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Table 1 Differentially expressed genes in the fetal liver, placental labyrinth, and junctional zone at E18.5

From: Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice

Tissue Gene CTRL group OB group WL group P value
OB vs. CTRL WL vs. CTRL WL vs. OB
Fetal liver Kat2a (Gcn5) 2.92 ± 0.90 4.77 ± 1.48 4.14 ± 1.51 0.004 0.118 0.622
Kat3a (Crebbp) 0.71 ± 0.19 1.14 ± 0.34 1.04 ± 0.37 0.008 0.055 0.745
Kat6b (Myst4) 0.97 ± 0.29 1.65 ± 0.48 1.26 ± 0.41 0.004 0.209 0.209
Kat13d (Clock) 2.19 ± 0.59 3.67 ± 0.89 3.16 ± 1.23 <0.001 0.307 0.445
Hdac2 0.43 ± 0.17 0.20 ± 0.07 0.26 ± 0.13 0.004 0.065 0.496
Hdac6 1.44 ± 0.43 2.29 ± 0.71 1.78 ± 0.74 0.012 0.445 0.339
Brd2 0.25 ± 0.07 0.34 ± 0.07 0.37 ± 0.10 0.039 0.024 0.731
Prmt1 0.50 ± 0.15 0.78 ± 0.21 0.61 ± 0.23 0.008 0.431 0.279
Prmt7 7.1 ± 2.6 11.6 ± 3.9 8.5 ± 3.0 0.016 0.496 0.166
Gck 0.81 ± 0.56 0.26 ± 0.24 0.76 ± 0.61 0.031 0.940 0.088
Lepr 0.22 ± 0.09 0.25 ± 0.07 0.17 ± 0.05 0.637 0.377 0.039
Labyrinth Kat1 (Hat1) 0.024 ± 0.011 0.041 ± 0.013 0.037 ± 0.010 0.012 0.029 0.463
Kat3a (Crebbp) 1.22 ± 0.42 1.49 ± 0.43 1.84 ± 0.60 0.215 0.029 0.192
Kat3b (Ep300) 0.012 ± 0.006 0.030 ± 0.014 0.029 ± 0.014 0.003 0.006 0.907
Kat13b (Ncoa3) 0.045 ± 0.022 0.084 ± 0.033 0.087 ± 0.028 0.017 0.003 0.871
Hdac2 0.35 ± 0.15 0.23 ± 0.15 0.18 ± 0.08 0.124 0.014 0.448
Hdac3 4.03 ± 1.41 2.60 ± 0.62 3.81 ± 1.43 0.021 0.797 0.053
Hdac10 0.22 ± 0.08 0.10 ± 0.05 0.22 ± 0.10 0.003 0.978 0.003
Sirt4 0.32 ± 0.14 0.23 ± 0.07 0.37 ± 0.16 0.124 0.478 0.046
Brd2 0.73 ± 0.26 0.91 ± 0.18 1.06 ± 0.31 0.124 0.036 0.266
Kmt1d (Ehmt1) 2.09 ± 0.74 1.34 ± 0.37 2.50 ± 1.15 0.029 0.402 0.017
Mbd5 0.031 ± 0.010 0.022 ± 0.007 0.035 ± 0.013 0.053 0.480 0.021
Mecp2 0.035 ± 0.012 0.029 ± 0.010 0.045 ± 0.012 0.247 0.112 0.007
Hsd11β1 49.7 ± 25.5 26.1 ± 13.8 52.1 ± 32.0 0.046 0.892 0.065
Irs1 0.71 ± 0.36 0.38 ± 0.19 0.65 ± 0.41 0.043 0.777 0.124
Tph1 0.021 ± 0.010 0.012 ± 0.006 0.021 ± 0.009 0.033 0.978 0.04951
Junctional zone Kat3b (Ep300) 0.029 ± 0.008 0.042 ± 0.012 0.045 ± 0.012 0.101 0.040 0.743
  1. Data are represented as mean expression levels ± St.Dev. When the p value was significant, an arrow showing the sense of variation was added ( downregulation, upregulation)