Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol. 2007;27(6):1248–58.
Article
CAS
PubMed
Google Scholar
Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res. 2009;104(5):576–88.
Article
CAS
PubMed
Google Scholar
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, et al. Histone h3 lysine 36 methyltransferase hypb/setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010;107(7):2956–61.
Article
PubMed
PubMed Central
Google Scholar
Jiang H, Xia Q, Xin S, Lun Y, Song J, Tang D, et al. Abnormal epigenetic modifications in peripheral t cells from patients with abdominal aortic aneurysm are correlated with disease development. J Vasc Res. 2015;52(6):404–13.
Article
CAS
PubMed
Google Scholar
Findeisen HM, Kahles FK, Bruemmer D. Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis. Current Atherosclerosis Reports. 2013;15(4):319.
Article
CAS
PubMed
Google Scholar
Greissel A, Culmes M, Napieralski R, Wagner E, Gebhard H, Schmitt M, et al. Alternation of histone and DNA methylation in human atherosclerotic carotid plaques. Thromb Haemost. 2015;114(2):390–402.
CAS
PubMed
Google Scholar
Pullamsetti SS, Perros F, Chelladurai P, Yuan J, Stenmark K. Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: Therapeutic implications for pulmonary hypertension (2015 grover conference series). Pulm Circ. 2016;6(4):448–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Costantino S, Ambrosini S, Paneni F. The epigenetic landscape in the cardiovascular complications of diabetes. J Endocrinol Invest. 2019;42(5):505–11.
Article
CAS
PubMed
Google Scholar
Lazarewicz K, Watson P. Giant cell arteritis. BMJ. 2019;365:l1964.
Article
PubMed
Google Scholar
Zarzour A, Kim HW, Weintraub NL. Epigenetic regulation of vascular diseases. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019;39(6):984–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yan MS, Marsden PA. Epigenetics in the vascular endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35(11):2297–306.
Article
CAS
PubMed
PubMed Central
Google Scholar
Khyzha N, Alizada A, Wilson MD, Fish JE. Epigenetics of atherosclerosis: emerging mechanisms and methods. Trends Mol Med. 2017;23(4):332–47.
Article
CAS
PubMed
Google Scholar
Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Annu Rev Physiol. 2012;74:13–40.
Article
CAS
PubMed
Google Scholar
Liang M. Epigenetic mechanisms and hypertension. Hypertension. 2018;72(6):1244–54.
Article
CAS
PubMed
Google Scholar
Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, et al. Regulation of chromatin structure by site-specific histone h3 methyltransferases. Nature. 2000;406(6796):593–9.
Article
CAS
PubMed
Google Scholar
Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, et al. Histone demethylation mediated by the nuclear amine oxidase homolog lsd1. Cell. 2004;119(7):941–53.
Article
CAS
PubMed
Google Scholar
Kaniskan HU, Martini ML, Jin J. Inhibitors of protein methyltransferases and demethylases. Chem Rev. 2018;118(3):989–1068.
Article
CAS
PubMed
Google Scholar
Greer EL, Shi Y. Histone methylation: A dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13(5):343–57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yi X, Jiang XJ, Fang ZM. Histone methyltransferase smyd2: Ubiquitous regulator of disease. Clin Epigenetics. 2019;11(1):112.
Article
PubMed
PubMed Central
Google Scholar
Hamamoto R, Saloura V, Nakamura Y. Critical roles of non-histone protein lysine methylation in human tumorigenesis. Nat Rev Cancer. 2015;15(2):110–24.
Article
CAS
PubMed
Google Scholar
Spellmon N, Holcomb J, Trescott L, Sirinupong N, Yang Z. Structure and function of set and mynd domain-containing proteins. Int J Mol Sci. 2015;16(1):1406–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wesche J, Kuhn S, Kessler BM, Salton M, Wolf A. Protein arginine methylation: a PROMINENT modification and its demethylation. Cell Mol Life Sci. 2017;74(18):3305–15.
