Articles

Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circul...

Authors: Graeme P. Young, Erin L. Symonds, Hans Jørgen Nielsen, Linnea Ferm, Ib J. Christensen, Evelien Dekker, Manon van der Vlugt, Rosalie C. Mallant-Hent, Nicky Boulter, Betty Yu, Michelle Chan, Gregor Tevz, Lawrence C. LaPointe and Susanne K. Pedersen

Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression ...

Authors: Anna Rugowska, Alicja Starosta and Patryk Konieczny

Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer

Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

Authors: Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner, Liguo Wang, Jeanette E. Eckel-Passow, Erik P. Castle, Melissa L. Stanton, R. Houston Thompson, Alexander S. Parker, Thai H. Ho and Keith D. Robertson

Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer

Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognosis prediction of breast cancer. However, limited data exist regarding invasive lobular brea...

Authors: Medha Suman, Pierre-Antoine Dugué, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean and Melissa C. Southey

BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response

The aim of this paper was to investigate the protective effects of bromodomain containing 4 (BRD4) inhibition on the temporomandibular joint osteoarthritis (TMJ OA) induced by compressive mechanical stress and...

Authors: Ziwei Huang, Ren Yang, Lu Zhang, Mengjiao Zhu, Caixia Zhang, Juan Wen and Huang Li

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival

Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for...

Authors: M. Cabezón, R. Malinverni, J. Bargay, B. Xicoy, S. Marcé, A. Garrido, M. Tormo, L. Arenillas, R. Coll, J. Borras, M. J. Jiménez, M. Hoyos, D. Valcárcel, L. Escoda, F. Vall-Llovera, A. Garcia…

Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised mechanism linking early life exposures and subsequent di...

Authors: N. Robinson, H. Brown, Elie Antoun, Keith M. Godfrey, Mark A. Hanson, Karen A. Lillycrop, Sarah R. Crozier, Robert Murray, M. S. Pearce, C. L. Relton, V. Albani and J. A. McKay

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation an...

Authors: Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari…

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility

Autism spectrum disorder (ASD) has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of AS...

Authors: Nicolás Garrido, Fabio Cruz, Rocio Rivera Egea, Carlos Simon, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Millissia Ben Maamar and Michael K. Skinner

Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

The pattern of lung function development from pre-adolescence to adulthood plays a significant role in the pathogenesis of respiratory diseases. Inconsistent findings in genetic studies on lung function trajec...

Authors: Shadia Khan Sunny, Hongmei Zhang, Fawaz Mzayek, Caroline L. Relton, Susan Ring, A. John Henderson, Susan Ewart, John W. Holloway and S. Hasan Arshad

Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

Use of cannabidiol (CBD), the primary non-psychoactive compound found in cannabis, has recently risen dramatically, while relatively little is known about the underlying molecular mechanisms of its effects. Pr...

Authors: Nicole M. Wanner, Mathia Colwell, Chelsea Drown and Christopher Faulk

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also ...

Authors: Xiaolin Zhang, Xiuli Shao, Ruijia Zhang, Rongli Zhu and Rui Feng

DNA methylation epi-signature is associated with two molecularly and phenotypically distinct clinical subtypes of Phelan-McDermid syndrome

Phelan-McDermid syndrome is characterized by a range of neurodevelopmental phenotypes with incomplete penetrance and variable expressivity. It is caused by a variable size and breakpoint microdeletions in the ...

Authors: L. C. Schenkel, E. Aref-Eshghi, K. Rooney, J. Kerkhof, M. A. Levy, H. McConkey, R. C. Rogers, K. Phelan, S. M. Sarasua, L. Jain, R. Pauly, L. Boccuto, B. DuPont, G. Cappuccio, N. Brunetti-Pierri, C. E. Schwartz…

Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from hematopoietic stem and progenitor cells (HSPCs). Patients with CMML are frequently treated with epigenetic ther...

