Articles

Sort by
Previous Page Page 1 of 22 Next Page
  1. Research

    MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer

    Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and...

    Alejandra Sandoval-Bórquez, Iva Polakovicova, Nicolás Carrasco-Véliz, Lorena Lobos-González, Ismael Riquelme, Gonzalo Carrasco-Avino, Carolina Bizama, Enrique Norero, Gareth I. Owen, Juan C. Roa and Alejandro H. Corvalán

    Clinical Epigenetics 2017 9:114

    Published on: 17 October 2017

  2. Research

    Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma

    Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences...

    E. Georg Luebeck, Kit Curtius, William D. Hazelton, Sean Maden, Ming Yu, Prashanthi N. Thota, Deepa T. Patil, Amitabh Chak, Joseph E. Willis and William M. Grady

    Clinical Epigenetics 2017 9:113

    Published on: 16 October 2017

  3. Research

    Epigenome-wide association study of asthma and wheeze in childhood and adolescence

    Asthma heritability has only been partially explained by genetic variants and is known to be sensitive to environmental factors, implicating epigenetic modifications such as DNA methylation in its pathogenesis.

    Ryan Arathimos, Matthew Suderman, Gemma C. Sharp, Kimberley Burrows, Raquel Granell, Kate Tilling, Tom R. Gaunt, John Henderson, Susan Ring, Rebecca C. Richmond and Caroline L. Relton

    Clinical Epigenetics 2017 9:112

    Published on: 13 October 2017

  4. Research

    Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women

    Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adr...

    Raquel Patrícia Ataíde Lima, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Darlene Camati Persuhn, Alexandre Sérgio da Silva, Maria da Conceição Rodrigues Gonçalves, Alessio Tony Cavalcanti de Almeida, Ronei Marcos de Moraes, Eliseu Verly Junior, Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Luciano Pirola, Marciane Magnani, Naila Francis Paulo de Oliveira, Patrícia Oliveira Prada and Maria José de Carvalho Costa

    Clinical Epigenetics 2017 9:110

    Published on: 13 October 2017

  5. Research

    Mosaic genome-wide maternal isodiploidy: an extreme form of imprinting disorder presenting as prenatal diagnostic challenge

    Uniparental disomy of certain chromosomes are associated with a group of well-known genetic syndromes referred to as imprinting disorders. However, the extreme form of uniparental disomy affecting the whole ge...

    Susanne Bens, Manuel Luedeke, Tanja Richter, Melanie Graf, Julia Kolarova, Gotthold Barbi, Krisztian Lato, Thomas F. Barth and Reiner Siebert

    Clinical Epigenetics 2017 9:111

    Published on: 13 October 2017

  6. Research

    Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

    KIBRA has been suggested as a key regulator of the Hippo signaling pathway, regulating organ size, cell contact inhibition, tissue regeneration as well as tumorigenesis and cystogenesis. We recently reported t...

    Katrin Schelleckes, Boris Schmitz, Giuliano Ciarimboli, Malte Lenders, Hermann J. Pavenstädt, Edwin Herrmann, Stefan-Martin Brand and Eva Brand

    Clinical Epigenetics 2017 9:109

    Published on: 6 October 2017

  7. Research

    A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

    Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in childre...

    Lia Gore, Timothy J. Triche Jr, Jason E. Farrar, Daniel Wai, Christophe Legendre, Gerald C. Gooden, Winnie S. Liang, John Carpten, David Lee, Frank Alvaro, Margaret E. Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran…

    Clinical Epigenetics 2017 9:108

    Published on: 5 October 2017

  8. Review

    Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

    Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing t...

    Igor Gošev, Martina Zeljko, Željko Đurić, Ivana Nikolić, Milorad Gošev, Sanja Ivčević, Dino Bešić, Zoran Legčević and Frane Paić

    Clinical Epigenetics 2017 9:106

    Published on: 3 October 2017

  9. Research

    Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

    There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregn...

    Elise Beau Vangeel, Ehsan Pishva, Titia Hompes, Daniel van den Hove, Diether Lambrechts, Karel Allegaert, Kathleen Freson, Benedetta Izzi and Stephan Claes

    Clinical Epigenetics 2017 9:107

    Published on: 3 October 2017

  10. Research

    Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4+ T cells in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by lymphocytic infiltration and overproduction of autoantibodies, leading to significant morbidity and mortality. However, the ...

