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  1. Recombinant human growth hormone (rhGH) has shown a great growth-promoting potential in children with idiopathic short stature (ISS). However, the response to rhGH differs across individuals, largely due to ge...

    Authors: Xiaojian Shao, Catherine Le Stunff, Warren Cheung, Tony Kwan, Mark Lathrop, Tomi Pastinen and Pierre Bougnères
    Citation: Clinical Epigenetics 2022 14:65
  2. Placental mesenchymal dysplasia (PMD) is a morphological abnormality resembling partial hydatidiform moles. It is often associated with androgenetic/biparental mosaicism (ABM) and complicated by Beckwith–Wiede...

    Authors: Saori Aoki, Ken Higashimoto, Hidenori Hidaka, Yasufumi Ohtsuka, Shigehisa Aoki, Hiroyuki Mishima, Koh-ichiro Yoshiura, Kazuhiko Nakabayashi, Kenichiro Hata, Hitomi Yatsuki, Satoshi Hara, Takashi Ohba, Hidetaka Katabuchi and Hidenobu Soejima
    Citation: Clinical Epigenetics 2022 14:64
  3. We previously showed that continued folic acid (FA) supplementation beyond the first trimester of pregnancy appears to have beneficial effects on neurocognitive performance in children followed for up to 11 ye...

    Authors: Miroslava Ondičová, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty and Colum P. Walsh
    Citation: Clinical Epigenetics 2022 14:63
  4. Sex differences are known to play a role in disease aetiology, progression and outcome. Previous studies have revealed autosomal epigenetic differences between males and females in some tissues, including diff...

    Authors: Olivia A. Grant, Yucheng Wang, Meena Kumari, Nicolae Radu Zabet and Leonard Schalkwyk
    Citation: Clinical Epigenetics 2022 14:62
  5. Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) analysis represents a liquid biopsy approach for real-time monitoring of tumor evolution. DNA methylation is considered to be an early event in ...

    Authors: Α. Markou, D. Londra, V. Tserpeli, Ι. Kollias, E. Tsaroucha, I. Vamvakaris, K. Potaris, I. Pateras, Α. Kotsakis, V. Georgoulias and Ε. Lianidou
    Citation: Clinical Epigenetics 2022 14:61
  6. The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has...

    Authors: Tesa Severson, Xintao Qiu, Mohammed Alshalalfa, Martin Sjöström, David Quigley, Andries Bergman, Henry Long, Felix Feng, Matthew L. Freedman, Wilbert Zwart and Mark M. Pomerantz
    Citation: Clinical Epigenetics 2022 14:60
  7. Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking envi...

    Authors: M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler and J. F. Felix
    Citation: Clinical Epigenetics 2022 14:59
  8. Genomic technologies can be subject to significant batch-effects which are known to reduce experimental power and to potentially create false positive results. The Illumina Infinium Methylation BeadChip is a p...

    Authors: Jason P. Ross, Susan van Dijk, Melinda Phang, Michael R. Skilton, Peter L. Molloy and Yalchin Oytam
    Citation: Clinical Epigenetics 2022 14:58
  9. Bronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by impaired pulmonary development which persists into later life. While advan...

    Authors: Xuting Wang, Hye-Youn Cho, Michelle R. Campbell, Vijayalakshmi Panduri, Silvina Coviello, Mauricio T. Caballero, Deepa Sambandan, Steven R. Kleeberger, Fernando P. Polack, Gaston Ofman and Douglas A. Bell
    Citation: Clinical Epigenetics 2022 14:57
  10. DNA methylation biomarkers for early detection, risk stratification and treatment response in cancer have been of great interest over the past decades. Nevertheless, clinical implementation of these biomarkers...

    Authors: Maartje Massen, Kim Lommen, Kim A. D. Wouters, Johan Vandersmissen, Wim van Criekinge, James G. Herman, Veerle Melotte, Leo J. Schouten, Manon van Engeland and Kim M. Smits
    Citation: Clinical Epigenetics 2022 14:56
  11. Panic disorder (PD) is characterized by recurrent panic attacks and higher affection of women as compared to men. The lifetime prevalence of PD is about 2–3% in the general population leading to tremendous dis...

