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  1. SETD1B is a component of a histone methyltransferase complex that specifically methylates Lys-4 of histone H3 (H3K4) and is responsible for the epigenetic control of chromatin structure and gene expression. De...

    Authors: I. M. Krzyzewska, S. M. Maas, P. Henneman, K. v. d. Lip, A. Venema, K. Baranano, A. Chassevent, E. Aref-Eshghi, A. J. van Essen, T. Fukuda, H. Ikeda, M. Jacquemont, H.-G. Kim, A. Labalme, S. M. E. Lewis, G. Lesca…

    Citation: Clinical Epigenetics 2019 11:156

    Content type: Research

    Published on:

  2. The glucocorticoid receptor (NR3C1, GR) is frequently downregulated in breast tumors, and evidence suggests it acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer. We previously found tha...

    Authors: Hilary Snider, Brithica Villavarajan, Yingwei Peng, Lois E. Shepherd, Andrew C. Robinson and Christopher R. Mueller

    Citation: Clinical Epigenetics 2019 11:155

    Content type: Research

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  3. Aberrant DNA methylation is involved in gastric carcinogenesis and may serve as a useful biomarker in the diagnosis and detection of gastric cancer (GC) recurrence.

    Authors: Wen-Liang Fang, Ming-Huang Chen, Kuo-Hung Huang, Shih-Ching Chang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu and Yi-Ming Shyr

    Citation: Clinical Epigenetics 2019 11:154

    Content type: Research

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  4. One major reason of the high mortality of epithelial ovarian cancer (EOC) is due to platinum-based chemotherapy resistance. Aberrant DNA methylation may be a potential mechanism underlying the development of p...

    Authors: Hua Tian, Li Yan, Li Xiao-fei, Sun Hai-yan, Chen Juan and Kang Shan

    Citation: Clinical Epigenetics 2019 11:153

    Content type: Research

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  5. Men often undergo repeat prostate biopsies because of suspicion of missed cancer. We assessed if (i) methylation of selected genes in prostate tissue vary with aging and (ii) methylation alterations in repeat ...

    Authors: Valentina Fiano, Daniela Zugna, Chiara Grasso, Morena Trevisan, Luisa Delsedime, Luca Molinaro, Paola Cassoni, Mauro Papotti, Franco Merletti, Olof Akre, Andreas Pettersson, Laura De Marco and Lorenzo Richiardi

    Citation: Clinical Epigenetics 2019 11:152

    Content type: Research

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  6. Platelet-endothelial aggregation receptor 1 (PEAR-1) is a transmembrane receptor involved in platelet activation and megakaryopoiesis whose expression is driven by DNA methylation. PEAR1 variants were associated ...

    Authors: Benedetta Izzi, Francesco Gianfagna, Wen-Yi Yang, Katrien Cludts, Amalia De Curtis, Peter Verhamme, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Jan A. Staessen, Marc F. Hoylaerts and Licia Iacoviello

    Citation: Clinical Epigenetics 2019 11:151

    Content type: Research

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  7. It is widely accepted that genomic instability is associated with several mechanisms involving oxidative stress, which can increase the rate of DNA breaks. Such factors include smoking, impairments in body com...

    Authors: Alejandra Locken-Castilla, Elda Leonor Pacheco-Pantoja, Fátima Rodríguez-Brito, Sherlin May-Kim, Victor López-Rivas and Angel Ceballos-Cruz

    Citation: Clinical Epigenetics 2019 11:150

    Content type: Research

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  8. Programmed epigenetic modifications occurring at early postnatal brain developmental stages may have a long-lasting impact on brain function and complex behavior throughout life. Notably, it is now emerging th...

    Authors: Mariella Cuomo, Simona Keller, Daniela Punzo, Tommaso Nuzzo, Ornella Affinito, Lorena Coretti, Massimo Carella, Valeria de Rosa, Ermanno Florio, Francesca Boscia, Vittorio Enrico Avvedimento, Sergio Cocozza, Francesco Errico, Alessandro Usiello and Lorenzo Chiariotti

    Citation: Clinical Epigenetics 2019 11:149

    Content type: Research

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  9. The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not progress to aggressive stages, may be ...

