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  1. Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20–25% of all cancer deaths. For choosing the most appropriate therapy regi...

    Authors: Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl

    Citation: Clinical Epigenetics 2021 13:38

    Content type: Research

    Published on:

  2. Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we e...

    Authors: C. Christiansen, J. E. Castillo-Fernandez, A. Domingo-Relloso, W. Zhao, J. S. El-Sayed Moustafa, P.-C. Tsai, J. Maddock, K. Haack, S. A. Cole, S. L. R. Kardia, M. Molokhia, M. Suderman, C. Power, C. Relton, A. Wong, D. Kuh…

    Citation: Clinical Epigenetics 2021 13:36

    Content type: Research

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  3. Epigenetic inactivation of O6-methylguanine DNA-methyltransferase (MGMT) is associated with increased sensitivity to alkylating chemotherapeutic agents in glioblastoma patients. The genetic background underlying

    Authors: Lijie Wang, Afsaneh Mohammadnejad, Weilong Li, Jesper Lund, Shuxia Li, Signe Clemmensen, Maria Timofeeva, Mette Soerensen, Jonas Mengel-From, Kaare Christensen, Jacob Hjelmborg and Qihua Tan

    Citation: Clinical Epigenetics 2021 13:35

    Content type: Research

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  4. Glycosylation, one of the most fundamental post-translational modifications, is altered in cancer and is subject in part, to epigenetic regulation. As there are many epigenetic-targeted therapies currently in ...

    Authors: Gordon Greville, Esther Llop, Jane Howard, Stephen F. Madden, Antoinette S. Perry, Rosa Peracaula, Pauline M. Rudd, Amanda McCann and Radka Saldova

    Citation: Clinical Epigenetics 2021 13:34

    Content type: Research

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  5. Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are respon...

    Authors: Hang-Yu Chen, Wei-Long Zhang, Lei Zhang, Ping Yang, Fang Li, Ze-Ruo Yang, Jing Wang, Meng Pang, Yun Hong, Changjian Yan, Wei Li, Jia Liu, Nuo Xu, Long Chen, Xiu-Bing Xiao, Yan Qin…

    Citation: Clinical Epigenetics 2021 13:33

    Content type: Research

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  6. There is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for a transplant biopsy. In this pilot study, the potential of circulatin...

    Authors: Jeroen G. H. P. Verhoeven, Carla C. Baan, Annemiek M. A. Peeters, Marian C. Clahsen-van Groningen, Daan Nieboer, Mariëlle Herzog, Marc Eccleston, Dennis A. Hesselink and Karin Boer

    Citation: Clinical Epigenetics 2021 13:32

    Content type: Research

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  7. Transcription factor B cell lymphoma 6 (BCL6) is a master regulator of T follicular helper (Tfh) cells, which play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechani...

    Authors: Limin Liu, Longyuan Hu, Linxuan Yang, Sujie Jia, Pei Du, Xiaoli Min, Jiali Wu, Haijing Wu, Hai Long, Qianjin Lu and Ming Zhao

    Citation: Clinical Epigenetics 2021 13:31

    Content type: Research

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  8. Whereas duplications in 11p15.5 covering both imprinting centers (ICs) and their subordinated genes account for up to 1% of Beckwith–Wiedemann and Silver–Russell syndrome patients (BWS, SRS), the deletions in ...

    Authors: Thomas Eggermann, Matthias Begemann and Lutz Pfeiffer

    Citation: Clinical Epigenetics 2021 13:30

    Content type: Research

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  9. Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests ...

    Authors: Sara Pischedda, Daniel O’Connor, Benjamin P. Fairfax, Antonio Salas, Federico Martinon-Torres, Andrew J. Pollard and Johannes Trück

    Citation: Clinical Epigenetics 2021 13:29

    Content type: Research

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  10. Patients suffering from the BCR-ABL1-negative myeloproliferative disease prefibrotic primary myelofibrosis (pre-PMF) have a certain risk for progression to myelofibrosis. Accurate risk estimation for this fibroti...

