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  1. Content type: Research

    Deletions of the imprinting centre 1 (IC1) in 11p15.5 are rare and their clinical significance is not only influenced by their parental origin but also by their exact genomic localization. In case the maternal...

    Authors: Florian Kraft, Katharina Wesseler, Matthias Begemann, Ingo Kurth, Miriam Elbracht and Thomas Eggermann

    Citation: Clinical Epigenetics 2019 11:30

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  2. Content type: Research

    Nearly 25% of long intergenic non-coding RNAs (lincRNAs) recruit chromatin-modifying proteins (e.g., EZH2) to silence target genes. HOX antisense intergenic RNA (HOTAIR) is deregulated in diverse cancers and c...

    Authors: Yu Ren, Yun-fei Wang, Jing Zhang, Qi-xue Wang, Lei Han, Mei Mei and Chun-sheng Kang

    Citation: Clinical Epigenetics 2019 11:29

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  3. Content type: Research

    Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function th...

    Authors: Yuko Kurushima, Pei-Chien Tsai, Juan Castillo-Fernandez, Alexessander Couto Alves, Julia Sarah El-Sayed Moustafa, Caroline Le Roy, Tim D. Spector, Mark Ide, Francis J. Hughes, Kerrin S. Small, Claire J. Steves and Jordana T. Bell

    Citation: Clinical Epigenetics 2019 11:27

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  4. Content type: Research

    Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulabi...

    Authors: Xiao Wang, Kristina Sundquist, Peter J. Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A. Memon, Jan Sundquist and Bengt Zöller

    Citation: Clinical Epigenetics 2019 11:28

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  5. Content type: Research

    Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million childre...

    Authors: Yonghui Wu, Xinyi Lin, Ives Yubin Lim, Li Chen, Ai Ling Teh, Julia L. MacIsaac, Kok Hian Tan, Michael S. Kobor, Yap Seng Chong, Peter D. Gluckman and Neerja Karnani

    Citation: Clinical Epigenetics 2019 11:26

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  6. Content type: Research

    Blood-based gene expression or epigenetic biomarkers of Parkinson’s disease (PD) are highly desirable. However, accuracy and specificity need to be improved, and methods for the integration of gene expression ...

    Authors: Changliang Wang, Liang Chen, Yang Yang, Menglei Zhang and Garry Wong

    Citation: Clinical Epigenetics 2019 11:24

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  7. Content type: Research

    Circular RNA (circRNA) is involved in the pathological processes of various diseases. CircRNA is more stable than linear RNAs and is expressed in high levels in tissues, making it a better biomarker candidate ...

    Authors: Hangyu Wu, Siyang Wu, Yingchao Zhu, Mei Ye, Jun Shen, Yan Liu, Yisheng Zhang and Shizhong Bu

    Citation: Clinical Epigenetics 2019 11:22

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  8. Content type: Research

    Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis ...

    Authors: Jesper Beltoft Lund, Shuxia Li, Jan Baumbach, Anne Marie Svane, Jacob Hjelmborg, Lene Christiansen, Kaare Christensen, Paul Redmond, Riccardo E. Marioni, Ian J. Deary and Qihua Tan

    Citation: Clinical Epigenetics 2019 11:23

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  9. Content type: Research

    It is well established that obesity is associated with dysregulation of the ratio between the two major adipokines leptin and adiponectin. Furthermore, it was recently reported that maternal obesity has a sign...

    Authors: Perrine Nogues, Esther Dos Santos, Hélène Jammes, Paul Berveiller, Lucie Arnould, François Vialard and Marie-Noëlle Dieudonné

    Citation: Clinical Epigenetics 2019 11:20

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  10. Content type: Research

    Human-assisted reproductive technologies (ART) are a widely accepted treatment for infertile couples. At the same time, many studies have suggested the correlation between ART and increased incidences of norma...

    Authors: Hiromitsu Hattori, Hitoshi Hiura, Akane Kitamura, Naoko Miyauchi, Norio Kobayashi, Souta Takahashi, Hiroaki Okae, Koichi Kyono, Masayo Kagami, Tsutomu Ogata and Takahiro Arima

    Citation: Clinical Epigenetics 2019 11:21

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  11. Content type: Research

    Differentiation of induced pluripotent stem cells (iPSCs) toward hematopoietic progenitor cells (HPCs) raises high hopes for disease modeling, drug screening, and cellular therapy. Various differentiation prot...

