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  1. Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes,...

    Authors: Kharah M. Ross, Judith E. Carroll, Steve Horvath, Calvin J. Hobel, Mary E. Coussons-Read and Christine Dunkel Schetter

    Citation: Clinical Epigenetics 2020 12:120

    Content type: Research

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  2. Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa...

    Authors: Disline Manli Tantoh, Ming-Chi Wu, Chun-Chao Chuang, Pei-Hsin Chen, Yeu Sheng Tyan, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw

    Citation: Clinical Epigenetics 2020 12:117

    Content type: Research

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  3. Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA...

    Authors: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson…

    Citation: Clinical Epigenetics 2020 12:116

    Content type: Research

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  4. Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. ...

    Authors: Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, David M. Howard, Craig W. Ritchie, Steve Horvath, Caroline Hayward, Andrew M. McIntosh, David J. Porteous, Ian J. Deary, Kathryn L. Evans and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:115

    Content type: Research

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  5. Major depressive disorder (MDD) represents a serious global health concern. The urge for efficient MDD treatment strategies is presently hindered by the incomplete knowledge of its underlying pathomechanism. D...

    Authors: Nicole Moschny, Tristan Zindler, Kirsten Jahn, Marie Dorda, Colin F. Davenport, Lutz Wiehlmann, Hannah B. Maier, Franziska Eberle, Stefan Bleich, Alexandra Neyazi and Helge Frieling

    Citation: Clinical Epigenetics 2020 12:114

    Content type: Research

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  6. Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may...

    Authors: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:113

    Content type: Research

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  7. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li

    Citation: Clinical Epigenetics 2020 12:112

    Content type: Research

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  8. The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confoundin...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Masashi Mikami, Takahiro Arima, Tsutomu Ogata, Maki Fukami and Masayo Kagami

    Citation: Clinical Epigenetics 2020 12:111

    Content type: Research

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  9. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho

    Citation: Clinical Epigenetics 2020 12:110

    Content type: Research

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  10. Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously...

    Authors: Julia Romanowska, Øystein A. Haaland, Astanand Jugessur, Miriam Gjerdevik, Zongli Xu, Jack Taylor, Allen J. Wilcox, Inge Jonassen, Rolv T. Lie and Håkon K. Gjessing

    Citation: Clinical Epigenetics 2020 12:109

    Content type: Methodology

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  11. IGF1 is a key molecule in the regulation of growth and metabolism. Low IGF1 secretion is known to cause growth restriction in childhood, as well as deregulated lipid metabolism, cardiovascular disease, and dia...

    Authors: Masato Kantake, Naho Ikeda, Hirofumi Nakaoka, Natsuki Ohkawa, Toshitaka Tanaka, Kazuki Miyabayashi, Hiromichi Shoji and Toshiaki Shimizu

    Citation: Clinical Epigenetics 2020 12:108

    Content type: Research

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  12. H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigate...

    Authors: Jiayi Pei, Magdalena Harakalova, Thomas A. Treibel, R Thomas Lumbers, Bastiaan J. Boukens, Igor R. Efimov, Jip T. van Dinter, Arantxa González, Begoña López, Hamid El Azzouzi, Noortje van den Dungen, Christian G. M. van Dijk, Merle M. Krebber, Hester M. den Ruijter, Gerard Pasterkamp, Dirk J. Duncker…

    Citation: Clinical Epigenetics 2020 12:106

    Content type: Research

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  13. DNA methylation (DNAm) age constitutes a powerful tool to assess the molecular age and overall health status of biological samples. Recently, it has been shown that tissue-specific DNAm age predictors may pres...

    Authors: Mariana Boroni, Alessandra Zonari, Carolina Reis de Oliveira, Kallie Alkatib, Edgar Andres Ochoa Cruz, Lear E. Brace and Juliana Lott de Carvalho

    Citation: Clinical Epigenetics 2020 12:105

    Content type: Research

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  14. Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be...

    Authors: Marion Ouidir, Pauline Mendola, Germaine M. Buck Louis, Kurunthachalam Kannan, Cuilin Zhang and Fasil Tekola-Ayele

    Citation: Clinical Epigenetics 2020 12:103

    Content type: Research

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  15. Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic insulin production or a weak cellu...

    Authors: Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, Eric P. K. Mensah-Brown and Bright Starling Emerald

    Citation: Clinical Epigenetics 2020 12:104

    Content type: Review

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  16. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C...

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis

    Citation: Clinical Epigenetics 2020 12:102

    Content type: Short report

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  17. Oxytocin is an important neuromodulator involved in cognition and socio-emotional processing that exerts its central activities via oxytocin receptors. Epigenetic alterations in the oxytocin receptor gene (OXTR) ...

    Authors: Chun Il Park, Hae Won Kim, Sumoa Jeon, Jee In Kang and Se Joo Kim

    Citation: Clinical Epigenetics 2020 12:101

    Content type: Research

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  18. A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre...