    Authors: Ulrich Lehmann, Helge Stark, Stephan Bartels, Jerome Schlue, Guntram Büsche and Hans Kreipe

    Citation: Clinical Epigenetics 2021 13:28

    Content type: Research

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  11. Prior work in mice has shown that some retrotransposed elements remain substantially methylated during DNA methylation reprogramming of germ cells. In the pig, however, information about this process is scarce...

    Authors: Isabel Gómez-Redondo, Benjamín Planells, Sebastián Cánovas, Elena Ivanova, Gavin Kelsey and Alfonso Gutiérrez-Adán

    Citation: Clinical Epigenetics 2021 13:27

    Content type: Research

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  12. Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect pati...

    Authors: Jinke Sui, Xianrui Wu, Chenyang Wang, Guoqiang Wang, Chengcheng Li, Jing Zhao, Yuzi Zhang, Jianxing Xiang, Yu Xu, Weiqi Nian, Fuao Cao, Guanyu Yu, Zheng Lou, Liqiang Hao, Lianjie Liu, Bingsi Li…

    Citation: Clinical Epigenetics 2021 13:26

    Content type: Research

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  13. Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stim...

    Authors: Katherine M. Bever, Dwayne L. Thomas II, Jiajia Zhang, Ernie A. Diaz Rivera, Gary L. Rosner, Qingfeng Zhu, Julie M. Nauroth, Brian Christmas, Elizabeth D. Thompson, Robert A. Anders, Carol Judkins, Meizheng Liu, Elizabeth M. Jaffee, Nita Ahuja, Lei Zheng and Nilofer S. Azad

    Citation: Clinical Epigenetics 2021 13:25

    Content type: Short report

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  14. Fabry disease (FD) is a rare X-linked disease caused by mutations in GLA gene with consequent lysosomal accumulation of globotriaosylceramide (Gb3). Women with FD often show highly heterogeneous symptoms that ...

    Authors: Teodolinda Di Risi, Roberta Vinciguerra, Mariella Cuomo, Rosa Della Monica, Eleonora Riccio, Sirio Cocozza, Massimo Imbriaco, Giovanni Duro, Antonio Pisani and Lorenzo Chiariotti

    Citation: Clinical Epigenetics 2021 13:24

    Content type: Review

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  15. The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric ...

    Authors: Joshua S. Danoff, Kelly L. Wroblewski, Andrew J. Graves, Graham C. Quinn, Allison M. Perkeybile, William M. Kenkel, Travis S. Lillard, Hardik I. Parikh, Hudson F. Golino, Simon G. Gregory, C. Sue Carter, Karen L. Bales and Jessica J. Connelly

    Citation: Clinical Epigenetics 2021 13:23

    Content type: Research

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  16. The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein–Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extens...

    Authors: Mansheng Zhu, Qixiang Liang, Tao Chen, Qian Kong, Gengtai Ye, Shitong Yu, Xunjun Li, Qinglie He, Hao Liu, Yanfeng Hu, Jiang Yu and Guoxin Li

    Citation: Clinical Epigenetics 2021 13:22

    Content type: Research

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  17. Acute leukemia is an epigenetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however these incompletely predict outcomes,...

    Authors: A. D. van Dijk, F. W. Hoff, Y. H. Qiu, J. Chandra, E. Jabbour, E. S. J. M. de Bont, T. M. Horton and S. M. Kornblau

    Citation: Clinical Epigenetics 2021 13:21

    Content type: Research

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  18. Transcriptional analysis is widely used to study the molecular biology of cancer and hold great biomarker potential for clinical patient stratification. Yet, accurate transcriptional profiling requires RNA of ...

    Authors: Trine B. Mattesen, Claus L. Andersen and Jesper B. Bramsen

    Citation: Clinical Epigenetics 2021 13:20

    Content type: Research

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  19. Acute coronary syndrome (ACS) is a cardiac emergency with high mortality. Exposure to high copper (Cu) concentration has been linked to ACS. However, whether DNA methylation contributes to the association betw...

