Skip to main content

Cancer epigenetics and diagnostics

Section information

Section Editors : Carmen Jeronimo and Maria Berdasco

Associate Editors : Nita Ahuja, James Chim (haematological-based cancers only); Jim Davie, James Flanagan, Mario Fraga, Michéle Hoffmann, Bozena Kaminska (gliomas), Gwen Lomberk, Graham K Packham, Arpad Patai (colorectal/GI cancers), Qian Tao, Raul Urrutia, Keishi Yamashita

The development of genome-wide techniques has rapidly improved the comprehensive knowledge of epigenetic alterations in cancer. Currently, a vast number of genes and their associated molecular pathways that show epigenetic differences between normal and tumoral cells have been identified, emphasizing the crucial role of epigenetic factors in cancer etiology and progression.  This section publishes original epigenetic research focused on the identification of epigenetic biomarkers associated with cancer diagnosis or tumor progression. Manuscripts on epigenetic biomarkers leading to a better definition of therapy response are also accepted (pharmacoepigenetics). Submissions on reports from human clinical trials providing insights on the clinical application of epigenetic biomarkers are welcomed.

Page 1 of 7

  1. Bladder cancer (BC) is the 5th most common cancer in the USA. Non-muscle invasive bladder cancer represents about 70% of all cases and has generally a favorable outcome. However, recurrence rates as high as 60...

    Authors: Paolo Piatti, Yap Ching Chew, Michiko Suwoto, Taikun Yamada, Benjamin Jara, Xi-Yu Jia, Wei Guo, Saum Ghodoussipour, Siamak Daneshmand, Hamed Ahmadi, Jeffrey Rice, Jeffrey Bhasin, Faith Holloway, Yvonne Tsai, Yoshitomo Chihara and Gangning Liang

    Citation: Clinical Epigenetics 2021 13:84

    Content type: Research

    Published on:

  2. Epigenetic (“above genetics”) modifications can alter the gene expression without altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA methylation, histone methylation, histone acet...

    Authors: Ning Jin, Tiffany L. George, Gregory A. Otterson, Claire Verschraegen, Haitao Wen, David Carbone, James Herman, Erin M. Bertino and Kai He

    Citation: Clinical Epigenetics 2021 13:83

    Content type: Review

    Published on:

  3. Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51...

    Authors: Julia Stomper, Ruth Meier, Tobias Ma, Dietmar Pfeifer, Gabriele Ihorst, Nadja Blagitko-Dorfs, Gabriele Greve, Dennis Zimmer, Uwe Platzbecker, Anne Hagemeijer, Annette Schmitt-Gräff and Michael Lübbert

    Citation: Clinical Epigenetics 2021 13:77

    Content type: Research

    Published on:

  4. The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone acetyl...

    Authors: Wafaa S. Ramadan, Iman M. Talaat, Mahmood Y. Hachim, Annette Lischka, Timo Gemoll and Raafat El-Awady

    Citation: Clinical Epigenetics 2021 13:72

    Content type: Research

    Published on:

  5. Epigenetic alterations are known contributors to cancer development and aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are present in cells of the tumor microenvironment, ...

    Authors: Iris Lodewijk, Sandra P. Nunes, Rui Henrique, Carmen Jerónimo, Marta Dueñas and Jesús M. Paramio

    Citation: Clinical Epigenetics 2021 13:63

    Content type: Review

    Published on:

  6. The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients t...

    Authors: Rocio Rosas-Alonso, Julian Colmenarejo-Fernandez, Olga Pernia, Carlos Rodriguez-Antolín, Isabel Esteban, Ismael Ghanem, Dario Sanchez-Cabrero, Itsaso Losantos-Garcia, Sara Palacios-Zambrano, Gema Moreno-Bueno, Javier de Castro, Virginia Martinez-Marin and Inmaculada Ibanez-de-Caceres

    Citation: Clinical Epigenetics 2021 13:52

    Content type: Research

    Published on:

  7. Altered DNA methylation patterns play important roles in cancer development and progression. We examined whether expression levels of genes directly or indirectly involved in DNA methylation and demethylation ...