    Authors: Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz

    Citation: Clinical Epigenetics 2020 12:100

    Content type: Review

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    The Correction to this article has been published in Clinical Epigenetics 2020 12:107

  19. Little is known about how genetics and epigenetics interplay in depression. Evidence suggests that genetic variants may change vulnerability to depression by modulating DNA methylation (DNAm) and non-coding RN...

    Authors: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Jörgen Jonsson, Mathias Rask-Andersen, Jessica Mwinyi and Helgi B. Schiöth

    Citation: Clinical Epigenetics 2020 12:99

    Content type: Research

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  20. Ten-eleven translocation (Tet) methyl-cytosine dioxygenases (including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in embryonic development and adult tissue homeostasis. The exp...

    Authors: Huan Yan, Li Tan, Yuqi Liu, Ning Huang, Jing Cang and Hao Wang

    Citation: Clinical Epigenetics 2020 12:98

    Content type: Research

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  21. Increasing life expectancy but also healthspan seems inaccessible as of yet but it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil molecular mechanisms involved in...

    Authors: Clémence Topart, Emilie Werner and Paola B. Arimondo

    Citation: Clinical Epigenetics 2020 12:97

    Content type: Review

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  22. Currently the leading cause of global disability, clinical depression is a heterogeneous condition characterised by low mood, anhedonia and cognitive impairments. Its growing incidence among young people, ofte...

    Authors: Coral R. Lapsley, Rachelle Irwin, Margaret McLafferty, Sara Jayne Thursby, Siobhan M. O’Neill, Anthony J. Bjourson, Colum P. Walsh and Elaine K. Murray

    Citation: Clinical Epigenetics 2020 12:85

    Content type: Research

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  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Elena Ivanova, Sebastian Canovas, Soledad Garcia-Martínez, Raquel Romar, Jordana S. Lopes, Dimitrios Rizos, Maria J. Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey and Pilar Coy

    Citation: Clinical Epigenetics 2020 12:96

    Content type: Correction

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    The original article was published in Clinical Epigenetics 2020 12:64

  24. Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w...

    Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith…

    Citation: Clinical Epigenetics 2020 12:95

    Content type: Research

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  25. PD-L1 (programmed cell death 1 ligand 1) expression in melanoma has been associated with a better response to anti-PD-1 (programmed cell death 1) therapy. However, patients with PD-L1-negative melanomas can re...

    Authors: Friederike Hoffmann, Romina Zarbl, Dennis Niebel, Judith Sirokay, Anne Fröhlich, Christian Posch, Tobias A. W. Holderried, Peter Brossart, Gonzalo Saavedra, Pia Kuster, Sebastian Strieth, Gerrit H. Gielen, Sandra S. Ring, Jörn Dietrich, Torsten Pietsch, Lukas Flatz…

    Citation: Clinical Epigenetics 2020 12:94

    Content type: Research

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  26. Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ...

    Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher

    Citation: Clinical Epigenetics 2020 12:93

    Content type: Research

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  27. The initiation of adolescent smoking is difficult to detect using carbon monoxide or cotinine assays. Previously, we and others have shown that the methylation of cg05575921 is an accurate predictor of adult s...

    Authors: Kelsey Dawes, Allan Andersen, Emma Papworth, Brandon Hundley, Natasha Hutchens, Heba El Manawy, Ashley Becker, Luke Sampson, Willem Philibert, Frederick X. Gibbons, Meg Gerrard and Robert Philibert

    Citation: Clinical Epigenetics 2020 12:92

    Content type: Research

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  28. Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as...

    Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li

    Citation: Clinical Epigenetics 2020 12:91

    Content type: Research

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  29. DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specific changes are known to reflect the type and severity of the disease. Therefore, there is a ...

    Authors: Dilys Lam, Phuc-Loi Luu, Jenny Z. Song, Wenjia Qu, Gail P. Risbridger, Mitchell G. Lawrence, Jennifer Lu, Matt Trau, Darren Korbie, Susan J. Clark, Ruth Pidsley and Clare Stirzaker

    Citation: Clinical Epigenetics 2020 12:90

    Content type: Methodology

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  30. Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera...

    Authors: Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:89

    Content type: Research

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  31. Eukaryotic histone methyltransferases 2 (EHMT2 or G9A) has been regarded as a potential target for non-small cell lung cancer (NSCLC) therapy. This study investigated the regulatory roles of G9A in tumorigenes...

    Authors: Rajendra P. Pangeni, Lu Yang, Keqiang Zhang, Jinhui Wang, Wendong Li, Chao Guo, Xinwei Yun, Ting Sun, Jami Wang and Dan J. Raz

    Citation: Clinical Epigenetics 2020 12:88

    Content type: Research

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  32. Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer...