    Authors: Darina Czamara, Alexa Neufang, Roman Dieterle, Stella Iurato, Janine Arloth, Jade Martins, Marcus Ising, Elisabeth E. Binder and Angelika Erhardt
    Citation: Clinical Epigenetics 2022 14:55
  12. Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial ...

    Authors: Valentin Costes, Aurélie Chaulot-Talmon, Eli Sellem, Jean-Philippe Perrier, Anne Aubert-Frambourg, Luc Jouneau, Charline Pontlevoy, Chris Hozé, Sébastien Fritz, Mekki Boussaha, Chrystelle Le Danvic, Marie-Pierre Sanchez, Didier Boichard, Laurent Schibler, Hélène Jammes, Florence Jaffrézic…
    Citation: Clinical Epigenetics 2022 14:54
  13. DNA methylation is an epigenetic mechanism involved in human development. Numerous epigenome-wide association studies (EWAS) have investigated the associations of DNA methylation at single CpG sites with child...

    Authors: Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil and Esther Walton
    Citation: Clinical Epigenetics 2022 14:53
  14. epi-cblC is a recently discovered inherited disorder of intracellular vitamin B12 metabolism associating hematological, neurological, and cardiometabolic outcomes. It is produced by an epimutation at the promoter...

    Authors: Abderrahim Oussalah, Youssef Siblini, Sébastien Hergalant, Céline Chéry, Pierre Rouyer, Catia Cavicchi, Renzo Guerrini, Pierre-Emmanuel Morange, David Trégouët, Mihaela Pupavac, David Watkins, Tomi Pastinen, Wendy K. Chung, Can Ficicioglu, François Feillet, D. Sean Froese…
    Citation: Clinical Epigenetics 2022 14:52
  15. LINC00114 could promote the development of colorectal cancer, but its mechanism has been rarely discussed in esophageal cancer (EC). Herein, we explored the molecular mechanism of LINC00114 via mediating enhan...

    Authors: Jianzhang Qin, Yishuai Li, Zhe Li, Xuebo Qin, Xuetao Zhou, Hao Zhang and Shujun Li
    Citation: Clinical Epigenetics 2022 14:51
  16. TIGIT is an immune checkpoint under investigation as therapeutic target. Understanding the regulation of TIGIT on an epigenetic level might support the development of companion biomarkers.

    Authors: Dennis Niebel, Anne Fröhlich, Romina Zarbl, Simon Fietz, Luka de Vos, Timo J. Vogt, Jörn Dietrich, Judith Sirokay, Pia Kuster, Gonzalo Saavedra, Susana Ramírez Valladolid, Friederike Hoffmann, Sebastian Strieth, Jennifer Landsberg and Dimo Dietrich
    Citation: Clinical Epigenetics 2022 14:50
  17. Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal disease affecting preterm infants. NEC develops suddenly and is characterized by gut barrier destruction, an inflammatory response...

    Authors: Misty Good, Tianjiao Chu, Patricia Shaw, Lila S. Nolan, Joseph Wrobleski, Carlos Castro, Qingqing Gong, Olivia DeWitt, David N. Finegold and David Peters
    Citation: Clinical Epigenetics 2022 14:49
  18. Altered DNA methylation (DNAm) may be one pathway through which early-life adversity (ELA) contributes to adverse mental and physical health outcomes. This study investigated whether the presence versus absenc...

    Authors: Jennifer A. Sumner, Simone Gambazza, Xu Gao, Andrea A. Baccarelli, Monica Uddin and Katie A. McLaughlin
    Citation: Clinical Epigenetics 2022 14:48
  19. Obsessive–compulsive disorder (OCD) is a prevalent and severe clinical condition. Robust evidence suggests a gene-environment interplay in its etiopathogenesis, yet the underlying molecular clues remain only p...

    Authors: Claudio D’Addario, Mariangela Pucci, Fabio Bellia, Antonio Girella, Annalaura Sabatucci, Federico Fanti, Matteo Vismara, Beatrice Benatti, Luca Ferrara, Federica Fasciana, Laura Celebre, Caterina Viganò, Luca Elli, Manuel Sergi, Mauro Maccarrone, Valeria Buzzelli…
    Citation: Clinical Epigenetics 2022 14:47
  20. Acute myocardial infarction (AMI) has been one of the most fatal diseases among all types of heart diseases due to its rapid onset and high rates of fatality. Understanding accurately how multi-omics molecular...