Article
CAS
PubMed
Google Scholar
Dillon SC, Zhang X, Trievel RC, Cheng X. The set-domain protein superfamily: protein lysine methyltransferases. Genome Biol. 2005;6(8):227.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li R, Yi X, Wei X, Huo B, Guo X, Cheng C, et al. Ezh2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection. Cell Death Dis. 2018;9(2):180.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yi X, Jiang X, Li X, Jiang DS. Histone lysine methylation and congenital heart disease: from bench to bedside (review). Int J Mol Med. 2017;40(4):953–64.
Article
CAS
PubMed
Google Scholar
Jiang DS, Yi X, Li R, Su YS, Wang J, Chen ML, et al. The histone methyltransferase mixed lineage leukemia (mll) 3 may play a potential role on clinical dilated cardiomyopathy. Mol Med. 2017;23:196–203.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yi X, Tao Y, Lin X, Dai Y, Yang T, Yue X, et al. Histone methyltransferase setd2 is critical for the proliferation and differentiation of myoblasts. Biochim Biophys Acta Mol Cell Res. 2017;1864(4):697–707.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yi X, Jiang XJ, Li XY, Jiang DS. Histone methyltransferases: novel targets for tumor and developmental defects. Am J Transl Res. 2015;7(11):2159–75.
CAS
PubMed
PubMed Central
Google Scholar
Li R, Wei X, Jiang DS. Protein methylation functions as the posttranslational modification switch to regulate autophagy. Cell Mol Life Sci. 2019;76(19):3711–22.
Article
CAS
PubMed
Google Scholar
Gao S, Wang Z, Wang W, Hu X, Chen P, Li J, et al. The lysine methyltransferase smyd2 methylates the kinase domain of type ii receptor bmpr2 and stimulates bone morphogenetic protein signaling. J Biol Chem. 2017;292(30):12702–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xia M, Liu J, Wu X, Liu S, Li G, Han C, et al. Histone methyltransferase ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme a20. Immunity. 2013;39(3):470–81.
Article
CAS
PubMed
Google Scholar
Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, et al. Trim48 promotes ask1 activation and cell death through ubiquitination-dependent degradation of the ask1-negative regulator prmt1. Cell Rep. 2017;21(9):2447–57.
Article
CAS
PubMed
Google Scholar
Chi L, Ahmed A, Roy AR, Vuong S, Cahill LS, Caporiccio L, et al. G9a controls placental vascular maturation by activating the notch pathway. Development. 2017;144(11):1976–87.
Article
CAS
PubMed
Google Scholar
Chang CW, Wakeland AK, Parast MM. Trophoblast lineage specification, differentiation and their regulation by oxygen tension. J Endocrinol. 2018;236(1):R43–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rodesch F, Simon P, Donner C, Jauniaux E. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet Gynecol. 1992;80(2):283–5.
CAS
PubMed
Google Scholar
Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN, Burton GJ. Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol. 2000;157(6):2111–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Burton GJ, Fowden AL. The placenta: a multifaceted, transient organ. Philos Trans R Soc Lond B Biol Sci. 2015;370(1663):20140066.
Article
PubMed
PubMed Central
Google Scholar
Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, et al. Hif-kdm3a-mmp12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proc Natl Acad Sci U S A. 2016;113(46):E7212–E21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, et al. Failure of blood-island formation and vasculogenesis in flk-1-deficient mice. Nature. 1995;376(6535):62–6.
Article
CAS
PubMed
Google Scholar
Wu Y, Ferguson JE 3rd, Wang H, Kelley R, Ren R, McDonough H, et al. Prdm6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. J Mol Cell Cardiol. 2008;44(1):47–58.
Article
CAS
PubMed
Google Scholar
Boeckel JN, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly RT, et al. Jumonji domain-containing protein 6 (jmjd6) is required for angiogenic sprouting and regulates splicing of vegf-receptor 1. Proc Natl Acad Sci U S A. 2011;108(8):3276–81.
Article
PubMed
PubMed Central
Google Scholar
Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, et al. Down-regulation of mir-101 in endothelial cells promotes blood vessel formation through reduced repression of ezh2. PLoS One. 2011;6(1):e16282.