    Authors: Pinpin Long, Qiuhong Wang, Yizhi Zhang, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Xuezhen Liu, Min Zhou, Yu Yuan, Kang Liu, Jing Jiang, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen, Jing Yuan…

    Citation: Clinical Epigenetics 2021 13:19

    Content type: Research

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  20. Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia has been reported to regulate the activity of important carc...

    Authors: Hongzhen Li, Chunyan Peng, Chenhui Zhu, Shuang Nie, Xuetian Qian, Zhao Shi, Mengyue Shi, Yan Liang, Xiwei Ding, Shu Zhang, Bin Zhang, Xihan Li, Guifang Xu, Ying Lv, Lei Wang, Helmut Friess…

    Citation: Clinical Epigenetics 2021 13:18

    Content type: Research

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  21. Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the nex...

    Authors: Sanaz Keyhan, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, David L. Corcoran, Adelheid Soubry, Catherine Hoyo and Susan K. Murphy

    Citation: Clinical Epigenetics 2021 13:17

    Content type: Research

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  22. Obesity confers enhanced risk for multiple diseases including cancer. The DNA methylation alterations in obesity-related genes have been implicated in several human solid tumors. However, the underlying role a...

    Authors: Ting-juan Zhang, Zi-jun Xu, Yu Gu, Ji-chun Ma, Xiang-mei Wen, Wei Zhang, Zhao-qun Deng, Jun Qian, Jiang Lin and Jing-dong Zhou

    Citation: Clinical Epigenetics 2021 13:16

    Content type: Research

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  23. To date, no predictive or prognostic molecular biomarkers except BRCA mutations are clinically established for epithelial ovarian cancer (EOC) despite being the deadliest gynecological malignancy. Aim of this bio...

    Authors: Karolin Heinze, Matthias Rengsberger, Mieczyslaw Gajda, Lars Jansen, Linea Osmers, Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Matthias Dürst, Norman Häfner and Ingo B. Runnebaum

    Citation: Clinical Epigenetics 2021 13:15

    Content type: Research

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  24. Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circul...

    Authors: Graeme P. Young, Erin L. Symonds, Hans Jørgen Nielsen, Linnea Ferm, Ib J. Christensen, Evelien Dekker, Manon van der Vlugt, Rosalie C. Mallant-Hent, Nicky Boulter, Betty Yu, Michelle Chan, Gregor Tevz, Lawrence C. LaPointe and Susanne K. Pedersen

    Citation: Clinical Epigenetics 2021 13:14

    Content type: Research

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  25. Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

    Authors: Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner, Liguo Wang, Jeanette E. Eckel-Passow, Erik P. Castle, Melissa L. Stanton, R. Houston Thompson, Alexander S. Parker, Thai H. Ho and Keith D. Robertson

    Citation: Clinical Epigenetics 2021 13:12

    Content type: Research

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  26. Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognosis prediction of breast cancer. However, limited data exist regarding invasive lobular brea...

    Authors: Medha Suman, Pierre-Antoine Dugué, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean and Melissa C. Southey

    Citation: Clinical Epigenetics 2021 13:11

    Content type: Research

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  27. The aim of this paper was to investigate the protective effects of bromodomain containing 4 (BRD4) inhibition on the temporomandibular joint osteoarthritis (TMJ OA) induced by compressive mechanical stress and...

    Authors: Ziwei Huang, Ren Yang, Lu Zhang, Mengjiao Zhu, Caixia Zhang, Juan Wen and Huang Li

    Citation: Clinical Epigenetics 2021 13:10

    Content type: Research

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  28. Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for...

    Authors: M. Cabezón, R. Malinverni, J. Bargay, B. Xicoy, S. Marcé, A. Garrido, M. Tormo, L. Arenillas, R. Coll, J. Borras, M. J. Jiménez, M. Hoyos, D. Valcárcel, L. Escoda, F. Vall-Llovera, A. Garcia…

    Citation: Clinical Epigenetics 2021 13:9

    Content type: Research

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  29. High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised mechanism linking early life exposures and subsequent di...

