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  1. Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. Studies have indicated that estrogen can regulate the expression of miRNAs in numerous malignancies. MiR-570-3p has been shown to have a regu...

    Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen and Ruinian Zheng
    Citation: Clinical Epigenetics 2024 16:81
  2. Older patients are at risk for acute kidney injury and chronic kidney disease. Age-related increases in DNA methylation at CpG islands have been linked to aging-related diseases like cancer and cardiovascular ...

    Authors: Po-Lung Yang, Tai-Shuan Lai, Yu-Hsiang Chou, Liang-Chuan Lai, Shuei-Liong Lin and Yung-Ming Chen
    Citation: Clinical Epigenetics 2024 16:80
  3. As new treatment options for patients with higher-risk myelodysplastic syndromes are emerging, identification of prognostic markers for hypomethylating agent (HMA) treatment and understanding mechanisms of the...

    Authors: Theodora Chatzilygeroudi, Vasiliki Chondrou, Ruben Boers, Stavroula Siamoglou, Katerina Athanasopoulou, Evgenia Verigou, Joost Gribnau, Spyridon Alexis, Vassiliki Labropoulou, Alexandra Kourakli, George P. Patrinos, Argyro Sgourou and Argiris Symeonidis
    Citation: Clinical Epigenetics 2024 16:79
  4. Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion globally. Most people affected are with type 2 diabetes mellitus (T2DM), which is caused b...

    Authors: Kukkala Kiran Kumar, Elhadi Husein Aburawi, Milos Ljubisavljevic, Melvin Khee Shing Leow, Xu Feng, Suraiya Anjum Ansari and Bright Starling Emerald
    Citation: Clinical Epigenetics 2024 16:78
  5. The major challenge in routine endocervical curettage (ECC) among Human Papillomavirus (HPV) 16/18-positive patients is that only a small fraction benefit. Nevertheless, current reported models often overestim...

    Authors: Yingnan Lu, Haiyue Wu, Kun Fu, YuFei Shen, Lucia Li, Zexi Liao, Yingzhen Liu, Yanan Kang and Yu Zhang
    Citation: Clinical Epigenetics 2024 16:77
  6. Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA methyltransferase DNMT3A gene. Typical TBRS clinical features are overgrowth, ...

    Authors: Dovile Zebrauskiene, Egle Sadauskiene, Justas Dapkunas, Visvaldas Kairys, Joris Balciunas, Aleksandras Konovalovas, Ruta Masiuliene, Gunda Petraityte, Nomeda Valeviciene, Mindaugas Mataciunas, Jurate Barysiene, Violeta Mikstiene, Migle Tomkuviene and Egle Preiksaitiene
    Citation: Clinical Epigenetics 2024 16:76
  7. Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetic...

    Authors: Joan Jiménez-Balado, Isabel Fernández-Pérez, Cristina Gallego-Fábrega, Uxue Lazcano, Carolina Soriano-Tárraga, Marta Vallverdú-Prats, Marina Mola-Caminal, Lucía Rey-Álvarez, Adrià Macias-Gómez, Antoni Suárez-Pérez, Eva Giralt-Steinhauer, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Ángel Ois, Manel Esteller, Jaume Roquer…
    Citation: Clinical Epigenetics 2024 16:75
  8. Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can influence the in-utero environment and subsequent off...

    Authors: Wei Q. Deng, Marie Pigeyre, Sandi M. Azab, Samantha L. Wilson, Natalie Campbell, Nathan Cawte, Katherine M. Morrison, Stephanie A. Atkinson, Padmaja Subbarao, Stuart E. Turvey, Theo J. Moraes, Piush Mandhane, Meghan B. Azad, Elinor Simons, Guillaume Pare and Sonia S. Anand
    Citation: Clinical Epigenetics 2024 16:74
  9. Silver–Russell syndrome (SRS) is a representative imprinting disorder characterized by pre- and postnatal growth failure. We encountered two Japanese SRS cases with a de novo pathogenic frameshift variant of HMGA...

    Authors: Kaori Yamoto, Hirotomo Saitsu, Yumiko Ohkubo, Masayo Kagami and Tsutomu Ogata
    Citation: Clinical Epigenetics 2024 16:73
  10. Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since the discovery of the Warburg effect in tumor cells. Numerous ...

    Authors: Yue Hu, Zhenglin He, Zongjun Li, Yihan Wang, Nan Wu, Hongyan Sun, Zilong Zhou, Qianying Hu and Xianling Cong
    Citation: Clinical Epigenetics 2024 16:72
  11. Methylation of serotonin-related genes has been proposed as a plausible gene-by-environment link which may mediate environmental stress, depressive and anxiety symptoms. DNA methylation is often measured in bl...

