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  1. The aetiology and pathophysiology of complex diseases are driven by the interaction between genetic and environmental factors. The variability in risk and outcomes in these diseases are incompletely explained ...

    Authors: Maria Pia Campagna, Alexandre Xavier, Jeannette Lechner-Scott, Vicky Maltby, Rodney J. Scott, Helmut Butzkueven, Vilija G. Jokubaitis and Rodney A. Lea
    Citation: Clinical Epigenetics 2021 13:214
  2. Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in adrenocortical adenomas. The present study aims to e...

    Authors: Chuan Wang, Yujing Sun, Xiaofei Yin, Ruoqi Feng, Ruiying Feng, Mingyue Xu, Kai Liang, Ruxing Zhao, Gangli Gu, Xuewen Jiang, Peng Su, Xiaofang Zhang and Jinbo Liu
    Citation: Clinical Epigenetics 2021 13:213
  3. Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce gene...

    Authors: Youssef Siblini, Céline Chéry, Pierre Rouyer, Jérémie Raso, Amélia Julien, Sébastien Hergalant, Aurélie François, Lina Bezdetnaya, Guillaume Vogin, Jean-Louis Guéant and Abderrahim Oussalah
    Citation: Clinical Epigenetics 2021 13:212
  4. Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated ...

    Authors: U. Schagdarsurengin, C. Luo, H. Slanina, D. Sheridan, S. Füssel, N. Böğürcü-Seidel, S. Gattenloehner, G. B. Baretton, L. C. Hofbauer, F. Wagenlehner and T. Dansranjav
    Citation: Clinical Epigenetics 2021 13:211
  5. The thymic microenvironment is mainly comprised of thymic epithelial cells, the cytokines, exosomes, surface molecules, and hormones from the cells, and plays a vital role in the development, differentiation, ...

    Authors: Cexun Hu, Keyu Zhang, Feng Jiang, Hui Wang and Qixiang Shao
    Citation: Clinical Epigenetics 2021 13:210
  6. Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...

    Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Brent A. Coull, Andrea A. Baccarelli, Robert O. Wright, Chitra Amarasiriwardena, Diane R. Gold, Emily Oken, Marie-France Hivert and Andres Cardenas
    Citation: Clinical Epigenetics 2021 13:208
  7. A shift in the proportions of blood immune cells is a hallmark of cancer development. Here, we investigated whether methylation-derived immune cell type ratios and methylation-derived neutrophil-to-lymphocyte ...

    Authors: Mehdi Manoochehri, Thomas Hielscher, Nasim Borhani, Clarissa Gerhäuser, Olivia Fletcher, Anthony J. Swerdlow, Yon-Dschun Ko, Hiltrud Brauch, Thomas Brüning and Ute Hamann
    Citation: Clinical Epigenetics 2021 13:207
  8. DNA methylation (DNAm) performs excellently in the discrimination of current and former smokers from never smokers, where AUCs > 0.9 are regularly reported using a single CpG site (cg05575921; AHRR). However, the...

    Authors: Ryan J. Langdon, Paul Yousefi, Caroline L. Relton and Matthew J. Suderman
    Citation: Clinical Epigenetics 2021 13:206
  9. Hypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of early-life exposures and the development of cardiovascular risk facto...

    Authors: Giulietta S. Monasso, Vincent W. V. Jaddoe, Leanne K. Küpers and Janine F. Felix
    Citation: Clinical Epigenetics 2021 13:205
  10. GGC repeat expansions in NOTCH2NLC are associated with neuronal intranuclear inclusion disease. Very recently, asymptomatic carriers with NOTCH2NLC repeat expansions were reported. In these asymptomatic individua...

    Authors: Hiromi Fukuda, Daisuke Yamaguchi, Kristofor Nyquist, Yasushi Yabuki, Satoko Miyatake, Yuri Uchiyama, Kohei Hamanaka, Ken Saida, Eriko Koshimizu, Naomi Tsuchida, Atsushi Fujita, Satomi Mitsuhashi, Kazuyuki Ohbo, Yuki Satake, Jun Sone, Hiroshi Doi…
    Citation: Clinical Epigenetics 2021 13:204
  11. In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammat...

    Authors: Gesa M. Richter, Jochen Kruppa, H. Gencay Keceli, Emel Tuğba Ataman-Duruel, Christian Graetz, Nicole Pischon, Gunar Wagner, Carsten Rendenbach, Yvonne Jockel-Schneider, Orlando Martins, Corinna Bruckmann, Ingmar Staufenbiel, Andre Franke, Rahime M. Nohutcu, Søren Jepsen, Henrik Dommisch…
    Citation: Clinical Epigenetics 2021 13:203
  12. Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one of the main contributing factors. Various tissues display sex differences in DNA methylation; how...

