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  1. The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylate...

    Authors: Alba Fernández-Sanlés, Sergi Sayols-Baixeras, Isaac Subirana, Mariano Sentí, S. Pérez-Fernández, Manuel de Castro Moura, Manel Esteller, Jaume Marrugat and Roberto Elosua

    Citation: Clinical Epigenetics 2021 13:86

    Content type: Research

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  2. Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level ...

    Authors: Ida K. Karlsson, Malin Ericsson, Yunzhang Wang, Juulia Jylhävä, Sara Hägg, Anna K. Dahl Aslan, Chandra A. Reynolds and Nancy L. Pedersen

    Citation: Clinical Epigenetics 2021 13:85

    Content type: Research

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  3. Bladder cancer (BC) is the 5th most common cancer in the USA. Non-muscle invasive bladder cancer represents about 70% of all cases and has generally a favorable outcome. However, recurrence rates as high as 60...

    Authors: Paolo Piatti, Yap Ching Chew, Michiko Suwoto, Taikun Yamada, Benjamin Jara, Xi-Yu Jia, Wei Guo, Saum Ghodoussipour, Siamak Daneshmand, Hamed Ahmadi, Jeffrey Rice, Jeffrey Bhasin, Faith Holloway, Yvonne Tsai, Yoshitomo Chihara and Gangning Liang

    Citation: Clinical Epigenetics 2021 13:84

    Content type: Research

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  4. Epigenetic (“above genetics”) modifications can alter the gene expression without altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA methylation, histone methylation, histone acet...

    Authors: Ning Jin, Tiffany L. George, Gregory A. Otterson, Claire Verschraegen, Haitao Wen, David Carbone, James Herman, Erin M. Bertino and Kai He

    Citation: Clinical Epigenetics 2021 13:83

    Content type: Review

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  5. Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate pre...

    Authors: Kristine L. Haftorn, Yunsung Lee, William R. P. Denault, Christian M. Page, Haakon E. Nustad, Robert Lyle, Håkon K. Gjessing, Anni Malmberg, Maria C. Magnus, Øyvind Næss, Darina Czamara, Katri Räikkönen, Jari Lahti, Per Magnus, Siri E. Håberg, Astanand Jugessur…

    Citation: Clinical Epigenetics 2021 13:82

    Content type: Research

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  6. Eosinophilic esophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. The diagnosis relies on histological examination of esophageal mucosal biopsies and requires the presen...

    Authors: Caterina Strisciuglio, Felicity Payne, Komal Nayak, Marialuisa Andreozzi, Alessandra Vitale, Erasmo Miele and Matthias Zilbauer

    Citation: Clinical Epigenetics 2021 13:81

    Content type: Short report

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  7. Colonoscopy and the fecal immunochemical test (FIT) are currently the most widely used screening modalities for colorectal cancer (CRC), however, both with their own limitations. Here we aim to identify and va...

    Authors: Glenn Rademakers, Maartje Massen, Alexander Koch, Muriel X. Draht, Nikkie Buekers, Kim A. D. Wouters, Nathalie Vaes, Tim De Meyer, Beatriz Carvalho, Gerrit A. Meijer, James G. Herman, Kim M. Smits, Manon van Engeland and Veerle Melotte

    Citation: Clinical Epigenetics 2021 13:80

    Content type: Research

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  8. Diagnostic biomarkers for detecting chronic obstructive pulmonary disease (COPD) in acute coronary syndrome (ACS) patients are not available. SERPINA1, coding for the most potent circulating anti-inflammatory pro...

    Authors: John Charles Rotondo, Giorgio Aquila, Lucia Oton-Gonzalez, Rita Selvatici, Paola Rizzo, Monica De Mattei, Rita Pavasini, Mauro Tognon, Gianluca Calogero Campo and Fernanda Martini

    Citation: Clinical Epigenetics 2021 13:79

    Content type: Research

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  9. Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic m...

