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  1. Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or ...

    Authors: Cristina Gallardo-Escribano, Verónica Buonaiuto, M. Isabel Ruiz-Moreno, Antonio Vargas-Candela, Alberto Vilches-Perez, Javier Benitez-Porres, Angel Ramon Romance-Garcia, Alejandro Ruiz-Moreno, Ricardo Gomez-Huelgas and M. Rosa Bernal-Lopez

    Citation: Clinical Epigenetics 2020 12:144

    Content type: Research

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  2. Accessible chromatin plays a central role in gene expression and chromatin architecture. Current accessible chromatin approaches depend on limited digestion/cutting and pasting adaptors at the accessible DNA, ...

    Authors: Hang Gyeong Chin, Zhiyi Sun, Udayakumar S. Vishnu, Pengying Hao, Paloma Cejas, George Spracklin, Pierre-Olivier Estève, Shuang-yong Xu, Henry W. Long and Sriharsa Pradhan

    Citation: Clinical Epigenetics 2020 12:143

    Content type: Methodology

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  3. Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a ...

    Authors: Hideyuki Takeshima, Yukie Yoda, Mika Wakabayashi, Naoko Hattori, Satoshi Yamashita and Toshikazu Ushijima

    Citation: Clinical Epigenetics 2020 12:142

    Content type: Research

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  4. Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated throug...

    Authors: Tarryn Willmer, Julia H. Goedecke, Stephanie Dias, Johan Louw and Carmen Pheiffer

    Citation: Clinical Epigenetics 2020 12:141

    Content type: Research

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  5. Cocaine use accelerates human immunodeficiency virus (HIV) progression and worsens HIV outcomes. We assessed whether DNA methylation in blood mediates the association between cocaine use and HIV severity in a ...

    Authors: Chang Shu, Amy C. Justice, Xinyu Zhang, Zuoheng Wang, Dana B. Hancock, Eric O. Johnson and Ke Xu

    Citation: Clinical Epigenetics 2020 12:140

    Content type: Research

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  6. PADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect ...

    Authors: Maria Vittoria Cubellis, Laura Pignata, Ankit Verma, Angela Sparago, Rosita Del Prete, Maria Monticelli, Luciano Calzari, Vincenzo Antona, Daniela Melis, Romano Tenconi, Silvia Russo, Flavia Cerrato and Andrea Riccio

    Citation: Clinical Epigenetics 2020 12:139

    Content type: Research

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  7. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur

    Citation: Clinical Epigenetics 2020 12:138

    Content type: Research

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  8. Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that...

    Authors: Andrea Stoccoro, Adam R. Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Stella Gagliardi, Katie Lunnon, Lucia Migliore and Fabio Coppedè

    Citation: Clinical Epigenetics 2020 12:137

    Content type: Research

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  9. Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, ...

    Authors: Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang and Xiao-dong Zhang

    Citation: Clinical Epigenetics 2020 12:135

    Content type: Research

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  10. Intrauterine exposure to a disturbed maternal glucose metabolism is associated with adverse offspring outcomes. DNA methylation is a potential mechanism underlying these associations. We examined whether mater...

    Authors: Madelon L. Geurtsen, Vincent W. V. Jaddoe, Romy Gaillard and Janine F. Felix

    Citation: Clinical Epigenetics 2020 12:134

    Content type: Research

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  11. Atrial natriuretic peptide (ANP), one of the main members of the natriuretic peptides system, has been associated with hypertension and related complications, but the underlying molecular mechanisms are not ve...

    Authors: Jing Li, Jinhua Zhu, Liyun Ren, Shengqi Ma, Bin Shen, Jia Yu, Rongyan Zhang, Mingzhi Zhang, Yan He and Hao Peng

    Citation: Clinical Epigenetics 2020 12:133

    Content type: Research

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  12. Epigenetic mechanisms play an important role in the chemoresistance of acute myeloid leukemia (AML). The clinical response to epigenetic modifier-based chemotherapy in patients with relapsed/refractory AML (r/...

    Authors: Lixin Wang, Jianmin Luo, Guofeng Chen, Meiyun Fang, Xudong Wei, Yinghua Li, Zhuogang Liu, Yin Zhang, Sujun Gao, Jianliang Shen, Xin Wang, Xiaoning Gao, Wei Zhou, Yigai Ma, Hui Liu, Xinquan Li…

    Citation: Clinical Epigenetics 2020 12:132

    Content type: Research

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  13. The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methyla...

    Authors: Deepak B. Poduval, Elisabet Ognedal, Zuzana Sichmanova, Eivind Valen, Gjertrud T. Iversen, Laura Minsaas, Per E. Lønning and Stian Knappskog

    Citation: Clinical Epigenetics 2020 12:131

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur

    Citation: Clinical Epigenetics 2020 12:130

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2020 12:123

  15. Alzheimer’s disease (AD) is the most common type of dementia, and patients with advanced AD frequently lose the ability to identify family members. The fusiform gyrus (FUS) of the brain is critical in facial r...