Article
CAS
PubMed
PubMed Central
Google Scholar
Delgado-Olguin P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, et al. Ezh2-mediated repression of a transcriptional pathway upstream of mmp9 maintains integrity of the developing vasculature. Development. 2014;141(23):4610–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kurihara T, Shimizu-Hirota R, Shimoda M, Adachi T, Shimizu H, Weiss SJ, et al. Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation. 2012;126(25):3070–80.
Article
CAS
PubMed
Google Scholar
Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, et al. The microvascular niche instructs t cells in large vessel vasculitis via the vegf-jagged1-notch pathway. Sci Transl Med. 2017;9(399):eaal3322.
Article
CAS
PubMed
PubMed Central
Google Scholar
Spuul P, Daubon T, Pitter B, Alonso F, Fremaux I, Kramer I, et al. Vegf-a/notch-induced podosomes proteolyse basement membrane collagen-iv during retinal sprouting angiogenesis. Cell Rep. 2016;17(2):484–500.
Article
CAS
PubMed
Google Scholar
Feng Y, Yang Y, Ortega MM, Copeland JN, Zhang M, Jacob JB, et al. Early mammalian erythropoiesis requires the dot1l methyltransferase. Blood. 2010;116(22):4483–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473(7347):317–25.
Article
CAS
PubMed
Google Scholar
Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG. Targeting epigenetics and non-coding rnas in atherosclerosis: From mechanisms to therapeutics. Pharmacol Ther. 2019;196:15–43.
Article
CAS
PubMed
Google Scholar
Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28(5):812–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wierda RJ, Rietveld IM, van Eggermond MC, Belien JA, van Zwet EW, Lindeman JH, et al. Global histone h3 lysine 27 triple methylation levels are reduced in vessels with advanced atherosclerotic plaques. Life Sci. 2015;129:3–9.
Article
CAS
PubMed
Google Scholar
Greissel A, Culmes M, Burgkart R, Zimmermann A, Eckstein HH, Zernecke A, et al. Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques. Cardiovasc Pathol. 2016;25(2):79–86.
Article
CAS
PubMed
Google Scholar
Lv YC, Tang YY, Zhang P, Wan W, Yao F, He PP, et al. Histone methyltransferase enhancer of zeste homolog 2-mediated abca1 promoter DNA methylation contributes to the progression of atherosclerosis. PLoS One. 2016;11(6):e0157265.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kumar A, Kumar S, Vikram A, Hoffman TA, Naqvi A, Lewarchik CM, et al. Histone and DNA methylation-mediated epigenetic downregulation of endothelial kruppel-like factor 2 by low-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol. 2013;33(8):1936–42.
Article
CAS
PubMed
Google Scholar
Xiaoling Y, Li Z, ShuQiang L, Shengchao M, Anning Y, Ning D, et al. Hyperhomocysteinemia in apoe-/- mice leads to overexpression of enhancer of zeste homolog 2 via mir-92a regulation. PLoS One. 2016;11(12):e0167744.
Article
CAS
PubMed
PubMed Central
Google Scholar
Esse R, Florindo C, Imbard A, Rocha MS, de Vriese AS, Smulders YM, et al. Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim Biophys Acta. 2013;1832(10):1708–14.
Article
CAS
PubMed
Google Scholar
Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, et al. Vascular smooth muscle lrp6 limits arteriosclerotic calcification in diabetic ldlr-/- mice by restraining noncanonical wnt signals. Circ Res. 2015;117(2):142–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang Y, Cheng X, Tian W, Zhou B, Wu X, Xu H, et al. Mrtf-a steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells. Nucleic Acids Res. 2014;42(16):10460–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang J, Li Q, Cai W, Zhang X, Yang B, Li X, et al. Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of h3k27 in vascular smooth muscle cells. Br J Pharmacol. 2019;176(17):3206–19.
CAS
PubMed
PubMed Central
Google Scholar
Lockman K, Taylor JM, Mack CP. The histone demethylase, jmjd1a, interacts with the myocardin factors to regulate smc differentiation marker gene expression. Circ Res. 2007;101(12):e115–23.
Article
CAS
PubMed
Google Scholar
Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, et al. Prism/prdm6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006;26(7):2626–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Elia L, Kunderfranco P, Carullo P, Vacchiano M, Farina FM, Hall IF, et al. Uhrf1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease. J Clin Invest. 2018;128(6):2473–86.
