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Cancer epigenetics and diagnostics

Section information

Section Editors : Carmen Jeronimo and Maria Berdasco

Associate Editors : Nita Ahuja, James Chim (haematological-based cancers only); Jim Davie, James Flanagan, Mario Fraga, Michéle Hoffmann, Bozena Kaminska (gliomas), Gwen Lomberk, Graham K Packham, Arpad Patai (colorectal/GI cancers), Qian Tao, Raul Urrutia, Keishi Yamashita

The development of genome-wide techniques has rapidly improved the comprehensive knowledge of epigenetic alterations in cancer. Currently, a vast number of genes and their associated molecular pathways that show epigenetic differences between normal and tumoral cells have been identified, emphasizing the crucial role of epigenetic factors in cancer etiology and progression.  This section publishes original epigenetic research focused on the identification of epigenetic biomarkers associated with cancer diagnosis or tumor progression. Manuscripts on epigenetic biomarkers leading to a better definition of therapy response are also accepted (pharmacoepigenetics). Submissions on reports from human clinical trials providing insights on the clinical application of epigenetic biomarkers are welcomed.

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  1. To date, no predictive or prognostic molecular biomarkers except BRCA mutations are clinically established for epithelial ovarian cancer (EOC) despite being the deadliest gynecological malignancy. Aim of this bio...

    Authors: Karolin Heinze, Matthias Rengsberger, Mieczyslaw Gajda, Lars Jansen, Linea Osmers, Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Matthias Dürst, Norman Häfner and Ingo B. Runnebaum

    Citation: Clinical Epigenetics 2021 13:15

    Content type: Research

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  2. Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circul...

    Authors: Graeme P. Young, Erin L. Symonds, Hans Jørgen Nielsen, Linnea Ferm, Ib J. Christensen, Evelien Dekker, Manon van der Vlugt, Rosalie C. Mallant-Hent, Nicky Boulter, Betty Yu, Michelle Chan, Gregor Tevz, Lawrence C. LaPointe and Susanne K. Pedersen

    Citation: Clinical Epigenetics 2021 13:14

    Content type: Research

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  3. Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

    Authors: Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner, Liguo Wang, Jeanette E. Eckel-Passow, Erik P. Castle, Melissa L. Stanton, R. Houston Thompson, Alexander S. Parker, Thai H. Ho and Keith D. Robertson

    Citation: Clinical Epigenetics 2021 13:12

    Content type: Research

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  4. Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognosis prediction of breast cancer. However, limited data exist regarding invasive lobular brea...

    Authors: Medha Suman, Pierre-Antoine Dugué, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean and Melissa C. Southey

    Citation: Clinical Epigenetics 2021 13:11

    Content type: Research

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  5. Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

    Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:184

    Content type: Research

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  6. Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with human papillomavirus (HPV)-related HNSCC rising to concerning levels. Extensive clinical, genetic and epigenetic...

    Authors: Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D’Silva, Laura S. Rozek and Maureen A. Sartor

    Citation: Clinical Epigenetics 2020 12:175

    Content type: Research

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  7. The utility of O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that...

    Authors: Mitsuto Hanihara, Kunio Miyake, Atsushi Watanabe, Yuriko Yamada, Naoki Oishi, Tomoyuki Kawataki, Takeshi Inukai, Tetsuo Kondo and Hiroyuki Kinouchi

    Citation: Clinical Epigenetics 2020 12:174

    Content type: Research

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  8. Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...

    Authors: Chunfang Tao, Juan Luo, Jun Tang, Danfeng Zhou, Shujun Feng, Zhu Qiu, Thomas C. Putti, Tingxiu Xiang, Qiao Tao, Lili Li and Guosheng Ren

    Citation: Clinical Epigenetics 2020 12:173

    Content type: Research

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  9. Previous studies suggest the tumor suppressor role of long non-coding RNA (lncRNA) STXBP5-AS1 in cervical and gastric cancer, but its expression pattern and functional mechanism are still elusive in pancreatic ca...

    Authors: Shi Chen, Long Huang, Ge Li, Funan Qiu, Yaodong Wang, Can Yang, Jingjing Pan, Zhangwei Wu, Jiangzhi Chen and Yifeng Tian

    Citation: Clinical Epigenetics 2020 12:168

    Content type: Research

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  10. Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observ...

    Authors: Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle and Aurélien A. Sérandour

    Citation: Clinical Epigenetics 2020 12:163

    Content type: Research

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  11. Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of th...

    Authors: Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song…

    Citation: Clinical Epigenetics 2020 12:162

    Content type: Research

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  12. Gastric cancer (GC) is a digestive system cancer with a high mortality rate globally. Previous experiences and studies have provided clinicians with ample evidence to diagnose and treat patients with reasonabl...

