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  1. Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we co...

    Authors: Yuan-Yuan Gu, Guan-Nan Zhou, Qing Wang, Jing-Xin Ding and Ke-Qin Hua

    Citation: Clinical Epigenetics 2020 12:57

    Content type: Research

    Published on:

  2. Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are ...

    Authors: Jian Fan, Jun Li, Shicheng Guo, Chengcheng Tao, Haikun Zhang, Wenjing Wang, Ying Zhang, Dake Zhang, Shigang Ding and Changqing Zeng

    Citation: Clinical Epigenetics 2020 12:56

    Content type: Research

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  3. Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation...

    Authors: Rosalind Tang, Laura D. Howe, Matthew Suderman, Caroline L. Relton, Andrew A. Crawford and Lotte C. Houtepen

    Citation: Clinical Epigenetics 2020 12:55

    Content type: Research

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  4. The genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as many T-cell genes, with a strong MHC associati...

    Authors: R. Pitaksalee, A. N. Burska, S. Ajaib, J. Rogers, R. Parmar, K. Mydlova, X. Xie, A. Droop, J. S. Nijjar, P. Chambers, P. Emery, R. Hodgett, I. B. McInnes and F. Ponchel

    Citation: Clinical Epigenetics 2020 12:54

    Content type: Research

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  5. Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated tha...

    Authors: Carolina Serena, Monica Millan, Miriam Ejarque, Alfonso Saera-Vila, Elsa Maymó-Masip, Catalina Núñez-Roa, Diandra Monfort-Ferré, Margarida Terrón-Puig, Michelle Bautista, Margarita Menacho, Marc Martí, Eloy Espin, Joan Vendrell and Sonia Fernández-Veledo

    Citation: Clinical Epigenetics 2020 12:53

    Content type: Research

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  6. Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-...

    Authors: Delnaz Roshandel, Zhuo Chen, Angelo J. Canty, Shelley B. Bull, Rama Natarajan and Andrew D. Paterson

    Citation: Clinical Epigenetics 2020 12:52

    Content type: Research

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  7. DNA methylation is associated with body mass index (BMI), but it is not clear if methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we explore the causal nature and predictive ...

    Authors: Zoe E. Reed, Matthew J. Suderman, Caroline L. Relton, Oliver S. P. Davis and Gibran Hemani

    Citation: Clinical Epigenetics 2020 12:50

    Content type: Research

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  8. DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-qu...

    Authors: Anne Seeboth, Daniel L. McCartney, Yunzhang Wang, Robert F. Hillary, Anna J. Stevenson, Rosie M. Walker, Archie Campbell, Kathryn L. Evans, Andrew M. McIntosh, Sara Hägg, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:49

    Content type: Research

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  9. Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts...

    Authors: Mitchell G. Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A. Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A. Taylor, Gail P. Risbridger and Susan J. Clark

    Citation: Clinical Epigenetics 2020 12:48

    Content type: Research

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  10. Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the pr...

    Authors: Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo and Dianshuai Gao

    Citation: Clinical Epigenetics 2020 12:47

    Content type: Research

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  11. Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).

    Authors: Mark W. Logue, Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, Filomene G. Morrison, Zhenwei Zhou, Yuanchao Zheng, Alicia K. Smith, Nikolaos P. Daskalakis, Andrew Ratanatharathorn, Monica Uddin, Caroline M. Nievergelt, Allison E. Ashley-Koch, Dewleen G. Baker, Jean C. Beckham, Melanie E. Garrett…

    Citation: Clinical Epigenetics 2020 12:46

    Content type: Research

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  12. DNA methylation (DNAm) age has been widely accepted as an epigenetic biomarker for biological aging. Emerging evidence suggests that DNAm age can be tissue-specific and female breast tissue ages faster than ot...

