Fig. 3From: Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in miceBody weight and fetal and placental weights in OB and WL dams at E18.5. a Dams pregnant body weight gain (percentage of initial weight). NS nonsignificant. (a) P < 0.001 OB vs. CTRL. (c) P < 0.001 WL vs. OB. n = 13 CTRL, 11 OB, 17 WL. b Dams carcass weight (percentage of initial weight) at sacrifice. NS nonsignificant. (a) P < 0.001 OB vs. CTRL, (c) P < 0.001 WL vs. OB. n = 13 CTRL, 10 OB, 16 WL. c Fetal weight. NS nonsignificant. (a) P < 0.001 OB vs. CTRL. (c) P < 0.001 WL vs. OB. Data from males and females were combined as there was no effect of sex on fetal weight. n = 75 CTRL, 74 OB, 119 WL. d Proportion of small for gestational age (SGA) fetuses. Data from males and females were combined as there was no effect of sex on fetal weight. CTRL (n = 7 SGA/75 fetuses), OB (n = 21/74), WL (n = 14/119). Maternal obesity: odds ratio (OR) of being SGA = 3.2 (95 % CI 1.19–9.76, P = 0.028). e Placental weight. (s) P < 0.001 males vs. females. n = 36 CTRL F, 39 CTRL M, 35 OB F, 39 OB M, 61 WL F, 58 WL M. f Fetal-weight-to-placental weight ratio index. (a) P = 0.001 OB vs. CTRL. (c) P < 0.001 WL vs. OB. (s) P = 0.001 males vs. females. n = 36 CTRL F, 39 CTRL M, 35 OB F, 39 OB M, 61 WL F, 58 WL MBack to article page