Articles

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA m...

Authors: Lara Kular, Maria Needhamsen, Milena Z. Adzemovic, Tatiana Kramarova, David Gomez-Cabrero, Ewoud Ewing, Eliane Piket, Jesper Tegnér, Stephan Beck, Fredrik Piehl, Lou Brundin and Maja Jagodic

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitu...

Authors: Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng and Shiow-Lin Pan

Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein

Hypertension is one of primary clinical presentations of pre-eclampsia. The occurrence and progress of hypertension are closely related to vascular dysfunction. However, information is limited regarding the pa...

Authors: Qinqin Gao, Xiaorong Fan, Ting Xu, Huan Li, Yun He, Yuxian Yang, Jie Chen, Hongmei Ding, Jianying Tao and Zhice Xu

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus

Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting altera...

Authors: Tobias Wiechmann, Simone Röh, Susann Sauer, Darina Czamara, Janine Arloth, Maik Ködel, Madita Beintner, Lisanne Knop, Andreas Menke, Elisabeth B. Binder and Nadine Provençal

Prenatal epigenetics diets play protective roles against environmental pollution

It is thought that germ cells and preimplantation embryos during development are most susceptible to endogenous and exogenous environmental factors because the epigenome in those cells is undergoing dramatic e...

Authors: Shizhao Li, Min Chen, Yuanyuan Li and Trygve O. Tollefsbol

Epigenetics in cancer therapy and nanomedicine

The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of thei...

Authors: Annalisa Roberti, Adolfo F. Valdes, Ramón Torrecillas, Mario F. Fraga and Agustin F. Fernandez

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data

DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyse...

Authors: Yujie He, Lot D. de Witte, Lotte C. Houtepen, Danny M. Nispeling, Zhida Xu, Qiong Yu, Yaqin Yu, Elly M. Hol, René S. Kahn and Marco P. Boks

Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription

Circadian rhythms orchestrate crucial physiological functions and behavioral aspects around a day in almost all living forms. The circadian clock is a time tracking system that permits organisms to predict and...

Authors: Ignacio Pacheco-Bernal, Fernando Becerril-Pérez and Lorena Aguilar-Arnal

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the ...

Authors: Simin Tang, Jun Zhou, Huan Jing, Meijuan Liao, Sen Lin, Zhenxing Huang, Teng Huang, Jiying Zhong and HanbingWang

Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer

TP53 is frequently mutated across various tissue types of cancers. In normal cells, long interspersed nuclear element-1 (LINE-1, L1) is mostly repressed by DNA methylation in its 5′ untranslated region but is act...

Authors: Yun-Joo Shin, Younghoon Kim, Xianyu Wen, Nam-Yun Cho, Sun Lee, Woo Ho Kim and Gyeong Hoon Kang

Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas

To identify novel epigenetic signatures that could provide predictive information that is complementary to promoter methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene for predicting ...

Authors: An-An Yin, Ya-Long He, Amandine Etcheverry, Yu-He Liu, Marc Aubry, Jill Barnholtz-Sloan, Bo-Lin Liu, Jean Mosser, Zi-Fan Lu and Xiang Zhang

Circulating cell-free DNA use for diagnosing cholangiocarcinoma

Authors: Steven Sorscher

ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a predicted transcription factor with potential role in hematopoietic development. Recent evidence linked low methylation level of ZBTB12 exon1 to myoc...

Authors: Fabrizia Noro, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello and Benedetta Izzi

Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene

Obstetric complications have long been retrospectively associated with a wide range of short- and long-term health consequences, including neurodevelopmental alterations such as those observed in schizophrenia...

Authors: Helena Palma-Gudiel, Elisenda Eixarch, Fátima Crispi, Sebastián Morán, Anthony S. Zannas and Lourdes Fañanás

Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure

Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apopto...

Authors: Yun Huang, Aiguo Ren, Linlin Wang, Lei Jin, Shanshan Lin, Zhiwen Li and Jasmine A. McDonald

Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact

miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic mi...

Authors: Zhenhai Li, Kwan Yeung Wong, George A. Calin, Wee-Joo Chng, Godfrey Chi-fung Chan and Chor Sang Chim

UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvem...

Authors: Takeshi Niinuma, Hiroshi Kitajima, Masahiro Kai, Eiichiro Yamamoto, Akira Yorozu, Kazuya Ishiguro, Hajime Sasaki, Gota Sudo, Mutsumi Toyota, Tomo Hatahira, Reo Maruyama, Takashi Tokino, Hiroshi Nakase, Tamotsu Sugai and Hiromu Suzuki

Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM_2.5 concentrations

DNA methylation is associated with cancer, metabolic, neurological, and autoimmune disorders. Hypomethylation of aryl hydrocarbon receptor repressor (AHRR) especially at cg05575921 is associated with smoking a...

