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  1. While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...

    Authors: Yang Gao, Allison Jones, Peter A. Fasching, Matthias Ruebner, Matthias W. Beckmann, Martin Widschwendter and Andrew E. Teschendorff
    Citation: Clinical Epigenetics 2015 7:126
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:63

  2. There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection and palpation, which are provided on an opportunistic basis, indicating a need for development of n...

    Authors: Scott M. Langevin, Melissa Eliot, Rondi A. Butler, Agnes Cheong, Xiang Zhang, Michael D. McClean, Devin C. Koestler and Karl T. Kelsey
    Citation: Clinical Epigenetics 2015 7:125
    Content type: Research Published on:

  3. ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADA...

    Authors: Sergio Alonso, Beatriz González, Tatiana Ruiz-Larroya, Mercedes Durán Domínguez, Takaharu Kato, Akihiro Matsunaga, Koichi Suzuki, Alex Y. Strongin, Pepita Gimènez-Bonafé and Manuel Perucho
    Citation: Clinical Epigenetics 2015 7:124
    Content type: Research Published on:

  4. Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years...

    Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine
    Citation: Clinical Epigenetics 2015 7:123
    Content type: Review Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:27

  5. Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. Th...

    Authors: Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison and Bernhard T. Baune
    Citation: Clinical Epigenetics 2015 7:122
    Content type: Review Published on:

  6. Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during ea...

    Authors: Dieuwertje E. G. Kok, Rosalie A. M. Dhonukshe-Rutten, Carolien Lute, Sandra G. Heil, André G. Uitterlinden, Nathalie van der Velde, Joyce B. J. van Meurs, Natasja M. van Schoor, Guido J. E. J. Hooiveld, Lisette C. P. G. M. de Groot, Ellen Kampman and Wilma T. Steegenga
    Citation: Clinical Epigenetics 2015 7:121
    Content type: Research Published on:

  7. The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and fem...

    Authors: Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta and Ivana Antonucci
    Citation: Clinical Epigenetics 2015 7:120
    Content type: Review Published on:

  8. The Response Evaluation Criteria in Solid Tumors (RECIST) guideline and Common Terminology Criteria for Adverse Events (CTCAE) criteria are used to assess chemotherapy efficiency and toxicity in patients with ...

    Authors: Hong Wang, Bingfeng Zhang, Dan Chen, Wenying Xia, Jiexin Zhang, Fang Wang, Jian Xu, Yan Zhang, Meijuan Zhang, Lixia Zhang, Yachun Lu, Yan Geng, Peijun Huang, Puwen Huang, Hong Wang and Shiyang Pan
    Citation: Clinical Epigenetics 2015 7:119
    Content type: Research Published on:

  9. Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particula...

    Authors: Vicki E. Maltby, Moira C. Graves, Rodney A. Lea, Miles C. Benton, Katherine A. Sanders, Lotti Tajouri, Rodney J. Scott and Jeannette Lechner-Scott
    Citation: Clinical Epigenetics 2015 7:118
    Content type: Short report Published on:

  10. Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, signifi...

    Authors: Cheng Zhang, Jiang F. Zhong, Andres Stucky, Xue-Lian Chen, Michael F. Press and Xi Zhang
    Citation: Clinical Epigenetics 2015 7:117
    Content type: Review Published on:

  11. Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classific...

    Authors: Tanja Božić, Qiong Lin, Joana Frobel, Stefan Wilop, Melanie Hoffmann, Carsten Müller-Tidow, Tim H. Brümmendorf, Edgar Jost and Wolfgang Wagner
    Citation: Clinical Epigenetics 2015 7:116
    Content type: Short report Published on:

  12. Peroxisome proliferator-activated receptor gamma (PPAR-γ) has been demonstrated to be involved in anti-inflammatory reactions, but its role in acute-on-chronic hepatitis B liver failure (ACHBLF) is unclear. Th...

