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Citation: Clinical Epigenetics 2023 15:46
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Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including ...
Citation: Clinical Epigenetics 2023 15:45 -
DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion
Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechan...
Citation: Clinical Epigenetics 2023 15:44 -
H4-methylation regulators mediated epitranscriptome patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma
Epigenetic modifications are involved in the remodeling of the tumor microenvironment (TME) and the regulation of immune response. Nonetheless, the role of histone H4 methylation (H4M) modification in the TME ...
Citation: Clinical Epigenetics 2023 15:43 -
A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome
Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity t...
Citation: Clinical Epigenetics 2023 15:42 -
A systematic evaluation of normalization methods and probe replicability using infinium EPIC methylation data
The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes. These probe types exhibit different technical char...
Citation: Clinical Epigenetics 2023 15:41 -
Supratentorial CNS-PNETs in children; a Swedish population-based study with molecular re-evaluation and long-term follow-up
Molecular analyses have shown that tumours diagnosed as supratentorial primitive neuro-ectodermal tumours of the central nervous system (CNS-PNETs) in the past represent a heterogenous group of rare childhood ...
Citation: Clinical Epigenetics 2023 15:40 -
Clinical advances in epigenetic therapies for lymphoma
Advances in understanding of cancer biology, genomics, epigenomics, and immunology have resulted in development of several therapeutic options that expand cancer care beyond traditional chemotherapy or radioth...
Citation: Clinical Epigenetics 2023 15:39 -
Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure
Hypertension is a crucial risk factor for developing cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP)...
Citation: Clinical Epigenetics 2023 15:38 -
DNA methylation landscape reveals LIN7A as a decitabine-responsive marker in patients with t(8;21) acute myeloid leukemia
Despite its inconsistent response rate, decitabine, a demethylating agent, is often used as a non-intensive alternative therapeutic agent for acute myeloid leukemia (AML). It has been reported that relapsed/re...
Citation: Clinical Epigenetics 2023 15:37 -
Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
Selenium, an essential trace element, has previously been investigated as a pro-apoptotic and DNA demethylation agent. It sensitizes the response to chemotherapy in patients who were refractory to cytotoxic ag...
Citation: Clinical Epigenetics 2023 15:36 -
Molecular characterisation of 36 multilocus imprinting disturbance (MLID) patients: a comprehensive approach
Imprinting disorders (ImpDis) comprise diseases which are caused by aberrant regulation of monoallelically and parent-of-origin-dependent expressed genes. A characteristic molecular change in ImpDis patients i...
Citation: Clinical Epigenetics 2023 15:35 -
EBS-seq: enrichment-based method for accurate analysis of 5-hydroxymethylcytosine at single-base resolution
A growing body of research has emphasized 5-hydroxymethylcytosine (5hmC) as an important epigenetic mark. High-resolution methods to detect 5hmC require high sequencing depth and are therefore expensive. Many ...
Citation: Clinical Epigenetics 2023 15:34 -
Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion ...
Citation: Clinical Epigenetics 2023 15:33 -
Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort
DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed E...
Citation: Clinical Epigenetics 2023 15:32 -
DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort
Exposure to indoor air pollution during pregnancy has been linked to neurodevelopmental delay in toddlers. Epigenetic modification, particularly DNA methylation (DNAm), may explain this link. In this study, we...
Citation: Clinical Epigenetics 2023 15:31 -
Phospholipase C delta 1 inhibits WNT/β‐catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma
PLCD1, located at 3p22, encodes an enzyme that mediates cellular metabolism and homeostasis, intracellular signal transduction and movement. PLCD1 plays a pivotal role in tumor suppression of several types of can...
Citation: Clinical Epigenetics 2023 15:30 -
Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications
Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Seve...
Citation: Clinical Epigenetics 2023 15:29 -
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. Whil...
Citation: Clinical Epigenetics 2023 15:28 -
A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes
miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives. ...
Citation: Clinical Epigenetics 2023 15:27 -
Novel DNA methylation biomarkers in stool and blood for early detection of colorectal cancer and precancerous lesions
Early detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC). Here, we developed new candidate CpG site biomarkers for CRC and evaluate...