Authors: Disline Manli Tantoh, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Chin Lin, Hou-Wei Chu, Pei-Hsin Chen, Shu-Yi Hsu, Wen-Hsiu Liu, Chen-Chang Ho, Chia-Chi Lung, Ming-Fang Wu, Yi-Ching Liaw, Tonmoy Debnath and Yung-Po Liaw

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enha...

Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi…

DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the ...

Authors: Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende…

Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk

It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, ...

Authors: Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemaker, Nick Orr, Katarzyna Tomczyk…

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine

Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quanti...

Authors: Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger and Gabriela Aust

Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome

ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation...

Authors: Eric G. Bend, Erfan Aref-Eshghi, David B. Everman, R. Curtis Rogers, Sara S. Cathey, Eloise J. Prijoles, Michael J. Lyons, Heather Davis, Katie Clarkson, Karen W. Gripp, Dong Li, Elizabeth Bhoj, Elaine Zackai, Paul Mark, Hakon Hakonarson, Laurie A. Demmer…

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosi...

Authors: Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou and Song-Mei Liu

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

Ageing is one of the principal risk factors for many chronic diseases. However, there is considerable between-person variation in the rate of ageing and individual differences in their susceptibility to diseas...

Authors: Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Michael E. Ernst and Joanne Ryan

DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing t...

Authors: Pooja Sagvekar, Pankaj Kumar, Vijay Mangoli, Sadhana Desai and Srabani Mukherjee

Novel parent-of-origin-specific differentially methylated loci on chromosome 16

Congenital malformations associated with maternal uniparental disomy of chromosome 16, upd(16)mat, resemble those observed in newborns with the lethal developmental lung disease, alveolar capillary dysplasia w...

Authors: Katharina V. Schulze, Przemyslaw Szafranski, Harry Lesmana, Robert J. Hopkin, Aaron Hamvas, Jennifer A. Wambach, Marwan Shinawi, Gladys Zapata, Claudia M. B. Carvalho, Qian Liu, Justyna A. Karolak, James R. Lupski, Neil A. Hanchard and Paweł Stankiewicz

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood b...

Authors: Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic II, Christine A. Iacobuzio-Donahue…

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predic...

Authors: Paula S. Ramos, Kip D. Zimmerman, Sandra Haddad, Carl D. Langefeld, Thomas A. Medsger Jr and Carol A. Feghali-Bostwick

Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We inves...

Authors: F. Perrier, V. Viallon, S. Ambatipudi, A. Ghantous, C. Cuenin, H. Hernandez-Vargas, V. Chajès, L. Baglietto, M. Matejcic, H. Moreno-Macias, T. Kühn, H. Boeing, A. Karakatsani, A. Kotanidou, A. Trichopoulou, S. Sieri…

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with c...

Authors: Andres Cardenas, Sabrina Faleschini, Andrea Cortes Hidalgo, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Dawn L. DeMeo, Augusto A. Litonjua, Alexander Neumann, Janine F. Felix, Vincent W. V. Jaddoe, Hanan El Marroun, Henning Tiemeier, Emily Oken, Marie-France Hivert and Heather H. Burris

Control of viral infections by epigenetic-targeted therapy

Epigenetics is defined as the science that studies the modifications of gene expression that are not owed to mutations or changes in the genetic sequence. Recently, strong evidences are pinpointing toward a so...

Authors: Zeina Nehme, Sébastien Pasquereau and Georges Herbein

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifical...

Authors: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner and Bharati Bapat

Genome-wide methylation profiling of Beckwith-Wiedemann syndrome patients without molecular confirmation after routine diagnostics

Beckwith-Wiedemann syndrome (BWS) is caused due to the disturbance of imprinted genes at chromosome 11p15. The molecular confirmation of this syndrome is possible in approximately 85% of the cases, whereas in ...

Authors: I. M. Krzyzewska, M. Alders, S. M. Maas, J. Bliek, A. Venema, P. Henneman, F. I. Rezwan, K. v. d. Lip, A. N. Mul, D. J. G. Mackay and M. M. A. M. Mannens

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distingu...

Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove and Katie Lunnon

Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA

Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is signifi...

Authors: Yoon Dae Han, Tae Jeong Oh, Tae-Ha Chung, Hui Won Jang, Youn Nam Kim, Sungwhan An and Nam Kyu Kim

Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival

The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evide...

Authors: Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z. Ratajczak and Gabriela Schneider

Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases

Major challenges in understanding the functional consequences of genetic risk factors for human disease are which tissues and cell types are affected and the limited availability of suitable tissue. The aim of...