Article
PubMed
PubMed Central
Google Scholar
Lehrke M, Kahles F, Makowska A, Tilstam PV, Diebold S, Marx J, et al. Pde4 inhibition reduces neointima formation and inhibits vcam-1 expression and histone methylation in an epac-dependent manner. J Mol Cell Cardiol. 2015;81:23–33.
Article
CAS
PubMed
Google Scholar
Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, et al. 2014 esc guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the european society of cardiology (esc). Eur Heart J. 2014;35(41):2873–926.
Article
PubMed
Google Scholar
Howard DP, Banerjee A, Fairhead JF, Perkins J, Silver LE, Rothwell PM, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the oxford vascular study. Circulation. 2013;127(20):2031–7.
Article
PubMed
PubMed Central
Google Scholar
Oller J, Mendez-Barbero N, Ruiz EJ, Villahoz S, Renard M, Canelas LI, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease adamts1 and in a mouse model of marfan syndrome. Nat Med. 2017;23(2):200–12.
Article
CAS
PubMed
Google Scholar
Guo X, Fang ZM, Wei X, Huo B, Yi X, Cheng C, et al. Hdac6 is associated with the formation of aortic dissection in human. Mol Med. 2019;25(1):10.
Article
PubMed
PubMed Central
Google Scholar
Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, et al. Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circ Res. 2017;120(2):341–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Toghill BJ, Saratzis A, Freeman PJ, Sylvius N, collaborators U, Bown MJ. Smyd2 promoter DNA methylation is associated with abdominal aortic aneurysm (aaa) and smyd2 expression in vascular smooth muscle cells. Clin Epigenetics 2018;10:29.
Gomez D, Coyet A, Ollivier V, Jeunemaitre X, Jondeau G, Michel JB, et al. Epigenetic control of vascular smooth muscle cells in marfan and non-marfan thoracic aortic aneurysms. Cardiovasc Res. 2011;89(2):446–56.
Article
CAS
PubMed
Google Scholar
Januzzi JL, Eagle KA, Cooper JV, Fang J, Sechtem U, Myrmel T, et al. Acute aortic dissection presenting with congestive heart failure: results from the international registry of acute aortic dissection. J Am Coll Cardiol. 2005;46(4):733–5.
Article
PubMed
Google Scholar
Stoll S, Wang C, Qiu H. DNA methylation and histone modification in hypertension. Int J Mol Sci. 2018;19(4):1174.
Article
CAS
PubMed Central
Google Scholar
Wise IA, Charchar FJ. Epigenetic modifications in essential hypertension. Int J Mol Sci. 2016;17(4):451.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee HA, Cho HM, Lee DY, Kim KC, Han HS, Kim IK. Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications. Hypertension. 2012;59(3):621–6.
Article
CAS
PubMed
Google Scholar
Arif M, Sadayappan S, Becker RC, Martin LJ, Urbina EM. Epigenetic modification: a regulatory mechanism in essential hypertension. Hypertens Res. 2019;42(8):1099–113.
Article
CAS
PubMed
Google Scholar
Mehrotra A, Joe B, de la Serna IL. Swi/snf chromatin remodeling enzymes are associated with cardiac hypertrophy in a genetic rat model of hypertension. J Cell Physiol. 2013;228(12):2337–42.
Article
CAS
PubMed
Google Scholar
Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D'Abreo C, et al. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem. 2005;280(26):24824–38.
Article
CAS
PubMed
Google Scholar
Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: From marvel to menace. Circulation. 2006;113(13):1708–14.
Article
CAS
PubMed
Google Scholar
Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD. do Nascimento GR et al. Histone demethylase lsd1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered no-cgmp relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011;301(5):H1862–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yu L, Yang G, Weng X, Liang P, Li L, Li J, et al. Histone methyltransferase set1 mediates angiotensin ii-induced endothelin-1 transcription and cardiac hypertrophy in mice. Arterioscler Thromb Vasc Biol. 2015;35(5):1207–17.
Article
CAS
PubMed
Google Scholar
Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Pulmonary arterial hypertension: Pathogenesis and clinical management. BMJ. 2018;360:j5492.