    Authors: S. E. P. Bruzzone, B. Ozenne, P. M. Fisher, G. Ortega, P. S. Jensen, V. H. Dam, C. Svarer, G. M. Knudsen, K. P. Lesch and V. G. Frokjaer
    Citation: Clinical Epigenetics 2024 16:71
  12. Obesity is a global public health concern linked to chronic diseases such as cardiovascular disease and type 2 diabetes (T2D). Emerging evidence suggests that epigenetic modifications, particularly DNA methyla...

    Authors: Wenran Li, Mingfeng Xia, Hailuan Zeng, Huandong Lin, Andrew E. Teschendorff, Xin Gao and Sijia Wang
    Citation: Clinical Epigenetics 2024 16:70
  13. Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for impro...

    Authors: Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord and Karolina A. Aberg
    Citation: Clinical Epigenetics 2024 16:69
  14. Large B-cell lymphoma (LBCL) is the most common lymphoma and is known to be a biologically heterogeneous disease regarding genetic, phenotypic, and clinical features. Although the prognosis is good, one-third ...

    Authors: Olivia Carlund, Elina Thörn, Pia Osterman, Maja Fors, Andy Dernstedt, Mattias N. E. Forsell, Martin Erlanson, Mattias Landfors, Sofie Degerman and Magnus Hultdin
    Citation: Clinical Epigenetics 2024 16:68
  15. DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid early detection and/or therapeutic treatm...

    Authors: Nikhil Nadiger, Jyothisha Kana Veed, Priyanka Chinya Nataraj and Arpita Mukhopadhyay
    Citation: Clinical Epigenetics 2024 16:67
  16. There is an unmet need for precise biomarkers for early non-invasive breast cancer detection. Here, we aimed to identify blood-based DNA methylation biomarkers that are associated with breast cancer.

    Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Pei-Yi Ong, Patricia T. Kin, Chia Wei Lim, Jens Samol, Ngiap Chuan Tan, Hai-Yang Law, Min-Han Tan, Soo-Chin Lee, Peter Ang and Ann S. G. Lee
    Citation: Clinical Epigenetics 2024 16:66
  17. Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is know...

    Authors: Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones and Brandy A. Wicklow
    Citation: Clinical Epigenetics 2024 16:65
  18. Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among...

    Authors: Niek G. C. Bloks, Amanda Dicks, Zainab Harissa, Rob G. H. H. Nelissen, Ghazaleh Hajmousa, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Farshid Guilak and Ingrid Meulenbelt
    Citation: Clinical Epigenetics 2024 16:64
  19. Decitabine (DAC), a DNA methyltransferase inhibitor, has shown efficacy combined with chemotherapy for relapsed or refractory (R/R) acute myeloid leukemia (AML) in adults, but less is known about its efficacy ...

    Authors: Na Zhang, Hong Li, Dan Wang, Zhen Wang, Jia-Shi Zhu, Kai Chen, Hui Jiang, Jing-Bo Shao and Cheng Cai
    Citation: Clinical Epigenetics 2024 16:63
  20. Temple syndrome (TS14) is a rare imprinting disorder caused by maternal UPD14, imprinting defects or paternal microdeletions which lead to an increase in the maternal expressed genes and a silencing the patern...

    Authors: Neus Baena, David Monk, Cinthia Aguilera, Mario F. Fraga, Agustín F. Fernández, Elisabeth Gabau, Raquel Corripio, Nuria Capdevila, Juan Pablo Trujillo, Anna Ruiz and Miriam Guitart
    Citation: Clinical Epigenetics 2024 16:62
  21. Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially...

    Authors: Line Hjort, Sandra Stokholm Bredgaard, Eleonora Manitta, Irene Marques, Anja Elaine Sørensen, David Martino, Louise Groth Grunnet, Louise Kelstrup, Azadeh Houshmand-Oeregaard, Tine Dalsgaard Clausen, Elisabeth Reinhardt Mathiesen, Sjurdur Frodi Olsen, Richard Saffery, Romain Barrès, Peter Damm, Allan Arthur Vaag…
    Citation: Clinical Epigenetics 2024 16:61
  22. While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA ...

