Ng M. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 384: ed. 2014 May 29;766–81.
Lee CYW, Koren G. Maternal obesity: effects on pregnancy and the role of pre-conception counselling. J Obstet Gynaecol. 2010;30:101–6.
Article
CAS
PubMed
Google Scholar
Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, et al. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015;212:227. e1–227.e7.
Article
PubMed
Google Scholar
Gaudet L, Ferraro ZM, Wen SW, Walker M. Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. BioMed Res Int. 2014;2014:1–22.
Article
Google Scholar
Liu L, Hong Z, Zhang L. Associations of prepregnancy body mass index and gestational weight gain with pregnancy outcomes in nulliparous women delivering single live babies. Sci Rep. 2015;5:12863.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rajasingam D, Seed PT, Briley AL, Shennan AH, Poston L. A prospective study of pregnancy outcome and biomarkers of oxidative stress in nulliparous obese women. Am J Obstet Gynecol. 2009;200:395. e1–395.e9.
Article
PubMed
Google Scholar
Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991;303:1019–22.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fernandez-Twinn DS, Ozanne SE. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome. Physiol Behav. 2006;88:234–43.
Article
CAS
PubMed
Google Scholar
Hanson MA, Gluckman PD. Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev. 2014;94:1027–76.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hayes EK, Lechowicz A, Petrik JJ, Storozhuk Y, Paez-Parent S, Dai Q, et al. Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental casculature. Reiss I, editor. PLoS ONE. 2012;7:e33370.
Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, et al. An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory. FASEB J. 2013;27:3928–37.
Article
CAS
PubMed
Google Scholar
Tarrade A, Rousseau-Ralliard D, Aubrière M-C, Peynot N, Dahirel M, Bertrand-Michel J, et al. Sexual dimorphism of the feto-placental phenotype in response to a high fat and control maternal diets in a rabbit model. Zenclussen AC, editor. PLoS ONE. 2013;8:e83458.
Georgiades P, Ferguson-Smith AC, Burton GJ. Comparative developmental anatomy of the murine and human definitive placentae. Placenta. 2002;23:3–19.
Article
CAS
PubMed
Google Scholar
McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest. 2009;119(2):323–35.
PubMed Central
CAS
PubMed
Google Scholar
Plata M del M, Williams L, Seki Y, Hartil K, Kaur H, Lin C-L, et al. Critical periods of increased fetal vulnerability to a maternal high fat diet. Reprod Biol Endocrinol RBE. 2014;12:80.
Article
Google Scholar
Swanson AM, David AL. Animal models of fetal growth restriction: considerations for translational medicine. Placenta. 2015;36:623–30.
Article
CAS
PubMed
Google Scholar
Attig L, Gabory A, Junien C. Early nutrition and epigenetic programming: chasing shadows. Curr Opin Clin Nutr Metab Care. 2010;13:284–93.
Article
CAS
PubMed
Google Scholar
Delahaye F, Wijetunga NA, Heo HJ, Tozour JN, Zhao YM, Greally JM, et al. Sexual dimorphism in epigenomic responses of stem cells to extreme fetal growth. Nat Commun. 2014;5:5187.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fu Q. Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. Physiol Genomics. 2004;20:108–16.
Article
CAS
PubMed
Google Scholar
MacLennan NK. Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics. 2004;18:43–50.
Article
PubMed
Google Scholar
Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest. 2008;118:2316–24.
Article
PubMed Central
CAS
PubMed
Google Scholar
Raychaudhuri N, Raychaudhuri S, Thamotharan M, Devaskar SU. Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring. J Biol Chem. 2008;283:13611–26.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gabory A, Attig L, Junien C. Developmental programming and epigenetics. Am J Clin Nutr. 2011;94:1943S–52S.
Article
CAS
PubMed
Google Scholar
Donohoe DR, Bultman SJ. Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression. J Cell Physiol. 2012;227:3169–77.
Article
PubMed Central
CAS
PubMed
Google Scholar
Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007;27:363–88.
Article
CAS
PubMed
Google Scholar
Paden MM, Avery DM. Preconception counseling to prevent the complications of obesity during pregnancy. Am J Clin Med. 2012;9:30–5.