    Authors: Reka Toth, Heiko Schiffmann, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Sören Weidemann, Patrick Lebok, Christoph Fraune, Sarah Minner, Thorsten Schlomm, Guido Sauter, Christoph Plass, Yassen Assenov, Ronald Simon, Jan Meiners and Clarissa Gerhäuser

    Citation: Clinical Epigenetics 2019 11:148

    Content type: Research

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  10. Current diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, resulting in overdiagnosis and overtreatment of clinically insignificant tumors. Thus, to improve the management of PC, novel bi...

    Authors: Maibritt Nørgaard, Christa Haldrup, Marianne Trier Bjerre, Søren Høyer, Benedicte Ulhøi, Michael Borre and Karina D. Sørensen

    Citation: Clinical Epigenetics 2019 11:147

    Content type: Research

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  11. Psychiatric symptomatology during late childhood and early adolescence tends to persist later in life. In the present longitudinal study, we aimed to identify changes in genome-wide DNA methylation patterns th...

    Authors: Leticia M. Spindola, Marcos L. Santoro, Pedro M. Pan, Vanessa K. Ota, Gabriela Xavier, Carolina M. Carvalho, Fernanda Talarico, Patrick Sleiman, Michael March, Renata Pellegrino, Elisa Brietzke, Rodrigo Grassi-Oliveira, Jair J. Mari, Ary Gadelha, Euripedes C. Miguel, Luis A. Rohde…

    Citation: Clinical Epigenetics 2019 11:146

    Content type: Research

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  12. The two most common repetitive elements (REs) in humans, long interspersed nuclear element-1 (LINE-1) and Alu element (Alu), have been linked to various cancers. Hepatitis C virus (HCV) may cause hepatocellula...

    Authors: Yinan Zheng, Ryan A. Hlady, Brian T. Joyce, Keith D. Robertson, Chunyan He, Drew R. Nannini, Warren A. Kibbe, Chad J. Achenbach, Robert L. Murphy, Lewis R. Roberts and Lifang Hou

    Citation: Clinical Epigenetics 2019 11:145

    Content type: Research

    Published on:

  13. After publication of the original article [1], authors have requested to add a ‘J’ as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson.

    Authors: Malgorzata Pienkowska, Sanaa Choufani, Andrei L. Turinsky, Tanya Guha, Diana M. Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard J. Gilbertson, Jonathan L. Finlay, Nada Jabado, Christian Thomas…

    Citation: Clinical Epigenetics 2019 11:144

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2019 11:117

  14. Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in...

    Authors: Linn Gillberg, Andreas D. Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W. Hansen, Nicolas Rapin, Johanne B. Mogensen, Minmin Liu, Inge H. Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A. Jones and Kirsten Grønbæk

    Citation: Clinical Epigenetics 2019 11:143

    Content type: Research

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  15. Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associ...

    Authors: Kenneth Westerman, Paola Sebastiani, Paul Jacques, Simin Liu, Dawn DeMeo and José M. Ordovás

    Citation: Clinical Epigenetics 2019 11:142

    Content type: Research

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  16. The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (...

    Authors: Sylvain Garciaz, Lia N’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, Mathilde Poplineau, Nadine Platet, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, François Bertucci, Boris Calmels, Christian Récher, Daniel Birnbaum, Christian Chabannon, Norbert Vey…

    Citation: Clinical Epigenetics 2019 11:141

    Content type: Research

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  17. Vigilant management of women with high-risk human papillomavirus (hrHPV) is necessary in cancer screening programs. To this end, we evaluated the performance of S5 (targeting DNA methylation in HPV16, HPV18, H...

    Authors: Rubí Hernández-López, Attila T. Lorincz, Leticia Torres-Ibarra, Caroline Reuter, Dorota Scibior-Bentkowska, Rhian Warman, Belinda Nedjai, Indira Mendiola-Pastrana, Leith León-Maldonado, Berenice Rivera-Paredez, Paula Ramírez-Palacios, Eduardo Lazcano-Ponce, Jack Cuzick and Jorge Salmerón

    Citation: Clinical Epigenetics 2019 11:140

    Content type: Research

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  18. B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocystei...

    Authors: Yu An, Lingli Feng, Xiaona Zhang, Ying Wang, Yushan Wang, Lingwei Tao, Zhongsheng Qin and Rong Xiao

    Citation: Clinical Epigenetics 2019 11:139

    Content type: Research

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  19. Bisphenol A (BPA), an estrogen-like endocrine disruptor used in plastics, has been associated with development and promotion of breast cancer, so plastic manufacturers shifted towards less-studied analogs, BPF...

