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  1. DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variat...

    Authors: Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey…

    Citation: Clinical Epigenetics 2020 12:158

    Content type: Research

    Published on:

  2. Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host,...

    Authors: Sandra Atlante, Alessia Mongelli, Veronica Barbi, Fabio Martelli, Antonella Farsetti and Carlo Gaetano

    Citation: Clinical Epigenetics 2020 12:156

    Content type: Review

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  3. A genome-wide study identified de novo DNA methylation alterations in leukocytes of children at paediatric intensive care unit (PICU) discharge, offering a biological basis for their impaired long-term developmen...

    Authors: Ines Verlinden, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen Joosten, Sascha C. Verbruggen, Greet Van den Berghe and Ilse Vanhorebeek

    Citation: Clinical Epigenetics 2020 12:155

    Content type: Research

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  4. Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and valid...

    Authors: Brendan F. Miller, Thomas R. Pisanic II, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza-Huei Wang and Laura Elnitski

    Citation: Clinical Epigenetics 2020 12:154

    Content type: Methodology

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  5. Massively parallel sequencing of maternal cell-free DNA (cfDNA) is widely used to test fetal genetic abnormalities in non-invasive prenatal testing (NIPT). However, sequencing-based approaches are still of hig...

    Authors: Juozas Gordevičius, Milda Narmontė, Povilas Gibas, Kotryna Kvederavičiūtė, Vita Tomkutė, Priit Paluoja, Kaarel Krjutškov, Andres Salumets and Edita Kriukienė

    Citation: Clinical Epigenetics 2020 12:153

    Content type: Research

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  6. Pathogenic CDKN1C gain-of-function variants on the maternal allele were initially reported as a cause of IMAGe syndrome characterized by intrauterine growth retardation, metaphyseal dysplasia, primary adrenal ins...

    Authors: Gerhard Binder, Julian Ziegler, Roland Schweizer, Wisam Habhab, Tobias B. Haack, Tilman Heinrich and Thomas Eggermann

    Citation: Clinical Epigenetics 2020 12:152

    Content type: Research

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  7. Infants born very preterm are more likely to experience neonatal morbidities compared to their term peers. Variations in DNA methylation (DNAm) associated with these morbidities may yield novel information abo...

    Authors: Todd M. Everson, T. Michael O’Shea, Amber Burt, Karen Hermetz, Brian S. Carter, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Antoine Soliman, Sheri A. DellaGrotta, Lynne M. Dansereau, James F. Padbury, Barry M. Lester…

    Citation: Clinical Epigenetics 2020 12:151

    Content type: Research

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  8. miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in carcinogenesis. Given the presence of a promotor-associated CpG island for its host gene, EVL, we hypothesized that intronic miR-342-3p is...

    Authors: Min Yue Zhang, George A. Calin, Kit San Yuen, Dong Yan Jin and Chor Sang Chim

    Citation: Clinical Epigenetics 2020 12:150

    Content type: Research

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  9. Growing evidence shows that epigenetic modifications play a role in Alzheimer’s disease (AD). We performed an epigenome-wide association study (EWAS) to evaluate the DNA methylation differences using postmorte...

    Authors: Qingqin S. Li, Yu Sun and Tania Wang

    Citation: Clinical Epigenetics 2020 12:149

    Content type: Research

    Published on:

  12. Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the ...

    Authors: Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura and Vassiliki Saloura

    Citation: Clinical Epigenetics 2020 12:146

    Content type: Review

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  13. Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease,...

    Authors: Rachel L. Clifford, Chen Xi Yang, Nick Fishbane, Jamie Patel, Julia L. MacIsaac, Lisa M. McEwen, Sean T. May, Marcos Castellanos-Uribe, Parameswaran Nair, Ma’en Obeidat, Michael S. Kobor, Alan J. Knox and Tillie-Louise Hackett

    Citation: Clinical Epigenetics 2020 12:145

    Content type: Research

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  14. Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or ...