Article
PubMed
PubMed Central
Google Scholar
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D42–50.
Article
PubMed
Google Scholar
Jacobs W, van de Veerdonk MC, Trip P, de Man F, Heymans MW, Marcus JT, et al. The right ventricle explains sex differences in survival in idiopathic pulmonary arterial hypertension. Chest. 2014;145(6):1230–6.
Article
PubMed
Google Scholar
Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 2010;122(2):156–63.
Article
PubMed
Google Scholar
Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, et al. Predicting survival in pulmonary arterial hypertension: insights from the registry to evaluate early and long-term pulmonary arterial hypertension disease management (reveal). Circulation. 2010;122(2):164–72.
Article
PubMed
Google Scholar
Tuder RM, Archer SL, Dorfmuller P, Erzurum SC, Guignabert C, Michelakis E, et al. Relevant issues in the pathology and pathobiology of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D4–12.
Article
PubMed
PubMed Central
Google Scholar
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996;334(5):296–301.
Article
CAS
PubMed
Google Scholar
Ataya A, Patel S, Cope J, Alnuaimat H. Pulmonary arterial hypertension and associated conditions. Dis Mon. 2016;62(11):379–402.
Article
PubMed
Google Scholar
Luna RCP, de Oliveira Y, Lisboa JVC, Chaves TR, de Araujo TAM, de Sousa EE, et al. Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension. Braz J Med Biol Res. 2018;51(12):e7437.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang Q, Lu Z, Singh D, Raj JU. Bix-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Proliferation. 2012;45(4):335–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aljubran SA, Cox R Jr, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, et al. Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PLoS One. 2012;7(5):e37712.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shi ZL, Fang K, Li ZH, Ren DH, Zhang JY, Sun J. Ezh2 inhibition ameliorates transverse aortic constriction-induced pulmonary arterial hypertension in mice. Can Respir J. 2018;2018:9174926.
Article
PubMed
PubMed Central
Google Scholar
Segovia C, San Jose-Eneriz E, Munera-Maravilla E, Martinez-Fernandez M, Garate L, Miranda E, et al. Inhibition of a g9a/dnmt network triggers immune-mediated bladder cancer regression. Nat Med. 2019;25(7):1073–81.
Article
CAS
PubMed
Google Scholar
Cooper ME, Johnston CI. Optimizing treatment of hypertension in patients with diabetes. JAMA. 2000;283(24):3177–9.
Article
CAS
PubMed
Google Scholar
El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205(10):2409–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chalmers J, Cooper ME. Ukpds and the legacy effect. N Engl J Med. 2008;359(15):1618–20.
Article
CAS
PubMed
Google Scholar
Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009;58(5):1229–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taube A, Schlich R, Sell H, Eckardt K, Eckel J. Inflammation and metabolic dysfunction: Links to cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2012;302(11):H2148–65.
Article
CAS
PubMed
Google Scholar
Goldfine AB, Shoelson SE. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest. 2017;127(1):83–93.
Article
PubMed
PubMed Central
Google Scholar
Pollack RM, Donath MY, LeRoith D, Leibowitz G. Anti-inflammatory agents in the treatment of diabetes and its vascular complications. Diabetes Care. 2016;39(Suppl 2):S244–52.
Article
CAS
PubMed
Google Scholar
Han P, Gao D, Zhang W, Liu S, Yang S, Li X. Puerarin suppresses high glucose-induced mcp-1 expression via modulating histone methylation in cultured endothelial cells. Life Sciences. 2015;130:103–7.
Article
CAS
PubMed
Google Scholar
Paneni F, Costantino S, Battista R, Castello L, Capretti G, Chiandotto S, et al. Adverse epigenetic signatures by histone methyltransferase set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2015;8(1):150–8.
Article
CAS
PubMed
Google Scholar
Reddy MA, Villeneuve LM, Wang M, Lanting L, Natarajan R. Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice. Circ Res. 2008;103(6):615–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liao Y, Gou L, Chen L, Zhong X, Zhang D, Zhu H, et al. Nadph oxidase 4 and endothelial nitric oxide synthase contribute to endothelial dysfunction mediated by histone methylations in metabolic memory. Free Radical Biology and Medicine. 2018;115:383–94.