Authors: Johannes Lorenz Berg, Bianca Perfler, Stefan Hatzl, Marie-Christina Mayer, Sonja Wurm, Barbara Uhl, Andreas Reinisch, Ingeborg Klymiuk, Sascha Tierling, Gudrun Pregartner, Gerhard Bachmaier, Andrea Berghold, Klaus Geissler, Martin Pichler, Gerald Hoefler, Herbert Strobl…

High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ ce...

Authors: Mingju Cao, Xiaojian Shao, Peter Chan, Warren Cheung, Tony Kwan, Tomi Pastinen and Bernard Robaire

Reproductive technologies, female infertility, and the risk of imprinting-related disorders

Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes t...

Authors: Patricia Fauque, Jacques De Mouzon, Aviva Devaux, Sylvie Epelboin, Marie-José Gervoise-Boyer, Rachel Levy, Morgane Valentin, Géraldine Viot, Arianne Bergère, Claire De Vienne, Philippe Jonveaux and Fabienne Pessione

Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

Necrotizing enterocolitis (NEC) remains one of the overall leading causes of death in premature infants, and the pathogenesis is unpredictable and not well characterized. The aim of our study was to determine ...

Authors: Misty Good, Tianjiao Chu, Patricia Shaw, Lora McClain, Austin Chamberlain, Carlos Castro, Jamie M. Rimer, Belgacem Mihi, Qingqing Gong, Lila S. Nolan, Krista Cooksey, Laura Linneman, Pranjal Agrawal, David N. Finegold and David Peters

Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

While Alzheimer’s disease (AD) remains one of the most challenging diseases to tackle, genome-wide genetic/epigenetic studies reveal many disease-associated risk loci, which sheds new light onto disease herita...

Authors: Qi Wang, Yinghua Chen, Benjamin Readhead, Kewei Chen, Yi Su, Eric M. Reiman and Joel T. Dudley

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. Here, we studied pathogenic and nonpathogenic simian immunod...

Authors: Simon P. Jochems, Beatrice Jacquelin, Nicolas Tchitchek, Florence Busato, Fabien Pichon, Nicolas Huot, Yi Liu, Mickaël J. Ploquin, Elodie Roché, Rémi Cheynier, Nathalie Dereuddre-Bosquet, Christiane Stahl-Henning, Roger Le Grand, Jorg Tost and Michaela Müller-Trutwin

DNA methylation patterns of β-globin cluster in β-thalassemia patients

Reactivation of fetal hemoglobin (HbF, α₂γ₂) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster d...

Authors: Xiuqin Bao, Yangjin Zuo, Diyu Chen and Cunyou Zhao

Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential

Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of immunity and inflammation which have emerged as potential targets for immunomodulating therapies. The prevalence and sign...

Authors: Krzysztof T. Jurdziński, Jan Potempa and Aleksander M. Grabiec

Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

Fetal growth restriction (FGR) is associated with an increased susceptibility for various noncommunicable diseases in adulthood, including cardiovascular and renal disease. During FGR, reduced uteroplacental b...

Authors: Fieke Terstappen, Jorg J. A. Calis, Nina D. Paauw, Jaap A. Joles, Bas B. van Rijn, Michal Mokry, Torsten Plösch and A. Titia Lely

Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

Epigenetic modification mechanisms involved in keloid: current status and prospect

Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix. However, common therapeu...

Authors: Wenchang Lv, Yuping Ren, Kai Hou, Weijie Hu, Yi Yi, Mingchen Xiong, Min Wu, Yiping Wu and Qi Zhang

Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications ...

Authors: Amanda F. C. Lopes

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming

Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated li...

Authors: Karen L. Leung, Smriti Sanchita, Catherine T. Pham, Brett A. Davis, Mariam Okhovat, Xiangming Ding, Phillip Dumesic, Tristan R. Grogan, Kevin J. Williams, Marco Morselli, Feiyang Ma, Lucia Carbone, Xinmin Li, Matteo Pellegrini, Daniel A. Dumesic and Gregorio D. Chazenbalk

DNA methylation signatures to predict the cervicovaginal microbiome status

The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.