    Authors: Ze-Hua Zhao, Yu-Chen Fan, Qi Zhao, Cheng-Yun Dou, Xiang-Fen Ji, Jing Zhao, Shuai Gao, Xin-You Li and Kai Wang
    Citation: Clinical Epigenetics 2015 7:115
    Content type: Research Published on:

  13. Many human tumors show aberrant activation of a group of germline-specific genes, termed cancer-germline (CG) genes, several of which appear to exert oncogenic functions. Although activation of CG genes in tum...

    Authors: Julie Cannuyer, Aurélie Van Tongelen, Axelle Loriot and Charles De Smet
    Citation: Clinical Epigenetics 2015 7:114
    Content type: Research Published on:

  14. Active smoking is a major preventable public health problem and an established critical factor for epigenetic modification. In this systematic review, we identified 17 studies addressing the association of act...

    Authors: Xu Gao, Min Jia, Yan Zhang, Lutz Philipp Breitling and Hermann Brenner
    Citation: Clinical Epigenetics 2015 7:113
    Content type: Review Published on:

  15. Epigenetic modulation of gene activity occurs in response to non-genetic factors such as body weight status, physical activity, dietary factors, and environmental toxins. In addition, each of these factors is ...

    Authors: Bidisha Paul, Stephen Barnes, Wendy Demark-Wahnefried, Casey Morrow, Carolina Salvador, Christine Skibola and Trygve O. Tollefsbol
    Citation: Clinical Epigenetics 2015 7:112
    Content type: Review Published on:

  16. Prostate cancer (PC) can be stratified into distinct molecular subtypes based on TMPRSS2-ERG gene fusion status, but its potential prognostic value remains controversial. Likewise, routine clinicopathological fea...

    Authors: Siri H. Strand, Soren Hoyer, Anne-Sofie Lynnerup, Christa Haldrup, Tine Maj Storebjerg, Michael Borre, Torben F. Orntoft and Karina D. Sorensen
    Citation: Clinical Epigenetics 2015 7:111
    Content type: Research Published on:

  17. Aberrant DNA methylation at imprinted loci is an important molecular mechanism contributing to several developmental and pathological disorders including cancer. However, knowledge about imprinting defects due...

    Authors: Sumadi Lukman Anwar, Till Krech, Britta Hasemeier, Elisa Schipper, Nora Schweitzer, Arndt Vogel, Hans Kreipe and Ulrich Lehmann
    Citation: Clinical Epigenetics 2015 7:110
    Content type: Research Published on:

  18. Long non-coding RNAs (lncRNAs) have been claimed as key molecular players in gene expression regulation, being involved in diverse epigenetic processes. They are aberrantly expressed in various tumors, but the...

    Authors: Mónica Martínez-Fernández, Andrew Feber, Marta Dueñas, Cristina Segovia, Carolina Rubio, Maria Fernandez, Felipe Villacampa, José Duarte, Fernando F. López-Calderón, Ma José Gómez-Rodriguez, Daniel Castellano, Jose L. Rodriguez-Peralto, Federico de la Rosa, Stephan Beck and Jesús M. Paramio
    Citation: Clinical Epigenetics 2015 7:109
    Content type: Short report Published on:

  19. Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of cognitive impairment in Alzheimer’s disease (AD). Howev...

    Authors: M. Cuadrado-Tejedor, C. Garcia-Barroso, J. Sanzhez-Arias, S. Mederos, O. Rabal, A. Ugarte, R. Franco, M. Pascual-Lucas, V. Segura, G. Perea, J. Oyarzabal and A. Garcia-Osta
    Citation: Clinical Epigenetics 2015 7:108
    Content type: Research Published on:

  20. Subtelomeric regions dynamically change their epigenetic pattern during development and progression of several malignancies and degenerative disorders. However, DNA methylation of human subtelomeres and their ...