Article
CAS
PubMed
Google Scholar
Villeneuve LM, Kato M, Reddy MA, Wang M, Lanting L, Natarajan R. Enhanced levels of microrna-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase suv39h1. Diabetes. 2010;59(11):2904–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone h3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A. 2008;105(26):9047–52.
Article
PubMed
PubMed Central
Google Scholar
Syreeni A, El-Osta A, Forsblom C, Sandholm N, Parkkonen M, Tarnow L, et al. Genetic examination of setd7 and suv39h1/h2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes. Diabetes. 2011;60(11):3073–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Zhang J, Yang J, Xu L, Hu Q, Xu C, et al. Histone demethylase kdm3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats. Atherosclerosis. 2017;257:152–63.
Article
CAS
PubMed
Google Scholar
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, et al. Jmjd1a is a signal-sensing scaffold that regulates acute chromatin dynamics via swi/snf association for thermogenesis. Nat Commun. 2015;6:7052.
Article
CAS
PubMed
Google Scholar
Wen R, Ruiz MA, Feng B, Chakrabarti S. Polycomb repressive complex 2 regulates mir-200b in retinal endothelial cells: Potential relevance in diabetic retinopathy. Plos One. 2015;10(4):e0123987.
Article
CAS
Google Scholar
Floris I, Descamps B, Vardeu A, Mitic T, Posadino AM, Shantikumar S, et al. Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microrna-101 and histone methyltransferase enhancer of zester homolog-2. Arterioscler Thromb Vasc Biol. 2015;35(3):664–74.
Article
CAS
PubMed
Google Scholar
Weng X, Zhang Y, Li Z, Yu L, Xu F, Fang M, et al. Class ii transactivator (ciita) mediates ifn-gamma induced enos repression by enlisting suv39h1. Biochim Biophys Acta Gene Regul Mech. 2019;1862(2):163–72.
Article
CAS
PubMed
Google Scholar
Weng X, Yu L, Liang P, Chen D, Cheng X, Yang Y, et al. Endothelial mrtf-a mediates angiotensin ii induced cardiac hypertrophy. J Mol Cell Cardiol. 2015;80:23–33.
Article
CAS
PubMed
Google Scholar
Weng X, Yu L, Liang P, Li L, Dai X, Zhou B, et al. A crosstalk between chromatin remodeling and histone h3k4 methyltransferase complexes in endothelial cells regulates angiotensin ii-induced cardiac hypertrophy. J Mol Cell Cardiol. 2015;82:48–58.
Article
CAS
PubMed
Google Scholar
Okabe J, Orlowski C, Balcerczyk A, Tikellis C, Thomas MC, Cooper ME, et al. Distinguishing hyperglycemic changes by set7 in vascular endothelial cells. Circ Res. 2012;110(8):1067–76.
Article
CAS
PubMed
Google Scholar
Lee K, Na W, Lee JY, Na J, Cho H, Wu H, et al. Molecular mechanism of jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. J Neurochem. 2012;122(2):272–82.
Article
CAS
PubMed
Google Scholar
Yu S, Chen X, Xiu M, He F, Xing J, Min D, et al. The regulation of jmjd3 upon the expression of nf-kappab downstream inflammatory genes in lps activated vascular endothelial cells. Biochem Biophys Res Commun. 2017;485(1):62–8.
Article
CAS
PubMed
Google Scholar
Barroso M, Kao D, Blom HJ. Tavares de Almeida I, Castro R, Loscalzo J et al. S-adenosylhomocysteine induces inflammation through nfkb: A possible role for ezh2 in endothelial cell activation. Biochim Biophys Acta. 2016;1862(1):82–92.
Article
CAS
PubMed
Google Scholar
Liu D, Perkins JT, Petriello MC, Hennig B. Exposure to coplanar pcbs induces endothelial cell inflammation through epigenetic regulation of nf-kappab subunit p65. Toxicol Appl Pharmacol. 2015;289(3):457–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gu L, Hitzel J, Moll F, Kruse C, Malik RA, Preussner J, et al. The histone demethylase phf8 is essential for endothelial cell migration. PLoS One. 2016;11(1):e0146645.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wojtala M, Macierzynska-Piotrowska E, Rybaczek D, Pirola L, Balcerczyk A. Pharmacological and transcriptional inhibition of the g9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacol Res. 2018;128:252–63.