Authors: Nuno R. Nené, James Barrett, Allison Jones, Iona Evans, Daniel Reisel, John F. Timms, Tobias Paprotka, Andreas Leimbach, Dorella Franchi, Nicoletta Colombo, Line Bjørge, Michal Zikan, David Cibula and Martin Widschwendter

High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial d...

Authors: Sharvari S. Deshpande, Harishankar Nemani, Gandhimathi Arumugam, Avinash Ravichandran and Nafisa H. Balasinor

Correction to: Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jessica M. Salmon, Michael Bots, Eva Vidacs, Kym L. Stanley, Peter Atadja, Johannes Zuber and Ricky W. Johnstone

Altered immune phenotype and DNA methylation in panic disorder

Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for imm...

Authors: Curtis L. Petersen, Ji-Qing Chen, Lucas A. Salas and Brock C. Christensen

Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis

Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare life-threatening disorder caused by amyloidogenic coding mutations located in TTR gene. To understand the high phenotypic variability observed among ca...

Authors: Antonella De Lillo, Gita A. Pathak, Flavio De Angelis, Marco Di Girolamo, Marco Luigetti, Mario Sabatelli, Federico Perfetto, Sabrina Frusconi, Dario Manfellotto, Maria Fuciarelli and Renato Polimanti

5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with human papillomavirus (HPV)-related HNSCC rising to concerning levels. Extensive clinical, genetic and epigenetic...

Authors: Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D’Silva, Laura S. Rozek and Maureen A. Sartor

Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma

The utility of O⁶-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that...

Authors: Mitsuto Hanihara, Kunio Miyake, Atsushi Watanabe, Yuriko Yamada, Naoki Oishi, Tomoyuki Kawataki, Takeshi Inukai, Tetsuo Kondo and Hiroyuki Kinouchi

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling

Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However...

Authors: Chunfang Tao, Juan Luo, Jun Tang, Danfeng Zhou, Shujun Feng, Zhu Qiu, Thomas C. Putti, Tingxiu Xiang, Qiao Tao, Lili Li and Guosheng Ren

Epimutations in human sperm from patients with impaired spermatogenesis

Authors: Joana Marques, Filipa Carvalho, Alberto Barros and Mário Sousa

Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays

High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly important, either by supplementing or replacing the traditional cytology-based cervical Pap smear. However, hrHPV screening lacks...

Authors: Carolin Dippmann, Martina Schmitz, Kristina Wunsch, Stefanie Schütze, Katrin Beer, Christiane Greinke, Hans Ikenberg, Heike Hoyer, Ingo B. Runnebaum, Alfred Hansel and Matthias Dürst

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

Patients with cardiovascular disease (CVD) and type 2 diabetes (DM2) have a high residual risk for experiencing a major adverse cardiac event. Dysregulation of epigenetic mechanisms of gene transcription in in...

Authors: Sylwia Wasiak, Kim E. Dzobo, Brooke D. Rakai, Yannick Kaiser, Miranda Versloot, Mahnoush Bahjat, Stephanie C. Stotz, Li Fu, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Erik S. G. Stroes, Jeffrey Kroon and Ewelina Kulikowski

Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs

Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo develop...

Authors: Iraia Muñoa-Hoyos, John A. Halsall, Manu Araolaza, Carl Ward, Idoia Garcia, Itziar Urizar-Arenaza, Marta Gianzo, Paloma Garcia, Bryan Turner and Nerea Subirán

Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of clinically aggressive diseases associated with poor prognosis. Except for ALK + anaplastic large-cell lymphoma (ALCL), most peripheral T-c...

Authors: Ping Zhang and Mingzhi Zhang

LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression

Previous studies suggest the tumor suppressor role of long non-coding RNA (lncRNA) STXBP5-AS1 in cervical and gastric cancer, but its expression pattern and functional mechanism are still elusive in pancreatic ca...

