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  1. Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w...

    Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith…

    Citation: Clinical Epigenetics 2020 12:95

    Content type: Research

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  2. PD-L1 (programmed cell death 1 ligand 1) expression in melanoma has been associated with a better response to anti-PD-1 (programmed cell death 1) therapy. However, patients with PD-L1-negative melanomas can re...

    Authors: Friederike Hoffmann, Romina Zarbl, Dennis Niebel, Judith Sirokay, Anne Fröhlich, Christian Posch, Tobias A. W. Holderried, Peter Brossart, Gonzalo Saavedra, Pia Kuster, Sebastian Strieth, Gerrit H. Gielen, Sandra S. Ring, Jörn Dietrich, Torsten Pietsch, Lukas Flatz…

    Citation: Clinical Epigenetics 2020 12:94

    Content type: Research

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  3. Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ...

    Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher

    Citation: Clinical Epigenetics 2020 12:93

    Content type: Research

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  4. The initiation of adolescent smoking is difficult to detect using carbon monoxide or cotinine assays. Previously, we and others have shown that the methylation of cg05575921 is an accurate predictor of adult s...

    Authors: Kelsey Dawes, Allan Andersen, Emma Papworth, Brandon Hundley, Natasha Hutchens, Heba El Manawy, Ashley Becker, Luke Sampson, Willem Philibert, Frederick X. Gibbons, Meg Gerrard and Robert Philibert

    Citation: Clinical Epigenetics 2020 12:92

    Content type: Research

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  5. Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as...

    Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li

    Citation: Clinical Epigenetics 2020 12:91

    Content type: Research

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  6. DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specific changes are known to reflect the type and severity of the disease. Therefore, there is a ...

    Authors: Dilys Lam, Phuc-Loi Luu, Jenny Z. Song, Wenjia Qu, Gail P. Risbridger, Mitchell G. Lawrence, Jennifer Lu, Matt Trau, Darren Korbie, Susan J. Clark, Ruth Pidsley and Clare Stirzaker

    Citation: Clinical Epigenetics 2020 12:90

    Content type: Methodology

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  7. Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera...

    Authors: Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner

    Citation: Clinical Epigenetics 2020 12:89

    Content type: Research

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  8. Eukaryotic histone methyltransferases 2 (EHMT2 or G9A) has been regarded as a potential target for non-small cell lung cancer (NSCLC) therapy. This study investigated the regulatory roles of G9A in tumorigenes...

    Authors: Rajendra P. Pangeni, Lu Yang, Keqiang Zhang, Jinhui Wang, Wendong Li, Chao Guo, Xinwei Yun, Ting Sun, Jami Wang and Dan J. Raz

    Citation: Clinical Epigenetics 2020 12:88

    Content type: Research

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  9. Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer...

    Authors: Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang…

    Citation: Clinical Epigenetics 2020 12:87

    Content type: Research

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  10. Silver-Russell syndrome (SRS) is characterized by growth failure and dysmorphic features. Major (epi)genetic causes of SRS are loss of methylation on chromosome 11p15 (11p15 LOM) and maternal uniparental disom...

    Authors: Takanobu Inoue, Akie Nakamura, Megumi Iwahashi-Odano, Kanako Tanase-Nakao, Keiko Matsubara, Junko Nishioka, Yoshihiro Maruo, Yukihiro Hasegawa, Hiroshi Suzumura, Seiji Sato, Yoshiyuki Kobayashi, Nobuyuki Murakami, Kazuhiko Nakabayashi, Kazuki Yamazawa, Tomoko Fuke, Satoshi Narumi…

    Citation: Clinical Epigenetics 2020 12:86

    Content type: Research

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  11. Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallm...

    Authors: Aparna Vasanthakumar, Justin W. Davis, Kenneth Idler, Jeffrey F. Waring, Elizabeth Asque, Bridget Riley-Gillis, Shaun Grosskurth, Gyan Srivastava, Sungeun Kim, Kwangsik Nho, Kelly N. H. Nudelman, Kelley Faber, Yu Sun, Tatiana M. Foroud, Karol Estrada, Liana G. Apostolova…

    Citation: Clinical Epigenetics 2020 12:84

    Content type: Research

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  12. Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mech...

    Authors: Hatim Boughanem, Amanda Cabrera-Mulero, Pablo Hernández-Alonso, Mercedes Clemente-Postigo, Felipe F. Casanueva, Francisco José Tinahones, Sonsoles Morcillo, Ana B. Crujeiras and Manuel Macias-Gonzalez

    Citation: Clinical Epigenetics 2020 12:83

    Content type: Research

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  13. Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogene...

    Authors: Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao and Tingxiu Xiang

    Citation: Clinical Epigenetics 2020 12:82

    Content type: Research

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  14. Hepatitis B virus (HBV)-related liver disease induces liver damage by hepatic immune and inflammatory response. The association between aberrant peripheral blood mononuclear cell (PBMC) DNA methylation and pro...