    Authors: Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez-Romero, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Voisin and Nir Eynon
    Citation: Clinical Epigenetics 2021 13:202
  13. Glioblastoma (GBM) is a malignant human brain tumor that has an extremely poor prognosis. Classic mutations such as IDH (isocitrate dehydrogenase) mutations, EGFR (epidermal growth factor receptor) alternations, ...

    Authors: Yin-Cheng Huang, Joseph Chieh-Yu Lai, Pei-Hua Peng, Kuo-Chen Wei and Kou-Juey Wu
    Citation: Clinical Epigenetics 2021 13:201
  14. Depression is a common, complex, and debilitating mental disorder estimated to be under-diagnosed and insufficiently treated in society. Liability to depression is influenced by both genetic and environmental ...

    Authors: Anna Starnawska, Lina Bukowski, Ana Chernomorchenko, Betina Elfving, Heidi Kaastrup Müller, Edwin van den Oord, Karolina Aberg, Jerry Guintivano, Jakob Grove, Ole Mors, Anders D. Børglum, Anders L. Nielsen, Per Qvist and Nicklas Heine Staunstrup
    Citation: Clinical Epigenetics 2021 13:200
  15. Histone modification is an important form of epigenetic regulation. Thereinto, histone methylation is a critical determination of chromatin states, participating in multiple cellular processes. As a conserved ...

    Authors: Chu Xiao, Tao Fan, He Tian, Yujia Zheng, Zheng Zhou, Shuofeng Li, Chunxiang Li and Jie He
    Citation: Clinical Epigenetics 2021 13:199
  16. Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. Recently, DNA methylation-based inference of alcohol consumption from blood wa...

    Authors: Silvana C. E. Maas, Athina Vidaki, Alexander Teumer, Ricardo Costeira, Rory Wilson, Jenny van Dongen, Marian Beekman, Uwe Völker, Hans J. Grabe, Sonja Kunze, Karl-Heinz Ladwig, Joyce B. J. van Meurs, André G. Uitterlinden, Trudy Voortman, Dorret I. Boomsma, P. Eline Slagboom…
    Citation: Clinical Epigenetics 2021 13:198
  17. 5-Hydroxymethylcytosine (5hmC) is a significant DNA epigenetic modification. However, the 5hmC modification alterations in genomic regions encoding long non-coding RNA (lncRNA) and their clinical significance ...

    Authors: Meng Zhou, Ping Hou, Congcong Yan, Lu Chen, Ke Li, Yiran Wang, Jingting Zhao, Jianzhong Su and Jie Sun
    Citation: Clinical Epigenetics 2021 13:197
  18. DNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutat...

    Authors: Teoman Deger, Ruben G. Boers, Vanja de Weerd, Lindsay Angus, Marjolijn M. J. van der Put, Joachim B. Boers, Z. Azmani, Wilfred F. J. van IJcken, Dirk J. Grünhagen, Lisanne F. van Dessel, Martijn P. J. K. Lolkema, Cornelis Verhoef, Stefan Sleijfer, John W. M. Martens, Joost Gribnau and Saskia M. Wilting
    Citation: Clinical Epigenetics 2021 13:196
  19. The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation i...

    Authors: Yuqing Chen, Irfahan Kassam, Suk Hiang Lau, Jaspal S. Kooner, Rory Wilson, Annette Peters, Juliane Winkelmann, John C. Chambers, Vincent T. Chow, Chiea Chuen Khor, Rob M. van Dam, Yik-Ying Teo, Marie Loh and Xueling Sim
    Citation: Clinical Epigenetics 2021 13:195
  20. Methylation analysis of circulating cell-free DNA (cirDNA), as a liquid biopsy, has a significant potential to advance the detection, prognosis, and treatment of cancer, as well as many genetic disorders. The ...

    Authors: Mohammad Amin Kerachian, Marjan Azghandi, Sina Mozaffari-Jovin and Alain R. Thierry
    Citation: Clinical Epigenetics 2021 13:193
  21. Identifying biomarkers associated with Alzheimer’s disease (AD) progression may enable patient enrichment and improve clinical trial designs. Epigenome-wide association studies have revealed correlations betwe...

    Authors: Qingqin S. Li, Aparna Vasanthakumar, Justin W. Davis, Kenneth B. Idler, Kwangsik Nho, Jeffrey F. Waring and Andrew J. Saykin
    Citation: Clinical Epigenetics 2021 13:191
  22. High-grade serous ovarian cancer (HGSOC) is the most common type of epigenetically heterogeneous ovarian cancer. Methylation typing has previously been used in many tumour types but not in HGSOC. Methylation t...

