Endocrinology and metabolic disease

Section information

Section edited by Richard Saffery and Charlotte Ling  
Non-communicable disorders of metabolic/endocrine origin are amongst the largest contributors to the burden of mortality and morbidity in the 21st century. Mounting evidence links epigenetic disruption throughout the life course in the etiology of such conditions, though a full understanding of their origin requires an in-depth examination of the interplay between genetic, epigenetic and environmental factors. Submissions to this section should increase our understanding of the role of epigenetic processes in the etiology of diseases of metabolic or endocrine origin in either animal model or human observational studies. 

  1. Research

    Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

    Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...

    Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki and Charlotte Ling

    Clinical Epigenetics 2017 9:102

    Published on: 21 September 2017

  2. Research

    DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

    Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are un...

    Zaihua Zhu, Weida Meng, Peiru Liu, Xiaoxia Zhu, Yun Liu and Hejian Zou

    Clinical Epigenetics 2017 9:99

    Published on: 15 September 2017

  3. Short report

    Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery

    Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can i...

    Samantha E. Day, Luis A. Garcia, Richard L. Coletta, Latoya E. Campbell, Tonya R. Benjamin, Elena A. De Filippis, James A. Madura II, Lawrence J. Mandarino, Lori R. Roust and Dawn K. Coletta

    Clinical Epigenetics 2017 9:96

    Published on: 2 September 2017

  4. Research

    Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

    Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...

    Bram G. Janssen, Hyang-Min Byun, Harry A. Roels, Wilfried Gyselaers, Joris Penders, Andrea A. Baccarelli and Tim S. Nawrot

    Clinical Epigenetics 2017 9:66

    Published on: 21 June 2017

  5. Research

    Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

    Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These mechanisms, including DNA methylation, influence ...

    Donia Macartney-Coxson, Miles C. Benton, Ray Blick, Richard S. Stubbs, Ronald D. Hagan and Michael A. Langston

    Clinical Epigenetics 2017 9:48

    Published on: 3 May 2017

  6. Research

    Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy

    Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP,...

    Azadeh Houshmand-Oeregaard, Ninna S. Hansen, Line Hjort, Louise Kelstrup, Christa Broholm, Elisabeth R. Mathiesen, Tine D. Clausen, Peter Damm and Allan Vaag

    Clinical Epigenetics 2017 9:37

    Published on: 13 April 2017

  7. Research

    Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

    A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes i...

    Chandrakumar Sathishkumar, Paramasivam Prabu, Mahalingam Balakumar, Raji Lenin, Durai Prabhu, Ranjith Mohan Anjana, Viswanathan Mohan and Muthuswamy Balasubramanyam

    Clinical Epigenetics 2016 8:125

    Published on: 24 November 2016

  8. Research

    DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance

    Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations b...

    Ailsa Maria Main, Linn Gillberg, Anna Louisa Jacobsen, Emma Nilsson, Anette Prior Gjesing, Torben Hansen, Oluf Pedersen, Rasmus Ribel-Madsen and Allan Vaag

    Clinical Epigenetics 2016 8:89

    Published on: 2 September 2016

  9. Research

    Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

    Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skelet...

    Samantha E. Day, Richard L. Coletta, Joon Young Kim, Latoya E. Campbell, Tonya R. Benjamin, Lori R. Roust, Elena A. De Filippis, Valentin Dinu, Gabriel Q. Shaibi, Lawrence J. Mandarino and Dawn K. Coletta

    Clinical Epigenetics 2016 8:77

    Published on: 18 July 2016

  10. Research

    PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns

    Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to prote...

    Sandra Côté, Valérie Gagné-Ouellet, Simon-Pierre Guay, Catherine Allard, Andrée-Anne Houde, Patrice Perron, Jean-Patrice Baillargeon, Daniel Gaudet, Renée Guérin, Diane Brisson, Marie-France Hivert and Luigi Bouchard

    Clinical Epigenetics 2016 8:72

    Published on: 22 June 2016

  11. Research

    Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

    There is growing interest in the hypertriglyceridemic waist (HTGW) phenotype, defined as high waist circumference (≥95 cm in males and ≥80 cm in females) combined with high serum triglyceride concentration (≥2...

    Manju Mamtani, Hemant Kulkarni, Thomas D. Dyer, Harald H. H. Göring, Jennifer L. Neary, Shelley A. Cole, Jack W. Kent, Satish Kumar, David C. Glahn, Michael C. Mahaney, Anthony G. Comuzzie, Laura Almasy, Joanne E. Curran, Ravindranath Duggirala, John Blangero and Melanie A. Carless

    Clinical Epigenetics 2016 8:6

    Published on: 20 January 2016

  12. Research

    The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women

    Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator...

    Peter Arner, Indranil Sinha, Anders Thorell, Mikael Rydén, Karin Dahlman-Wright and Ingrid Dahlman

    Clinical Epigenetics 2015 7:93

    Published on: 8 September 2015

  13. Review

    Recent developments on the role of epigenetics in obesity and metabolic disease

    The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity...

    Susan J. van Dijk, Ross L. Tellam, Janna L. Morrison, Beverly S. Muhlhausler and Peter L. Molloy

    Clinical Epigenetics 2015 7:66

    Published on: 11 July 2015