    Authors: Ho-Sun Lee, Boram Kim and Taesung Park
    Citation: Clinical Epigenetics 2024 16:60
  23. Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S. Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel
    Citation: Clinical Epigenetics 2024 16:59

    The original article was published in Clinical Epigenetics 2024 16:35

  24. Alzheimer’s disease (AD) prevalence is twice as high in non-Hispanic Blacks (NHBs) as in non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant methylation at imprint control...

    Authors: Sebnem E. Cevik, David A. Skaar, Dereje D. Jima, Andy J. Liu, Truls Østbye, Heather E. Whitson, Randy L. Jirtle, Cathrine Hoyo and Antonio Planchart
    Citation: Clinical Epigenetics 2024 16:58
  25. Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has...

    Authors: Yan Qi, Xiangchao Meng, Jing Li, Aoyue He, Jie Hao, Xu Zhao, Ruonan Zhao, Rongrong Chen and Rongqiang Zhang
    Citation: Clinical Epigenetics 2024 16:57
  26. Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as a means to identify women at risk of developi...

    Authors: Mary Jo Fackler, Madison Pleas, Youran Li, Anushri Soni, Deyin Xing, Leslie Cope, Syed Ali, Quang Van Le, Chu Van Nguyen, Han Thi Pham, Long Minh Duong, Eunice Vanden Berg, Reubina Wadee, Pamela Michelow, Wenlong Carl Chen, Maureen Joffe…
    Citation: Clinical Epigenetics 2024 16:56
  27. CSLCs(Cancer stem cell-like cells), which are central to tumorigenesis, are intrinsically influenced by epigenetic modifications. This study aimed to elucidate the underlying mechanism involving the DNMT1/miR-...

    Authors: Qing Yuan, Rubo Wang, Xiang Li, Fei Sun, Jiazhi Lin, Zhimin Fu and Jiansong Zhang
    Citation: Clinical Epigenetics 2024 16:55
  28. The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes, ranging from pluripotency and development to carcinogenesis...

    Authors: Yuxi Cheng, Zhengzheng Song, Xiaodan Fang and Zhangui Tang
    Citation: Clinical Epigenetics 2024 16:54
  29. The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging...

    Authors: Anil P. S. Ori, Loes M. Olde Loohuis, Jerry Guintivano, Eilis Hannon, Emma Dempster, David St. Clair, Nick J. Bass, Andrew McQuillin, Jonathan Mill, Patrick F. Sullivan, Rene S. Kahn, Steve Horvath and Roel A. Ophoff
    Citation: Clinical Epigenetics 2024 16:53
  30. Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate pathological mechanisms of DCM cause diastolic dysfunction, follo...

    Authors: Xiaozhu Ma, Shuai Mei, Qidamugai Wuyun, Li Zhou, Dating Sun and Jiangtao Yan
    Citation: Clinical Epigenetics 2024 16:52
  31. The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and curious. While selenium has shown promise in reducing cancer risks through supplementatio...

    Authors: Dezhi Chen, Bo Cai, Yingying Zhu, Yimin Ma, Xiaoting Yu, Jieqi Xiong, Jiaying Shen, Weiwei Tie, Yisheng Zhang and Fei Guo
    Citation: Clinical Epigenetics 2024 16:51
  32. Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understanding these changes is important to elucidate fundamental aspects of cancer. It is also ...

    Authors: Divya R. Jacob, Wilfried M. Guiblet, Hulkar Mamayusupova, Mariya Shtumpf, Isabella Ciuta, Luminita Ruje, Svetlana Gretton, Milena Bikova, Clark Correa, Emily Dellow, Shivam P. Agrawal, Navid Shafiei, Anastasija Drobysevskaja, Chris M. Armstrong, Jonathan D. G. Lam, Yevhen Vainshtein…
    Citation: Clinical Epigenetics 2024 16:50
  33. Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complicati...

    Authors: Adrián Mosquera Orgueira, Olga Krali, Carlos Pérez Míguez, Andrés Peleteiro Raíndo, José Ángel Díaz Arias, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Manuel Fernández Sanmartín, Daniel Sinnet, Mats Heyman, Gudmar Lönnerholm, Ulrika Norén-Nyström, Kjeld Schmiegelow and Jessica Nordlund
    Citation: Clinical Epigenetics 2024 16:49
  34. miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells hav...

    Authors: Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou and Shenmeng Gao
    Citation: Clinical Epigenetics 2024 16:48
  35. The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most commo...

    Authors: Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter and Markus Wirth
    Citation: Clinical Epigenetics 2024 16:47
  36. Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typicall...

    Authors: Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin…
    Citation: Clinical Epigenetics 2024 16:46
  37. In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obt...