    Authors: Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang…

    Citation: Clinical Epigenetics 2020 12:87

    Content type: Research

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  33. Silver-Russell syndrome (SRS) is characterized by growth failure and dysmorphic features. Major (epi)genetic causes of SRS are loss of methylation on chromosome 11p15 (11p15 LOM) and maternal uniparental disom...

    Authors: Takanobu Inoue, Akie Nakamura, Megumi Iwahashi-Odano, Kanako Tanase-Nakao, Keiko Matsubara, Junko Nishioka, Yoshihiro Maruo, Yukihiro Hasegawa, Hiroshi Suzumura, Seiji Sato, Yoshiyuki Kobayashi, Nobuyuki Murakami, Kazuhiko Nakabayashi, Kazuki Yamazawa, Tomoko Fuke, Satoshi Narumi…

    Citation: Clinical Epigenetics 2020 12:86

    Content type: Research

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  34. Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallm...

    Authors: Aparna Vasanthakumar, Justin W. Davis, Kenneth Idler, Jeffrey F. Waring, Elizabeth Asque, Bridget Riley-Gillis, Shaun Grosskurth, Gyan Srivastava, Sungeun Kim, Kwangsik Nho, Kelly N. H. Nudelman, Kelley Faber, Yu Sun, Tatiana M. Foroud, Karol Estrada, Liana G. Apostolova…

    Citation: Clinical Epigenetics 2020 12:84

    Content type: Research

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  35. Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mech...

    Authors: Hatim Boughanem, Amanda Cabrera-Mulero, Pablo Hernández-Alonso, Mercedes Clemente-Postigo, Felipe F. Casanueva, Francisco José Tinahones, Sonsoles Morcillo, Ana B. Crujeiras and Manuel Macias-Gonzalez

    Citation: Clinical Epigenetics 2020 12:83

    Content type: Research

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  36. Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogene...

    Authors: Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao and Tingxiu Xiang

    Citation: Clinical Epigenetics 2020 12:82

    Content type: Research

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  37. Hepatitis B virus (HBV)-related liver disease induces liver damage by hepatic immune and inflammatory response. The association between aberrant peripheral blood mononuclear cell (PBMC) DNA methylation and pro...

    Authors: Kang Li, Ling Qin, Sanjie Jiang, Ang Li, Chi Zhang, Guihai Liu, Jianping Sun, Huanqing Sun, Yan Zhao, Ning Li and Yonghong Zhang

    Citation: Clinical Epigenetics 2020 12:81

    Content type: Research

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  38. The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigene...

    Authors: Nathan A. Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jian-Hua Luo, Yan P. Yu, Sunduz Keles and David F. Jarrard

    Citation: Clinical Epigenetics 2020 12:80

    Content type: Research

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  39. Vascular endothelial growth factor A (VEGF-A) is a chemokine that induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis. It is ...

    Authors: Vesna Gorenjak, Dwaine R. Vance, Sébastien Dade, Maria G. Stathopoulou, Lauren Doherty, Ting Xie, Helena Murray, Christine Masson, John Lamont, Peter Fitzgerald and Sophie Visvikis-Siest

    Citation: Clinical Epigenetics 2020 12:79

    Content type: Research

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  40. Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal gr...

    Authors: Fasil Tekola-Ayele, Xuehuo Zeng, Marion Ouidir, Tsegaselassie Workalemahu, Cuilin Zhang, Fabien Delahaye and Ronald Wapner

    Citation: Clinical Epigenetics 2020 12:78

    Content type: Research

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  41. This study aimed to determine the epigenetic biomarkers of diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). This retrospective study is based on the Shanghai Xinjing community preven...

    Authors: Tao Li, Yi Xu, Yongyong Shi, Jianhua Chen, Senlin Lin, Jianfeng Zhu, Xian Xu, Lina Lu and Haidong Zou

    Citation: Clinical Epigenetics 2020 12:77

    Content type: Research

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  42. A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we e...

    Authors: Jose Vladimir Sandoval-Sierra, Francisco I. Salgado García, Jeffrey H. Brooks, Karen J. Derefinko and Khyobeni Mozhui

    Citation: Clinical Epigenetics 2020 12:76

    Content type: Research

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  43. Epigenetic abnormalities caused by superovulation have recently attracted increasing attention. Superovulation with exogenous hormones may prevent oocytes from establishing an appropriate epigenetic state, and...

    Authors: Ying Huo, Zhi Qiang Yan, Peng Yuan, Meng Qin, Ying Kuo, Rong Li, Li Ying Yan, Huai Liang Feng and Jie Qiao

    Citation: Clinical Epigenetics 2020 12:75

    Content type: Research

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  44. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...

    Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nuša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom

    Citation: Clinical Epigenetics 2020 12:74

    Content type: Research

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  45. Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transc...

    Authors: Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li and Lixiang Xue

    Citation: Clinical Epigenetics 2020 12:72

    Content type: Review

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