic regulation of gene expression. To explore whether this is involved in placenta...

    Authors: N. D. Paauw, A. T. Lely, J. A. Joles, A. Franx, P. G. Nikkels, M. Mokry and B. B. van Rijn

    Citation: Clinical Epigenetics 2018 10:85

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  36. Content type: Research

    Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk ...

    Authors: Xu Gao, Yan Zhang, Ben Schöttker and Hermann Brenner

    Citation: Clinical Epigenetics 2018 10:84

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  37. Content type: Research

    Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 ...

    Authors: Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand and Sherita Hill Golden

    Citation: Clinical Epigenetics 2018 10:82

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  38. Content type: Research

    Malignant pleural mesothelioma (MPM) is a very rare and highly aggressive cancer of the pleura associated in most cases with asbestos exposure. To date, no really efficient treatments are available for this pa...

    Authors: Douae Bensaid, Thibaut Blondy, Sophie Deshayes, Virginie Dehame, Philippe Bertrand, Marc Grégoire, Mohammed Errami and Christophe Blanquart

    Citation: Clinical Epigenetics 2018 10:79

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  39. Content type: Research

    Assisted reproductive technology (ART) has been associated with low birth weight of fresh embryo transfer (FRESH) derived and increased birth weight of frozen embryo transfer (FET)-derived newborns. Owing to t...

    Authors: Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen and Nina Kaminen-Ahola

    Citation: Clinical Epigenetics 2018 10:80

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  40. Content type: Research

    Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs,...

    Authors: Fleur S. Peters, Annemiek M. A. Peeters, Pooja R. Mandaviya, Joyce B. J. van Meurs, Leo J. Hofland, Jacqueline van de Wetering, Michiel G. H. Betjes, Carla C. Baan and Karin Boer

    Citation: Clinical Epigenetics 2018 10:81

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  41. Content type: Research

    High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modif...

    Authors: Varun Sasidharan Nair, Haytham El Salhat, Rowaida Z. Taha, Anne John, Bassam R. Ali and Eyad Elkord

    Citation: Clinical Epigenetics 2018 10:78

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  42. Content type: Research

    An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an alter...

    Authors: D. Gentilini, E. Somigliana, L. Pagliardini, E. Rabellotti, P. Garagnani, L. Bernardinelli, E. Papaleo, M. Candiani, A. M. Di Blasio and P. Viganò

    Citation: Clinical Epigenetics 2018 10:77

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  43. Content type: Research

    Primary testing for high-risk HPV (hrHPV) is increasingly implemented in cervical cancer screening programs. Many hrHPV-positive women, however, harbor clinically irrelevant infections, demanding additional di...

    Authors: Iris Babion, Barbara C. Snoek, Putri W. Novianti, Annelieke Jaspers, Nienke van Trommel, Daniëlle A. M. Heideman, Chris J. L. M. Meijer, Peter J. F. Snijders, Renske D. M. Steenbergen and Saskia M. Wilting

    Citation: Clinical Epigenetics 2018 10:76

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  44. Content type: Research

    Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations betwee...

    Authors: Marija Klasić, Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Ivan Biruš, Paula Dobrinić, Nicholas T. Ventham, Irena Trbojević-Akmačić, Mirna Šimurina, Jerko Štambuk, Genadij Razdorov, Nicholas A. Kennedy, Jack Satsangi, Ana M. Dias, Salome Pinho, Vito Annese…

    Citation: Clinical Epigenetics 2018 10:75

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  45. Content type: Correction

    After publication of the original article [1], it came to the publishers’ attention that the below author’s corrections provided at the proofing stage had been misinterpreted.

    Authors: Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin and Pierre Bougnères

    Citation: Clinical Epigenetics 2018 10:74

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    The original article was published in Clinical Epigenetics 2018 10:57

  46. Content type: Methodology

    Mislabeled, contaminated or poorly performing samples can threaten power in methylation microarray analyses or even result in spurious associations. We describe a set of quality checks for the popular Illumina...

    Authors: Jonathan A. Heiss and Allan C. Just

    Citation: Clinical Epigenetics 2018 10:73

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  47. Content type: Research

    Current standard methods used to detect and monitor bladder cancer (BC) are invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker classifier for BC monitoring and validate...

    Authors: Antoine G. van der Heijden, Lourdes Mengual, Mercedes Ingelmo-Torres, Juan J. Lozano, Cindy C. M. van Rijt-van de Westerlo, Montserrat Baixauli, Bogdan Geavlete, Cristian Moldoveanud, Cosmin Ene, Colin P. Dinney, Bogdan Czerniak, Jack A. Schalken, Lambertus A. L. M. Kiemeney, Maria J. Ribal, J. Alfred Witjes and Antonio Alcaraz

    Citation: Clinical Epigenetics 2018 10:71

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  48. Content type: Research

    Active demethylation of 5-methyl-2′-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2′-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2′-deoxycytidine (5-fdC) and 5-carboxy-2′-d...

    Authors: Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, Magdalena Bodnar, Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Anna Szpila, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski…

    Citation: Clinical Epigenetics 2018 10:72

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