    Authors: Sandra Fitzgerald, Basharat Bhat, Cristin Print and Gregory T. Jones
    Citation: Clinical Epigenetics 2024 16:45
  38. The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance betwe...

    Authors: Lucía Labaut, Agustín Lage-Castellanos, María José Rodrigo, Silvia Herrero-Roldán, Colter Mitchell, Jonah Fisher and Inmaculada León
    Citation: Clinical Epigenetics 2024 16:44
  39. Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, pro...

    Authors: Ke-Xin Li, Jia-Ru Li, Sheng-Jia Zuo, Xudong Li, Xian-Tong Chen, Pei-Yi Xiao, Hui-Tao Li, Ling Sun, Tao Qian, Hao-Min Zhang, Dongxing Zhu, Xi-Yong Yu, Guojun Chen and Xue-Yan Jiang
    Citation: Clinical Epigenetics 2024 16:42
  40. Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly a...

    Authors: Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang and Weixiang Chen
    Citation: Clinical Epigenetics 2024 16:41
  41. MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx), attributable to promoter hypermethylation. Long noncoding RNA genes (lncGs) play pivo...

    Authors: Abarna Sinha, Abhisikta Ghosh, Arnab Ghosh, Sonia Mathai, Jaydip Bhaumik, Asima Mukhopadhyay, Arindam Maitra, Nidhan K. Biswas and Sharmila Sengupta
    Citation: Clinical Epigenetics 2024 16:40
  42. Alzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the developme...

    Authors: Yuanyuan Qin, Ping Yang, Wanhong He, Dongze Li, Lisha Zeng, Junle Li, Tingting Zhou, Juan Peng, Ling Cao and Wei Huang
    Citation: Clinical Epigenetics 2024 16:39
  43. Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this quest...

    Authors: Mark W. Miller, Erika J. Wolf, Xiang Zhao, Mark W. Logue and Sage E. Hawn
    Citation: Clinical Epigenetics 2024 16:38
  44. The recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in health and diseases. This study used COVID-19 as a disease model to investi...

    Authors: Yuan-Yuan Li, Ming-Ming Yuan, Yuan-Yuan Li, Shan Li, Jing-Dong Wang, Yu-Fei Wang, Qian Li, Jun Li, Rong-Rong Chen, Jin-Min Peng and Bin Du
    Citation: Clinical Epigenetics 2024 16:37
  45. Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide approach, we aimed to investigate DNA methylation changes occurring secondary ...

    Authors: Céline Dubath, Eleonora Porcu, Aurélie Delacrétaz, Claire Grosu, Nermine Laaboub, Marianna Piras, Armin von Gunten, Philippe Conus, Kerstin Jessica Plessen, Zoltán Kutalik and Chin Bin Eap
    Citation: Clinical Epigenetics 2024 16:36
  46. We previously reported in the “Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function” randomized clinical trial (RCT) that vitamin C (500 mg/day) supplementation to pregnant smokers...

    Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S. Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel
    Citation: Clinical Epigenetics 2024 16:35

    The Correction to this article has been published in Clinical Epigenetics 2024 16:59

  47. Cell-free DNA (cfDNA) contains a large amount of molecular information that can be used for multi-cancer early detection (MCED), including changes in epigenetic status of cfDNA, such as cfDNA fragmentation pro...

    Authors: Pin Cui, Xiaozhou Zhou, Shu Xu, Weihuang He, Guozeng Huang, Yong Xiong, Chuxin Zhang, Tingmin Chang, Mingji Feng, Hanming Lai and Yi Pan
    Citation: Clinical Epigenetics 2024 16:34
  48. Whole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome profiling (RRMP), which employs restriction enzyme for depletion of A...

    Authors: Qingmo Yang, Xingqiang Zhu, Yulu Liu, Zhi He, Huan Xu, Hailing Zheng, Zhiming Huang, Dan Wang, Xiaofang Lin, Ping Guo and Hongliang Chen
    Citation: Clinical Epigenetics 2024 16:33
  49. People living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less susceptible to AIDS-related complications, they remain highly vulnerable to non-communica...

    Authors: Christian K. Dye, Haotian Wu, Gabriela L. Jackson, Altaye Kidane, Rejoice Nkambule, Nomthandazo G. Lukhele, Bongiwe Prudence Malinga, Rhinos Chekenyere, Wafaa M. El-Sadr, Andrea A. Baccarelli and Tiffany G. Harris
    Citation: Clinical Epigenetics 2024 16:32