    Authors: Cristina Gallardo-Escribano, Verónica Buonaiuto, M. Isabel Ruiz-Moreno, Antonio Vargas-Candela, Alberto Vilches-Perez, Javier Benitez-Porres, Angel Ramon Romance-Garcia, Alejandro Ruiz-Moreno, Ricardo Gomez-Huelgas and M. Rosa Bernal-Lopez

    Citation: Clinical Epigenetics 2020 12:144

    Content type: Research

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  15. Accessible chromatin plays a central role in gene expression and chromatin architecture. Current accessible chromatin approaches depend on limited digestion/cutting and pasting adaptors at the accessible DNA, ...

    Authors: Hang Gyeong Chin, Zhiyi Sun, Udayakumar S. Vishnu, Pengying Hao, Paloma Cejas, George Spracklin, Pierre-Olivier Estève, Shuang-yong Xu, Henry W. Long and Sriharsa Pradhan

    Citation: Clinical Epigenetics 2020 12:143

    Content type: Methodology

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  16. Epigenetic reprogramming using DNA demethylating drugs is a promising approach for cancer therapy, but its efficacy is highly dependent on the dosing regimen. Low-dose treatment for a prolonged period shows a ...

    Authors: Hideyuki Takeshima, Yukie Yoda, Mika Wakabayashi, Naoko Hattori, Satoshi Yamashita and Toshikazu Ushijima

    Citation: Clinical Epigenetics 2020 12:142

    Content type: Research

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  17. Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated throug...

    Authors: Tarryn Willmer, Julia H. Goedecke, Stephanie Dias, Johan Louw and Carmen Pheiffer

    Citation: Clinical Epigenetics 2020 12:141

    Content type: Research

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  18. Cocaine use accelerates human immunodeficiency virus (HIV) progression and worsens HIV outcomes. We assessed whether DNA methylation in blood mediates the association between cocaine use and HIV severity in a ...

    Authors: Chang Shu, Amy C. Justice, Xinyu Zhang, Zuoheng Wang, Dana B. Hancock, Eric O. Johnson and Ke Xu

    Citation: Clinical Epigenetics 2020 12:140

    Content type: Research

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  19. PADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect ...

    Authors: Maria Vittoria Cubellis, Laura Pignata, Ankit Verma, Angela Sparago, Rosita Del Prete, Maria Monticelli, Luciano Calzari, Vincenzo Antona, Daniela Melis, Romano Tenconi, Silvia Russo, Flavia Cerrato and Andrea Riccio

    Citation: Clinical Epigenetics 2020 12:139

    Content type: Research

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  20. Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain larg...

    Authors: Laura Moody, Sylvia L. Crowder, Andrew D. Fruge, Julie L. Locher, Wendy Demark-Wahnefried, Laura Q. Rogers, Ashley Delk-Licata, William R. Carroll, Sharon A. Spencer, Molly Black, John W. Erdman Jr, Hong Chen, Yuan-Xiang Pan and Anna E. Arthur

    Citation: Clinical Epigenetics 2020 12:138

    Content type: Research

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  21. Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that...

    Authors: Andrea Stoccoro, Adam R. Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Stella Gagliardi, Katie Lunnon, Lucia Migliore and Fabio Coppedè

    Citation: Clinical Epigenetics 2020 12:137

    Content type: Research

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  23. Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, ...

    Authors: Ying Yuan, Hongfeng Yuan, Guang Yang, Haolin Yun, Man Zhao, Zixian Liu, Lina Zhao, Yu Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang and Xiao-dong Zhang

    Citation: Clinical Epigenetics 2020 12:135

    Content type: Research

    Published on:

  24. Intrauterine exposure to a disturbed maternal glucose metabolism is associated with adverse offspring outcomes. DNA methylation is a potential mechanism underlying these associations. We examined whether mater...

    Authors: Madelon L. Geurtsen, Vincent W. V. Jaddoe, Romy Gaillard and Janine F. Felix

    Citation: Clinical Epigenetics 2020 12:134

    Content type: Research

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  25. Atrial natriuretic peptide (ANP), one of the main members of the natriuretic peptides system, has been associated with hypertension and related complications, but the underlying molecular mechanisms are not ve...