    Authors: James R. Castle, Nan Lin, Jinpeng Liu, Anna Maria V. Storniolo, Aditi Shendre, Lifang Hou, Steve Horvath, Yunlong Liu, Chi Wang and Chunyan He

    Citation: Clinical Epigenetics 2020 12:45

    Content type: Research

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  13. Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neigh...

    Authors: Cavin K. Ward-Caviness, Shirley Pu, Chantel L. Martin, Sandro Galea, Monica Uddin, Derek E. Wildman, Karestan Koenen and Allison E. Aiello

    Citation: Clinical Epigenetics 2020 12:44

    Content type: Research

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  14. Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathoge...

    Authors: Catarina Salgado, Nelleke Gruis, Bastiaan T. Heijmans, Jan Oosting and Remco van Doorn

    Citation: Clinical Epigenetics 2020 12:43

    Content type: Short report

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  15. Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngea...

    Authors: Yu Jiang, Lei Liu, Qin Xiang, Xiaoqian He, Yan Wang, Dishu Zhou, Can Zou, Qian Chen, Mingyu Peng, Jin He, Xianyao Jiang, Tingxiu Xiang and Yucheng Yang

    Citation: Clinical Epigenetics 2020 12:41

    Content type: Research

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  16. We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility in Chinese patients w...

    Authors: Chen Chen, Xiaojie Huang, Wei Yin, Muyun Peng, Fang Wu, Xia Wu, Jingqun Tang, Mingjiu Chen, Xiang Wang, Alicia Hulbert, Malcolm V. Brock, Wenliang Liu, James G. Herman and Fenglei Yu

    Citation: Clinical Epigenetics 2020 12:39

    Content type: Research

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  17. Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 m...

    Authors: Yuqiu Ge, Gaoxiang Ma, Hanting Liu, Yadi Lin, Gang Zhang, Mulong Du, Meilin Wang, Haiyan Chu, Haiyan Zhang and Zhengdong Zhang

    Citation: Clinical Epigenetics 2020 12:37

    Content type: Research

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  18. The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regula...

    Authors: Sam Kint, Wim Trypsteen, Ward De Spiegelaere, Eva Malatinkova, Sabine Kinloch-de Loes, Tim De Meyer, Wim Van Criekinge and Linos Vandekerckhove

    Citation: Clinical Epigenetics 2020 12:36

    Content type: Research

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  19. Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for ob...

    Authors: Heather E. Rizzo, Elia N. Escaname, Nicholas B. Alana, Elizabeth Lavender, Jonathan Gelfond, Roman Fernandez, Matthew A. Hibbs, Jonathan M. King, Nicholas R. Carr and Cynthia L. Blanco

    Citation: Clinical Epigenetics 2020 12:34

    Content type: Research

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  20. While a considerable number of tumor-specific hypermethylated loci have been identified in renal cell cancer (RCC), DNA methylation of loci showing successive increases in normal, tumoral, and metastatic tissu...

    Authors: Jürgen Serth, Inga Peters, Natalia Dubrowinskaja, Christel Reese, Knut Albrecht, Michael Klintschar, Marcel Lafos, Alexander Grote, Albert Becker, Jörg Hennenlotter, Arnulf Stenzl, Hossein Tezval and Markus A. Kuczyk

    Citation: Clinical Epigenetics 2020 12:33

    Content type: Research

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  21. Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues fr...

    Authors: Nur Jury, Sebastian Abarzua, Ivan Diaz, Miguel V. Guerra, Estibaliz Ampuero, Paula Cubillos, Pablo Martinez, Andrea Herrera-Soto, Cristian Arredondo, Fabiola Rojas, Marcia Manterola, Adriana Rojas, Martín Montecino, Lorena Varela-Nallar and Brigitte van Zundert

    Citation: Clinical Epigenetics 2020 12:32

    Content type: Research

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  22. The NuRD (Nucleosome Remodeling and Deacetylation) complex is a repressive complex in gene transcription by modulating chromatin accessibility of target genes to transcription factors and RNA polymerase II. Al...

