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  1. Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this quest...

    Authors: Mark W. Miller, Erika J. Wolf, Xiang Zhao, Mark W. Logue and Sage E. Hawn
    Citation: Clinical Epigenetics 2024 16:38
  2. The recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in health and diseases. This study used COVID-19 as a disease model to investi...

    Authors: Yuan-Yuan Li, Ming-Ming Yuan, Yuan-Yuan Li, Shan Li, Jing-Dong Wang, Yu-Fei Wang, Qian Li, Jun Li, Rong-Rong Chen, Jin-Min Peng and Bin Du
    Citation: Clinical Epigenetics 2024 16:37
  3. Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide approach, we aimed to investigate DNA methylation changes occurring secondary ...

    Authors: Céline Dubath, Eleonora Porcu, Aurélie Delacrétaz, Claire Grosu, Nermine Laaboub, Marianna Piras, Armin von Gunten, Philippe Conus, Kerstin Jessica Plessen, Zoltán Kutalik and Chin Bin Eap
    Citation: Clinical Epigenetics 2024 16:36
  4. We previously reported in the “Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function” randomized clinical trial (RCT) that vitamin C (500 mg/day) supplementation to pregnant smokers...

    Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S. Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel
    Citation: Clinical Epigenetics 2024 16:35
  5. Cell-free DNA (cfDNA) contains a large amount of molecular information that can be used for multi-cancer early detection (MCED), including changes in epigenetic status of cfDNA, such as cfDNA fragmentation pro...

    Authors: Pin Cui, Xiaozhou Zhou, Shu Xu, Weihuang He, Guozeng Huang, Yong Xiong, Chuxin Zhang, Tingmin Chang, Mingji Feng, Hanming Lai and Yi Pan
    Citation: Clinical Epigenetics 2024 16:34
  6. Whole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome profiling (RRMP), which employs restriction enzyme for depletion of A...

    Authors: Qingmo Yang, Xingqiang Zhu, Yulu Liu, Zhi He, Huan Xu, Hailing Zheng, Zhiming Huang, Dan Wang, Xiaofang Lin, Ping Guo and Hongliang Chen
    Citation: Clinical Epigenetics 2024 16:33
  7. People living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less susceptible to AIDS-related complications, they remain highly vulnerable to non-communica...

    Authors: Christian K. Dye, Haotian Wu, Gabriela L. Jackson, Altaye Kidane, Rejoice Nkambule, Nomthandazo G. Lukhele, Bongiwe Prudence Malinga, Rhinos Chekenyere, Wafaa M. El-Sadr, Andrea A. Baccarelli and Tiffany G. Harris
    Citation: Clinical Epigenetics 2024 16:32
  8. Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may im...

    Authors: Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Arno Téblick, Karolijn Dulfer, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe
    Citation: Clinical Epigenetics 2024 16:31
  9. Spinal cord injury (SCI) is a severe neurological disorder that causes neurological impairment and disability. Neural stem/progenitor cells (NS/PCs) derived from induced pluripotent stem cells (iPSCs) represen...

    Authors: Yubiao Yang, Boyuan Ma, Jinyu Chen, Derong Liu, Jun Ma, Bo Li, Jian Hao and Xianhu Zhou
    Citation: Clinical Epigenetics 2024 16:30
  10. Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often r...

    Authors: Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R. Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T. Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen…
    Citation: Clinical Epigenetics 2024 16:29
  11. E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspec...

    Authors: Charles de Ponthaud, Solafah Abdalla, Marie-Pierre Belot, Xiaojian Shao, Christophe Penna, Antoine Brouquet and Pierre Bougnères
    Citation: Clinical Epigenetics 2024 16:28
  12. Chronological and biological age correlate with DNA methylation levels at specific sites in the genome. Linear combinations of multiple methylation sites, termed epigenetic clocks, can inform us the chronologi...

    Authors: Naor Sagy, Noa Meyrom, Pazit Beckerman, Oren Pleniceanu and Daniel Z. Bar
    Citation: Clinical Epigenetics 2024 16:27
  13. Disulfidptosis is a recently discovered form of programmed cell death that could impact cancer development. Nevertheless, the prognostic significance of disulfidptosis-related genes (DRGs) in lung adenocarcino...

    Authors: Fangchao Zhao, Lei Su, Xuefeng Wang, Jiusong Luan, Xin Zhang, Yishuai Li, Shujun Li and Ling Hu
    Citation: Clinical Epigenetics 2024 16:26
  14. Cancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different tissues and cancer types enable the ident...