    Authors: Suleyman Vural, Alida Palmisano, William C. Reinhold, Yves Pommier, Beverly A. Teicher and Julia Krushkal

    Citation: Clinical Epigenetics 2021 13:49

    Content type: Research

    Published on:

  8. Chromatin modifiers and their implications in oncogenesis have been an exciting area of cancer research. These are enzymes that modify chromatin via post-translational modifications such as methylation, acetyl...

    Authors: Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt and Vassiliki Saloura

    Citation: Clinical Epigenetics 2021 13:45

    Content type: Review

    Published on:

  9. Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-m...

    Authors: Carmen S. Tellez, Maria A. Picchi, Daniel Juri, Kieu Do, Dhimant H. Desai, Shantu G. Amin, Julie A. Hutt, Piotr T. Filipczak and Steven A. Belinsky

    Citation: Clinical Epigenetics 2021 13:44

    Content type: Research

    Published on:

  10. Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for comparison, with solid cancers. We also e...

    Authors: Arce Domingo-Relloso, Tianxiao Huan, Karin Haack, Angela L. Riffo-Campos, Daniel Levy, M. Daniele Fallin, Mary Beth Terry, Ying Zhang, Dorothy A. Rhoades, Miguel Herreros-Martinez, Esther Garcia-Esquinas, Shelley A. Cole, Maria Tellez-Plaza and Ana Navas-Acien

    Citation: Clinical Epigenetics 2021 13:43

    Content type: Research

    Published on:

  11. Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20–25% of all cancer deaths. For choosing the most appropriate therapy regi...

    Authors: Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl

    Citation: Clinical Epigenetics 2021 13:38

    Content type: Research

    Published on:

  12. BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF chromatin remodelling complex, with key roles in modulating DNA accessibility. Dysregulation of BRG1 is observed, but functionally uncharacterised...

    Authors: Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia R. Kafer, Samuel Rogers, Phuc-Loi Luu, Anthony J. Cesare, Susan J. Clark and Phillippa C. Taberlay

    Citation: Clinical Epigenetics 2021 13:37

    Content type: Research

    Published on:

  13. Glycosylation, one of the most fundamental post-translational modifications, is altered in cancer and is subject in part, to epigenetic regulation. As there are many epigenetic-targeted therapies currently in ...

    Authors: Gordon Greville, Esther Llop, Jane Howard, Stephen F. Madden, Antoinette S. Perry, Rosa Peracaula, Pauline M. Rudd, Amanda McCann and Radka Saldova

    Citation: Clinical Epigenetics 2021 13:34

    Content type: Research

    Published on:

  14. Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are respon...

    Authors: Hang-Yu Chen, Wei-Long Zhang, Lei Zhang, Ping Yang, Fang Li, Ze-Ruo Yang, Jing Wang, Meng Pang, Yun Hong, Changjian Yan, Wei Li, Jia Liu, Nuo Xu, Long Chen, Xiu-Bing Xiao, Yan Qin…

    Citation: Clinical Epigenetics 2021 13:33

    Content type: Research

    Published on:

  15. Patients suffering from the BCR-ABL1-negative myeloproliferative disease prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to myelofibrosis. Accurate risk estimation for this fibroti...

    Authors: Ulrich Lehmann, Helge Stark, Stephan Bartels, Jerome Schlue, Guntram Büsche and Hans Kreipe

    Citation: Clinical Epigenetics 2021 13:28

    Content type: Research

    Published on:

  16. Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect pati...

    Authors: Jinke Sui, Xianrui Wu, Chenyang Wang, Guoqiang Wang, Chengcheng Li, Jing Zhao, Yuzi Zhang, Jianxing Xiang, Yu Xu, Weiqi Nian, Fuao Cao, Guanyu Yu, Zheng Lou, Liqiang Hao, Lianjie Liu, Bingsi Li…

    Citation: Clinical Epigenetics 2021 13:26

    Content type: Research

    Published on:

  17. The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein–Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extens...