    Authors: Simin Shao, Haowei Cao, Zhongkun Wang, Dongmei Zhou, Chaoshen Wu, Shu Wang, Dian Xia and Daoyong Zhang

    Citation: Clinical Epigenetics 2020 12:31

    Content type: Research

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  23. The vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain hom...

    Authors: Xiang Wei, Xin Yi, Xue-Hai Zhu and Ding-Sheng Jiang

    Citation: Clinical Epigenetics 2020 12:30

    Content type: Review

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  24. The association between obesity and cardiovascular disease (CVD) is proven, but why some adults with obesity develop CVD while others remain disease-free is poorly understood. Here, we investigated whether mit...

    Authors: Sarah Corsi, Simona Iodice, Luisella Vigna, Akin Cayir, John C. Mathers, Valentina Bollati and Hyang-Min Byun

    Citation: Clinical Epigenetics 2020 12:29

    Content type: Research

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  25. Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epitheli...

    Authors: Eva Galle, Bernard Thienpont, Sarah Cappuyns, Tom Venken, Pieter Busschaert, Matthias Van Haele, Eric Van Cutsem, Tania Roskams, Jos van Pelt, Chris Verslype, Jeroen Dekervel and Diether Lambrechts

    Citation: Clinical Epigenetics 2020 12:27

    Content type: Research

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  26. Radiation is an important therapeutic tool. However, radiotherapy has the potential to promote co-evolution of genetic and epigenetic changes that can drive tumour heterogeneity, formation of radioresistant ce...

    Authors: Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell and Helena Carén

    Citation: Clinical Epigenetics 2020 12:26

    Content type: Research

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  27. Although massive studies have been conducted to investigate the mechanisms of esophageal squamous cell carcinoma (ESCC) carcinogenesis, the understanding of molecular alterations during the malignant transform...

    Authors: Yarui Ma, Siyuan He, Aiai Gao, Ying Zhang, Qing Zhu, Pei Wang, Beibei Yang, Huihui Yin, Yifei Li, Jinge Song, Pinli Yue, Mo Li, Dandan Zhang, Yun Liu, Xiaobing Wang, Mingzhou Guo…

    Citation: Clinical Epigenetics 2020 12:25

    Content type: Research

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  28. Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clini...

    Authors: Friederike Hoffmann, Dennis Niebel, Pia Aymans, Sandra Ferring-Schmitt, Dimo Dietrich and Jennifer Landsberg

    Citation: Clinical Epigenetics 2020 12:24

    Content type: Research

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  29. Ageing-associated molecular changes have been assumed to trigger malignant transformations and the epigenetic clock, and the DNA methylation age has been shown to be highly correlated with chronological age. H...

    Authors: Xiaofan Lu, Yujie Zhou, Jialin Meng, Liyun Jiang, Jun Gao, Xiaole Fan, Yanfeng Chen, Yu Cheng, Yang Wang, Bing Zhang, Hangyu Yan and Fangrong Yan

    Citation: Clinical Epigenetics 2020 12:23

    Content type: Research

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  30. There are seven insulin-like growth factor binding proteins (IGFBPs) that bind insulin-like growth factors (IGFs). IGFBP like protein1 (IGFBPL1) is a new member of this family. The function and mechanism of IG...

    Authors: Yingge Liu, Meiying Zhang, Tao He, Weili Yang, Lidong Wang, Lirong Zhang and Mingzhou Guo

    Citation: Clinical Epigenetics 2020 12:22

    Content type: Research

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  31. In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential concepts in the framework of molecular biology are still mis...

    Authors: Walter Doerfler

    Citation: Clinical Epigenetics 2020 12:21

    Content type: Hypothesis

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  32. Alzheimer’s disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Geneti...