    Authors: Tengda Li, Xin Chen, Mingli Gu, Anmei Deng and Cheng Qian

    Citation: Clinical Epigenetics 2020 12:161

    Content type: Research

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  13. Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and valid...

    Authors: Brendan F. Miller, Thomas R. Pisanic II, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang and Laura Elnitski

    Citation: Clinical Epigenetics 2020 12:154

    Content type: Methodology

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  14. miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in carcinogenesis. Given the presence of a promotor-associated CpG island for its host gene, EVL, we hypothesized that intronic miR-342-3p is...

    Authors: Min Yue Zhang, George A. Calin, Kit San Yuen, Dong Yan Jin and Chor Sang Chim

    Citation: Clinical Epigenetics 2020 12:150

    Content type: Research

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  15. Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the ...

    Authors: Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura and Vassiliki Saloura

    Citation: Clinical Epigenetics 2020 12:146

    Content type: Review

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  16. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur

    Citation: Clinical Epigenetics 2020 12:138

    Content type: Research

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  17. Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, ...

    Authors: Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang and Xiao-dong Zhang

    Citation: Clinical Epigenetics 2020 12:135

    Content type: Research

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  18. The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methyla...

    Authors: Deepak B. Poduval, Elisabet Ognedal, Zuzana Sichmanova, Eivind Valen, Gjertrud T. Iversen, Laura Minsaas, Per E. Lønning and Stian Knappskog

    Citation: Clinical Epigenetics 2020 12:131

    Content type: Research

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  19. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis

    Citation: Clinical Epigenetics 2020 12:127

    Content type: Research

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  20. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li

    Citation: Clinical Epigenetics 2020 12:112

    Content type: Research

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  21. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho

    Citation: Clinical Epigenetics 2020 12:110

    Content type: Research

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  22. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C...

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis

    Citation: Clinical Epigenetics 2020 12:102

    Content type: Short report

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  23. A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre...

    Authors: Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz

    Citation: Clinical Epigenetics 2020 12:100

    Content type: Review

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    The Correction to this article has been published in Clinical Epigenetics 2020 12:107

  24. Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w...

    Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith…

    Citation: Clinical Epigenetics 2020 12:95

    Content type: Research

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  25. Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ...

    Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher

    Citation: Clinical Epigenetics 2020 12:93

    Content type: Research

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  26. Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as...

    Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li

    Citation: Clinical Epigenetics 2020 12:91

    Content type: Research

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  27. Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera...

    Authors: Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:89

    Content type: Research

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  28. Eukaryotic histone methyltransferases 2 (EHMT2 or G9A) has been regarded as a potential target for non-small cell lung cancer (NSCLC) therapy. This study investigated the regulatory roles of G9A in tumorigenes...

    Authors: Rajendra P. Pangeni, Lu Yang, Keqiang Zhang, Jinhui Wang, Wendong Li, Chao Guo, Xinwei Yun, Ting Sun, Jami Wang and Dan J. Raz

    Citation: Clinical Epigenetics 2020 12:88

    Content type: Research

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  29. Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer...

    Authors: Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang…

    Citation: Clinical Epigenetics 2020 12:87

    Content type: Research

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  30. Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogene...

    Authors: Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao and Tingxiu Xiang

    Citation: Clinical Epigenetics 2020 12:82

    Content type: Research

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  31. The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigene...

    Authors: Nathan A. Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jian-Hua Luo, Yan P. Yu, Sunduz Keles and David F. Jarrard

    Citation: Clinical Epigenetics 2020 12:80

    Content type: Research

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  32. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...

    Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nuša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom

    Citation: Clinical Epigenetics 2020 12:74

    Content type: Research

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  33. Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples usin...

    Authors: Rulong Shen, Tong Cheng, Chuanliang Xu, Rex C. Yung, Jiandong Bao, Xing Li, Hongyu Yu, Shaohua Lu, Huixiong Xu, Hongxun Wu, Jian Zhou, Wenbo Bu, Xiaonan Wang, Han Si, Panying Shi, Pengcheng Zhao…

    Citation: Clinical Epigenetics 2020 12:71

    Content type: Methodology

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  34. Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis, prognosis, and recurrence prediction of colore...

    Authors: Shih-Ching Chang, Phui-Ly Liew, Muhamad Ansar, Shih-Yun Lin, Sheng-Chao Wang, Chin-Sheng Hung, Jian-Yu Chen, Shikha Jain and Ruo-Kai Lin

    Citation: Clinical Epigenetics 2020 12:67

    Content type: Research

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  35. Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we co...

    Authors: Yuan-Yuan Gu, Guan-Nan Zhou, Qing Wang, Jing-Xin Ding and Ke-Qin Hua

    Citation: Clinical Epigenetics 2020 12:57

    Content type: Research

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  36. Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts...