    Authors: Jing Li, Jinhua Zhu, Liyun Ren, Shengqi Ma, Bin Shen, Jia Yu, Rongyan Zhang, Mingzhi Zhang, Yan He and Hao Peng

    Citation: Clinical Epigenetics 2020 12:133

    Content type: Research

    Published on:

  26. Epigenetic mechanisms play an important role in the chemoresistance of acute myeloid leukemia (AML). The clinical response to epigenetic modifier-based chemotherapy in patients with relapsed/refractory AML (r/...

    Authors: Lixin Wang, Jianmin Luo, Guofeng Chen, Meiyun Fang, Xudong Wei, Yinghua Li, Zhuogang Liu, Yin Zhang, Sujun Gao, Jianliang Shen, Xin Wang, Xiaoning Gao, Wei Zhou, Yigai Ma, Hui Liu, Xinquan Li…

    Citation: Clinical Epigenetics 2020 12:132

    Content type: Research

    Published on:

  27. The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methyla...

    Authors: Deepak B. Poduval, Elisabet Ognedal, Zuzana Sichmanova, Eivind Valen, Gjertrud T. Iversen, Laura Minsaas, Per E. Lønning and Stian Knappskog

    Citation: Clinical Epigenetics 2020 12:131

    Content type: Research

    Published on:

  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur

    Citation: Clinical Epigenetics 2020 12:130

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2020 12:123

  29. Alzheimer’s disease (AD) is the most common type of dementia, and patients with advanced AD frequently lose the ability to identify family members. The fusiform gyrus (FUS) of the brain is critical in facial r...

    Authors: Dingailu Ma, Irfete S. Fetahu, Mei Wang, Rui Fang, Jiahui Li, Hang Liu, Tobin Gramyk, Isabella Iwanicki, Sophie Gu, Winnie Xu, Li Tan, Feizhen Wu and Yujiang G. Shi

    Citation: Clinical Epigenetics 2020 12:129

    Content type: Research

    Published on:

  30. Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely re...

    Authors: Ji Hyae Lim, Yu-Jung Kang, Hye Jin Bak, Mi Sun Kim, Hyun Jung Lee, Dong Wook Kwak, You Jung Han, Moon Young Kim, Hyeyeon Boo, Shin Young Kim and Hyun Mee Ryu

    Citation: Clinical Epigenetics 2020 12:128

    Content type: Research

    Published on:

  31. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis

    Citation: Clinical Epigenetics 2020 12:127

    Content type: Research

    Published on:

  32. Although metabolic associate fatty liver disease (MAFLD) is associated with obesity, it can also occur in lean patients. MAFLD is more aggressive in lean patients compared to obese patients, with a higher risk...

    Authors: Diana Buzova, Andrea Maugeri, Antonio Liguori, Cecilia Napodano, Oriana Lo Re, Jude Oben, Anna Alisi, Antonio Gasbarrini, Antonio Grieco, Jan Cerveny, Luca Miele and Manlio Vinciguerra

    Citation: Clinical Epigenetics 2020 12:126

    Content type: Research

    Published on:

  33. Dyskeratosis congenita (DKC) and idiopathic aplastic anemia (AA) are bone marrow failure syndromes that share characteristics of premature aging with severe telomere attrition. Aging is also reflected by DNA m...

    Authors: Olivia Cypris, Monika Eipel, Julia Franzen, Corinna Rösseler, Vithurithra Tharmapalan, Chao-Chung Kuo, Margherita Vieri, Miloš Nikolić, Martin Kirschner, Tim H. Brümmendorf, Martin Zenke, Angelika Lampert, Fabian Beier and Wolfgang Wagner

    Citation: Clinical Epigenetics 2020 12:125

    Content type: Research

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  34. Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (SSc-ILD), driving its mortality. Specific biomarkers associated with the evolution of the ...

    Authors: Julien Guiot, Monique Henket, Béatrice Andre, Marielle Herzog, Nathalie Hardat, Makon-Sebastien Njock, Catherine Moermans, Michel Malaise and Renaud Louis

    Citation: Clinical Epigenetics 2020 12:124

    Content type: Research

    Published on:

  35. Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered...