Google Scholar
Forsum E, Brantsæter AL, Olafsdottir A-S, Olsen SF, Thorsdottir I. Weight loss before conception: a systematic literature review. Food Nutr Res. 2013;57.
Villamor E, Cnattingius S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. The Lancet. 2006;368:1164–70.
Article
Google Scholar
Diouf I, Charles MA, Thiebaugeorges O, Forhan A, Kaminski M, Heude B, et al. Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes. Eur J Epidemiol. 2011;26:789–96.
Article
PubMed Central
PubMed
Google Scholar
Gabory A, Ferry L, Fajardy I, Jouneau L, Gothié J-D, Vigé A, et al. Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. Aguila MB, editor. PLoS ONE. 2012;7:e47986.
Mao J, Zhang X, Sieli PT, Falduto MT, Torres KE, Rosenfeld CS. Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta. Proc Natl Acad Sci. 2010;107:5557–62.
Article
PubMed Central
CAS
PubMed
Google Scholar
Clifton VL. Review: sex and the human placenta: mediating differential strategies of fetal growth and survival. Placenta. 2010;31:S33–9.
Article
PubMed
Google Scholar
Attig L, Vigé A, Gabory A, Karimi M, Beauger A, Gross M-S, et al. Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures. PloS One. 2013;8, e66816.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth: maternal obesity and placental nutrient transport. Obesity. 2015;23:1663–70.
Article
CAS
PubMed
Google Scholar
Gheorghe CP, Goyal R, Mittal A, Longo LD. Gene expression in the placenta: maternal stress and epigenetic responses. Int J Dev Biol. 2010;54:507–23.
Article
PubMed Central
CAS
PubMed
Google Scholar
King V, Hibbert N, Seckl JR, Norman JE, Drake AJ. The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent. Placenta. 2013;34:1087–90.
Article
CAS
PubMed
Google Scholar
Sasson IE, Vitins AP, Mainigi MA, Moley KH, Simmons RA. Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice. Diabetologia. 2015;58:615–24.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 2009;23:271–8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Strakovsky RS, Zhang X, Zhou D, Pan Y-X. Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats: programming gluconeogenesis by gestational high fat diet. J Physiol. 2011;589:2707–17.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lane RH, MacLennan NK, Hsu JL, Janke SM, Pham TD. Increased hepatic peroxisome proliferator-activated receptor-γ coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Endocrinology. 2002;143:2486–90.
CAS
PubMed
Google Scholar
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999;274:305–15.
Article
CAS
PubMed
Google Scholar
Mele J, Muralimanoharan S, Maloyan A, Myatt L. Impaired mitochondrial function in human placenta with increased maternal adiposity. AJP Endocrinol Metab. 2014;307:E419–25.
Article
CAS
Google Scholar
Dube E, Gravel A, Martin C, Desparois G, Moussa I, Ethier-Chiasson M, et al. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. Biol Reprod. 2012;87:14–4.
Muramatsu-Kato K, Itoh H, Kobayashi-Kohmura Y, Murakami H, Uchida T, Suzuki K, et al. Comparison between placental gene expression of 11β-hydroxysteroid dehydrogenases and infantile growth at 10 months of age: placental 11βHSD and infantile growth. J Obstet Gynaecol Res. 2014;40:465–72.
Article
CAS
PubMed
Google Scholar
Struwe E, Berzl GM, Schild RL, Beckmann MW, Dörr HG, Rascher W, et al. Simultaneously reduced gene expression of cortisol-activating and cortisol-inactivating enzymes in placentas of small-for-gestational-age neonates. Am J Obstet Gynecol. 2007;197:43. e1–43.e6.
Article
PubMed
Google Scholar
Street ME, Viani I, Ziveri MA, Volta C, Smerieri A, Bernasconi S. Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth. Eur J Endocrinol Eur Fed Endocr Soc. 2011;164:45–52.
Article
CAS
Google Scholar
Colomiere M, Permezel M, Riley C, Desoye G, Lappas M. Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. Eur J Endocrinol. 2009;160:567–78.
Article
CAS
PubMed
Google Scholar
Hiden U, Glitzner E, Hartmann M, Desoye G. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat. 2009;215:60–8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, et al. A transient placental source of serotonin for the fetal forebrain. Nature. 2011;472:347–50.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goeden N, Velasquez JC, Bonnin A. Placental tryptophan metabolism as a potential novel pathway for the developmental origins of mental diseases. Transl Dev Psychiatry. 2013;1:20593.