Citation: Clinical Epigenetics 2023 15:26 -
Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis
Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African Americans. Despite this, African Americans are dramatically underrepr...
Citation: Clinical Epigenetics 2023 15:25 -
Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review
Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above 90%. However, advanced-stage disease accounts for most case...
Citation: Clinical Epigenetics 2023 15:24 -
DNA methylation in peripheral blood leukocytes for the association with glucose metabolism and invasive breast cancer
Insulin resistance (IR) is a well-established factor for breast cancer (BC) risk in postmenopausal women, but the interrelated molecular pathways on the methylome are not explicitly described. We conducted a p...
Citation: Clinical Epigenetics 2023 15:23 -
Identification of m7G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure
N7-methylguanosine (m7G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in...
Citation: Clinical Epigenetics 2023 15:22 -
Liver saturated fat content associates with hepatic DNA methylation in obese individuals
Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Altho...
Citation: Clinical Epigenetics 2023 15:21 -
Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis
Pregnancy in women with multiple sclerosis (wwMS) is associated with a reduction of long-term disability progression. The mechanism that drives this effect is unknown, but converging evidence suggests a role f...
Citation: Clinical Epigenetics 2023 15:20 -
Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide
Natural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and limited therapeutic options. Therefore, there is an urgent need to ex...
Citation: Clinical Epigenetics 2023 15:19 -
Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics
Oncogenic overexpression of integrin-β7 (ITGB7) in cases of high-risk multiple myeloma (MM) was reported to promote enhanced interactions between neoplastic plasma-B cells and stromal cells to develop cell-adhesi...
Citation: Clinical Epigenetics 2023 15:18 -
E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis
Super-enhancer-associated lncRNAs play important roles in the occurrence and development of malignant tumors, including hepatocellular carcinoma (HCC).
Citation: Clinical Epigenetics 2023 15:17 -
Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study
People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...
Citation: Clinical Epigenetics 2023 15:16 -
A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma
N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP .....
Citation: Clinical Epigenetics 2023 15:15 -
The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methyl...
Citation: Clinical Epigenetics 2023 15:14 -
Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients
Collagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression pattern and the function of COL12A1 in intrahepatic cholangiocarcinoma (iCCA) remain unknown....
Citation: Clinical Epigenetics 2023 15:13 -
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2
Histone methylation modification plays an irreplaceable role in the wheezing diseases. The aim of this study was to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing through inhibiting h...
Citation: Clinical Epigenetics 2023 15:12 -
Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells
Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be...
Citation: Clinical Epigenetics 2023 15:11 -
Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells
Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc finger transcription factor superfamily, which consists of hundreds of members that play critical roles in all steps of tumorigenesis.
Citation: Clinical Epigenetics 2023 15:10 -
Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts
In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adve...
Citation: Clinical Epigenetics 2023 15:9 -
Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric c...
Citation: Clinical Epigenetics 2023 15:8 -
Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose...
Citation: Clinical Epigenetics 2023 15:7 -
Drugging the epigenome in the age of precision medicine
Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease areas with several approved therapies marketed, primarily for cancer. Despite the over...
Citation: Clinical Epigenetics 2023 15:6 -
Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. While ...
Citation: Clinical Epigenetics 2023 15:5 -
Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer
To explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated the genetic and DNA methylation profile...
Citation: Clinical Epigenetics 2023 15:4 -
Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
Citation: Clinical Epigenetics 2023 15:3 -
Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA
Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis meth...
Citation: Clinical Epigenetics 2023 15:2 -
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression
Depression is a multifactorial disorder representing a significant public health burden. Previous studies have linked multiple single nucleotide polymorphisms with depressive phenotypes and suicidal behavior. ...
Citation: Clinical Epigenetics 2023 15:1 -
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation
Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of which is associated with significant pulmonary, cardiovascular, and neurologic complicati...
Citation: Clinical Epigenetics 2022 14:195 -
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity
The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental interactions are involved. Moreover, the lack of prognostic biomarkers make...
Citation: Clinical Epigenetics 2022 14:194 -
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...
Citation: Clinical Epigenetics 2022 14:193 -
Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...
Citation: Clinical Epigenetics 2022 14:192
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- ISSN: 1868-7083 (electronic)