    Authors: Xiaoli Luo, Yi Hu, Junwei Shen, Xinwen Liu, Tao Wang, Li Li and Jue Li
    Citation: Clinical Epigenetics 2022 14:46
  21. The pathoanatomic cause of chronic low back pain (cLBP) cannot be identified for up to 90% of individuals. However, dysfunctional processing of endogenous nociceptive input, measured as conditioned pain modula...

    Authors: Burel R. Goodin, Demario S. Overstreet, Terence M. Penn, Rahm Bakshi, Tammie L. Quinn, Andrew Sims, Travis Ptacek, Pamela Jackson, D. Leann Long and Edwin N. Aroke
    Citation: Clinical Epigenetics 2022 14:45
  22. Beckwith–Wiedemann syndrome (BWS, OMIM # 130650) is an imprinting disorder, associated with overgrowth and increased risk of embryonal tumors. Patients carrying hypomethylation in the KCNQ1OT1:TSS DMR (11p15.5) s...

    Authors: Pierpaola Tannorella, Luciano Calzari, Cecilia Daolio, Ester Mainini, Alessandro Vimercati, Davide Gentilini, Fiorenza Soli, Annalisa Pedrolli, Maria Teresa Bonati, Lidia Larizza and Silvia Russo
    Citation: Clinical Epigenetics 2022 14:43
  23. SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple “-omics” methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly rec...

    Authors: Paola Peinado, Alvaro Andrades, Marta Cuadros, Maria Isabel Rodriguez, Isabel F. Coira, Daniel J. Garcia, Maria S. Benitez-Cantos, Carlos Cano, Eduardo Zarzuela, Javier Muñoz, Claudia Loidi, Monica Saiz and Pedro P. Medina
    Citation: Clinical Epigenetics 2022 14:42
  24. Imprinting disorders are a group of congenital diseases which are characterized by molecular alterations affecting differentially methylated regions (DMRs). To date, at least twelve imprinting disorders have b...

    Authors: Thomas Eggermann, Elzem Yapici, Jet Bliek, Arrate Pereda, Matthias Begemann, Silvia Russo, Pierpaola Tannorella, Luciano Calzari, Guiomar Perez de Nanclares, Paola Lombardi, I. Karen Temple, Deborah Mackay, Andrea Riccio, Masayo Kagami, Tsutomu Ogata, Pablo Lapunzina…
    Citation: Clinical Epigenetics 2022 14:41
  25. Ambient air pollutant (AAP) exposure is associated with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. Previous studies have shown methylation of immune genes associate ...

    Authors: Juan Aguilera, Xiaorui Han, Shu Cao, John Balmes, Fred Lurmann, Tim Tyner, Liza Lutzker, Elizabeth Noth, S. Katharine Hammond, Vanitha Sampath, Trevor Burt, P. J. Utz, Purvesh Khatri, Nima Aghaeepour, Holden Maecker, Mary Prunicki…
    Citation: Clinical Epigenetics 2022 14:40
  26. This work is aimed at improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis by generating a multi-omic disease signature.

    Authors: Denis Seyres, Alessandra Cabassi, John J. Lambourne, Frances Burden, Samantha Farrow, Harriet McKinney, Joana Batista, Carly Kempster, Maik Pietzner, Oliver Slingsby, Thong Huy Cao, Paulene A. Quinn, Luca Stefanucci, Matthew C. Sims, Karola Rehnstrom, Claire L. Adams…
    Citation: Clinical Epigenetics 2022 14:39
  27. Psoriasis is a chronic and hyperproliferative skin disease featured by hyperkeratosis with parakeratosis, Munro micro-abscess, elongation of rete pegs, granulosa thinning, and lymphocyte infiltration. We previ...

    Authors: Xiaoqing Xu, Xianfa Tang, Yuxi Zhang, Zhaobing Pan, Qingping Wang, Lili Tang, Caihong Zhu, Hui Cheng and Fusheng Zhou
    Citation: Clinical Epigenetics 2022 14:38
  28. DNA methylation alterations have emerged as hallmarks of cancer and have been proposed as screening, prognostic, and predictive biomarkers. Traditional approaches for methylation analysis have relied on bisulf...