    Authors: Samrat Roy Choudhury, Yi Cui, Jacob R. Milton, Jian Li and Joseph Irudayaraj
    Citation: Clinical Epigenetics 2015 7:107
    Content type: Research Published on:

  21. To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and ther...

    Authors: Monika Bauden, Dorian Pamart, Daniel Ansari, Marielle Herzog, Mark Eccleston, Jake Micallef, Bodil Andersson and Roland Andersson
    Citation: Clinical Epigenetics 2015 7:106
    Content type: Research Published on:

  22. Drug metabolizing enzymes (DMEs) exhibit dramatic inter- and intra-individual variability in expression and activity. However, the mechanisms determining this variability have not been fully elucidated. The ai...

    Authors: Wataru Habano, Kohei Kawamura, Natsuki Iizuka, Jun Terashima, Tamotsu Sugai and Shogo Ozawa
    Citation: Clinical Epigenetics 2015 7:105
    Content type: Research Published on:

  23. CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily,...

    Authors: Nilufer Sayar, Gurbet Karahan, Ozlen Konu, Betul Bozkurt, Onder Bozdogan and Isik G. Yulug
    Citation: Clinical Epigenetics 2015 7:104
    Content type: Research Published on:

  25. The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The cur...

    Authors: Praveen Rajendran, Wan-Mohaiza Dashwood, Li Li, Yuki Kang, Eunah Kim, Gavin Johnson, Kay A. Fischer, Christiane V. Löhr, David E. Williams, Emily Ho, Masayuki Yamamoto, David A. Lieberman and Roderick H. Dashwood
    Citation: Clinical Epigenetics 2015 7:102
    Content type: Research Published on:

  26. Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5–8.7 % of CRCs. It has been shown that SAC has a worse prognosis and different histological and molecula...

    Authors: Pablo Conesa-Zamora, José García-Solano, María del Carmen Turpin, Patricia Sebastián-León, Daniel Torres-Moreno, Eduardo Estrada, Anne Tuomisto, Jamie Wilce, Markus J. Mäkinen, Miguel Pérez-Guillermo and Ana Conesa
    Citation: Clinical Epigenetics 2015 7:101
    Content type: Research Published on:

  27. A number of clinico-pathological criteria and molecular profiles have been used to stratify patients into high- and low-risk groups. Currently, there are still no effective methods to determine which patients ...

    Authors: Christophe Legendre, Gerald C. Gooden, Kyle Johnson, Rae Anne Martinez, Winnie S. Liang and Bodour Salhia
    Citation: Clinical Epigenetics 2015 7:100
    Content type: Research Published on:

  28. The vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling pathway is involved in cancer-related biological functions and is a therapeutic target in cancer. However, the influence of epigene...

    Authors: Jee Yeon Kim, Junha Hwang, Seo Hyun Lee, Hyo Jin Lee, Jaroslav Jelinek, Hyeseon Jeong, Jae Sung Lim, Jin Man Kim, Kyu Sang Song, Byung Hoon Kim, Sukhoon Lee and Jei Kim
    Citation: Clinical Epigenetics 2015 7:99
    Content type: Research Published on:

  29. Global deregulation of DNA methylation is one of the crucial causes of hepato cellular carcinoma (HCC). It has been reported that the anti-cancer drug 5-azacytidine (5-AZA) mediates the activation of tumor sup...

    Authors: Sahar Olsadat Sajadian, Sabrina Ehnert, Haghighat Vakilian, Eirini Koutsouraki, Georg Damm, Daniel Seehofer, Wolfgang Thasler, Steven Dooley, Hossein Baharvand, Bence Sipos and Andreas K. Nussler
    Citation: Clinical Epigenetics 2015 7:98
    Content type: Research Published on:

  30. Aberrant epigenetic silencing of tumor suppressor genes has been recognized as a driving force in cancer. Epigenetic drugs such as the DNA methylation inhibitor decitabine reactivate genes and are effective in...

    Authors: Taichun Qin, Jiali Si, Noël J-M Raynal, Xiaodan Wang, Vazganush Gharibyan, Saira Ahmed, Xin Hu, Chunlei Jin, Yue Lu, Jingmin Shu, Marcos RH Estecio, Jaroslav Jelinek and Jean-Pierre J. Issa
    Citation: Clinical Epigenetics 2015 7:97
    Content type: Research Published on:

  31. A growing body of evidence suggests that the risk of development and progression of a variety of human chronic diseases depends on epigenetic modifications triggered by environmental cues during early life sen...