    Authors: N. Robinson, H. Brown, Elie Antoun, Keith M. Godfrey, Mark A. Hanson, Karen A. Lillycrop, Sarah R. Crozier, Robert Murray, M. S. Pearce, C. L. Relton, V. Albani and J. A. McKay

    Citation: Clinical Epigenetics 2021 13:8

    Content type: Research

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  30. The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation an...

    Authors: Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari…

    Citation: Clinical Epigenetics 2021 13:7

    Content type: Research

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  31. Autism spectrum disorder (ASD) has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of AS...

    Authors: Nicolás Garrido, Fabio Cruz, Rocio Rivera Egea, Carlos Simon, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Millissia Ben Maamar and Michael K. Skinner

    Citation: Clinical Epigenetics 2021 13:6

    Content type: Research

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  32. The pattern of lung function development from pre-adolescence to adulthood plays a significant role in the pathogenesis of respiratory diseases. Inconsistent findings in genetic studies on lung function trajec...

    Authors: Shadia Khan Sunny, Hongmei Zhang, Fawaz Mzayek, Caroline L. Relton, Susan Ring, A. John Henderson, Susan Ewart, John W. Holloway and S. Hasan Arshad

    Citation: Clinical Epigenetics 2021 13:5

    Content type: Research

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  33. Use of cannabidiol (CBD), the primary non-psychoactive compound found in cannabis, has recently risen dramatically, while relatively little is known about the underlying molecular mechanisms of its effects. Pr...

    Authors: Nicole M. Wanner, Mathia Colwell, Chelsea Drown and Christopher Faulk

    Citation: Clinical Epigenetics 2021 13:4

    Content type: Research

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  34. Dilated cardiomyopathy (DCM) is a serious cardiac heterogeneous pathological disease, which may be caused by mutations in the LMNA gene. Lamins interact with not only lamina-associated domains (LADs) but also ...

    Authors: Xiaolin Zhang, Xiuli Shao, Ruijia Zhang, Rongli Zhu and Rui Feng

    Citation: Clinical Epigenetics 2021 13:3

    Content type: Research

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  35. Phelan-McDermid syndrome is characterized by a range of neurodevelopmental phenotypes with incomplete penetrance and variable expressivity. It is caused by a variable size and breakpoint microdeletions in the ...

    Authors: L. C. Schenkel, E. Aref-Eshghi, K. Rooney, J. Kerkhof, M. A. Levy, H. McConkey, R. C. Rogers, K. Phelan, S. M. Sarasua, L. Jain, R. Pauly, L. Boccuto, B. DuPont, G. Cappuccio, N. Brunetti-Pierri, C. E. Schwartz…

    Citation: Clinical Epigenetics 2021 13:2

    Content type: Research

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  36. Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from hematopoietic stem and progenitor cells (HSPCs). Patients with CMML are frequently treated with epigenetic ther...

    Authors: Johannes Lorenz Berg, Bianca Perfler, Stefan Hatzl, Marie-Christina Mayer, Sonja Wurm, Barbara Uhl, Andreas Reinisch, Ingeborg Klymiuk, Sascha Tierling, Gudrun Pregartner, Gerhard Bachmaier, Andrea Berghold, Klaus Geissler, Martin Pichler, Gerald Hoefler, Herbert Strobl…

    Citation: Clinical Epigenetics 2021 13:1

    Content type: Research

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  37. Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ ce...

    Authors: Mingju Cao, Xiaojian Shao, Peter Chan, Warren Cheung, Tony Kwan, Tomi Pastinen and Bernard Robaire

    Citation: Clinical Epigenetics 2020 12:192

    Content type: Research

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  38. Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes t...