Article
Google Scholar
Martinez JA, Milagro FI, Claycombe KJ, Schalinske KL. Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr Int Rev J. 2014;5:71–81.
Article
CAS
Google Scholar
Han H-S, Choi D, Choi S, Koo S-H. Roles of protein arginine methyltransferases in the control of glucose metabolism. Endocrinol Metab. 2014;29:435.
Article
Google Scholar
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, et al. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell. 2008;32:221–31.
Article
CAS
PubMed
Google Scholar
Bogaerts A, Ameye L, Martens E, Devlieger R. Weight loss in obese pregnant women and risk for adverse perinatal outcomes. Obstet Gynecol. 2015;125:566–75.
Article
PubMed
Google Scholar
Tuersunjiang N, Odhiambo JF, Long NM, Shasa DR, Nathanielsz PW, Ford SP. Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels. Am J Physiol Endocrinol Metab. 2013;305:E868–78.
Article
PubMed Central
CAS
PubMed
Google Scholar
Srinivasan M. Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype. AJP Endocrinol Metab. 2005;290:E129–34.
Article
Google Scholar
Zambrano E, Martínez-Samayoa PM, Rodríguez-González GL, Nathanielsz PW. RAPID REPORT: dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats: dietary intervention to reverse metabolic programming outcomes. J. Physiol. 2010;588:1791–9.
Article
CAS
Google Scholar
Du Y, Liu B, Guo F, Xu G, Ding Y, Liu Y, et al. The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. Chowen JA, editor. PLoS ONE. 2012;7:e47358.
Wang X, Lacza Z, Sun YE, Han W. Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons. Diabetologia. 2014;57:236–45.
Article
CAS
PubMed
Google Scholar
Fyffe SL, Neul JL, Samaco RC, Chao H-T, Ben-Shachar S, Moretti P, et al. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron. 2008;59:947–58.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ganguly A, Chen Y, Shin B-C, Devaskar SU. Prenatal caloric restriction enhances DNA methylation and MeCP2 recruitment with reduced murine placental glucose transporter isoform 3 expression. J Nutr Biochem. 2014;25:259–66.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nicholas LM, Rattanatray L, MacLaughlin SM, Ozanne SE, Kleemann DO, Walker SK, et al. Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring. FASEB J. 2013;27:3786–96.
Article
CAS
PubMed
Google Scholar
Wu LL-Y, Dunning KR, Yang X, Russell DL, Lane M, Norman RJ, et al. High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates. Endocrinology. 2010;151:5438–45.
Article
CAS
PubMed
Google Scholar
Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94:1533–40.
Article
CAS
PubMed
Google Scholar
Luzzo KM, Wang Q, Purcell SH, Chi M, Jimenez PT, Grindler N, et al. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. Clarke H, editor. PLoS ONE. 2012;7:e49217.
Wei Y, Yang C-R, Wei Y-P, Ge Z-J, Zhao Z-A, Zhang B, et al. Enriched environment-induced maternal weight loss reprograms metabolic gene expression in mouse offspring. J Biol Chem. 2015;290:4604–19.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ge Z-J, Luo S-M, Lin F, Liang Q-X, Huang L, Wei Y-C, et al. DNA methylation in oocytes and liver of female mice and their offspring: effects of high-fat-diet-induced obesity. Environ Health Perspect. 2014;122:159–64.
PubMed Central
PubMed
Google Scholar
Ding L, Pan R, Huang X, Wang J-X, Shen Y-T, Xu L, et al. Changes in histone acetylation during oocyte meiotic maturation in the diabetic mouse. Theriogenology. 2012;78:784–92.
Article
CAS
PubMed
Google Scholar
Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, et al. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol. 2008;41:91–102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, et al. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012;26:5106–14.
Article
PubMed Central
CAS
PubMed
Google Scholar
Suter MA, Ma J, Vuguin PM, Hartil K, Fiallo A, Harris RA, et al. In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model. Am J Obstet Gynecol. 2014;210:463. e1–463.e11.