    Authors: Jieyu Wang, Jun Li, Ruifang Chen, Huiran Yue, Wenzhi Li, Beibei Wu, Yang Bai, Guohua Zhu and Xin Lu
    Citation: Clinical Epigenetics 2021 13:190
  23. Racial/ethnic disparities in health reflect a combination of genetic and environmental causes, and DNA methylation may be an important mediator. We compared in an exploratory manner the blood DNA methylome of ...

    Authors: Min-Ae Song, Anna Eames Seffernick, Kellie J. Archer, Kellie M. Mori, Song-Yi Park, Linda Chang, Thomas Ernst, Maarit Tiirikainen, Karolina Peplowska, Lynne R. Wilkens, Loïc Le Marchand and Unhee Lim
    Citation: Clinical Epigenetics 2021 13:188

    The Editorial to this article has been published in Clinical Epigenetics 2021 13:189

  24. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the ...

    Authors: Maria Laura Saiz, Marta L. DeDiego, Darío López-García, Viviana Corte-Iglesias, Aroa Baragaño Raneros, Ivan Astola, Victor Asensi, Carlos López-Larrea and Beatriz Suarez-Alvarez
    Citation: Clinical Epigenetics 2021 13:187

    The Correction to this article has been published in Clinical Epigenetics 2021 13:209

  25. Lung cancer is the leading cause of cancer-related mortality. The alteration of DNA methylation plays a major role in the development of lung cancer. Methylation biomarkers become a possible method for lung ca...

    Authors: Lei Li, Zhujia Ye, Sai Yang, Hao Yang, Jing Jin, Yingying Zhu, Jinsheng Tao, Siyu Chen, Jiehan Xu, Yanying Liu, Weihe Liang, Bo Wang, Mengzhu Yang, Qiaoyun Huang, Zhiwei Chen, Weimin Li…
    Citation: Clinical Epigenetics 2021 13:185
  26. Current clinical guidelines suggest that breast cancers with low hormone receptor expression (LowHR) in 1–10% of tumor cells should be regarded as hormone receptor positive. However, clinical data show that th...

    Authors: Philipp Jurmeister, Karsten Weber, Sonia Villegas, Thomas Karn, Michael Untch, Anne Thieme, Volkmar Müller, Eliane Taube, Peter Fasching, Wolfgang D. Schmitt, Frederik Marmé, Elmar Stickeler, Bruno V. Sinn, Paul Jank, Christian Schem, Frederick Klauschen…
    Citation: Clinical Epigenetics 2021 13:184
  27. Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation...

    Authors: Rebecca C. Richmond, Carlos Sillero-Rejon, Jasmine N. Khouja, Claire Prince, Alexander Board, Gemma Sharp, Matthew Suderman, Caroline L. Relton, Marcus Munafò and Suzanne H. Gage
    Citation: Clinical Epigenetics 2021 13:183
  28. Stunting is a condition in which a child does not reach their full growth potential due to chronic undernutrition. It arises during the first 2 years of a child’s life and is associated with developmental defi...

    Authors: Kristyna Kupkova, Savera J. Shetty, Rashidul Haque, William A. Petri Jr. and David T. Auble
    Citation: Clinical Epigenetics 2021 13:182
  29. This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal wo...

    Authors: Lulu Wang, Zhenxing Mao, Xiaotian Liu, Dandan Wei, Pengling Liu, Luting Nie, Keliang Fan, Ning Kang, Yu Song, Qingqing Xu, Juan Wang, Mian Wang, Wei Liao, Tao Jing, Wenjie Li, Chongjian Wang…
    Citation: Clinical Epigenetics 2021 13:181
  30. Road traffic air pollution is linked with an increased risk of autistic spectrum disorder (ASD). The aim of this study is to assess the effect of exposure to prenatal or postnatal traffic-related air pollution...

    Authors: Qinfeng Zhou, Yu Tian, Chenlu Xu, Juling Wang and Yongtang Jin
    Citation: Clinical Epigenetics 2021 13:180
  31. Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our o...

    Authors: Patrice Gallet, Abderrahim Oussalah, Celso Pouget, Gunnar Dittmar, Celine Chery, Guillaume Gauchotte, Roger Jankowski, Jean Louis Gueant and Rémi Houlgatte
    Citation: Clinical Epigenetics 2021 13:179
  32. Authors: Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio and Daniela Furlan
    Citation: Clinical Epigenetics 2021 13:178

    The original article was published in Clinical Epigenetics 2021 13:154

  33. Maternal smoking during pregnancy (MSDP) affects development of multiple organ systems including the placenta, lung, brain, and vasculature. In particular, children exposed to MSDP show lifelong deficits in pu...

    Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Shannon M. O’Sullivan, Kristin Milner, Brittany Vuylsteke, Robert S. Tepper, David M. Haas, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel
    Citation: Clinical Epigenetics 2021 13:177
  34. Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the brain, and alterations to 5hmC in adult CNS tumors have been re...