    Authors: Theodora Kunovac Kallak, Emma Bränn, Emma Fransson, Åsa Johansson, Susanne Lager, Erika Comasco, Robert Lyle and Alkistis Skalkidou

    Citation: Clinical Epigenetics 2021 13:78

    Content type: Research

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  10. Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51...

    Authors: Julia Stomper, Ruth Meier, Tobias Ma, Dietmar Pfeifer, Gabriele Ihorst, Nadja Blagitko-Dorfs, Gabriele Greve, Dennis Zimmer, Uwe Platzbecker, Anne Hagemeijer, Annette Schmitt-Gräff and Michael Lübbert

    Citation: Clinical Epigenetics 2021 13:77

    Content type: Research

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  11. Dysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic m...

    Authors: Wan-Ru Wang, Nai-Tzu Chen, Nai-Yun Hsu, I-Ying Kuo, Hsin-Wen Chang, Jiu-Yao Wang and Huey-Jen Su

    Citation: Clinical Epigenetics 2021 13:76

    Content type: Research

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  12. The integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets....

    Authors: Guillermo Palou-Márquez, Isaac Subirana, Lara Nonell, Alba Fernández-Sanlés and Roberto Elosua

    Citation: Clinical Epigenetics 2021 13:75

    Content type: Research

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  13. Prenatal smoking exposure has been associated with childhood attention-deficit/hyperactivity disorder (ADHD). However, the mechanism underlying this relationship remains unclear. We assessed whether DNA methyl...

    Authors: Kunio Miyake, Chihiro Miyashita, Atsuko Ikeda-Araki, Ryu Miura, Sachiko Itoh, Keiko Yamazaki, Sumitaka Kobayashi, Hideyuki Masuda, Tadao Ooka, Zentaro Yamagata and Reiko Kishi

    Citation: Clinical Epigenetics 2021 13:74

    Content type: Research

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  14. Parthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this condition is mediated by parthenogenetic activation and is free from a...

    Authors: Yohei Masunaga, Masayo Kagami, Fumiko Kato, Takeshi Usui, Takako Yonemoto, Kazuo Mishima, Maki Fukami, Kazushi Aoto, Hirotomo Saitsu and Tsutomu Ogata

    Citation: Clinical Epigenetics 2021 13:73

    Content type: Research

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  15. The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone acetyl...

    Authors: Wafaa S. Ramadan, Iman M. Talaat, Mahmood Y. Hachim, Annette Lischka, Timo Gemoll and Raafat El-Awady

    Citation: Clinical Epigenetics 2021 13:72

    Content type: Research

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  16. Testicular germ cell tumors (TGCTs) are among the most common solid malignancies in young-adult men, and currently most mortality is due to metastatic disease and emergence of resistance to cisplatin. There is...

    Authors: João Lobo, Vera Constâncio, Pedro Leite-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Leendert H. J. Looijenga, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2021 13:70

    Content type: Research

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  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis

    Citation: Clinical Epigenetics 2021 13:69

    Content type: Correction

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    The original article was published in Clinical Epigenetics 2020 12:102

  18. Poor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeve...

    Authors: J. R. Pfeiffer, Angela C. Bustamante, Grace S. Kim, Don Armstrong, Annchen R. Knodt, Karestan C. Koenen, Ahmad R. Hariri and Monica Uddin

    Citation: Clinical Epigenetics 2021 13:68

    Content type: Research

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sara Gombert, Mathias Rhein, Andreas Winterpacht, Tino Münster, Thomas Hillemacher, Andreas Leffler and Helge Frieling

    Citation: Clinical Epigenetics 2021 13:67

    Content type: Correction

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    The original article was published in Clinical Epigenetics 2019 12:1

  20. Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedsi...

