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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice

Fig. 6

Maternal weight trajectories affect the expression of genes implicated in metabolism. We assessed the expression level of 32 genes implicated in metabolism or development using TaqMan low-density arrays. The expression of glucokinase (a) in the fetal liver and hydroxysteroid 11-β dehydrogenase 1 (b), insulin receptor substrate 1 (c), and tryptophan hydroxylase 1 (d) in the placental labyrinth was affected by maternal obesity or weight loss at E18.5. (a) P adj < 0.05 OB vs. CTRL, (c) P adj < 0.05 WL vs. OB. CTRL (n = 16), OB (n = 14), WL (n = 16)

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Clinical Epigenetics

ISSN: 1868-7083

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