    Authors: Dingailu Ma, Irfete S. Fetahu, Mei Wang, Rui Fang, Jiahui Li, Hang Liu, Tobin Gramyk, Isabella Iwanicki, Sophie Gu, Winnie Xu, Li Tan, Feizhen Wu and Yujiang G. Shi

    Citation: Clinical Epigenetics 2020 12:129

    Content type: Research

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  16. Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely re...

    Authors: Ji Hyae Lim, Yu-Jung Kang, Hye Jin Bak, Mi Sun Kim, Hyun Jung Lee, Dong Wook Kwak, You Jung Han, Moon Young Kim, Hyeyeon Boo, Shin Young Kim and Hyun Mee Ryu

    Citation: Clinical Epigenetics 2020 12:128

    Content type: Research

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  17. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis

    Citation: Clinical Epigenetics 2020 12:127

    Content type: Research

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  18. Although metabolic associate fatty liver disease (MAFLD) is associated with obesity, it can also occur in lean patients. MAFLD is more aggressive in lean patients compared to obese patients, with a higher risk...

    Authors: Diana Buzova, Andrea Maugeri, Antonio Liguori, Cecilia Napodano, Oriana Lo Re, Jude Oben, Anna Alisi, Antonio Gasbarrini, Antonio Grieco, Jan Cerveny, Luca Miele and Manlio Vinciguerra

    Citation: Clinical Epigenetics 2020 12:126

    Content type: Research

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  19. Dyskeratosis congenita (DKC) and idiopathic aplastic anemia (AA) are bone marrow failure syndromes that share characteristics of premature aging with severe telomere attrition. Aging is also reflected by DNA m...

    Authors: Olivia Cypris, Monika Eipel, Julia Franzen, Corinna Rösseler, Vithurithra Tharmapalan, Chao-Chung Kuo, Margherita Vieri, Miloš Nikolić, Martin Kirschner, Tim H. Brümmendorf, Martin Zenke, Angelika Lampert, Fabian Beier and Wolfgang Wagner

    Citation: Clinical Epigenetics 2020 12:125

    Content type: Research

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  20. Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (SSc-ILD), driving its mortality. Specific biomarkers associated with the evolution of the ...

    Authors: Julien Guiot, Monique Henket, Béatrice Andre, Marielle Herzog, Nathalie Hardat, Makon-Sebastien Njock, Catherine Moermans, Michel Malaise and Renaud Louis

    Citation: Clinical Epigenetics 2020 12:124

    Content type: Research

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  21. Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered...

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur

    Citation: Clinical Epigenetics 2020 12:123

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2020 12:130

  22. DNA methylation biomarkers in stool may have applications in early colorectal cancer (CRC) detection; however, their association with stages of CRC carcinogenesis or their performance in detecting various stag...

    Authors: Janhavi R. Raut, Zhong Guan, Petra Schrotz-King and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:122

    Content type: Review

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  23. Children conceived by assisted reproductive technologies (ART) have a moderate risk for a number of adverse events and conditions. The question whether this additional risk is associated with specific procedur...

    Authors: Julie Barberet, Fatima Barry, Cécile Choux, Magali Guilleman, Sara Karoui, Raymond Simonot, Céline Bruno and Patricia Fauque

    Citation: Clinical Epigenetics 2020 12:121

    Content type: Review

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  24. Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes,...

    Authors: Kharah M. Ross, Judith E. Carroll, Steve Horvath, Calvin J. Hobel, Mary E. Coussons-Read and Christine Dunkel Schetter

    Citation: Clinical Epigenetics 2020 12:120

    Content type: Research

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  25. Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa...

    Authors: Disline Manli Tantoh, Ming-Chi Wu, Chun-Chao Chuang, Pei-Hsin Chen, Yeu Sheng Tyan, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw

    Citation: Clinical Epigenetics 2020 12:117

    Content type: Research

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  26. Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA...

    Authors: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson…

    Citation: Clinical Epigenetics 2020 12:116

    Content type: Research

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  27. Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. ...

    Authors: Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, David M. Howard, Craig W. Ritchie, Steve Horvath, Caroline Hayward, Andrew M. McIntosh, David J. Porteous, Ian J. Deary, Kathryn L. Evans and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:115

    Content type: Research

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  28. Major depressive disorder (MDD) represents a serious global health concern. The urge for efficient MDD treatment strategies is presently hindered by the incomplete knowledge of its underlying pathomechanism. D...

    Authors: Nicole Moschny, Tristan Zindler, Kirsten Jahn, Marie Dorda, Colin F. Davenport, Lutz Wiehlmann, Hannah B. Maier, Franziska Eberle, Stefan Bleich, Alexandra Neyazi and Helge Frieling

    Citation: Clinical Epigenetics 2020 12:114

    Content type: Research

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  29. Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may...

    Authors: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:113

    Content type: Research

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  30. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li

    Citation: Clinical Epigenetics 2020 12:112

    Content type: Research

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  31. The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confoundin...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Masashi Mikami, Takahiro Arima, Tsutomu Ogata, Maki Fukami and Masayo Kagami

    Citation: Clinical Epigenetics 2020 12:111

    Content type: Research

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  32. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho

    Citation: Clinical Epigenetics 2020 12:110

    Content type: Research

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  33. Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously...