    Authors: Nasim Azizgolshani, Curtis L. Petersen, Youdinghuan Chen, Joshua J. Levy, Lucas A. Salas, Laurent Perreard, Lananh N. Nguyen and Brock C. Christensen
    Citation: Clinical Epigenetics 2021 13:176
  35. Organoids or spheroids have emerged as a physiologically relevant in vitro preclinical model to study patient-specific diseases. A recent study used spheroids of MCF10 cells to model breast cancer progression ...

    Authors: Jingwei Li, Kun Fang, Lavanya Choppavarapu, Ke Yang, Yini Yang, Junbai Wang, Ruifeng Cao, Ismail Jatoi and Victor X. Jin
    Citation: Clinical Epigenetics 2021 13:175
  36. Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The search for new therapeutic targets is therefore essential. In addition to a wide panel of genetic mutations, epigenetic...

    Authors: Laurie Herviou, Sara Ovejero, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva De Smedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien and Jérôme Moreaux
    Citation: Clinical Epigenetics 2021 13:174
  37. Thymic epithelial tumors (TETs) are rare neoplasms, originating from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined, and a deeper molecular characterization...

    Authors: Alessia Iaiza, Claudia Tito, Zaira Ianniello, Federica Ganci, Valentina Laquintana, Enzo Gallo, Andrea Sacconi, Silvia Masciarelli, Luciana De Angelis, Sara Aversa, Daniele Diso, Marco Anile, Vincenzo Petrozza, Francesco Facciolo, Enrico Melis, Edoardo Pescarmona…
    Citation: Clinical Epigenetics 2021 13:173
  38. Pancreatic cancer is one of the lethal cancers among solid malignancies. Pathological diagnosis of surgical margins is sometimes unreliable due to tissue shrinkage, invisible field cancerization and skipped le...

    Authors: Yuki Sunagawa, Masamichi Hayashi, Suguru Yamada, Hiroshi Tanabe, Keisuke Kurimoto, Nobutake Tanaka, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike and Yasuhiro Kodera
    Citation: Clinical Epigenetics 2021 13:172
  39. Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative...

    Authors: Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O’Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. DellaGrotta, Carmen J. Marsit and Barry M. Lester
    Citation: Clinical Epigenetics 2021 13:171
  40. Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing th...

    Authors: Daniel J. Simpson, Nelly N. Olova and Tamir Chandra
    Citation: Clinical Epigenetics 2021 13:170
  41. BCOR (BCL6 corepressor) is an epigenetic regulator gene involved in the specification of cell differentiation and body structure development. Recurrent somatic BCOR mutations have been identified in myelodyspl...

    Authors: Xiao Li, Feng Xu, Zheng Zhang, Juan Guo, Qi He, Lu-Xi Song, Dong Wu, Li-Yu Zhou, Ji-Ying Su, Chao Xiao, Chun-Kang Chang and Ling-Yun Wu
    Citation: Clinical Epigenetics 2021 13:169
  42. Disease progression and therapeutic resistance are hallmarks of advanced stage prostate cancer (PCa), which remains a major cause of cancer-related mortality around the world. Longitudinal studies, coupled wit...

    Authors: Romina Silva, Bruce Moran, Anne-Marie Baird, Colm J. O’Rourke, Stephen P. Finn, Ray McDermott, William Watson, William M. Gallagher, Donal J. Brennan and Antoinette S. Perry
    Citation: Clinical Epigenetics 2021 13:168
  43. In an effort to contribute to overcoming the platinum resistance exhibited by most solid tumors, we performed an array of epigenetic approaches, integrating next-generation methodologies and public clinical da...

    Authors: Javier Andrés Soto, Carlos Rodríguez-Antolín, Olga Vera, Olga Pernía, Isabel Esteban-Rodríguez, Maria Dolores Diestro, Javier Benitez, Fátima Sánchez-Cabo, Rafael Alvarez, Javier De Castro and Inmaculada Ibanez de Cáceres
    Citation: Clinical Epigenetics 2021 13:167
  44. DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity...

    Authors: Chunhong Hu, Xiaohan Liu, Yue Zeng, Junqi Liu and Fang Wu
    Citation: Clinical Epigenetics 2021 13:166
  45. Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ...

    Authors: Darina Czamara, Linda Dieckmann, Simone Röh, Sarah Kraemer, Rebecca C. Rancourt, Sara Sammallahti, Eero Kajantie, Hannele Laivuori, Johan G. Eriksson, Katri Räikkönen, Wolfgang Henrich, Andreas Plagemann, Elisabeth B. Binder, Thorsten Braun and Sonja Entringer
    Citation: Clinical Epigenetics 2021 13:165