Neurology and psychiatry

Section information

Section edited by Jonathan Mill
Neurological and psychiatric disease makes a huge contribution to the global burden of disease, but little is known about their underlying etiology. This section welcomes articles exploring the role of epigenetic processes across the spectrum of brain disorders. We are particularly interested in articles exploring the interplay between genetic, epigenetic and environmental factors, and the utility of molecular biomarkers for diagnostic and prognostic phenotyping. We would also welcome mechanistic studies exploring the functional pathways involved in mediating the effects of epigenetic variation in the central nervous system using disease-relevant tissue and model systems.

  1. Research

    Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

    There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregn...

    Elise Beau Vangeel, Ehsan Pishva, Titia Hompes, Daniel van den Hove, Diether Lambrechts, Karel Allegaert, Kathleen Freson, Benedetta Izzi and Stephan Claes

    Clinical Epigenetics 2017 9:107

    Published on: 3 October 2017

  2. Short report

    Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

    DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylat...

    Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon and Katie Lunnon

    Clinical Epigenetics 2017 9:47

    Published on: 3 May 2017

  3. Research

    Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

    Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de...

    Abhay Raina, Xiaoping Zhao, Megan L. Grove, Jan Bressler, Rebecca F. Gottesman, Weihua Guan, James S. Pankow, Eric Boerwinkle, Thomas H. Mosley and Myriam Fornage

    Clinical Epigenetics 2017 9:21

    Published on: 14 February 2017

  4. Research

    Epigenome-wide association study of DNA methylation in panic disorder

    Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility ...

    Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, Yoshiya Kawamura, Miki Bundo, Kazuya Iwamoto, Mamoru Tochigi, Kiyoto Kasai, Hisanobu Kaiya, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga and Tsukasa Sasaki

    Clinical Epigenetics 2017 9:6

    Published on: 21 January 2017

  5. Review

    Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review

    Epigenetic mechanisms are important for the regulation of gene expression and differentiation in the fetus and the newborn child. Symptoms of maternal depression and antidepressant use affects up to 20 % of pr...

    Anne-Cathrine F. Viuff, Lars Henning Pedersen, Kasper Kyng, Nicklas Heine Staunstrup, Anders Børglum and Tine Brink Henriksen

    Clinical Epigenetics 2016 8:94

    Published on: 7 September 2016

  6. Research

    Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells

    Immunoactivation is less evident in secondary progressive MS (SPMS) compared to relapsing-remitting disease. MicroRNA (miRNA) expression is integral to the regulation of gene expression; determining their impa...

    Katherine A. Sanders, Miles C. Benton, Rod A. Lea, Vicki E. Maltby, Susan Agland, Nathan Griffin, Rodney J. Scott, Lotti Tajouri and Jeannette Lechner-Scott

    Clinical Epigenetics 2016 8:87

    Published on: 27 August 2016

  7. Short report

    Hypomethylation of FAM63B in bipolar disorder patients

    Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi...

    Anna Starnawska, Ditte Demontis, Andrew McQuillin, Niamh L. O’Brien, Nicklas H. Staunstrup, Ole Mors, Anders L. Nielsen, Anders D. Børglum and Mette Nyegaard

    Clinical Epigenetics 2016 8:52

    Published on: 11 May 2016

  8. Research

    TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

    Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is...

    Naiara Celarain, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Rosa Larumbe, Laura Pulido, Carmen Echavarri and Maite Mendioroz

    Clinical Epigenetics 2016 8:37

    Published on: 5 April 2016

  9. Research

    Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

    Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The molecular pathways associated with...

    Sarah Brasa, Arne Mueller, Sébastien Jacquemont, Florian Hahne, Izabela Rozenberg, Thomas Peters, Yunsheng He, Christine McCormack, Fabrizio Gasparini, Salah-Dine Chibout, Olivier Grenet, Jonathan Moggs, Baltazar Gomez-Mancilla and Rémi Terranova

    Clinical Epigenetics 2016 8:15

    Published on: 5 February 2016

  10. Research

    DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder

    Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate the...

    Rosie May Walker, Andrea Nikie Christoforou, Daniel L. McCartney, Stewart W. Morris, Nicholas A. Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H. R. Blackwood, Andrew Mark McIntosh, David John Porteous and Kathryn Louise Evans

    Clinical Epigenetics 2016 8:5

    Published on: 20 January 2016

  11. Review

    Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders

    Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. Th...

    Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison and Bernhard T. Baune

    Clinical Epigenetics 2015 7:122

    Published on: 14 November 2015