    Authors: Mitchell G. Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A. Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A. Taylor, Gail P. Risbridger and Susan J. Clark

    Citation: Clinical Epigenetics 2020 12:48

    Content type: Research

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  37. Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the pr...

    Authors: Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo and Dianshuai Gao

    Citation: Clinical Epigenetics 2020 12:47

    Content type: Research

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  38. Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathoge...

    Authors: Catarina Salgado, Nelleke Gruis, Bastiaan T. Heijmans, Jan Oosting and Remco van Doorn

    Citation: Clinical Epigenetics 2020 12:43

    Content type: Short report

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  39. Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngea...

    Authors: Yu Jiang, Lei Liu, Qin Xiang, Xiaoqian He, Yan Wang, Dishu Zhou, Can Zou, Qian Chen, Mingyu Peng, Jin He, Xianyao Jiang, Tingxiu Xiang and Yucheng Yang

    Citation: Clinical Epigenetics 2020 12:41

    Content type: Research

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  40. We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility in Chinese patients w...

    Authors: Chen Chen, Xiaojie Huang, Wei Yin, Muyun Peng, Fang Wu, Xia Wu, Jingqun Tang, Mingjiu Chen, Xiang Wang, Alicia Hulbert, Malcolm V. Brock, Wenliang Liu, James G. Herman and Fenglei Yu

    Citation: Clinical Epigenetics 2020 12:39

    Content type: Research

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  41. Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 m...

    Authors: Yuqiu Ge, Gaoxiang Ma, Hanting Liu, Yadi Lin, Gang Zhang, Mulong Du, Meilin Wang, Haiyan Chu, Haiyan Zhang and Zhengdong Zhang

    Citation: Clinical Epigenetics 2020 12:37

    Content type: Research

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  42. While a considerable number of tumor-specific hypermethylated loci have been identified in renal cell cancer (RCC), DNA methylation of loci showing successive increases in normal, tumoral, and metastatic tissu...

    Authors: Jürgen Serth, Inga Peters, Natalia Dubrowinskaja, Christel Reese, Knut Albrecht, Michael Klintschar, Marcel Lafos, Alexander Grote, Albert Becker, Jörg Hennenlotter, Arnulf Stenzl, Hossein Tezval and Markus A. Kuczyk

    Citation: Clinical Epigenetics 2020 12:33

    Content type: Research

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  43. The NuRD (Nucleosome Remodeling and Deacetylation) complex is a repressive complex in gene transcription by modulating chromatin accessibility of target genes to transcription factors and RNA polymerase II. Al...

    Authors: Simin Shao, Haowei Cao, Zhongkun Wang, Dongmei Zhou, Chaoshen Wu, Shu Wang, Dian Xia and Daoyong Zhang

    Citation: Clinical Epigenetics 2020 12:31

    Content type: Research

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  44. Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epitheli...

    Authors: Eva Galle, Bernard Thienpont, Sarah Cappuyns, Tom Venken, Pieter Busschaert, Matthias Van Haele, Eric Van Cutsem, Tania Roskams, Jos van Pelt, Chris Verslype, Jeroen Dekervel and Diether Lambrechts

    Citation: Clinical Epigenetics 2020 12:27

    Content type: Research

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  45. Radiation is an important therapeutic tool. However, radiotherapy has the potential to promote co-evolution of genetic and epigenetic changes that can drive tumour heterogeneity, formation of radioresistant ce...

    Authors: Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell and Helena Carén

    Citation: Clinical Epigenetics 2020 12:26

    Content type: Research

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  46. Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clini...

    Authors: Friederike Hoffmann, Dennis Niebel, Pia Aymans, Sandra Ferring-Schmitt, Dimo Dietrich and Jennifer Landsberg

    Citation: Clinical Epigenetics 2020 12:24

    Content type: Research

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  47. There are seven insulin-like growth factor binding proteins (IGFBPs) that bind insulin-like growth factors (IGFs). IGFBP like protein1 (IGFBPL1) is a new member of this family. The function and mechanism of IG...

    Authors: Yingge Liu, Meiying Zhang, Tao He, Weili Yang, Lidong Wang, Lirong Zhang and Mingzhou Guo

    Citation: Clinical Epigenetics 2020 12:22

    Content type: Research

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  48. 5-Hydroxymethylcytosine (5hmC) is a novel epigenetic mark and may be involved in the mechanisms of tumorigenesis and malignant transformation. However, the role of 5hmC in ependymoma, the third most common bra...

    Authors: Tao Wu, Zhi-wei Zhang, Shiwei Li, Bo Wang, Zhijun Yang, Peng Li, Jing Zhang, Wei-min Tong, Chunde Li, Fu Zhao, Yamei Niu and Pinan Liu

    Citation: Clinical Epigenetics 2020 12:19

    Content type: Research

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