    Authors: Jose Vicente Sanchez-Mut, Liliane Glauser, David Monk and Johannes Gräff

    Citation: Clinical Epigenetics 2020 12:20

    Content type: Research

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  33. 5-Hydroxymethylcytosine (5hmC) is a novel epigenetic mark and may be involved in the mechanisms of tumorigenesis and malignant transformation. However, the role of 5hmC in ependymoma, the third most common bra...

    Authors: Tao Wu, Zhi-wei Zhang, Shiwei Li, Bo Wang, Zhijun Yang, Peng Li, Jing Zhang, Wei-min Tong, Chunde Li, Fu Zhao, Yamei Niu and Pinan Liu

    Citation: Clinical Epigenetics 2020 12:19

    Content type: Research

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  34. After publication of the original article [1], we were notified that.

    Authors: Maria Desemparats Saenz-de-Juano, Elena Ivanova, Katy Billooye, Anamaria-Cristina Herta, Johan Smitz, Gavin Kelsey and Ellen Anckaert

    Citation: Clinical Epigenetics 2020 12:18

    Content type: Correction

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    The original article was published in Clinical Epigenetics 2019 11:197

  35. The 5-hydroxymethylcytosine (5hmC) DNA modification is an epigenetic marker involved in a range of biological processes. Its function has been studied extensively in tumors, neurodegenerative diseases, and ath...

    Authors: Chaoran Dong, Jiemei Chen, Jilin Zheng, Yiming Liang, Tao Yu, Yupeng Liu, Feng Gao, Jie Long, Hangyu Chen, Qianhui Zhu, Zilong He, Songnian Hu, Chuan He, Jian Lin, Yida Tang and Haibo Zhu

    Citation: Clinical Epigenetics 2020 12:17

    Content type: Research

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  36. Breast cancer (BRCA) is a heterogeneous disease, characterized by different histopathological and clinical features and responses to various therapeutic measures. Despite the research progress of DNA methylati...

    Authors: Xiao-Qiong Chen, Fan Zhang, Qi-Chen Su, Chi Zeng, Fu-Hui Xiao and Yu Peng

    Citation: Clinical Epigenetics 2020 12:16

    Content type: Research

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  37. Severe obesity is a growing, worldwide burden and conventional therapies including radical change of diet and/or increased physical activity have limited results. Bariatric surgery has been proposed as an alte...

    Authors: Eliza Fraszczyk, Mirjam Luijten, Annemieke M. W. Spijkerman, Harold Snieder, Paul F. K. Wackers, Vincent W. Bloks, Carolina F. Nicoletti, Carla B. Nonino, Ana B. Crujeiras, Wim A. Buurman, Jan Willem Greve, Sander S. Rensen, Bruce H. R. Wolffenbuttel and Jana V. van Vliet-Ostaptchouk

    Citation: Clinical Epigenetics 2020 12:14

    Content type: Research

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  38. Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor m...

    Authors: Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Rowaida Z. Taha, Ayman A. Ahmed, Mohamed A. Kurer, Khaled Murshed, Nehad M. Alajez, Mohamed Abu Nada and Eyad Elkord

    Citation: Clinical Epigenetics 2020 12:13

    Content type: Research

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  39. DNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the mai...

    Authors: Shajedul Islam, Osamu Uehara, Hirofumi Matsuoka, Yasuhiro Kuramitsu, Bhoj Raj Adhikari, Daichi Hiraki, Seiko Toraya, Asiri Jayawardena, Ichiro Saito, Malsantha Muthumala, Hiroki Nagayasu, Yoshihiro Abiko and Itsuo Chiba

    Citation: Clinical Epigenetics 2020 12:12

    Content type: Research

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  40. Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to ...