    Authors: Miaomiao Sun, Bo Xu, Chao Chen, Youjie Zhu, Xiaomo Li and Kuisheng Chen
    Citation: Clinical Epigenetics 2024 16:25
  15. DNA methylation is a pivotal epigenetic modification that affects gene expression. Tumor immune microenvironment (TIME) comprises diverse immune cells and stromal components, creating a complex landscape that ...

    Authors: Daoqi Zhu, Siying Zeng, Chao Su, Jingjun Li, Yiwen Xuan, Yongkai Lin, Enwu Xu and Qin Fan
    Citation: Clinical Epigenetics 2024 16:24
  16. Authors: Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, Rémy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, Sébastien Hergalant, David Coelho, Jean-Louis Guéant and Rosa-Maria Guéant-Rodriguez
    Citation: Clinical Epigenetics 2024 16:23

    The original article was published in Clinical Epigenetics 2023 15:158

  17. Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DN...

    Authors: Y. E. Willems, A. deSteiguer, P. T. Tanksley, L. Vinnik, D. Fraemke, A. Okbay, D. Richter, G. G. Wagner, R. Hertwig, P. Koellinger, E. M. Tucker-Drob, K. P. Harden and Laurel Raffington
    Citation: Clinical Epigenetics 2024 16:22
  18. Environmental exposure, medical diagnostic and therapeutic applications, and industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation (< 100 mGy). C...

    Authors: Jihye Park, Hae-June Lee, Yu Kyeong Han, Keunsoo Kang and Joo Mi Yi
    Citation: Clinical Epigenetics 2024 16:19
  19. Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteo...

    Authors: Yiwen Zhang, Yiping Kong, Wenjie Zhang, Jinlin He, Zhanqi Zhang, Yongjie Cai, Yiqing Zhao and Qiong Xu
    Citation: Clinical Epigenetics 2024 16:18
  20. Changes in DNA methylation are common events in the pathogenesis of acute myeloid leukemia (AML) and have been repeatedly reported as associated with prognosis. However, studies integrating these numerous and ...

    Authors: Šárka Šestáková, Cyril Šálek, Dávid Kundrát, Ela Cerovská, Jan Vydra, Ivana Ježíšková, Adam Folta, Jiří Mayer, Petr Cetkovský and Hana Remešová
    Citation: Clinical Epigenetics 2024 16:17
  21. Decitabine has been widely used to treat acute myeloid leukemia (AML); however as AML is a heterogeneous disease, not all patients benefit from decitabine. This study aimed to identify markers for predicting t...

    Authors: Yi Li, Xia Mao, Mengyuan Li, Li Li, Xiwen Tong and Lifang Huang
    Citation: Clinical Epigenetics 2024 16:16
  22. DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics change in asthma, we used publicly available DNAm (asthmatics, n ...

    Authors: Eskezeia Y. Dessie, Lili Ding and Tesfaye B. Mersha
    Citation: Clinical Epigenetics 2024 16:15
  23. Epigenetics plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Some studies have reported that YAP is involved in inflammatory response and can regulate target genes through epige...

    Authors: Hua Zhu, Jiali Lu, MingYue Fu, Ping Chen, Yali Yu, Min Chen, Qiu Zhao, Min Wu and Mei Ye
    Citation: Clinical Epigenetics 2024 16:14
  24. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essen...

    Authors: Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann…
    Citation: Clinical Epigenetics 2024 16:13
  25. The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter r...

    Authors: Xiuqin Bao, Yuanyi Gao, Zhongju Wang, Yuhua Ye, Diyu Chen, Yangjin Zuo, Cunyou Zhao and Xiangmin Xu
    Citation: Clinical Epigenetics 2024 16:12
  26. As an oncovirus, EBV is associated with multiple cancers, including solid tumors and hematological malignancies. EBV methylation plays an important role in regulating tumor occurrence. However, the EBV methyla...

    Authors: Cao-Li Tang, Xi-Zhao Li, Ting Zhou, Chang-Mi Deng, Cheng-Tao Jiang, Yu-Meng Zhang, Ying Liao, Tong-Min Wang, Yong-Qiao He, Wen-Qiong Xue, Wei-Hua Jia and Xiao-Hui Zheng
    Citation: Clinical Epigenetics 2024 16:11
  27. Metastasis is the primary cause of recurrence and death in patients with papillary thyroid carcinoma (PTC). LncRNA ACTA2-AS1, a long non-coding RNA, acts as a tumor suppressor in multiple types of human malign...