    Authors: Julia Romanowska, Øystein A. Haaland, Astanand Jugessur, Miriam Gjerdevik, Zongli Xu, Jack Taylor, Allen J. Wilcox, Inge Jonassen, Rolv T. Lie and Håkon K. Gjessing

    Citation: Clinical Epigenetics 2020 12:109

    Content type: Methodology

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  34. IGF1 is a key molecule in the regulation of growth and metabolism. Low IGF1 secretion is known to cause growth restriction in childhood, as well as deregulated lipid metabolism, cardiovascular disease, and dia...

    Authors: Masato Kantake, Naho Ikeda, Hirofumi Nakaoka, Natsuki Ohkawa, Toshitaka Tanaka, Kazuki Miyabayashi, Hiromichi Shoji and Toshiaki Shimizu

    Citation: Clinical Epigenetics 2020 12:108

    Content type: Research

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  35. H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigate...

    Authors: Jiayi Pei, Magdalena Harakalova, Thomas A. Treibel, R Thomas Lumbers, Bastiaan J. Boukens, Igor R. Efimov, Jip T. van Dinter, Arantxa González, Begoña López, Hamid El Azzouzi, Noortje van den Dungen, Christian G. M. van Dijk, Merle M. Krebber, Hester M. den Ruijter, Gerard Pasterkamp, Dirk J. Duncker…

    Citation: Clinical Epigenetics 2020 12:106

    Content type: Research

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  36. DNA methylation (DNAm) age constitutes a powerful tool to assess the molecular age and overall health status of biological samples. Recently, it has been shown that tissue-specific DNAm age predictors may pres...

    Authors: Mariana Boroni, Alessandra Zonari, Carolina Reis de Oliveira, Kallie Alkatib, Edgar Andres Ochoa Cruz, Lear E. Brace and Juliana Lott de Carvalho

    Citation: Clinical Epigenetics 2020 12:105

    Content type: Research

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  37. Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be...

    Authors: Marion Ouidir, Pauline Mendola, Germaine M. Buck Louis, Kurunthachalam Kannan, Cuilin Zhang and Fasil Tekola-Ayele

    Citation: Clinical Epigenetics 2020 12:103

    Content type: Research

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  38. Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic insulin production or a weak cellu...

    Authors: Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, Eric P. K. Mensah-Brown and Bright Starling Emerald

    Citation: Clinical Epigenetics 2020 12:104

    Content type: Review

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  39. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C...

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis

    Citation: Clinical Epigenetics 2020 12:102

    Content type: Short report

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  40. Oxytocin is an important neuromodulator involved in cognition and socio-emotional processing that exerts its central activities via oxytocin receptors. Epigenetic alterations in the oxytocin receptor gene (OXTR) ...

    Authors: Chun Il Park, Hae Won Kim, Sumoa Jeon, Jee In Kang and Se Joo Kim

    Citation: Clinical Epigenetics 2020 12:101

    Content type: Research

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  41. A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre...

    Authors: Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz

    Citation: Clinical Epigenetics 2020 12:100

    Content type: Review

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2020 12:107

  42. Little is known about how genetics and epigenetics interplay in depression. Evidence suggests that genetic variants may change vulnerability to depression by modulating DNA methylation (DNAm) and non-coding RN...

    Authors: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Jörgen Jonsson, Mathias Rask-Andersen, Jessica Mwinyi and Helgi B. Schiöth

    Citation: Clinical Epigenetics 2020 12:99

    Content type: Research

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  43. Ten-eleven translocation (Tet) methyl-cytosine dioxygenases (including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in embryonic development and adult tissue homeostasis. The exp...

    Authors: Huan Yan, Li Tan, Yuqi Liu, Ning Huang, Jing Cang and Hao Wang

    Citation: Clinical Epigenetics 2020 12:98

    Content type: Research

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  44. Increasing life expectancy but also healthspan seems inaccessible as of yet but it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil molecular mechanisms involved in...

    Authors: Clémence Topart, Emilie Werner and Paola B. Arimondo

    Citation: Clinical Epigenetics 2020 12:97

    Content type: Review

    Published on:

  45. Currently the leading cause of global disability, clinical depression is a heterogeneous condition characterised by low mood, anhedonia and cognitive impairments. Its growing incidence among young people, ofte...

    Authors: Coral R. Lapsley, Rachelle Irwin, Margaret McLafferty, Sara Jayne Thursby, Siobhan M. O’Neill, Anthony J. Bjourson, Colum P. Walsh and Elaine K. Murray

    Citation: Clinical Epigenetics 2020 12:85

    Content type: Research

    Published on:

  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Elena Ivanova, Sebastian Canovas, Soledad Garcia-Martínez, Raquel Romar, Jordana S. Lopes, Dimitrios Rizos, Maria J. Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey and Pilar Coy

    Citation: Clinical Epigenetics 2020 12:96

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2020 12:64