    Authors: Olivia Cypris, Joana Frobel, Shivam Rai, Julia Franzen, Stephanie Sontag, Roman Goetzke, Marcelo A. Szymanski de Toledo, Martin Zenke and Wolfgang Wagner

    Citation: Clinical Epigenetics 2019 11:19

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  12. Content type: Short report

    Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based o...

    Authors: Laura S. Bleker, Jeannette Milgrom, Alexandra Sexton-Oates, Tessa J. Roseboom, Alan W. Gemmill, Christopher J. Holt, Richard Saffery, Huibert Burger and Susanne R. de Rooij

    Citation: Clinical Epigenetics 2019 11:18

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  13. Content type: Research

    Neural tube defects (NTDs) are complex abnormalities associated with gene-environment interactions. The underlying cause has not been determined.

    Authors: Henan Zhang, Yi Guo, Hui Gu, Xiaowei Wei, Wei Ma, Dan Liu, Kun Yu, Wenting Luo, Ling Ma, Yusi Liu, Jia Xue, Jieting Huang, Yanfu Wang, Shanshan Jia, Naixuan Dong, Hongyan Wang…

    Citation: Clinical Epigenetics 2019 11:17

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  14. Content type: Research

    Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid perox...

    Authors: Xīn Gào, Yan Zhang, Barbara Burwinkel, Yang Xuan, Bernd Holleczek, Hermann Brenner and Ben Schöttker

    Citation: Clinical Epigenetics 2019 11:14

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  15. Content type: Research

    Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes...

    Authors: Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li and Nicholas D. E. Greene

    Citation: Clinical Epigenetics 2019 11:13

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  16. Content type: Research

    Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath’s DNA methylation (DN...

    Authors: Elina Sillanpää, Miina Ollikainen, Jaakko Kaprio, Xiaoling Wang, Tuija Leskinen, Urho M. Kujala and Timo Törmäkangas

    Citation: Clinical Epigenetics 2019 11:12

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  17. Content type: Research

    The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alteratio...

    Authors: Halina Was, Sylwia K. Krol, Dante Rotili, Antonello Mai, Bartosz Wojtas, Bozena Kaminska and Marta Maleszewska

    Citation: Clinical Epigenetics 2019 11:11

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  18. Content type: Research

    Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation i...

    Authors: Paula Walle, Ville Männistö, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling and Jussi Pihlajamäki

    Citation: Clinical Epigenetics 2019 11:10

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  19. Content type: Research

    In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic eff...

    Authors: Chao He, Jian Sun, Chao Liu, Yuhang Jiang and Yongqiang Hao

    Citation: Clinical Epigenetics 2019 11:8

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  20. Content type: Research

    Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D inv...

    Authors: Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant and Paola B. Arimondo

    Citation: Clinical Epigenetics 2019 11:9

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  21. Content type: Review

    Ovarian cancer is the deadliest gynecologic malignancy, with a 5-year survival rate of approximately 47%, a number that has remained constant over the past two decades. Early diagnosis improves survival, but u...

    Authors: Sara Moufarrij, Monica Dandapani, Elisa Arthofer, Stephanie Gomez, Aneil Srivastava, Micael Lopez-Acevedo, Alejandro Villagra and Katherine B. Chiappinelli

    Citation: Clinical Epigenetics 2019 11:7

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  22. Content type: Research

    Age-related macular degeneration (AMD) is a degenerative disorder of the central retina and the foremost cause of blindness. The retinal pigment epithelium (RPE) is a primary site of disease pathogenesis. The ...

    Authors: Louise F. Porter, Neil Saptarshi, Yongxiang Fang, Sonika Rathi, Anneke I. den Hollander, Eiko K. de Jong, Simon J. Clark, Paul N. Bishop, Timothy W. Olsen, Triantafillos Liloglou, Venkata R. M. Chavali and Luminita Paraoan

    Citation: Clinical Epigenetics 2019 11:6

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  23. Content type: Research

    Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mort...

    Authors: Jessica S. Jarmasz, Hannah Stirton, James R. Davie and Marc R. Del Bigio

    Citation: Clinical Epigenetics 2019 11:5

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  24. Content type: Research

    Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randoml...

    Authors: Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A. Pantaleo…

    Citation: Clinical Epigenetics 2019 11:2

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  25. Content type: Research

    Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me ha...

    Authors: Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz and Steven A. Johnsen

    Citation: Clinical Epigenetics 2019 11:4

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  26. Content type: Research

    The term pseudohypoparathyroidism (PHP) describes disorders derived from resistance to the parathyroid hormone. Albright hereditary osteodystrophy (AHO) is a disorder with several physical features that can oc...