    Authors: Alexander Vaiserman
    Citation: Clinical Epigenetics 2015 7:96
    Content type: Review Published on:

  32. Genome-wide DNA methylation (DNAm) studies have proven extremely useful to understand human hematopoiesis. Due to their active DNA content, nucleated red blood cells (nRBCs) contribute to epigenetic and transc...

    Authors: Olivia M. de Goede, Hamid R. Razzaghian, E. Magda Price, Meaghan J. Jones, Michael S. Kobor, Wendy P. Robinson and Pascal M. Lavoie
    Citation: Clinical Epigenetics 2015 7:95
    Content type: Research Published on:

  33. Scientific data has been transformed into music in order to raise awareness in the non-scientific community. While the general public is nowadays familiar with the genetic code, there is still a lack of knowle...

    Authors: David Brocks
    Citation: Clinical Epigenetics 2015 7:94
    Content type: Letter to the Editor Published on:

  34. Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator...

    Authors: Peter Arner, Indranil Sinha, Anders Thorell, Mikael Rydén, Karin Dahlman-Wright and Ingrid Dahlman
    Citation: Clinical Epigenetics 2015 7:93
    Content type: Research Published on:

  35. Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, pro...

    Authors: Kristina Harrison, Gwen Hoad, Paula Scott, Louise Simpson, Graham W. Horgan, Elizabeth Smyth, Steven D. Heys and Paul Haggarty
    Citation: Clinical Epigenetics 2015 7:92
    Content type: Research Published on:

  36. Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes...

    Authors: Daniel Nätt, Ingela Johansson, Tomas Faresjö, Johnny Ludvigsson and Annika Thorsell
    Citation: Clinical Epigenetics 2015 7:91
    Content type: Research Published on:

  37. 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate o...

    Authors: Keiko Matsubara, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Maki Fukami, Tsutomu Ogata and Kazuki Yamazawa
    Citation: Clinical Epigenetics 2015 7:90
    Content type: Short report Published on:

  38. Silencing of tumor suppressor genes (TSGs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. The methylation status of such genes can be used for ea...

    Authors: Imran Nawaz, Khalid Moumad, Debora Martorelli, Moulay Mustapha Ennaji, Xiaoying Zhou, Zhe Zhang, Riccardo Dolcetti, Meriem Khyatti, Ingemar Ernberg and Li-Fu Hu
    Citation: Clinical Epigenetics 2015 7:89
    Content type: Research Published on:

  39. DNA methylation (5-methylcytosine (5mC)) patterns are often altered in cancers. Ten-eleven translocation (Tet) proteins oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytos...

    Authors: Maria Eleftheriou, Ana Jimenez Pascual, Lee M. Wheldon, Christina Perry, Abdulkadir Abakir, Arvind Arora, Andrew D. Johnson, Dorothee T. Auer, Ian O. Ellis, Srinivasan Madhusudan and Alexey Ruzov
    Citation: Clinical Epigenetics 2015 7:88
    Content type: Short Report Published on:

  40. Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes li...

    Authors: Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman and Patricia Fauque
    Citation: Clinical Epigenetics 2015 7:87
    Content type: Review Published on:

  41. Epigenetic alterations, such as aberrant DNA methylation of promoter and enhancer regions, which lead to atypical gene expression, have been associated with carcinogenesis. In hepatocellular carcinoma (HCC), g...

    Authors: Fei Gao, Huifang Liang, Hanlin Lu, Junwen Wang, Meng Xia, Zhimei Yuan, Yu Yao, Tong Wang, Xiaolong Tan, Arian Laurence, Hua Xu, Jingjing Yu, Wei Xiao, Wei Chen, Ming Zhou, Xiuqing Zhang…
    Citation: Clinical Epigenetics 2015 7:86
    Content type: Research Published on:

  42. Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to...