PubMed Central
PubMed
Google Scholar
Vaiman D, Gascoin-Lachambre G, Boubred F, Mondon F, Feuerstein J-M, Ligi I, et al. The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model. Baud O, editor. PLoS ONE. 2011;6:e21222.
Yoo EJ, Chung J-J, Choe SS, Kim KH, Kim JB. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J Biol Chem. 2006;281:6608–15.
Article
CAS
PubMed
Google Scholar
Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011;331:1315–9.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sookoian S, Gemma C, Gianotti TF, Burgueño A, Castaño G, Pirola CJ. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr. 2008;87:1606–15.
CAS
PubMed
Google Scholar
Garaulet M, Corbalan MD, Madrid JA, Morales E, Baraza JC, Lee Y-C, et al. CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet. Int J Obes. 2010;34:516–23.
Article
CAS
Google Scholar
Turek FW. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005;308:1043–5.
Article
PubMed Central
CAS
PubMed
Google Scholar
Coste A, Louet J-F, Lagouge M, Lerin C, Antal MC, Meziane H, et al. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α. Proc Natl Acad Sci. 2008;105:17187–92.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, et al. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med. 2004;10:633–7.
Article
CAS
PubMed
Google Scholar
Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest. 2010;120:4316–31.
Article
PubMed Central
CAS
PubMed
Google Scholar
Marmorstein R, Zhou M-M. Writers and readers of histone acetylation: structure, mechanism, and inhibition. Cold Spring Harb Perspect Biol. 2014;6:a018762–2.
Wang F, Liu H, Blanton WP, Belkina A, Lebrasseur NK, Denis GV. Brd2 disruption in mice causes severe obesity without type 2 diabetes. Biochem J. 2010;425:71–83.
Article
CAS
Google Scholar
Jump DB, Tripathy S, Depner CM. Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr. 2013;33:249–69.
Article
PubMed Central
CAS
PubMed
Google Scholar
White CL, Purpera MN, Morrison CD. Maternal obesity is necessary for programming effect of high-fat diet on offspring. AJP Regul Integr Comp Physiol. 2009;296:R1464–72.
Article
CAS
Google Scholar
Howie GJ, Sloboda DM, Kamal T, Vickers MH. Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet: maternal high fat nutrition and obesity in offspring. J Physiol. 2009;587:905–15.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li J, Wang W, Liu C, Wang W, Li W, Shu Q, et al. Critical role of histone acetylation by p300 in human placental 11β-HSD2 expression. J Clin Endocrinol Metab. 2013;98:E1189–97.
Article
CAS
PubMed
Google Scholar
Vaiman D, Calicchio R, Miralles F. Landscape of transcriptional deregulations in the preeclamptic placenta. PLoS ONE. 2013;8(6), e65498.
Article
PubMed Central
CAS
PubMed
Google Scholar
Portha B, Fournier A, Ah Kioon MD, Mezger V, Movassat J. Early environmental factors, alteration of epigenetic marks and metabolic disease susceptibility. Biochimie. 2014;97:1–15.
Article
CAS
PubMed
Google Scholar
Andrikopoulos S, Blair AR, Deluca N, Fam BC, Proietto J. Evaluating the glucose tolerance test in mice. AJP Endocrinol Metab. 2008;295:E1323–32.
Article
CAS
Google Scholar
Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67.
Zeileis A, Hothorn T. Diagnostic checking in regression relationships. R News. 2002;2:7–10.
Google Scholar
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol. 1995;57:289–300.
Google Scholar
Fox J, Sanford W. An {R} companion to applied regression. second. Thousand Oaks {CA}: Sage; 2011.
Dilworth MR, Kusinski LC, Baker BC, Renshall LJ, Greenwood SL, Sibley CP, et al. Defining fetal growth restriction in mice: a standardized and clinically relevant approach. Placenta. 2011;32:914–6.
Article
CAS
PubMed
Google Scholar
Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:research0034.
Article
PubMed Central
PubMed
Google Scholar
Gabory A, Ripoche M-A, Le Digarcher A, Watrin F, Ziyyat A, Forné T, et al. H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Dev Camb Engl. 2009;136:3413–21.
CAS
Google Scholar
Zeileis A, Wiel MA, Hornik K, Hothorn T. Implementing a class of permutation tests: the coin package. J Stat Softw. 2008;28:1–23.
Google Scholar