Authors: Sally Mortlock, Restuadi Restuadi, Rupert Levien, Jane E. Girling, Sarah J. Holdsworth-Carson, Martin Healey, Zhihong Zhu, Ting Qi, Yang Wu, Samuel W. Lukowski, Peter A. W. Rogers, Jian Yang, Allan F. McRae, Jenny N. Fung and Grant W. Montgomery

The hyper-activation of transcriptional enhancers in breast cancer

Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific i...

Authors: Qing-Lan Li, Dan-Ya Wang, Lin-Gao Ju, Jie Yao, Chuan Gao, Pin-Ji Lei, Lian-Yun Li, Xiao-Lu Zhao and Min Wu

Correction to: Liver DNA methylation of FADS2 associates with FADS2 genotype

Following publication of the original article [1], the author reported the title of this article has been misspelled.

Authors: Paula Walle, Ville Männistö, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling and Jussi Pihlajamäki

SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas

Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The ...

Authors: Disline Manli Tantoh, Ming-Fang Wu, Chien-Chang Ho, Chia-Chi Lung, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Shu-Yi Hsu, Pei-Hsin Chen, Chin Lin, Hou-Wei Chu, Yi-Ching Liaw and Yung-Po Liaw

Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study

Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we char...

Authors: Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A. Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G. Mohile, Christine B. Ambrosone, Song Liu and Michelle C. Janelsins

RFX1 downregulation contributes to TLR4 overexpression in CD14⁺ monocytes via epigenetic mechanisms in coronary artery disease

Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory f...

Authors: Pei Du, Keqin Gao, Yu Cao, Shuang Yang, Yang Wang, Ren Guo, Ming Zhao and Sujie Jia

Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming

A multitude of recent studies has observed common epigenetic changes develop in tumour cells of multiple lineages following exposure to stresses such as hypoxia, chemotherapeutics, immunotherapy or targeted th...

Authors: Joachim Torrano, Abdullah Al Emran, Heinz Hammerlindl and Helmut Schaider

Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR

The human chromosome 14q32.2 imprinted region harbors the primary MEG3/DLK1:IG-differentially methylated region (DMR) and secondary MEG3:TSS-DMR. The MEG3:TSS-DMR can remain unmethylated only in the presence of u...

Authors: Masayo Kagami, Atsuhiro Yanagisawa, Miyuki Ota, Kentaro Matsuoka, Akie Nakamura, Keiko Matsubara, Kazuhiko Nakabayashi, Shuji Takada, Maki Fukami and Tsutomu Ogata

Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer

Epigenetic alternation is a common contributing factor to neoplastic transformation. Although previous studies have reported a cluster of aberrant promoter methylation changes associated with silencing of tumo...

Authors: Simeng Gu, Shujuan Lin, Ding Ye, Sangni Qian, Danjie Jiang, Xiaocong Zhang, Qilong Li, Jinhua Yang, Xiaojiang Ying, Zhenjun Li, Mengling Tang, Jianbing Wang, Mingjuan Jin and Kun Chen

A comparison of DNA methylation in newborn blood samples from infants with and without orofacial clefts

Isolated orofacial clefts are among the most common congenital birth defects. Although the underlying biological mechanisms remain largely unknown, clefts are thought to be complex disorders influenced by gene...

Authors: Zongli Xu, Rolv T. Lie, Allen J. Wilcox, Ola Didrik Saugstad and Jack A. Taylor

Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases

Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct epithelial cell lining. The misdiagnosis of CCA and other biliary diseases may occur due to the similarity of clinical manifestations and blood tests...

Authors: Wiphawan Wasenang, Ponlatham Chaiyarit, Siriporn Proungvitaya and Temduang Limpaiboon

Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors

The current prognosis of thymic epithelial tumors (TETs) is according to the World Health Organization (WHO) histologic classification and the Masaoka staging system. These methods of prognosis have certain li...

Authors: Songlin Li, Yuan Yuan, He Xiao, Jiajia Dai, Yunfei Ye, Qin Zhang, Zhimin Zhang, Yuhan Jiang, Jia Luo, Jing Hu, Chuan Chen and Ge Wang

Exploring the unique function of imprinting control centers in the PWS/AS-responsible region: finding from array-based methylation analysis in cases with variously sized microdeletions

Human 15q11–13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These ...

Authors: Keiko Matsubara, Masatsune Itoh, Kenji Shimizu, Shinji Saito, Keisuke Enomoto, Kazuhiko Nakabayashi, Kenichiro Hata, Kenji Kurosawa, Tsutomu Ogata, Maki Fukami and Masayo Kagami