    Authors: Federica Sarno, Giuditta Benincasa, Markus List, Albert-Lazlo Barabasi, Jan Baumbach, Fortunato Ciardiello, Sebastiano Filetti, Kimberly Glass, Joseph Loscalzo, Cinzia Marchese, Bradley A. Maron, Paola Paci, Paolo Parini, Enrico Petrillo, Edwin K. Silverman, Antonella Verrienti…

    Citation: Clinical Epigenetics 2021 13:66

    Content type: Review

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  21. Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression...

    Authors: Mojgan Sheikhpour, Mobina Maleki, Maryam Ebrahimi Vargoorani and Vahid Amiri

    Citation: Clinical Epigenetics 2021 13:65

    Content type: Review

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  22. Previous studies have shown that DNA methylation (DNAm) is associated with body mass index (BMI). However, it is unknown whether DNAm at pre-adolescence is associated with BMI status transition from pre- to po...

    Authors: Jiajing Wang, Hongmei Zhang, Faisal I. Rezwan, Caroline Relton, S. Hasan Arshad and John W. Holloway

    Citation: Clinical Epigenetics 2021 13:64

    Content type: Research

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  23. Epigenetic alterations are known contributors to cancer development and aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are present in cells of the tumor microenvironment, ...

    Authors: Iris Lodewijk, Sandra P. Nunes, Rui Henrique, Carmen Jerónimo, Marta Dueñas and Jesús M. Paramio

    Citation: Clinical Epigenetics 2021 13:63

    Content type: Review

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  24. Enhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistan...

    Authors: Chen Li, Yan Wang, Yueqing Gong, Tengrui Zhang, Jiaqi Huang, Zhen Tan and Lixiang Xue

    Citation: Clinical Epigenetics 2021 13:62

    Content type: Review

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  25. Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the cardiac muscle, frequently caused by mutations in MYBPC3. However, little is known about the upstream pathways and key regulators causin...

    Authors: J. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar…

    Citation: Clinical Epigenetics 2021 13:61

    Content type: Research

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  26. DNA methylation is a key epigenetic modification that can directly affect gene regulation. DNA methylation is highly influenced by environmental factors such as cigarette smoking, which is causally related to ...

    Authors: Chen Yao, Roby Joehanes, Rory Wilson, Toshiko Tanaka, Luigi Ferrucci, Anja Kretschmer, Holger Prokisch, Katharina Schramm, Christian Gieger, Annette Peters, Melanie Waldenberger, Carola Marzi, Christian Herder and Daniel Levy

    Citation: Clinical Epigenetics 2021 13:60

    Content type: Research

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  27. Lead, a known neurotoxicant, has previously received attention in Parkinson’s disease (PD) research, but epidemiologic studies have been limited in sample size and findings are equivocal. We generated two meth...

    Authors: Kimberly C. Paul, Steve Horvath, Irish Del Rosario, Jeff M. Bronstein and Beate Ritz

    Citation: Clinical Epigenetics 2021 13:59

    Content type: Short report

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  28. Valproic acid (VPA) is one of the most commonly used anti-epileptic drugs with pharmacological actions on GABA and blocking voltage-gated ion channels. VPA also inhibits histone deacetylase (HDAC) activity. Su...

    Authors: Sebastian Lunke, Scott Maxwell, Ishant Khurana, Harikrishnan K.N., Jun Okabe, Keith Al-Hasani and Assam El-Osta

    Citation: Clinical Epigenetics 2021 13:58

    Content type: Research

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  29. Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PA...

    Authors: Chiara Moccia, Maja Popovic, Elena Isaevska, Valentina Fiano, Morena Trevisan, Franca Rusconi, Silvia Polidoro and Lorenzo Richiardi

    Citation: Clinical Epigenetics 2021 13:57

    Content type: Research

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  30. An intronic GGGGCC (G4C2) hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), referred to as C9ALS/FTD. No ...

    Authors: Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown Jr., Martín Montecino and Brigitte van Zundert

    Citation: Clinical Epigenetics 2021 13:56

    Content type: Research

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  31. Cardiovascular disease (CVD) is the leading cause of mortality among US adults. African Americans have higher burden of CVD morbidity and mortality compared to any other racial group. Identifying biomarkers fo...