    Authors: Par Bahadur Pun, Yu-Ping Liao, Po-Hsuan Su, Hui-Chen Wang, Yu-Chih Chen, Yaw-Wen Hsu, Rui-Lan Huang, Cheng-Chang Chang and Hung-Cheng Lai
    Citation: Clinical Epigenetics 2015 7:85
    Content type: Research Published on:

  43. Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylat...

    Authors: Edward Curry, Ian Green, Nadine Chapman-Rothe, Elham Shamsaei, Sarah Kandil, Fanny L Cherblanc, Luke Payne, Emma Bell, Thota Ganesh, Nitipol Srimongkolpithak, Joachim Caron, Fengling Li, Anthony G. Uren, James P. Snyder, Masoud Vedadi, Matthew J. Fuchter…
    Citation: Clinical Epigenetics 2015 7:84
    Content type: Research Published on:

  44. Deleterious effects of prenatal tobacco smoking on fetal growth and newborn weight are well-established. One of the proposed mechanisms underlying this relationship is alterations in epigenetic programming. We...

    Authors: Marieke I. Bouwland-Both, Nina H. van Mil, Catharina P. Tolhoek, Lisette Stolk, Paul H. C. Eilers, Michael M. P. J. Verbiest, Bastiaan T. Heijmans, André G. Uitterlinden, Albert Hofman, Marinus H. van Ijzendoorn, Liesbeth Duijts, Johan C. de Jongste, Henning Tiemeier, Eric A. P. Steegers, Vincent W. V. Jaddoe and Régine P. M. Steegers-Theunissen
    Citation: Clinical Epigenetics 2015 7:83
    Content type: Research Published on:

  45. Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 hist...

    Authors: Serena Vella, Silvia Pomella, Pier Paolo Leoncini, Marta Colletti, Beatrice Conti, Victor E. Marquez, Antonio Strillacci, Josep Roma, Soledad Gallego, Giuseppe M. Milano, Maurizio C. Capogrossi, Alice Bertaina, Roberta Ciarapica and Rossella Rota
    Citation: Clinical Epigenetics 2015 7:82
    Content type: Research Published on:

  46. Many recent epigenetic studies report that cigarette smoking reduces DNA methylation in whole blood at the single CpG site cg19859270 within the GPR15 gene.

    Authors: Mario Bauer, Gunter Linsel, Beate Fink, Kirsten Offenberg, Anne Maria Hahn, Ulrich Sack, Heike Knaack, Markus Eszlinger and Gunda Herberth
    Citation: Clinical Epigenetics 2015 7:81
    Content type: Research Published on:

  47. Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-r...

    Authors: Valérie Gagné-Ouellet, Simon-Pierre Guay, Anne-Marie Boucher-Lafleur, Luigi Bouchard and Catherine Laprise
    Citation: Clinical Epigenetics 2015 7:80
    Content type: Letter to the Editor Published on:

  48. Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be se...

    Authors: Alexandra M. Binder, Jessica LaRocca, Corina Lesseur, Carmen J. Marsit and Karin B. Michels
    Citation: Clinical Epigenetics 2015 7:79
    Content type: Research Published on:

  49. Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obta...

    Authors: Karin van Veldhoven, Silvia Polidoro, Laura Baglietto, Gianluca Severi, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Domenico Palli, Giovanna Masala, Vittorio Krogh, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Kirsty Flower, Ed Curry, Nicholas Orr…
    Citation: Clinical Epigenetics 2015 7:67
    Content type: Research Published on:

  50. DNA methylation is a heritable and stable epigenetic mark implicated in complex human traits. Epigenome-wide association studies (EWAS) using array-based technology are becoming widely used to identify differe...

    Authors: Cristina Gallego-Fabrega, Caty Carrera, Elena Muiño, Joan Montaner, Jurek Krupinski and Israel Fernandez-Cadenas
    Citation: Clinical Epigenetics 2015 7:78
    Content type: Methodology Published on:
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Clinical Epigenetics

ISSN: 1868-7083

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