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Table 1 Differentially expressed genes in the fetal liver, placental labyrinth, and junctional zone at E18.5

From: Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice

Tissue

Gene

CTRL group

OB group

WL group

P value

OB vs. CTRL

WL vs. CTRL

WL vs. OB

Fetal liver

Kat2a (Gcn5)

2.92 ± 0.90

4.77 ± 1.48

4.14 ± 1.51

↗ 0.004

0.118

0.622

Kat3a (Crebbp)

0.71 ± 0.19

1.14 ± 0.34

1.04 ± 0.37

↗ 0.008

0.055

0.745

Kat6b (Myst4)

0.97 ± 0.29

1.65 ± 0.48

1.26 ± 0.41

↗ 0.004

0.209

0.209

Kat13d (Clock)

2.19 ± 0.59

3.67 ± 0.89

3.16 ± 1.23

↗ <0.001

0.307

0.445

Hdac2

0.43 ± 0.17

0.20 ± 0.07

0.26 ± 0.13

↘ 0.004

0.065

0.496

Hdac6

1.44 ± 0.43

2.29 ± 0.71

1.78 ± 0.74

↗ 0.012

0.445

0.339

Brd2

0.25 ± 0.07

0.34 ± 0.07

0.37 ± 0.10

↗ 0.039

0.024

0.731

Prmt1

0.50 ± 0.15

0.78 ± 0.21

0.61 ± 0.23

↗ 0.008

0.431

0.279

Prmt7

7.1 ± 2.6

11.6 ± 3.9

8.5 ± 3.0

↗ 0.016

0.496

0.166

Gck

0.81 ± 0.56

0.26 ± 0.24

0.76 ± 0.61

↘ 0.031

0.940

0.088

Lepr

0.22 ± 0.09

0.25 ± 0.07

0.17 ± 0.05

0.637

0.377

↘ 0.039

Labyrinth

Kat1 (Hat1)

0.024 ± 0.011

0.041 ± 0.013

0.037 ± 0.010

↗ 0.012

↗ 0.029

0.463

Kat3a (Crebbp)

1.22 ± 0.42

1.49 ± 0.43

1.84 ± 0.60

0.215

↗ 0.029

0.192

Kat3b (Ep300)

0.012 ± 0.006

0.030 ± 0.014

0.029 ± 0.014

↗ 0.003

↗ 0.006

0.907

Kat13b (Ncoa3)

0.045 ± 0.022

0.084 ± 0.033

0.087 ± 0.028

↗ 0.017

↗ 0.003

0.871

Hdac2

0.35 ± 0.15

0.23 ± 0.15

0.18 ± 0.08

0.124

↘ 0.014

0.448

Hdac3

4.03 ± 1.41

2.60 ± 0.62

3.81 ± 1.43

↘ 0.021

0.797

0.053

Hdac10

0.22 ± 0.08

0.10 ± 0.05

0.22 ± 0.10

↘ 0.003

0.978

↗ 0.003

Sirt4

0.32 ± 0.14

0.23 ± 0.07

0.37 ± 0.16

0.124

0.478

↗ 0.046

Brd2

0.73 ± 0.26

0.91 ± 0.18

1.06 ± 0.31

0.124

↗ 0.036

0.266

Kmt1d (Ehmt1)

2.09 ± 0.74

1.34 ± 0.37

2.50 ± 1.15

↘ 0.029

0.402

↗ 0.017

Mbd5

0.031 ± 0.010

0.022 ± 0.007

0.035 ± 0.013

0.053

0.480

↗ 0.021

Mecp2

0.035 ± 0.012

0.029 ± 0.010

0.045 ± 0.012

0.247

0.112

↗ 0.007

Hsd11β1

49.7 ± 25.5

26.1 ± 13.8

52.1 ± 32.0

↘ 0.046

0.892

0.065

Irs1

0.71 ± 0.36

0.38 ± 0.19

0.65 ± 0.41

↘ 0.043

0.777

0.124

Tph1

0.021 ± 0.010

0.012 ± 0.006

0.021 ± 0.009

↘ 0.033

0.978

↗ 0.04951

Junctional zone

Kat3b (Ep300)

0.029 ± 0.008

0.042 ± 0.012

0.045 ± 0.012

0.101

↗ 0.040

0.743

  1. Data are represented as mean expression levels ± St.Dev. When the p value was significant, an arrow showing the sense of variation was added (↘ downregulation, ↗ upregulation)
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Clinical Epigenetics

ISSN: 1868-7083

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