    Authors: Clara Snijders, Adam X. Maihofer, Andrew Ratanatharathorn, Dewleen G. Baker, Marco P. Boks, Elbert Geuze, Sonia Jain, Ronald C. Kessler, Ehsan Pishva, Victoria B. Risbrough, Murray B. Stein, Robert J. Ursano, Eric Vermetten, Christiaan H. Vinkers, Alicia K. Smith, Monica Uddin…

    Citation: Clinical Epigenetics 2020 12:11

    Content type: Research

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  41. The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D COMPASS complexes (complex of protein...

    Authors: William J. Lavery, Artem Barski, Susan Wiley, Elizabeth K. Schorry and Andrew W. Lindsley

    Citation: Clinical Epigenetics 2020 12:10

    Content type: Review

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  42. Down syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic...

    Authors: Loora Laan, Joakim Klar, Maria Sobol, Jan Hoeber, Mansoureh Shahsavani, Malin Kele, Ambrin Fatima, Muhammad Zakaria, Göran Annerén, Anna Falk, Jens Schuster and Niklas Dahl

    Citation: Clinical Epigenetics 2020 12:9

    Content type: Research

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  43. The occurrence of seizures in childhood is often associated with neurodevelopmental impairments and school underachievement. Common genetic variants associated with epilepsy have been identified and epigenetic...

    Authors: Doretta Caramaschi, Charlie Hatcher, Rosa H. Mulder, Janine F. Felix, Charlotte A. M. Cecil, Caroline L. Relton and Esther Walton

    Citation: Clinical Epigenetics 2020 12:8

    Content type: Research

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  44. We previously associated HIST1H1E mutations causing Rahman syndrome with a specific genome-wide methylation pattern.

    Authors: Andrea Ciolfi, Erfan Aref-Eshghi, Simone Pizzi, Lucia Pedace, Evelina Miele, Jennifer Kerkhof, Elisabetta Flex, Simone Martinelli, Francesca Clementina Radio, Claudia A. L. Ruivenkamp, Gijs W. E. Santen, Emilia Bijlsma, Daniela Barge-Schaapveld, Katrin Ounap, Victoria Mok Siu, R. Frank Kooy…

    Citation: Clinical Epigenetics 2020 12:7

    Content type: Short report

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  45. DNA methylation is associated with non-communicable diseases (NCDs) and related traits. Methylation data on continental African ancestries are currently scarce, even though there are known genetic and epigenet...

    Authors: H. Toinét Cronjé, Hannah R. Elliott, Cornelie Nienaber-Rousseau and Marlien Pieters

    Citation: Clinical Epigenetics 2020 12:6

    Content type: Research

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  46. Chronological age is a prominent risk factor for many types of cancers including colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even within the same age group, which ma...

    Authors: Ting Wang, Sean K. Maden, Georg E. Luebeck, Christopher I. Li, Polly A. Newcomb, Cornelia M. Ulrich, Ji-Hoon E. Joo, Daniel D. Buchanan, Roger L. Milne, Melissa C. Southey, Kelly T. Carter, Amber R. Willbanks, Yanxin Luo, Ming Yu and William M. Grady

    Citation: Clinical Epigenetics 2020 12:5

    Content type: Research

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  47. Poor-responsiveness of tumors to radiotherapy is a major clinical problem. Owing to the dynamic nature of the epigenome, the identification and targeting of potential epigenetic modifiers may be helpful to cur...

    Authors: Asmita Sharda, Mudasir Rashid, Sanket Girish Shah, Ajit Kumar Sharma, Saurav Raj Singh, Poonam Gera, Murali Krishna Chilkapati and Sanjay Gupta

    Citation: Clinical Epigenetics 2020 12:4

    Content type: Research

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  48. Non-alcoholic fatty liver disease is the most common chronic liver disease in children in western countries. Adverse early-life exposures are associated with higher liver fat percentages in children. Different...

    Authors: Madelon L. Geurtsen, Vincent W. V. Jaddoe, Lucas A. Salas, Susana Santos and Janine F. Felix

    Citation: Clinical Epigenetics 2019 12:3

    Content type: Research

    Published on: