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Section edited by Jonathan Mill
Neurological and psychiatric disease makes a huge contribution to the global burden of disease, but little is known about their underlying etiology. This section welcomes articles exploring the role of epigenetic processes across the spectrum of brain disorders. We are particularly interested in articles exploring the interplay between genetic, epigenetic and environmental factors, and the utility of molecular biomarkers for diagnostic and prognostic phenotyping. We would also welcome mechanistic studies exploring the functional pathways involved in mediating the effects of epigenetic variation in the central nervous system using disease-relevant tissue and model systems.
Review
Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and ...
Clinical Epigenetics 2017 9:67
Published on: 29 June 2017
Short report
DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylat...
Clinical Epigenetics 2017 9:47
Published on: 3 May 2017
Research
Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de...
Clinical Epigenetics 2017 9:21
Published on: 14 February 2017
Research
Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility ...
Clinical Epigenetics 2017 9:6
Published on: 21 January 2017
Review
Epigenetic mechanisms are important for the regulation of gene expression and differentiation in the fetus and the newborn child. Symptoms of maternal depression and antidepressant use affects up to 20 % of pr...
Clinical Epigenetics 2016 8:94
Published on: 7 September 2016
Research
Immunoactivation is less evident in secondary progressive MS (SPMS) compared to relapsing-remitting disease. MicroRNA (miRNA) expression is integral to the regulation of gene expression; determining their impa...
Clinical Epigenetics 2016 8:87
Published on: 27 August 2016
Review
Methyl CpG binding protein 2 (MeCP2) is a highly abundant chromosomal protein within the brain. It is hence not surprising that perturbations in its genome-wide distribution, and at particular loci within this...
Clinical Epigenetics 2016 8:58
Published on: 21 May 2016
Short report
Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi...
Clinical Epigenetics 2016 8:52
Published on: 11 May 2016
Research
Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is...
Clinical Epigenetics 2016 8:37
Published on: 5 April 2016
Research
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The molecular pathways associated with...
Clinical Epigenetics 2016 8:15
Published on: 5 February 2016
Research
Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate the...
Clinical Epigenetics 2016 8:5
Published on: 20 January 2016
Review
Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. Th...
Clinical Epigenetics 2015 7:122
Published on: 14 November 2015