    Authors: Tamara S. Rodems, Duane S. Juang, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Tim E. G. Krueger, Erika Heninger, Shuang G. Zhao, Jamie M. Sperger, David J. Beebe, Michael C. Haffner and Joshua M. Lang
    Citation: Clinical Epigenetics 2022 14:37
  29. Authors: Yan Wang, Liangying Dan, Qianqian Li, Lili Li, Lan Zhong, Bianfei Shao, Fang Yu, Sanxiu He, Shaorong Tian, Jin He, Qian Xiao, Thomas C. Putti, Xiaoqian He, Yixiao Feng, Yong Lin and Tingxiu Xiang
    Citation: Clinical Epigenetics 2022 14:36

    The original article was published in Clinical Epigenetics 2019 11:184

  30. Long non-coding RNAs (LncRNAs) are widely known for their various functions in cancer from tumor initiation to tumor progression and metastasis. Gliomas are the most prevalent primary forms of brain tumor, cla...

    Authors: Ali Mamivand, Shiva Bayat, Abolfazl Maghrouni, Sasan Shabani, Alireza Khoshnevisan, Hiva Saffar and Mina Tabrizi
    Citation: Clinical Epigenetics 2022 14:35
  31. Epigenetic posttranslational modifications are critical for fine-tuning gene expression in various biological processes. SETD8 is so far the only known lysyl methyltransferase in mammalian cells to produce mon...

    Authors: Libo Xu, Ling Zhang, Jicheng Sun, Xindan Hu, Dhan V. Kalvakolanu, Hui Ren and Baofeng Guo
    Citation: Clinical Epigenetics 2022 14:34
  32. Epstein–Barr virus DNA viral load is used as a surrogate marker to start Rituximab in transplant recipients at risk of developing PTLD. However, an elevated EBV DNAemia does not discriminate lymphoproliferatio...

    Authors: Chloé Borde, Frédérique Quignon, Corinne Amiel, Joël Gozlan, Vincent Marechal and Eolia Brissot
    Citation: Clinical Epigenetics 2022 14:33
  33. Recent studies have suggested that folic acid can restore abnormal DNA methylation and monocyte subset shifts caused by hyperhomocysteinemia (HHcy) and hyperlipidemia (HL). However, the exact mechanism of acti...

    Authors: Yang Xiang, Bin Liang, Xiaokang Zhang, Xueping Qiu, Qianyun Deng, Li Yu, Hong Yu, Zhibing Lu and Fang Zheng
    Citation: Clinical Epigenetics 2022 14:32
  34. Age is one of the strongest risk factors for the development of breast cancer, however, the underlying etiology linking age and breast cancer remains unclear. We have previously observed links between epigenet...

    Authors: Mariya Rozenblit, Erin Hofstatter, Zuyun Liu, Tess O’Meara, Anna Maria Storniolo, Disha Dalela, Vineet Singh, Lajos Pusztai and Morgan Levine
    Citation: Clinical Epigenetics 2022 14:30
  35. Physical activity impacts immune homeostasis and leads to rapid and marked increase in cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it is unknown if physical activity...

    Authors: Elmo W. I. Neuberger, Stephanie Sontag, Alexandra Brahmer, Keito F. A. Philippi, Markus P. Radsak, Wolfgang Wagner and Perikles Simon
    Citation: Clinical Epigenetics 2022 14:29
  36. We tested the ability of a novel DNA methylation biomarker set to distinguish metastatic pancreatic cancer cases from benign pancreatic cyst patients and to monitor tumor dynamics using quantitative DNA methyl...

    Authors: Lukas Vrba, Bernard W. Futscher, Marc Oshiro, George S. Watts, Emmanuel Menashi, Charles Hu, Hytham Hammad, Daniel R. Pennington, Umamaheshwari Golconda, Hemanth Gavini, Denise J. Roe, Rachna T. Shroff and Mark A. Nelson
    Citation: Clinical Epigenetics 2022 14:28
  37. Myeloid-derived suppressor cells (MDSCs), which include monocytic (mMDSCs) and granulocytic (gMDSCs) cells, are an immunosuppressive, heterogeneous population of cells upregulated in cancer and other pathologi...