    Authors: Patricia Fauque, Jacques De Mouzon, Aviva Devaux, Sylvie Epelboin, Marie-José Gervoise-Boyer, Rachel Levy, Morgane Valentin, Géraldine Viot, Arianne Bergère, Claire De Vienne, Philippe Jonveaux and Fabienne Pessione

    Citation: Clinical Epigenetics 2020 12:191

    Content type: Research

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  39. Necrotizing enterocolitis (NEC) remains one of the overall leading causes of death in premature infants, and the pathogenesis is unpredictable and not well characterized. The aim of our study was to determine ...

    Authors: Misty Good, Tianjiao Chu, Patricia Shaw, Lora McClain, Austin Chamberlain, Carlos Castro, Jamie M. Rimer, Belgacem Mihi, Qingqing Gong, Lila S. Nolan, Krista Cooksey, Laura Linneman, Pranjal Agrawal, David N. Finegold and David Peters

    Citation: Clinical Epigenetics 2020 12:190

    Content type: Research

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  40. While Alzheimer’s disease (AD) remains one of the most challenging diseases to tackle, genome-wide genetic/epigenetic studies reveal many disease-associated risk loci, which sheds new light onto disease herita...

    Authors: Qi Wang, Yinghua Chen, Benjamin Readhead, Kewei Chen, Yi Su, Eric M. Reiman and Joel T. Dudley

    Citation: Clinical Epigenetics 2020 12:189

    Content type: Research

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  41. The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. Here, we studied pathogenic and nonpathogenic simian immunod...

    Authors: Simon P. Jochems, Beatrice Jacquelin, Nicolas Tchitchek, Florence Busato, Fabien Pichon, Nicolas Huot, Yi Liu, Mickaël J. Ploquin, Elodie Roché, Rémi Cheynier, Nathalie Dereuddre-Bosquet, Christiane Stahl-Henning, Roger Le Grand, Jorg Tost and Michaela Müller-Trutwin

    Citation: Clinical Epigenetics 2020 12:188

    Content type: Research

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  42. Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of immunity and inflammation which have emerged as potential targets for immunomodulating therapies. The prevalence and sign...

    Authors: Krzysztof T. Jurdziński, Jan Potempa and Aleksander M. Grabiec

    Citation: Clinical Epigenetics 2020 12:186

    Content type: Review

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  43. Fetal growth restriction (FGR) is associated with an increased susceptibility for various noncommunicable diseases in adulthood, including cardiovascular and renal disease. During FGR, reduced uteroplacental b...

    Authors: Fieke Terstappen, Jorg J. A. Calis, Nina D. Paauw, Jaap A. Joles, Bas B. van Rijn, Michal Mokry, Torsten Plösch and A. Titia Lely

    Citation: Clinical Epigenetics 2020 12:185

    Content type: Research

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  44. Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal ...

    Authors: Xīn Gào, Yan Zhang, Daniel Boakye, Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:184

    Content type: Research

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  45. Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix. However, common therapeu...

    Authors: Wenchang Lv, Yuping Ren, Kai Hou, Weijie Hu, Yi Yi, Mingchen Xiong, Min Wu, Yiping Wu and Qi Zhang

    Citation: Clinical Epigenetics 2020 12:183

    Content type: Review

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  46. Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated li...

    Authors: Karen L. Leung, Smriti Sanchita, Catherine T. Pham, Brett A. Davis, Mariam Okhovat, Xiangming Ding, Phillip Dumesic, Tristan R. Grogan, Kevin J. Williams, Marco Morselli, Feiyang Ma, Lucia Carbone, Xinmin Li, Matteo Pellegrini, Daniel A. Dumesic and Gregorio D. Chazenbalk

    Citation: Clinical Epigenetics 2020 12:181

    Content type: Research

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  47. The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.

    Authors: Nuno R. Nené, James Barrett, Allison Jones, Iona Evans, Daniel Reisel, John F. Timms, Tobias Paprotka, Andreas Leimbach, Dorella Franchi, Nicoletta Colombo, Line Bjørge, Michal Zikan, David Cibula and Martin Widschwendter

    Citation: Clinical Epigenetics 2020 12:180

    Content type: Research

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