    Authors: Shuhui Wu, Jingjing Zhu, Tingting Jiang, Ting Cui, Qi Zuo, Guibin Zheng, Guojun Li, Jieyu Zhou and Xiang Chen
    Citation: Clinical Epigenetics 2024 16:10
  28. Malignant peripheral nerve sheath tumors (MPNSTs) account for 3–10% of pediatric sarcomas, 50% of which occur in neurofibromatosis type 1 (NF1). Sporadic MPNSTs diagnosis may be challenging due to the absence ...

    Authors: Sara Patrizi, Evelina Miele, Lorenza Falcone, Silvia Vallese, Sabrina Rossi, Sabina Barresi, Isabella Giovannoni, Lucia Pedace, Claudia Nardini, Ilaria Masier, Luana Abballe, Antonella Cacchione, Ida Russo, Angela Di Giannatale, Valentina Di Ruscio, Claudia Maria Salgado…
    Citation: Clinical Epigenetics 2024 16:9
  29. Cisplatin is an alkylating class of chemotherapeutic drugs used to treat cancer patients. However, cisplatin fails in long-term treatment, and drug resistance is the primary reason for tumor recurrence. Hence,...

    Authors: Abhiram Natu, Tripti Verma, Bharat Khade, Rahul Thorat, Poonam Gera, Sangita Dhara and Sanjay Gupta
    Citation: Clinical Epigenetics 2024 16:8
  30. The management of myocardial ischemia–reperfusion injury (MIRI) presents continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays distinct roles in various disease contexts and is h...

    Authors: Kun Liu, Hecheng Wang, Yiou Wang, Xiaoxu Zhang, Ruihu Wang, Zhaoxuan Zhang, Jian Wang, Xinran Lu, Xiaoyu Wu and Yanshuo Han
    Citation: Clinical Epigenetics 2024 16:7
  31. Studies have shown that tet methylcytosine dioxygenase 2 (TET2) is highly expressed in diabetic retinopathy (DR), which reduces the DNA methylation of downstream gene promoters and activates the transcription....

    Authors: Chunyang Cai, Chufeng Gu, Shuai He, Chunren Meng, Dongwei Lai, Jingfa Zhang and Qinghua Qiu
    Citation: Clinical Epigenetics 2024 16:6
  32. Among men, prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer death. Etiologic factors associated with both prostate carcinogenesis and somatic alterations in tumors ...

    Authors: Samuel R. Reynolds, Ze Zhang, Lucas A. Salas and Brock C. Christensen
    Citation: Clinical Epigenetics 2024 16:5
  33. Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other physiological processes. DNA methylation plays a significant role in modulating th...

    Authors: Ivona Bečeheli, Marina Horvatiček, Maja Perić, Barbara Nikolić, Cyrielle Holuka, Marija Klasić, Marina Ivanišević, Mirta Starčević, Gernot Desoye, Dubravka Hranilović, Jonathan D. Turner and Jasminka Štefulj
    Citation: Clinical Epigenetics 2024 16:4
  34. Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we c...

    Authors: Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek and Jean-Pierre J. Issa
    Citation: Clinical Epigenetics 2024 16:3
  35. The objective of this study was to examine and analyze differential methylation profiles in order to investigate the influence of hyper-methioninemia (HM) on the development of diabetic nephropathy (DN). Male ...

    Authors: Yongwei Jiang, GuoXiong Deng, Chengyin Liu, Han Tang, Jing Zheng, Xiaomu Kong, Meimei Zhao, Yi Liu, Peng Gao, Tianbao Li, Hailing Zhao, Yongtong Cao, Ping Li and Liang Ma
    Citation: Clinical Epigenetics 2024 16:1
  36. Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A ...

    Authors: Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone and Caterina Alfano
    Citation: Clinical Epigenetics 2023 15:197
  37. Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours. Pathogenic variants have been identified in more than 15 susceptibility genes; associated tumours are grouped into three Clusters,...

    Authors: Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Fishbein, Roberta Noberini, Ioannis N. Anastopoulos, Nicola Tufton, Eugenie S. Lim, Rupert Obholzer, Johnathan G. Hubbard, Mufaddal Moonim, Tiziana Bonaldi, Katherine L. Nathanson, Louise Izatt and Rebecca J. Oakey
    Citation: Clinical Epigenetics 2023 15:196
  38. DNA sequence variation and altered epigenetic regulation of the oxytocin receptor gene (OXTR) have been implicated in autism and autistic-like behaviors. While previous studies have examined subsegments of OXT...