    Authors: Mansheng Zhu, Qixiang Liang, Tao Chen, Qian Kong, Gengtai Ye, Shitong Yu, Xunjun Li, Qinglie He, Hao Liu, Yanfeng Hu, Jiang Yu and Guoxin Li

    Citation: Clinical Epigenetics 2021 13:22

    Content type: Research

    Published on:

  18. Acute leukemia is an epigenetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however these incompletely predict outcomes,...

    Authors: A. D. van Dijk, F. W. Hoff, Y. H. Qiu, J. Chandra, E. Jabbour, E. S. J. M. de Bont, T. M. Horton and S. M. Kornblau

    Citation: Clinical Epigenetics 2021 13:21

    Content type: Research

    Published on:

  19. Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia has been reported to regulate the activity of important carc...

    Authors: Hongzhen Li, Chunyan Peng, Chenhui Zhu, Shuang Nie, Xuetian Qian, Zhao Shi, Mengyue Shi, Yan Liang, Xiwei Ding, Shu Zhang, Bin Zhang, Xihan Li, Guifang Xu, Ying Lv, Lei Wang, Helmut Friess…

    Citation: Clinical Epigenetics 2021 13:18

    Content type: Research

    Published on:

  20. Obesity confers enhanced risk for multiple diseases including cancer. The DNA methylation alterations in obesity-related genes have been implicated in several human solid tumors. However, the underlying role a...

    Authors: Ting-juan Zhang, Zi-jun Xu, Yu Gu, Ji-chun Ma, Xiang-mei Wen, Wei Zhang, Zhao-qun Deng, Jun Qian, Jiang Lin and Jing-dong Zhou

    Citation: Clinical Epigenetics 2021 13:16

    Content type: Research

    Published on:

  21. To date, no predictive or prognostic molecular biomarkers except BRCA mutations are clinically established for epithelial ovarian cancer (EOC) despite being the deadliest gynecological malignancy. Aim of this bio...

    Authors: Karolin Heinze, Matthias Rengsberger, Mieczyslaw Gajda, Lars Jansen, Linea Osmers, Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Matthias Dürst, Norman Häfner and Ingo B. Runnebaum

    Citation: Clinical Epigenetics 2021 13:15

    Content type: Research

    Published on:

  22. Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circul...

    Authors: Graeme P. Young, Erin L. Symonds, Hans Jørgen Nielsen, Linnea Ferm, Ib J. Christensen, Evelien Dekker, Manon van der Vlugt, Rosalie C. Mallant-Hent, Nicky Boulter, Betty Yu, Michelle Chan, Gregor Tevz, Lawrence C. LaPointe and Susanne K. Pedersen

    Citation: Clinical Epigenetics 2021 13:14

    Content type: Research

    Published on:

  23. Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

    Authors: Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner, Liguo Wang, Jeanette E. Eckel-Passow, Erik P. Castle, Melissa L. Stanton, R. Houston Thompson, Alexander S. Parker, Thai H. Ho and Keith D. Robertson

    Citation: Clinical Epigenetics 2021 13:12

    Content type: Research

    Published on:

  24. Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognosis prediction of breast cancer. However, limited data exist regarding invasive lobular brea...

    Authors: Medha Suman, Pierre-Antoine Dugué, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean and Melissa C. Southey

    Citation: Clinical Epigenetics 2021 13:11

    Content type: Research

    Published on:

  25. Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

    Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:184

    Content type: Research

    Published on:

  26. Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with human papillomavirus (HPV)-related HNSCC rising to concerning levels. Extensive clinical, genetic and epigenetic...

    Authors: Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D’Silva, Laura S. Rozek and Maureen A. Sartor

    Citation: Clinical Epigenetics 2020 12:175

    Content type: Research

    Published on:

  27. The utility of O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that...

    Authors: Mitsuto Hanihara, Kunio Miyake, Atsushi Watanabe, Yuriko Yamada, Naoki Oishi, Tomoyuki Kawataki, Takeshi Inukai, Tetsuo Kondo and Hiroyuki Kinouchi

    Citation: Clinical Epigenetics 2020 12:174

    Content type: Research

    Published on:

  28. Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...