    Authors: F. M. Elli, L. deSanctis, M.A. Maffini, P. Bordogna, D. Tessaris, A. Pirelli, M. Arosio, A. Linglart and G. Mantovani

    Citation: Clinical Epigenetics 2019 11:3

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  27. Content type: Research

    DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine ...

    Authors: Richa Gupta, Jenny van Dongen, Yu Fu, Abdel Abdellaoui, Rachel F. Tyndale, Vidya Velagapudi, Dorret I. Boomsma, Tellervo Korhonen, Jaakko Kaprio, Anu Loukola and Miina Ollikainen

    Citation: Clinical Epigenetics 2019 11:1

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  28. Content type: Research

    There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neu...

    Authors: Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan and Chia-Ron Yang

    Citation: Clinical Epigenetics 2018 10:162

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  29. Content type: Research

    Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...

    Authors: Cavin K. Ward-Caviness, Golareh Agha, Brian H. Chen, Liliane Pfeiffer, Rory Wilson, Petra Wolf, Christian Gieger, Joel Schwartz, Pantel S. Vokonas, Lifang Hou, Allan C. Just, Stefania Bandinelli, Dena G. Hernandez, Andrew B. Singleton, Holger Prokisch, Thomas Meitinger…

    Citation: Clinical Epigenetics 2018 10:161

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  30. Content type: Short report

    Psoriasis (Ps) is a common chronic inflammatory skin disease. The keratinocytes of psoriatic skin defy normal apoptosis and exhibit active cell proliferation. Aberrant DNA methylation (DNAm) has been suggested...

    Authors: Changbing Shen, Leilei Wen, Randy Ko, Jing Gao, Xue Shen, Xianbo Zuo, Liangdan Sun, Yi-Hsiang Hsu, Xuejun Zhang, Yong Cui, Meng Wang and Fusheng Zhou

    Citation: Clinical Epigenetics 2018 10:160

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  31. Content type: Research

    Epigenetic age acceleration (an older methylation age compared to chronological age) correlates strongly with various age-related morbidities and mortality. Chronic systemic inflammation is thought to be a hal...

    Authors: Anna J. Stevenson, Daniel L. McCartney, Sarah E. Harris, Adele M. Taylor, Paul Redmond, John M. Starr, Qian Zhang, Allan F. McRae, Naomi R. Wray, Tara L. Spires-Jones, Barry W. McColl, Andrew M. McIntosh, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2018 10:159

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  32. Content type: Letter to the Editor

    Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. H...

    Authors: Qiumei Yao, Gareth J. Morgan and Chor Sang Chim

    Citation: Clinical Epigenetics 2018 10:158

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  33. Content type: Research

    Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication d...

    Authors: Xin Sun, Vijesh Vaghjiani, W. Samantha N. Jayasekara, Jason E. Cain and Justin C. St. John

    Citation: Clinical Epigenetics 2018 10:157

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  34. Content type: Research

    Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence ...

    Authors: Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth and Janis Klovins

    Citation: Clinical Epigenetics 2018 10:156

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  35. Content type: Research

    The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their immune-related outcomes, inc...

    Authors: Xinyu Zhang, Ying Hu, Bradley E. Aouizerat, Gang Peng, Vincent C. Marconi, Michael J. Corley, Todd Hulgan, Kendall J. Bryant, Hongyu Zhao, John H. Krystal, Amy C. Justice and Ke Xu

    Citation: Clinical Epigenetics 2018 10:155

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  36. Content type: Research

    The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown.

    Authors: Yue Hu, Mingrui Dai, Yayuan Zheng, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu and Xianghui Yu

    Citation: Clinical Epigenetics 2018 10:154

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  37. Content type: Research

    B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targ...

    Authors: Rui Deng, Peng Zhang, Weizhen Liu, Xiangyu Zeng, Xianxiong Ma, Liang Shi, Tao Wang, Yuping Yin, Weilong Chang, Pei Zhang, Guobin Wang and Kaixiong Tao

    Citation: Clinical Epigenetics 2018 10:153

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  38. Content type: Research

    Lung macrophages are major participants in the pulmonary innate immune response. In the cystic fibrosis (CF) lung, the inability of lung macrophages to successfully regulate the exaggerated inflammatory respon...

    Authors: Youdinghuan Chen, David A. Armstrong, Lucas A. Salas, Haley F. Hazlett, Amanda B. Nymon, John A. Dessaint, Daniel S. Aridgides, Diane L. Mellinger, Xiaoying Liu, Brock C. Christensen and Alix Ashare

    Citation: Clinical Epigenetics 2018 10:152

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  39. Content type: Correction

    Upon publication of the original article [1], it was noticed that the Figure captions of Figs. 2 and 3 were incorrectly given. The correct Figure captions are given below.