    Authors: Z. Awada, R. Nasr, R. Akika, V. Cahais, C. Cuenin, M. Zhivagui, Z. Herceg, A. Ghantous and N. K. Zgheib

    Citation: Clinical Epigenetics 2019 11:138

    Content type: Research

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  20. While the aberrant translocation of the mixed-lineage leukemia (MLL) gene drives pathogenesis of acute myeloid leukemia (AML), it represents an independent predictor for poor prognosis of adult AML patients. T...

    Authors: Jing Ye, Jie Zha, Yuanfei Shi, Yin Li, Delin Yuan, Qinwei Chen, Fusheng Lin, Zhihong Fang, Yong Yu, Yun Dai and Bing Xu

    Citation: Clinical Epigenetics 2019 11:137

    Content type: Research

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  21. The onset and development of malignant tumors are closely related to epigenetic modifications, and this has become a research hotspot. In recent years, a variety of epigenetic regulators have been discovered, ...

    Authors: Haoshen Yang, Wei Cui and Lihui Wang

    Citation: Clinical Epigenetics 2019 11:136

    Content type: Review

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  22. According to the “Developmental Origins of Health and Disease” (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution expo...

    Authors: N. D. Saenen, D. S. Martens, K. Y. Neven, R. Alfano, H. Bové, B. G. Janssen, H. A. Roels, M. Plusquin, K. Vrijens and T. S. Nawrot

    Citation: Clinical Epigenetics 2019 11:124

    Content type: Review

    Published on:

    The Article to this article has been published in Nature Communications 2019 10:3866

  23. Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate, and differentiate in t...

    Authors: Emilie G. Jaroy, Lourdes Acosta-Jimenez, Ryo Hotta, Allan M. Goldstein, Ragnhild Emblem, Arne Klungland and Rune Ougland

    Citation: Clinical Epigenetics 2019 11:135

    Content type: Review

    Published on:

  24. Persistence of latent, replication-competent provirus in CD4+ T cells of human immunodeficiency virus (HIV)-infected individuals on antiretroviral treatment (ART) is the main obstacle for virus eradication. Methy...

    Authors: César N. Cortés-Rubio, Gonzalo Salgado-Montes de Oca, Francisco J. Prado-Galbarro, Margarita Matías-Florentino, Akio Murakami-Ogasawara, Leticia Kuri-Cervantes, Ana P. Carranco-Arenas, Christopher E. Ormsby, Ivette K. Cortés-Rubio, Gustavo Reyes-Terán and Santiago Ávila-Ríos

    Citation: Clinical Epigenetics 2019 11:134

    Content type: Research

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  25. Studies demonstrate the impact of diet and physical activity on epigenetic biomarkers, specifically DNA methylation. However, no intervention studies have examined the combined impact of dietary and activity c...

    Authors: Elizabeth Hibler, Lei Huang, Jorge Andrade and Bonnie Spring

    Citation: Clinical Epigenetics 2019 11:133

    Content type: Research

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  28. Alzheimer’s disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would b...

    Authors: Mikko Konki, Maia Malonzo, Ida K. Karlsson, Noora Lindgren, Bishwa Ghimire, Johannes Smolander, Noora M. Scheinin, Miina Ollikainen, Asta Laiho, Laura L. Elo, Tapio Lönnberg, Matias Röyttä, Nancy L. Pedersen, Jaakko Kaprio, Harri Lähdesmäki, Juha O. Rinne…

    Citation: Clinical Epigenetics 2019 11:130

    Content type: Research

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  30. Breastfeeding is protective against many long-term diseases, yet the mechanisms involved are unknown. Leptin gene (LEP) is reported to be associated with body mass index (BMI). On the other hand, breastfeeding du...

    Authors: William B. Sherwood, Victoria Bion, Gabrielle A. Lockett, Ali H. Ziyab, Nelís Soto-Ramírez, Nandini Mukherjee, Ramesh J. Kurukulaaratchy, Susan Ewart, Hongmei Zhang, S. Hasan Arshad, Wilfried Karmaus, John W. Holloway and Faisal I. Rezwan

    Citation: Clinical Epigenetics 2019 11:128

    Content type: Short report

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  31. The most common sex chromosomal aneuploidy in males is Klinefelter syndrome, which is characterized by at least one supernumerary X chromosome. While these men have long been considered infertile, focal sperma...