    Authors: Kai Guo, Stephanie A. Eid, Sarah E. Elzinga, Crystal Pacut, Eva L. Feldman and Junguk Hur

    Citation: Clinical Epigenetics 2020 12:123

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2020 12:130

  36. DNA methylation biomarkers in stool may have applications in early colorectal cancer (CRC) detection; however, their association with stages of CRC carcinogenesis or their performance in detecting various stag...

    Authors: Janhavi R. Raut, Zhong Guan, Petra Schrotz-King and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:122

    Content type: Review

    Published on:

  37. Children conceived by assisted reproductive technologies (ART) have a moderate risk for a number of adverse events and conditions. The question whether this additional risk is associated with specific procedur...

    Authors: Julie Barberet, Fatima Barry, Cécile Choux, Magali Guilleman, Sara Karoui, Raymond Simonot, Céline Bruno and Patricia Fauque

    Citation: Clinical Epigenetics 2020 12:121

    Content type: Review

    Published on:

  38. Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes,...

    Authors: Kharah M. Ross, Judith E. Carroll, Steve Horvath, Calvin J. Hobel, Mary E. Coussons-Read and Christine Dunkel Schetter

    Citation: Clinical Epigenetics 2020 12:120

    Content type: Research

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  41. Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coa...

    Authors: Disline Manli Tantoh, Ming-Chi Wu, Chun-Chao Chuang, Pei-Hsin Chen, Yeu Sheng Tyan, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw

    Citation: Clinical Epigenetics 2020 12:117

    Content type: Research

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  42. Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA...

    Authors: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson…

    Citation: Clinical Epigenetics 2020 12:116

    Content type: Research

    Published on:

  43. Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. ...

    Authors: Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, David M. Howard, Craig W. Ritchie, Steve Horvath, Caroline Hayward, Andrew M. McIntosh, David J. Porteous, Ian J. Deary, Kathryn L. Evans and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:115

    Content type: Research

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  44. Major depressive disorder (MDD) represents a serious global health concern. The urge for efficient MDD treatment strategies is presently hindered by the incomplete knowledge of its underlying pathomechanism. D...

    Authors: Nicole Moschny, Tristan Zindler, Kirsten Jahn, Marie Dorda, Colin F. Davenport, Lutz Wiehlmann, Hannah B. Maier, Franziska Eberle, Stefan Bleich, Alexandra Neyazi and Helge Frieling

    Citation: Clinical Epigenetics 2020 12:114

    Content type: Research

    Published on:

  45. Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may...

    Authors: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:113

    Content type: Research

    Published on:

  46. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li

    Citation: Clinical Epigenetics 2020 12:112

    Content type: Research

    Published on:

  47. The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confoundin...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Masashi Mikami, Takahiro Arima, Tsutomu Ogata, Maki Fukami and Masayo Kagami

    Citation: Clinical Epigenetics 2020 12:111

    Content type: Research

    Published on:

  48. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho

    Citation: Clinical Epigenetics 2020 12:110

    Content type: Research

    Published on:

  49. Current technology allows rapid assessment of DNA sequences and methylation levels at a single-site resolution for hundreds of thousands of sites in the human genome, in thousands of individuals simultaneously...

    Authors: Julia Romanowska, Øystein A. Haaland, Astanand Jugessur, Miriam Gjerdevik, Zongli Xu, Jack Taylor, Allen J. Wilcox, Inge Jonassen, Rolv T. Lie and Håkon K. Gjessing

    Citation: Clinical Epigenetics 2020 12:109

    Content type: Methodology

    Published on:

  50. IGF1 is a key molecule in the regulation of growth and metabolism. Low IGF1 secretion is known to cause growth restriction in childhood, as well as deregulated lipid metabolism, cardiovascular disease, and dia...

    Authors: Masato Kantake, Naho Ikeda, Hirofumi Nakaoka, Natsuki Ohkawa, Toshitaka Tanaka, Kazuki Miyabayashi, Hiromichi Shoji and Toshiaki Shimizu

    Citation: Clinical Epigenetics 2020 12:108

    Content type: Research

    Published on:

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Clinical Epigenetics

ISSN: 1868-7083

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