    Authors: Nikolay Kondratyev, Arkady Golov, Margarita Alfimova, Tatiana Lezheiko and Vera Golimbet

    Citation: Clinical Epigenetics 2018 10:151

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    The original article was published in Clinical Epigenetics 2018 10:130

  40. Content type: Research

    Imprinted genes are regulated by DNA methylation at imprinting-associated differentially methylated regions (iDMRs). Abnormal expression of imprinted genes is implicated in imprinting disorders and tumors. In ...

    Authors: Hidenori Hidaka, Ken Higashimoto, Saori Aoki, Hiroyuki Mishima, Chisa Hayashida, Toshiyuki Maeda, Yasuo Koga, Hitomi Yatsuki, Keiichiro Joh, Hirokazu Noshiro, Ryuichi Iwakiri, Atsushi Kawaguchi, Koh-ichiro Yoshiura, Kazuma Fujimoto and Hidenobu Soejima

    Citation: Clinical Epigenetics 2018 10:150

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  41. Content type: Review

    Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is characterized by axonal degeneration and gliosis. Although the causes of MS remain unknown, gene dysregul...

    Authors: Xuan Yang, Yuzhang Wu, Bei Zhang and Bing Ni

    Citation: Clinical Epigenetics 2018 10:149

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  42. Content type: Research

    Increased lower body fat is associated with reduced cardiometabolic risk. The molecular basis for depot-specific differences in gluteofemoral (GF) compared with abdominal (A) subcutaneous adipocyte function is...

    Authors: Adeline Divoux, Katalin Sandor, Dora Bojcsuk, Amlan Talukder, Xiaoman Li, Balint L. Balint, Timothy F. Osborne and Steven R. Smith

    Citation: Clinical Epigenetics 2018 10:148

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  43. Content type: Research

    Prevention of unnecessary biopsies and overtreatment of indolent disease remains a challenge in the management of prostate cancer. Novel non-invasive tests that can identify clinically significant (intermediat...

    Authors: Fang Zhao, Ekaterina Olkhov-Mitsel, Shivani Kamdar, Renu Jeyapala, Julia Garcia, Rachel Hurst, Marcelino Yazbek Hanna, Robert Mills, Alexandra V. Tuzova, Eve O’Reilly, Sarah Kelly, Colin Cooper, Daniel Brewer, Antoinette S. Perry, Jeremy Clark, Neil Fleshner…

    Citation: Clinical Epigenetics 2018 10:147

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  44. Content type: Research

    Recent studies demonstrated that changes in DNA methylation (DNAm) and inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty. We aimed to investigate the association of DNAm profi...

    Authors: Danielle S. Bessa, Mariana Maschietto, Carlos Francisco Aylwin, Ana P. M. Canton, Vinicius N. Brito, Delanie B. Macedo, Marina Cunha-Silva, Heloísa M. C. Palhares, Elisabete A. M. R. de Resende, Maria de Fátima Borges, Berenice B. Mendonca, Irene Netchine, Ana C. V. Krepischi, Alejandro Lomniczi, Sergio R. Ojeda and Ana Claudia Latronico

    Citation: Clinical Epigenetics 2018 10:146

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  45. Content type: Research

    DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This mechanism is largely unstudied in papillary thyro...

    Authors: Isabella Maria Dias Payão Ortiz, Mateus Camargo Barros-Filho, Mariana Bisarro dos Reis, Caroline Moraes Beltrami, Fabio Albuquerque Marchi, Hellen Kuasne, Luísa Matos do Canto, Julia Bette Homem de Mello, Cecilie Abildgaard, Clóvis Antônio Lopes Pinto, Luiz Paulo Kowalski and Silvia Regina Rogatto

    Citation: Clinical Epigenetics 2018 10:144

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  46. Content type: Methodology

    The introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation (ChIP) from formalin-fixed paraffin-embedded (FFPE) tissues, has extended the a...

    Authors: Stefano Amatori, Giuseppe Persico, Claudio Paolicelli, Roman Hillje, Nora Sahnane, Francesco Corini, Daniela Furlan, Lucilla Luzi, Saverio Minucci, Marco Giorgio, Pier Giuseppe Pelicci and Mirco Fanelli

    Citation: Clinical Epigenetics 2018 10:143

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