Allergy, immunology, pathogens and inflammation

Section information

Section edited by Georges Herbein, Rachel Miller and Kari Nadeau

This section publishes high-quality and innovative research generated from basic science, animal and translational clinical studies that focus on epigenetic regulation in the induction or control of allergic disease, asthma and other immune responses and on epigenetic mechanisms involved in infectious diseases and inflammation. Research on the application of epigenetic analyses to the prediction, diagnosis, and treatment of allergic disease, infectious diseases and inflammation are particularly welcomed. These may also include reports on the interface between environmental exposures and epigenetic changes important to allergy, asthma, immunology, inflammation and infectious diseases. Laboratory studies that report on potentially new epigenetic targets related to allergy, asthma, immunology, inflammation and infectious diseases will also be considered.

  1. Research

    Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1

    Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA...

    Vicki E. Maltby, Rodney A. Lea, Katherine A. Sanders, Nicole White, Miles C. Benton, Rodney J. Scott and Jeannette Lechner-Scott

    Clinical Epigenetics 2017 9:71

    Published on: 18 July 2017

  2. Research

    Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

    Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...

    Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R. Jezioro, David Z. Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P. Perera, Andrew G. Rundle, Matthew S. Perzanowski, Steven N. Chillrud and Rachel L. Miller

    Clinical Epigenetics 2017 9:65

    Published on: 13 June 2017

  3. Research

    Pulmonary microRNA profiling: implications in upper lobe predominant lung disease

    Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulm...

    David A. Armstrong, Amanda B. Nymon, Carol S. Ringelberg, Corina Lesseur, Haley F. Hazlett, Louisa Howard, Carmen J. Marsit and Alix Ashare

    Clinical Epigenetics 2017 9:56

    Published on: 30 May 2017

  4. Letter to the Editor

    Combining omics data to identify genes associated with allergic rhinitis

    Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association stu...

    Andréanne Morin, Michel Laviolette, Tomi Pastinen, Louis-Philippe Boulet and Catherine Laprise

    Clinical Epigenetics 2017 9:3

    Published on: 18 January 2017

  5. Research

    Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

    Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus...

    Qing Zhang, Shu Ding, Huilin Zhang, Hai Long, Haijing Wu, Ming Zhao, Vera Chan, Chak-Sing Lau and Qianjin Lu

    Clinical Epigenetics 2016 8:126

    Published on: 24 November 2016

  6. Research

    Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation

    The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pr...

    Karin Boer, L. Elly A. de Wit, Fleur S. Peters, Dennis A. Hesselink, Leo J. Hofland, Michiel G. H. Betjes, Caspar W. N. Looman and Carla C. Baan

    Clinical Epigenetics 2016 8:116

    Published on: 16 November 2016

  7. Research

    Neonatal monocytes exhibit a unique histone modification landscape

    Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptible to infections, but the factors regulating neonatal-specific immune respon...

    Jennifer R. Bermick, Nathalie J. Lambrecht, Aaron D. denDekker, Steven L. Kunkel, Nicholas W. Lukacs, Cory M. Hogaboam and Matthew A. Schaller

    Clinical Epigenetics 2016 8:99

    Published on: 20 September 2016

  8. Research

    Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

    Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation. Two prominent ANCA autoantigens are myeloperoxid...

    Jiajin Yang, Heng Ge, Caroline J. Poulton, Susan L. Hogan, Yichun Hu, Britta E. Jones, Candace D. Henderson, Elizabeth A. McInnis, William F. Pendergraft III, J. Charles Jennette, Ronald J. Falk and Dominic J. Ciavatta

    Clinical Epigenetics 2016 8:85

    Published on: 12 August 2016

  9. Research

    Peripheral blood methylation profiling of female Crohn’s disease patients

    Crohn’s disease (CD) is a chronic inflammatory disorder belonging to the inflammatory bowel diseases (IBD). CD affects distinct parts of the gastrointestinal tract, leading to symptoms including diarrhea, feve...

    Andrew Y. F. Li Yim, Nicolette W. Duijvis, Jing Zhao, Wouter J. de Jonge, Geert R. A. M. D’Haens, Marcel M. A. M. Mannens, Adri N. P. M. Mul, Anje A. te Velde and Peter Henneman

    Clinical Epigenetics 2016 8:65

    Published on: 8 June 2016

  10. Research

    Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis

    Fibrosis of the intestine is a common and poorly understood complication of Crohn’s disease (CD) characterized by excessive deposition of extracellular matrix and accompanied by narrowing and obstruction of th...

    Tammy Sadler, Jeffrey M. Bhasin, Yaomin Xu, Jill Barnholz-Sloan, Yanwen Chen, Angela H. Ting and Eleni Stylianou

    Clinical Epigenetics 2016 8:30

    Published on: 12 March 2016

  11. Research

    Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

    Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretro...

    Kateřina Trejbalová, Denisa Kovářová, Jana Blažková, Ladislav Machala, David Jilich, Jan Weber, Dana Kučerová, Ondřej Vencálek, Ivan Hirsch and Jiří Hejnar

    Clinical Epigenetics 2016 8:19

    Published on: 19 February 2016

  12. Research

    H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

    The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chro...

    Zhe Zhang, Lihua Shi, Noor Dawany, Judith Kelsen, Michelle A. Petri and Kathleen E. Sullivan

    Clinical Epigenetics 2016 8:14

    Published on: 2 February 2016

  13. Research

    Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins

    Asthma is the most common chronic inflammatory disorder in children. The aetiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factor...

    Therese M. Murphy, Chloe C. Y. Wong, Louise Arseneault, Joe Burrage, Ruby Macdonald, Eilis Hannon, Helen L. Fisher, Antony Ambler, Terrie E. Moffitt, Avshalom Caspi and Jonathan Mill

    Clinical Epigenetics 2015 7:130

    Published on: 18 December 2015

  14. Research

    Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure

    Peroxisome proliferator-activated receptor gamma (PPAR-γ) has been demonstrated to be involved in anti-inflammatory reactions, but its role in acute-on-chronic hepatitis B liver failure (ACHBLF) is unclear. Th...

    Ze-Hua Zhao, Yu-Chen Fan, Qi Zhao, Cheng-Yun Dou, Xiang-Fen Ji, Jing Zhao, Shuai Gao, Xin-You Li and Kai Wang

    Clinical Epigenetics 2015 7:115

    Published on: 28 October 2015

  15. Research

    Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells

    Genome-wide DNA methylation (DNAm) studies have proven extremely useful to understand human hematopoiesis. Due to their active DNA content, nucleated red blood cells (nRBCs) contribute to epigenetic and transc...

    Olivia M. de Goede, Hamid R. Razzaghian, E. Magda Price, Meaghan J. Jones, Michael S. Kobor, Wendy P. Robinson and Pascal M. Lavoie

    Clinical Epigenetics 2015 7:95

    Published on: 11 September 2015

  16. Letter to the Editor

    DNA methylation signature of interleukin 1 receptor type II in asthma

    Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-r...

    Valérie Gagné-Ouellet, Simon-Pierre Guay, Anne-Marie Boucher-Lafleur, Luigi Bouchard and Catherine Laprise

    Clinical Epigenetics 2015 7:80

    Published on: 5 August 2015