Advertisement
Research
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by lymphocytic infiltration and overproduction of autoantibodies, leading to significant morbidity and mortality. However, the ...
Clinical Epigenetics 2017 9:104
Published on: 22 September 2017
Research
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among A...
Clinical Epigenetics 2017 9:103
Published on: 21 September 2017
Research
Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...
Clinical Epigenetics 2017 9:102
Published on: 21 September 2017
Research
Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatit...
Clinical Epigenetics 2017 9:101
Published on: 16 September 2017
Research
Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are un...
Clinical Epigenetics 2017 9:99
Published on: 15 September 2017
Letter to the Editor
In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implicati...
Clinical Epigenetics 2017 9:100
Published on: 15 September 2017
Review
Respiratory diseases hold several genome, epigenome, and transcriptional aberrations as a cause of the accumulated damage promoted by, among others, environmental risk factors. Such aberrations can also come a...
Clinical Epigenetics 2017 9:98
Published on: 8 September 2017
Research
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression o...
Clinical Epigenetics 2017 9:95
Published on: 6 September 2017
Research
Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marke...
Clinical Epigenetics 2017 9:97
Published on: 5 September 2017
Research
We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals. However, mechanisms related to this phenoty...
Clinical Epigenetics 2017 9:94
Published on: 2 September 2017
Short report
Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can i...
Clinical Epigenetics 2017 9:96
Published on: 2 September 2017
Research
Cellular senescence due to genomic instability is believed to be one of the mechanisms causing health problems in diabetes mellitus (DM). Low methylation levels of Alu elements or Alu hypomethylation, an epige...
Clinical Epigenetics 2017 9:93
Published on: 31 August 2017
Short report
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome,...
Clinical Epigenetics 2017 9:92
Published on: 30 August 2017
Research
Aberrant CpG island methylation has been increasingly recognized as a common event in myelodysplastic syndrome (MDS). To date, most of the previous studies of miR-124 in MDS have focused on epigenetic changes ...
Clinical Epigenetics 2017 9:91
Published on: 30 August 2017
Research
Imprinted domains have been identified as targets for aberrant DNA methylation during carcinogenesis, but it remains unclear when these epigenetic alterations occur and how they contribute to tumor progression...
Clinical Epigenetics 2017 9:90
Published on: 25 August 2017
Research
Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIP...
Clinical Epigenetics 2017 9:89
Published on: 25 August 2017
Research
DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cel...
Clinical Epigenetics 2017 9:88
Published on: 24 August 2017
Research
Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigeneti...
Clinical Epigenetics 2017 9:87
Published on: 17 August 2017
Research
Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...
Clinical Epigenetics 2017 9:86
Published on: 15 August 2017
Research
Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagno...
Clinical Epigenetics 2017 9:85
Published on: 15 August 2017
Research
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variat...
Clinical Epigenetics 2017 9:84
Published on: 15 August 2017
Research
Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) du...
Clinical Epigenetics 2017 9:83
Published on: 14 August 2017
Research
Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin ...
Clinical Epigenetics 2017 9:82
Published on: 11 August 2017
Research
Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the role of smoking in the development and progress of periodont...
Clinical Epigenetics 2017 9:81
Published on: 10 August 2017
Research
The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprog...
Clinical Epigenetics 2017 9:80
Published on: 8 August 2017