    Authors: Sandra Laurentino, Laura Heckmann, Sara Di Persio, Xiaolin Li, Gerd Meyer zu Hörste, Joachim Wistuba, Jann-Frederik Cremers, Jörg Gromoll, Sabine Kliesch, Stefan Schlatt and Nina Neuhaus

    Citation: Clinical Epigenetics 2019 11:127

    Content type: Research

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  32. The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore useful in studying large well-characterized cohorts ...

    Authors: Johannes Achenbach, Mathias Rhein, Sara Gombert, Fiona Meyer-Bockenkamp, Miro Buhck, Mirjam Eberhardt, Andreas Leffler, Helge Frieling and Matthias Karst

    Citation: Clinical Epigenetics 2019 11:126

    Content type: Research

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  33. Umbilical cord blood (UCB) is commonly used in epigenome-wide association studies of prenatal exposures. Accounting for cell type composition is critical in such studies as it reduces confounding due to the ce...

    Authors: Kristina Gervin, Lucas A. Salas, Kelly M. Bakulski, Menno C. van Zelm, Devin C. Koestler, John K. Wiencke, Liesbeth Duijts, Henriëtte A. Moll, Karl T. Kelsey, Michael S. Kobor, Robert Lyle, Brock C. Christensen, Janine F. Felix and Meaghan J. Jones

    Citation: Clinical Epigenetics 2019 11:125

    Content type: Methodology

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  34. Elastic net type regression methods have become very popular for prediction of certain outcomes in epigenome-wide association studies (EWAS). The methods considered accept biased coefficient estimates in retur...

    Authors: Solveig Engebretsen and Jon Bohlin

    Citation: Clinical Epigenetics 2019 11:123

    Content type: Letter to the Editor

    Published on:

  35. Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with ec...

    Authors: Meher Preethi Boorgula, Margaret A. Taub, Nicholas Rafaels, Michelle Daya, Monica Campbell, Sameer Chavan, Aniket Shetty, Chris Cheadle, Sangjucta Barkataki, Jinshui Fan, Gloria David, Terri H. Beaty, Ingo Ruczinski, Jon Hanifin, Lynda C. Schneider, Richard L. Gallo…

    Citation: Clinical Epigenetics 2019 11:122

    Content type: Research

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  36. Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorde...

    Authors: Oxana Bereshchenko, Oriana Lo Re, Fedor Nikulenkov, Sara Flamini, Jana Kotaskova, Tommaso Mazza, Marguerite-Marie Le Pannérer, Marcus Buschbeck, Cesarina Giallongo, Giuseppe Palumbo, Giovanni Li Volti, Valerio Pazienza, Libor Cervinek, Carlo Riccardi, Lumir Krejci, Sarka Pospisilova…

    Citation: Clinical Epigenetics 2019 11:121

    Content type: Research

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  37. Cervical cancer screening by combined cytology and HPV test has reduced the incidence of cervical cancer, but cytological screening lacks a higher sensitivity while HPV testing possesses a lower specificity. M...

    Authors: Xinlin Jiao, Siying Zhang, Jun Jiao, Teng Zhang, Wenjie Qu, Guy Mutangala Muloye, Beihua Kong, Qing Zhang and Baoxia Cui

    Citation: Clinical Epigenetics 2019 11:120

    Content type: Research

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  38. African Americans (AAs) experience premature chronic health outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA methylation (DNAm) levels at specific CpG positions are hallma...

    Authors: Salman M. Tajuddin, Dena G. Hernandez, Brian H. Chen, Nicole Noren Hooten, Nicolle A. Mode, Mike A. Nalls, Andrew B. Singleton, Ngozi Ejiogu, Kumaraswamy Naidu Chitrala, Alan B. Zonderman and Michele K. Evans

    Citation: Clinical Epigenetics 2019 11:119

    Content type: Research

    Published on:

  39. Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant epilepsy referred for adult epilepsy surgery. Though associated with prolonged febrile seizures (FS) in childhood, th...

    Authors: Laurence de Nijs, Kyonghwan Choe, Hellen Steinbusch, Olaf E. M. G. Schijns, Jim Dings, Daniel L. A. van den Hove, Bart P. F. Rutten and Govert Hoogland

    Citation: Clinical Epigenetics 2019 11:118

    Content type: Research

    Published on:

  40. Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atyp...

