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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Histone methylation and vascular biology

Fig. 3

Histone methylation is critical for atherosclerosis and neointima formation. Histone methyltransferases EZH2 and ASH2 participate in atherosclerosis via regulating endothelial dysfunction, foam cell formation, and vascular inflammation, respectively. Histone methyltransferases EZH2 and G9a and demethylase Jmjd1A are involved in neointima formation by affecting vascular smooth muscle cell (VSMC) proliferation, differentiation and phenotype switching

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