    Authors: Jelte Wieting, Kirsten Jahn, Stefan Bleich, Helge Frieling and Maximilian Deest
    Citation: Clinical Epigenetics 2023 15:195
  39. Clopidogrel resistance profoundly increases the risk of major cardiovascular events in coronary artery disease (CAD) patients. Here, we comprehensively analyse global m6A modification alterations in clopidogre...

    Authors: Ruoyan Yu, Qinglin Yu, Zhenwei Li, Jiyi Li, Jin Yang, Yingchu Hu, Nan Zheng, Xiaojin Li, Yudie Song, Jiahui Li, Xiaomin Chen, Weiping Du and Jia Su
    Citation: Clinical Epigenetics 2023 15:194
  40. Colon cancer (CC) is a heterogeneous disease that is categorized into four Consensus Molecular Subtypes (CMS) according to gene expression. Patients with loco-regional CC (stages II/III) lack prognostic factor...

    Authors: Irene Fernandez-De-Los-Reyes, Marisa Gomez-Dorronsoro, Iñaki Monreal-Santesteban, Agustín Fernandez-Fernandez, Mario Fraga, Pablo Azcue, Laura Alonso, Beatriz Fernandez-Marlasca, Javier Suarez, Alicia Cordoba-Iturriagagoitia and David Guerrero-Setas
    Citation: Clinical Epigenetics 2023 15:193
  41. Glioblastoma (GBM) is the most malignant and invasive human brain tumor. Histone demethylase 4B (KDM4B) is abnormally expressed in GBM, but the molecular mechanisms by which KDM4B affects the malignant tumor p...

    Authors: Zhongze Wang, Huarui Cai, Zekun Li, Wei Sun, Erhu Zhao and Hongjuan Cui
    Citation: Clinical Epigenetics 2023 15:192
  42. In 1990, David Barker proposed that prenatal nutrition is directly linked to adult cardiovascular disease. Since then, the relationship between adult cardiovascular risk, metabolic syndrome and birth weight ha...

    Authors: Tamara Carrizosa-Molina, Natalia Casillas-Díaz, Iris Pérez-Nadador, Claudia Vales-Villamarín, Miguel Ángel López-Martínez, Rosa Riveiro-Álvarez, Larry Wilhelm, Rita Cervera-Juanes, Carmen Garcés, Alejandro Lomniczi and Leandro Soriano-Guillén
    Citation: Clinical Epigenetics 2023 15:191
  43. Chronic migraine, a highly disabling migraine subtype, affects nearly 2% of the general population. Understanding migraine chronification is vital for developing better treatment and prevention strategies. An ...

    Authors: Divya Mehta, Irene de Boer, Heidi G. Sutherland, Judith A. Pijpers, Charlene Bron, Charlotte Bainomugisa, Larisa M. Haupt, Arn M. J. M. van den Maagdenberg, Lyn R. Griffiths, Dale R. Nyholt and Gisela M. Terwindt
    Citation: Clinical Epigenetics 2023 15:190
  44. Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a continental subarctic climate with severe winters, with the regular January average temperatur...

    Authors: Alena Kalyakulina, Igor Yusipov, Elena Kondakova, Maria Giulia Bacalini, Cristina Giuliani, Tatiana Sivtseva, Sergey Semenov, Artem Ksenofontov, Maria Nikolaeva, Elza Khusnutdinova, Raisa Zakharova, Maria Vedunova, Claudio Franceschi and Mikhail Ivanchenko
    Citation: Clinical Epigenetics 2023 15:189
  45. Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. The placenta is a central regulator of the in utero environment that orchestrates develo...

    Authors: Hachem Saddiki, Xueying Zhang, Elena Colicino, Ander Wilson, Itai Kloog, Robert O. Wright, Rosalind J. Wright and Corina Lesseur
    Citation: Clinical Epigenetics 2023 15:188
  46. Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natural killer/T cell lymphoma (ENKTL). However, the underlying mechanisms of EZH2 upregula...

    Authors: Boheng Li, Qidi Zhou, Qin Wan, Xuan Qiao, Shangying Chen, Jianbiao Zhou, Zhijun Wuxiao, Lei Luo, Siok-Bian Ng, Jieping Li and Wee-Joo Chng
    Citation: Clinical Epigenetics 2023 15:187
  47. Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treatment goal. This case of a 75-year-old patient with secondary AML receiving the combinat...

    Authors: Nora Rebeka Javorniczky, Olga Grishina, Inga Hund, Milena Pantic, Dietmar Pfeifer, Claudia Schmoor, Johanna Thomas, Justus Duyster, Heiko Becker and Michael Lübbert
    Citation: Clinical Epigenetics 2023 15:185