    Authors: Malgorzata Pienkowska, Sanaa Choufani, Andrei L. Turinsky, Tanya Guha, Diana M. Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard J. Gilbertson, Jonathan L. Finlay, Nada Jabado, Christian Thomas…

    Citation: Clinical Epigenetics 2019 11:117

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2019 11:144

  41. Oral squamous cell carcinoma (OSCC) is a genetic and epigenetic disease. There is growing evidence to suggest that environmental factors due to epigenetic changes can be involved in the OSCC pathogenesis. Alth...

    Authors: Soo Yeon Kim, Yu Kyeong Han, Jae Min Song, Chang Hun Lee, Keunsoo Kang, Joo Mi Yi and Hae Ryoun Park

    Citation: Clinical Epigenetics 2019 11:116

    Content type: Research

    Published on:

  42. Significant numbers of prostate cancer (PCa) patients experience tumour upstaging and upgrading in surgical specimens that cause serious problems in timely and proper selection of the treatment strategy. This ...

    Authors: Arnas Bakavicius, Kristina Daniunaite, Kristina Zukauskaite, Marija Barisiene, Sonata Jarmalaite and Feliksas Jankevicius

    Citation: Clinical Epigenetics 2019 11:115

    Content type: Research

    Published on:

  43. Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more general...

    Authors: Euan J. Rodger, Aniruddha Chatterjee, Peter A. Stockwell and Michael R. Eccles

    Citation: Clinical Epigenetics 2019 11:114

    Content type: Research

    Published on:

  44. H19 and IGF2 genes are imprinted and involved in regulating fetal and placental growth. The H19 differentially methylated region (DMR) is paternally methylated and maternally unmethylated and regulates the imprin...

    Authors: Yuko Yamaguchi, Chiharu Tayama, Junko Tomikawa, Rina Akaishi, Hiromi Kamura, Kentaro Matsuoka, Norio Wake, Hisanori Minakami, Kiyoko Kato, Takahiro Yamada, Kazuhiko Nakabayashi and Kenichiro Hata

    Citation: Clinical Epigenetics 2019 11:113

    Content type: Research

    Published on:

  46. DNA demethylation therapy is now used in practice for hematological tumors and is being developed for solid tumors. Nevertheless, it is difficult to achieve stable pharmacokinetics with the current DNA-demethy...

    Authors: Naoko Hattori, Magoichi Sako, Kana Kimura, Naoko Iida, Hideyuki Takeshima, Yoshitaka Nakata, Yutaka Kono and Toshikazu Ushijima

    Citation: Clinical Epigenetics 2019 11:111

    Content type: Research

    Published on:

  47. To compare DNA methylation in subjects positive vs negative for anti-citrullinated protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk.

    Authors: Xiaojian Shao, Marie Hudson, Ines Colmegna, Celia M. T. Greenwood, Marvin J. Fritzler, Philip Awadalla, Tomi Pastinen and Sasha Bernatsky

    Citation: Clinical Epigenetics 2019 11:110

    Content type: Research

    Published on:

  48. Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and mostly based on different CIMP definitions. The current...

    Authors: Min Jia, Yan Zhang, Lina Jansen, Viola Walter, Dominic Edelmann, Melanie Gündert, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Esther Herpel, Matthias Kloor, Alexis Ulrich, Barbara Burwinkel, Hendrik Bläker, Jenny Chang-Claude, Hermann Brenner…

    Citation: Clinical Epigenetics 2019 11:109

    Content type: Research

    Published on:

  49. Parkinson’s disease (PD) is characterized by the loss of midbrain dopaminergic neurons (DAn). Previously, we described the presence of DNA hyper- and hypo-methylation alterations in induced pluripotent stem ce...

    Authors: Rubén Fernández-Santiago, Angelika Merkel, Giancarlo Castellano, Simon Heath, Ángel Raya, Eduard Tolosa, María-José Martí, Antonella Consiglio and Mario Ezquerra

    Citation: Clinical Epigenetics 2019 11:108

    Content type: Short report

    Published on:

  50. Idiopathic scoliosis (IS) is a complex disease with an unclear etiology, and the worldwide prevalence is approximately 2–3%. As an important link between environmental factors and phenotypic differences, epige...

    Authors: Jiong Li, Guanteng Yang, Shaohua Liu, Longjie Wang, Zhuotao Liang and Hongqi Zhang

    Citation: Clinical Epigenetics 2019 11:107

    Content type: Research

    Published on:

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