    Authors: Isabella Berglund-Brown, Emily Nissen, Devin C. Koestler, Rondi A. Butler, Melissa N. Eliot, James F. Padbury, Lucas A. Salas, Annette M. Molinaro, Brock C. Christensen, John K. Wiencke and Karl T. Kelsey
    Citation: Clinical Epigenetics 2022 14:27
  38. Promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma multiforme and anaplastic astrocytoma. Patients with methy...

    Authors: Sascha Tierling, Wiebke M. Jürgens-Wemheuer, Alea Leismann, Julia Becker-Kettern, Michael Scherer, Arne Wrede, David Breuskin, Steffi Urbschat, Christoph Sippl, Joachim Oertel, Walter J. Schulz-Schaeffer and Jörn Walter
    Citation: Clinical Epigenetics 2022 14:26
  39. DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across...

    Authors: Rebecca Shepherd, Ingrid Bretherton, Ken Pang, Toby Mansell, Anna Czajko, Bowon Kim, Amanda Vlahos, Jeffrey D. Zajac, Richard Saffery, Ada Cheung and Boris Novakovic
    Citation: Clinical Epigenetics 2022 14:24
  40. Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often confounded by cell-type heterogeneity.

    Authors: Alok K. Maity, Timothy C. Stone, Vanessa Ward, Amy P. Webster, Zhen Yang, Aine Hogan, Hazel McBain, Margaraet Duku, Kai Man Alexander Ho, Paul Wolfson, David G. Graham, Stephan Beck, Andrew E. Teschendorff and Laurence B. Lovat
    Citation: Clinical Epigenetics 2022 14:23
  41. Multiple studies have reported the prognostic impact of DNA methylation changes in acute myeloid leukemia (AML). However, these epigenetic markers have not been thoroughly validated and therefore are still not...

    Authors: Šárka Šestáková, Ela Cerovská, Cyril Šálek, Dávid Kundrát, Ivana Ježíšková, Adam Folta, Jiří Mayer, Zdeněk Ráčil, Petr Cetkovský and Hana Remešová
    Citation: Clinical Epigenetics 2022 14:22
  42. Genome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we investigated cancer-related molecular changes dete...

    Authors: Natascia Marino, Rana German, Ram Podicheti, Douglas B. Rusch, Pam Rockey, Jie Huang, George E. Sandusky, Constance J. Temm, Sandra Althouse, Kenneth P. Nephew, Harikrishna Nakshatri, Jun Liu, Ashley Vode, Sha Cao and Anna Maria V. Storniolo
    Citation: Clinical Epigenetics 2022 14:21
  43. Although kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and non-immune-mediated complications. Current biomarkers of post-transplant compli...

    Authors: Iacopo Cristoferi, Tommaso Antonio Giacon, Karin Boer, Myrthe van Baardwijk, Flavia Neri, Manuela Campisi, Hendrikus J. A. N. Kimenai, Marian C. Clahsen - van Groningen, Sofia Pavanello, Lucrezia Furian and Robert C. Minnee
    Citation: Clinical Epigenetics 2022 14:20
  44. The development of accurate urinary biomarkers for non-invasive and cost-effective detection of primary and recurrent bladder tumours is recognized as one of the major clinical needs in bladder cancer diagnostics

    Authors: Anouk E. Hentschel, Irene J. Beijert, Judith Bosschieter, Paul C. Kauer, André N. Vis, Birgit I. Lissenberg-Witte, R. Jeroen A. van Moorselaar, Renske D. M. Steenbergen and Jakko A. Nieuwenhuijzen
    Citation: Clinical Epigenetics 2022 14:19
  45. Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due to suboptimal accuracy. Herein, we...

    Authors: Shang Chen, Yanqi Yu, Tao Li, Weimei Ruan, Jun Wang, Quanzhou Peng, Yingdian Yu, Tianfeng Cao, Wenyuan Xue, Xin Liu, Zhiwei Chen, Jiang Yu and Jian-Bing Fan
    Citation: Clinical Epigenetics 2022 14:18
  46. GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and...

    Authors: Tao Gao, John T. Wilkins, Yinan Zheng, Brian T. Joyce, David R. Jacobs Jr., Pamela J. Schreiner, Steve Horvath, Philip Greenland, Donald Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:16