    Wei Liao, Mengying Li, Haijing Wu, Sujie Jia, Nu Zhang, Yong Dai, Ming Zhao and Qianjin Lu

    Clinical Epigenetics 2017 9:104

    Published on: 22 September 2017

  11. Research

    An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

    Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among A...

    Karlijn A.C. Meeks, Peter Henneman, Andrea Venema, Tom Burr, Cecilia Galbete, Ina Danquah, Matthias B. Schulze, Frank P. Mockenhaupt, Ellis Owusu-Dabo, Charles N. Rotimi, Juliet Addo, Liam Smeeth, Silver Bahendeka, Joachim Spranger, Marcel M.A.M. Mannens, Mohammad H. Zafarmand…

    Clinical Epigenetics 2017 9:103

    Published on: 21 September 2017

  12. Research

    Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

    Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...

    Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki and Charlotte Ling

    Clinical Epigenetics 2017 9:102

    Published on: 21 September 2017

  13. Research

    Identification and characterization of interferon signaling-related microRNAs in occult hepatitis B virus infection

    Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatit...

    Yiying Wang, Peifu Zhu, Jing Qiu, Jie Wang, Huijuan Zhu, Yinwei Zhu, Lige Zhang, Jie Zhu, Xingxiang Liu and Chen Dong

    Clinical Epigenetics 2017 9:101

    Published on: 16 September 2017

  14. Research

    DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

    Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are un...

    Zaihua Zhu, Weida Meng, Peiru Liu, Xiaoxia Zhu, Yun Liu and Hejian Zou

    Clinical Epigenetics 2017 9:99

    Published on: 15 September 2017

  15. Review

    Histone code and long non-coding RNAs (lncRNAs) aberrations in lung cancer: implications in the therapy response

    Respiratory diseases hold several genome, epigenome, and transcriptional aberrations as a cause of the accumulated damage promoted by, among others, environmental risk factors. Such aberrations can also come a...

    Abril Marcela Herrera-Solorio, Leonel Armas-López, Oscar Arrieta, Joaquín Zúñiga, Patricia Piña-Sánchez and Federico Ávila-Moreno

    Clinical Epigenetics 2017 9:98

    Published on: 8 September 2017

  16. Research

    Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas

    Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression o...

    Cameron D. Lindsay, Morris A. Kostiuk, Jeff Harris, Daniel A. O’Connell, Hadi Seikaly and Vincent L. Biron

    Clinical Epigenetics 2017 9:95

    Published on: 6 September 2017

  17. Research

    Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients

    Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marke...

    Guro E. Lind, Marianne Guriby, Terje Ahlquist, Israr Hussain, Marine Jeanmougin, Kjetil Søreide, Hartwig Kørner, Ragnhild A. Lothe and Oddmund Nordgård

    Clinical Epigenetics 2017 9:97

    Published on: 5 September 2017

  18. Research

    Epigenetic regulation of inflammation in localized aggressive periodontitis

    We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals. However, mechanisms related to this phenoty...

    L. M. Shaddox, A. F. Mullersman, H. Huang, S. M. Wallet, T. Langaee and I. Aukhil

    Clinical Epigenetics 2017 9:94

    Published on: 2 September 2017

  19. Short report

    Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery

    Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can i...

    Samantha E. Day, Luis A. Garcia, Richard L. Coletta, Latoya E. Campbell, Tonya R. Benjamin, Elena A. De Filippis, James A. Madura II, Lawrence J. Mandarino, Lori R. Roust and Dawn K. Coletta

    Clinical Epigenetics 2017 9:96

    Published on: 2 September 2017

  20. Short report

    Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

    Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome,...

    T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani and F. Bondanini

    Clinical Epigenetics 2017 9:92

    Published on: 30 August 2017

  21. Research

    Pyrosequencing quantified methylation level of miR-124 predicts shorter survival for patients with myelodysplastic syndrome

    Aberrant CpG island methylation has been increasingly recognized as a common event in myelodysplastic syndrome (MDS). To date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes ...

    Hong Wang, Tong-Tong Zhang, Song Jin, Hong Liu, Xiang Zhang, Chang-Geng Ruan, De-Pei Wu, Yue Han and Xiao-Qin Wang

    Clinical Epigenetics 2017 9:91

    Published on: 30 August 2017

  22. Research

    The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

    Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIP...

    Daniel A. Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L. Calof, Arthur D. Lander, Xiaohui Xie and Kyoko Yokomori

    Clinical Epigenetics 2017 9:89

    Published on: 25 August 2017

Previous Page Page 1 of 22 Next Page