Fig. 1

A schematic diagram of histone methylation on lysine or arginine residues. Protein can be methylated by methyltransferases and S-adenosyl-l-methionine (AdoMet) is used as the primary methylgroup donor, while these modifications are reversible and can be erased by demethylases. a Protein lysine methyltransferases (PKMTs) catalyze monomethylation (Kme1), dimethylation (Kme2) and trimethylation (Kme3) of proteins on the ε-amine group of lysine. b Protein arginine methyltransferases (PRMTs) methylate the ω-amino group of arginine residues, resulting in either monomethylated (Rme1) or symmetric (Rme2s) or asymmetric (Rme2a) dimethylation. PKDMs protein lysine demethylases, PRDMs protein arginine demethylases