    Authors: Chunfang Tao, Juan Luo, Jun Tang, Danfeng Zhou, Shujun Feng, Zhu Qiu, Thomas C. Putti, Tingxiu Xiang, Qiao Tao, Lili Li and Guosheng Ren

    Citation: Clinical Epigenetics 2020 12:173

    Content type: Research

    Published on:

  29. Previous studies suggest the tumor suppressor role of long non-coding RNA (lncRNA) STXBP5-AS1 in cervical and gastric cancer, but its expression pattern and functional mechanism are still elusive in pancreatic ca...

    Authors: Shi Chen, Long Huang, Ge Li, Funan Qiu, Yaodong Wang, Can Yang, Jingjing Pan, Zhangwei Wu, Jiangzhi Chen and Yifeng Tian

    Citation: Clinical Epigenetics 2020 12:168

    Content type: Research

    Published on:

  30. Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observ...

    Authors: Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle and Aurélien A. Sérandour

    Citation: Clinical Epigenetics 2020 12:163

    Content type: Research

    Published on:

  31. Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of th...

    Authors: Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song…

    Citation: Clinical Epigenetics 2020 12:162

    Content type: Research

    Published on:

  32. Gastric cancer (GC) is a digestive system cancer with a high mortality rate globally. Previous experiences and studies have provided clinicians with ample evidence to diagnose and treat patients with reasonabl...

    Authors: Tengda Li, Xin Chen, Mingli Gu, Anmei Deng and Cheng Qian

    Citation: Clinical Epigenetics 2020 12:161

    Content type: Research

    Published on:

  33. Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and valid...

    Authors: Brendan F. Miller, Thomas R. Pisanic II, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang and Laura Elnitski

    Citation: Clinical Epigenetics 2020 12:154

    Content type: Methodology

    Published on:

  34. miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in carcinogenesis. Given the presence of a promotor-associated CpG island for its host gene, EVL, we hypothesized that intronic miR-342-3p is...

    Authors: Min Yue Zhang, George A. Calin, Kit San Yuen, Dong Yan Jin and Chor Sang Chim

    Citation: Clinical Epigenetics 2020 12:150

    Content type: Research

    Published on:

  35. Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the ...

    Authors: Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura and Vassiliki Saloura

    Citation: Clinical Epigenetics 2020 12:146

    Content type: Review

    Published on:

  36. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur

    Citation: Clinical Epigenetics 2020 12:138

    Content type: Research

    Published on:

  37. Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, ...

    Authors: Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang and Xiao-dong Zhang

    Citation: Clinical Epigenetics 2020 12:135

    Content type: Research

    Published on:

  38. The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methyla...

    Authors: Deepak B. Poduval, Elisabet Ognedal, Zuzana Sichmanova, Eivind Valen, Gjertrud T. Iversen, Laura Minsaas, Per E. Lønning and Stian Knappskog

    Citation: Clinical Epigenetics 2020 12:131

    Content type: Research

    Published on:

  39. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis

    Citation: Clinical Epigenetics 2020 12:127

    Content type: Research

    Published on:

  40. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li

    Citation: Clinical Epigenetics 2020 12:112

    Content type: Research

    Published on:

  41. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho

    Citation: Clinical Epigenetics 2020 12:110

    Content type: Research

    Published on:

  42. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C...

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis

    Citation: Clinical Epigenetics 2020 12:102

    Content type: Short report

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2021 13:69

  43. A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre...

    Authors: Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz

    Citation: Clinical Epigenetics 2020 12:100

    Content type: Review

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2020 12:107

  44. Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w...

    Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith…

    Citation: Clinical Epigenetics 2020 12:95

    Content type: Research

    Published on:

  45. Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ...

    Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher

    Citation: Clinical Epigenetics 2020 12:93

    Content type: Research

    Published on:

  46. Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as...

    Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li

    Citation: Clinical Epigenetics 2020 12:91

    Content type: Research

    Published on:

  47. Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera...

    Authors: Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:89

    Content type: Research

    Published on:

\