    Authors: Farah Ammous, Wei Zhao, Scott M. Ratliff, Thomas H. Mosley, Lawrence F. Bielak, Xiang Zhou, Patricia A. Peyser, Sharon L. R. Kardia and Jennifer A. Smith

    Citation: Clinical Epigenetics 2021 13:55

    Content type: Research

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  32. Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer-related death and represents a major health burden worldwide. Current therapies for NSCLC include chemotherapy, immunotherapy, and targeted mo...

    Authors: Claudia Dominici, Nicolas Sgarioto, Zhenbao Yu, Laura Sesma-Sanz, Jean-Yves Masson, Stéphane Richard and Noël J.-M. Raynal

    Citation: Clinical Epigenetics 2021 13:54

    Content type: Research

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  33. Intervertebral disc degeneration (IDD) is a major cause of lower back pain. This study aimed at exploring the effects of histone deacetylase 4 (HDAC4) and its upstream and downstream signaling molecules on IDD...

    Authors: Lin Xiao, Dongping Gong, Loufeng Liang, Anwei Liang, Huaxin Liang, Xiayi Xu and Hongli Teng

    Citation: Clinical Epigenetics 2021 13:53

    Content type: Research

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  34. The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients t...

    Authors: Rocio Rosas-Alonso, Julian Colmenarejo-Fernandez, Olga Pernia, Carlos Rodriguez-Antolín, Isabel Esteban, Ismael Ghanem, Dario Sanchez-Cabrero, Itsaso Losantos-Garcia, Sara Palacios-Zambrano, Gema Moreno-Bueno, Javier de Castro, Virginia Martinez-Marin and Inmaculada Ibanez-de-Caceres

    Citation: Clinical Epigenetics 2021 13:52

    Content type: Research

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  35. Hirschsprung disease (HSCR, OMIM 142623) is a rare congenital disorder that results from a failure to fully colonize the gut by enteric precursor cells (EPCs) derived from the neural crest. Such incomplete gut...

    Authors: Leticia Villalba-Benito, Daniel López-López, Ana Torroglosa, Carlos S. Casimiro-Soriguer, Berta Luzón-Toro, Raquel María Fernández, María José Moya-Jiménez, Guillermo Antiñolo, Joaquín Dopazo and Salud Borrego

    Citation: Clinical Epigenetics 2021 13:51

    Content type: Research

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  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alejandra Sandoval-Bórquez, Iva Polakovicova, Nicolás Carrasco-Véliz, Lorena Lobos-González, Ismael Riquelme, Gonzalo Carrasco-Avino, Carolina Bizama, Enrique Norero, Gareth I. Owen, Juan C. Roa and Alejandro H. Corvalán

    Citation: Clinical Epigenetics 2021 13:50

    Content type: Correction

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    The original article was published in Clinical Epigenetics 2017 9:114

  37. Altered DNA methylation patterns play important roles in cancer development and progression. We examined whether expression levels of genes directly or indirectly involved in DNA methylation and demethylation ...

    Authors: Suleyman Vural, Alida Palmisano, William C. Reinhold, Yves Pommier, Beverly A. Teicher and Julia Krushkal

    Citation: Clinical Epigenetics 2021 13:49

    Content type: Research

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  38. DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple facto...

    Authors: Anat Yaskolka Meir, Maria Keller, Stephan H. Bernhart, Ehud Rinott, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Schwarzfuchs, Ilan Shelef, Yftach Gepner, Jun Li, Yifei Lin, Matthias Blüher, Uta Ceglarek, Michael Stumvoll, Peter F. Stadler…

    Citation: Clinical Epigenetics 2021 13:48

    Content type: Research

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  39. Maternal smoking affects more than half a million pregnancies each year in the US and is known to result in fetal growth restriction as measured by lower birthweight and its associated long-term consequences. ...