Article
CAS
PubMed
Google Scholar
Diehl F, Rossig L, Zeiher AM, Dimmeler S, Urbich C. The histone methyltransferase mll is an upstream regulator of endothelial-cell sprout formation. Blood. 2007;109(4):1472–8.
Article
CAS
PubMed
Google Scholar
Pirola L, Ciesielski O, Balcerczyk A. The methylation status of the epigenome: Its emerging role in the regulation of tumor angiogenesis and tumor growth, and potential for drug targeting. Cancers (Basel) 2018;10(8): pii: E268.
Duan Y, Wu X, Zhao Q, Gao J, Huo D, Liu X, et al. Dot1l promotes angiogenesis through cooperative regulation of vegfr2 with ets-1. Oncotarget. 2016;7(43):69674–87.
Article
PubMed
PubMed Central
Google Scholar
Zhang Y, Liu J, Lin J, Zhou L, Song Y, Wei B, et al. The transcription factor gata1 and the histone methyltransferase set7 interact to promote vegf-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer. Oncotarget. 2016;7(9):9859–75.
PubMed
PubMed Central
Google Scholar
Cohn O, Feldman M, Weil L, Kublanovsky M, Levy D. Chromatin associated setd3 negatively regulates vegf expression. Sci Rep. 2016;6:37115.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen YT, Zhu F, Lin WR, Ying RB, Yang YP, Zeng LH. The novel ezh2 inhibitor, gsk126, suppresses cell migration and angiogenesis via down-regulating vegf-a. Cancer Chemother Pharmacol. 2016;77(4):757–65.
Article
CAS
PubMed
Google Scholar
Kunizaki M, Hamamoto R, Silva FP, Yamaguchi K, Nagayasu T, Shibuya M, et al. The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by smyd3. Cancer Res. 2007;67(22):10759–65.
Article
CAS
PubMed
Google Scholar
Salton M, Voss TC, Misteli T. Identification by high-throughput imaging of the histone methyltransferase ehmt2 as an epigenetic regulator of vegfa alternative splicing. Nucleic Acids Res. 2014;42(22):13662–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee JY, Park JH, Choi HJ, Won HY, Joo HS, Shin DH, et al. Lsd1 demethylates hif1alpha to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis. Oncogene. 2017;36(39):5512–21.
Article
CAS
PubMed
Google Scholar
Oh SY, Seok JY, Choi YS, Lee SH, Bae JS, Lee YM. The histone methyltransferase inhibitor bix01294 inhibits hif-1alpha stability and angiogenesis. Mol Cells. 2015;38(6):528–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kashyap V, Ahmad S, Nilsson EM, Helczynski L, Kenna S, Persson JL, et al. The lysine specific demethylase-1 (lsd1/kdm1a) regulates vegf-a expression in prostate cancer. Mol Oncol. 2013;7(3):555–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Gu Y, Zhang H, Ning Y, Song N, Hu J, et al. Amelioration of uremic toxin indoxyl sulfate-induced osteoblastic calcification by set domain containing lysine methyltransferase 7/9 protein. Nephron. 2019;141(4):287–94.
Article
CAS
PubMed
Google Scholar
Choi JY, Yoon SS, Kim SE, Ahn JS. Kdm4b histone demethylase and g9a regulate expression of vascular adhesion proteins in cerebral microvessels. Sci Rep. 2017;7:45005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang J, Ge H, Poulton CJ, Hogan SL, Hu Y, Jones BE, et al. Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Clin Epigenetics. 2016;8:85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karnewar S, Neeli PK, Panuganti D, Kotagiri S, Mallappa S, Jain N, et al. Metformin regulates mitochondrial biogenesis and senescence through ampk mediated h3k79 methylation: relevance in age-associated vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2018;1864(4 Pt A):1115–28.
Article
CAS
PubMed
Google Scholar