Authors: Shi Chen, Long Huang, Ge Li, Funan Qiu, Yaodong Wang, Can Yang, Jingjing Pan, Zhangwei Wu, Jiangzhi Chen and Yifeng Tian

Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a lifelong debilitating disease with a complex pathology not yet clearly defined. Susceptibility to ME/CFS involves genetic predisposition and exp...

Authors: A. M. Helliwell, E. C. Sweetman, P. A. Stockwell, C. D. Edgar, A. Chatterjee and W. P. Tate

Non-invasive detection of endometrial cancer by DNA methylation analysis in urine

The incidence of endometrial cancer is rising, and current diagnostics often require invasive biopsy procedures. Urine may offer an alternative sample type, which is easily accessible and allows repetitive sel...

Authors: Rianne van den Helder, Birgit M. M. Wever, Nienke E. van Trommel, Annina P. van Splunter, Constantijne H. Mom, Jenneke C. Kasius, Maaike C. G. Bleeker and Renske D. M. Steenbergen

Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging

Colon cancer (CC) is the third most common cancer worldwide, highlighting the importance of developing effective prevention strategies. Accumulating evidence supports that aspirin use reduces CC incidence. We ...

Authors: Faiza Noreen, Anna Chaber-Ciopinska, Jaroslaw Regula, Primo Schär and Kaspar Truninger

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observ...

Authors: Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle and Aurélien A. Sérandour

Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study

Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of th...

Authors: Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song…

Identification of the subtypes of gastric cancer based on DNA methylation and the prediction of prognosis

Gastric cancer (GC) is a digestive system cancer with a high mortality rate globally. Previous experiences and studies have provided clinicians with ample evidence to diagnose and treat patients with reasonabl...

Authors: Tengda Li, Xin Chen, Mingli Gu, Anmei Deng and Cheng Qian

Clinical efficacy and molecular biomarkers in a phase II study of tucidinostat plus R-CHOP in elderly patients with newly diagnosed diffuse large B-cell lymphoma

Elderly patients with diffuse large B-cell lymphoma (DLBCL) present with poor clinical outcome and intolerance to intensive chemotherapy. Histone deacetylase inhibitors (HDACIs) show anti-lymphoma activities a...

Authors: Mu-Chen Zhang, Ying Fang, Li Wang, Shu Cheng, Di Fu, Yang He, Yan Zhao, Chao-Fu Wang, Xu-Feng Jiang, Qi Song, Peng-Peng Xu and Wei-Li Zhao

Genome-wide methylation analysis in Silver–Russell syndrome, Temple syndrome, and Prader–Willi syndrome

Imprinting disorders (IDs) show overlapping phenotypes, particularly in Silver–Russell syndrome (SRS), Temple syndrome (TS14), and Prader–Willi syndrome (PWS). These three IDs include fetal and postnatal growt...

Authors: Kaori Hara-Isono, Keiko Matsubara, Tomoko Fuke, Kazuki Yamazawa, Kazuhito Satou, Nobuyuki Murakami, Shinji Saitoh, Kazuhiko Nakabayashi, Kenichiro Hata, Tsutomu Ogata, Maki Fukami and Masayo Kagami

Genetic and environmental causes of variation in epigenetic aging across the lifespan

DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variat...

Authors: Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey…

Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

Tobacco smoking is a well-known modifiable risk factor for many chronic diseases, including cardiovascular disease (CVD). One of the proposed underlying mechanism linking smoking to disease is via epigenetic m...

Authors: Silvana C. E. Maas, Michelle M. J. Mens, Brigitte Kühnel, Joyce B. J. van Meurs, André G. Uitterlinden, Annette Peters, Holger Prokisch, Christian Herder, Harald Grallert, Sonja Kunze, Melanie Waldenberger, Maryam Kavousi, Manfred Kayser and Mohsen Ghanbari