    Authors: Richard Xu, Xiumei Hong, Boyang Zhang, Wanyu Huang, Wenpin Hou, Guoying Wang, Xiaobin Wang, Tak Igusa, Liming Liang and Hongkai Ji

    Citation: Clinical Epigenetics 2021 13:47

    Content type: Research

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  40. Assessing functional ability is an important component of understanding healthy aging. Objective measures of functional ability include grip strength, gait speed, sit-to-stand time, and 6-min walk distance. Us...

    Authors: Curtis L. Petersen, Brock C. Christensen and John A. Batsis

    Citation: Clinical Epigenetics 2021 13:46

    Content type: Research

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  41. Chromatin modifiers and their implications in oncogenesis have been an exciting area of cancer research. These are enzymes that modify chromatin via post-translational modifications such as methylation, acetyl...

    Authors: Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt and Vassiliki Saloura

    Citation: Clinical Epigenetics 2021 13:45

    Content type: Review

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  42. Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-m...

    Authors: Carmen S. Tellez, Maria A. Picchi, Daniel Juri, Kieu Do, Dhimant H. Desai, Shantu G. Amin, Julie A. Hutt, Piotr T. Filipczak and Steven A. Belinsky

    Citation: Clinical Epigenetics 2021 13:44

    Content type: Research

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  43. Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic–hematopoietic cancers and, for comparison, with solid cancers. We also e...

    Authors: Arce Domingo-Relloso, Tianxiao Huan, Karin Haack, Angela L. Riffo-Campos, Daniel Levy, M. Daniele Fallin, Mary Beth Terry, Ying Zhang, Dorothy A. Rhoades, Miguel Herreros-Martinez, Esther Garcia-Esquinas, Shelley A. Cole, Maria Tellez-Plaza and Ana Navas-Acien

    Citation: Clinical Epigenetics 2021 13:43

    Content type: Research

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  44. Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom...

    Authors: Tess D. Pottinger, Sadiya S. Khan, Yinan Zheng, Wei Zhang, Hilary A. Tindle, Matthew Allison, Gretchen Wells, Aladdin H. Shadyab, Rami Nassir, Lisa Warsinger Martin, JoAnn E. Manson, Donald M. Lloyd-Jones, Philip Greenland, Andrea A. Baccarelli, Eric A. Whitsel and Lifang Hou

    Citation: Clinical Epigenetics 2021 13:42

    Content type: Research

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  45. Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms related to changes in DNA methylation (DNAm), may a...

    Authors: Diana L. Juvinao-Quintero, Riccardo E. Marioni, Carolina Ochoa-Rosales, Tom C. Russ, Ian J. Deary, Joyce B. J. van Meurs, Trudy Voortman, Marie-France Hivert, Gemma C. Sharp, Caroline L. Relton and Hannah R. Elliott

    Citation: Clinical Epigenetics 2021 13:40

    Content type: Research

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  46. In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's dise...

    Authors: Cecilia Fernández-Ponce, Roberto Navarro Quiroz, Anderson Díaz Perez, Gustavo Aroca Martinez, Andrés Cadena Bonfanti, Antonio Acosta Hoyos, Lorena Gómez Escorcia, Sandra Hernández Agudelo, Christian Orozco Sánchez, José Villarreal Camacho, Linda Atencio Ibarra, Jose Consuegra Machado, Alberto Espinoza Garavito, Francisco García-Cózar and Elkin Navarro Quiroz

    Citation: Clinical Epigenetics 2021 13:39

    Content type: Review

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  47. BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF chromatin remodelling complex, with key roles in modulating DNA accessibility. Dysregulation of BRG1 is observed, but functionally uncharacterised...

    Authors: Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia R. Kafer, Samuel Rogers, Phuc-Loi Luu, Anthony J. Cesare, Susan J. Clark and Phillippa C. Taberlay

    Citation: Clinical Epigenetics 2021 13:37

    Content type: Research

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