    Authors: Kang Li, Ling Qin, Sanjie Jiang, Ang Li, Chi Zhang, Guihai Liu, Jianping Sun, Huanqing Sun, Yan Zhao, Ning Li and Yonghong Zhang

    Citation: Clinical Epigenetics 2020 12:81

    Content type: Research

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  15. The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigene...

    Authors: Nathan A. Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jian-Hua Luo, Yan P. Yu, Sunduz Keles and David F. Jarrard

    Citation: Clinical Epigenetics 2020 12:80

    Content type: Research

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  16. Vascular endothelial growth factor A (VEGF-A) is a chemokine that induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis. It is ...

    Authors: Vesna Gorenjak, Dwaine R. Vance, Sébastien Dade, Maria G. Stathopoulou, Lauren Doherty, Ting Xie, Helena Murray, Christine Masson, John Lamont, Peter Fitzgerald and Sophie Visvikis-Siest

    Citation: Clinical Epigenetics 2020 12:79

    Content type: Research

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  17. Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal gr...

    Authors: Fasil Tekola-Ayele, Xuehuo Zeng, Marion Ouidir, Tsegaselassie Workalemahu, Cuilin Zhang, Fabien Delahaye and Ronald Wapner

    Citation: Clinical Epigenetics 2020 12:78

    Content type: Research

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  18. This study aimed to determine the epigenetic biomarkers of diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). This retrospective study is based on the Shanghai Xinjing community preven...

    Authors: Tao Li, Yi Xu, Yongyong Shi, Jianhua Chen, Senlin Lin, Jianfeng Zhu, Xian Xu, Lina Lu and Haidong Zou

    Citation: Clinical Epigenetics 2020 12:77

    Content type: Research

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  19. A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we e...

    Authors: Jose Vladimir Sandoval-Sierra, Francisco I. Salgado García, Jeffrey H. Brooks, Karen J. Derefinko and Khyobeni Mozhui

    Citation: Clinical Epigenetics 2020 12:76

    Content type: Research

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  20. Epigenetic abnormalities caused by superovulation have recently attracted increasing attention. Superovulation with exogenous hormones may prevent oocytes from establishing an appropriate epigenetic state, and...

    Authors: Ying Huo, Zhi Qiang Yan, Peng Yuan, Meng Qin, Ying Kuo, Rong Li, Li Ying Yan, Huai Liang Feng and Jie Qiao

    Citation: Clinical Epigenetics 2020 12:75

    Content type: Research

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  21. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...

    Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nuša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom

    Citation: Clinical Epigenetics 2020 12:74

    Content type: Research

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  22. Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transc...

    Authors: Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li and Lixiang Xue

    Citation: Clinical Epigenetics 2020 12:72

    Content type: Review

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  23. Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples usin...

    Authors: Rulong Shen, Tong Cheng, Chuanliang Xu, Rex C. Yung, Jiandong Bao, Xing Li, Hongyu Yu, Shaohua Lu, Huixiong Xu, Hongxun Wu, Jian Zhou, Wenbo Bu, Xiaonan Wang, Han Si, Panying Shi, Pengcheng Zhao…

    Citation: Clinical Epigenetics 2020 12:71

    Content type: Methodology

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  24. Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnorma...

    Authors: Manon Lernoux, Michael Schnekenburger, Hélène Losson, Koen Vermeulen, Hyunggu Hahn, Déborah Gérard, Jin-Young Lee, Aloran Mazumder, Muneer Ahamed, Christo Christov, Dong-Wook Kim, Mario Dicato, Guy Bormans, Byung Woo Han and Marc Diederich

    Citation: Clinical Epigenetics 2020 12:69

    Content type: Research

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  25. Adipogenesis, the process whereby preadipocytes differentiate into mature adipocytes, is crucial for maintaining metabolic homeostasis. Cholesterol-lowering statins increase type 2 diabetes (T2D) risk possibly...

    Authors: Amna Khamis, Raphael Boutry, Mickaël Canouil, Sumi Mathew, Stephane Lobbens, Hutokshi Crouch, Toby Andrew, Amar Abderrahmani, Filippo Tamanini and Philippe Froguel

    Citation: Clinical Epigenetics 2020 12:68

    Content type: Research

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  26. Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis, prognosis, and recurrence prediction of colore...

    Authors: Shih-Ching Chang, Phui-Ly Liew, Muhamad Ansar, Shih-Yun Lin, Sheng-Chao Wang, Chin-Sheng Hung, Jian-Yu Chen, Shikha Jain and Ruo-Kai Lin

    Citation: Clinical Epigenetics 2020 12:67

    Content type: Research

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  27. Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying t...

    Authors: Jee Yeon Kim, Bong-Geun Choi, Jaroslav Jelinek, Dae Hyun Kim, Seo Hyun Lee, Kwangjo Cho, Seo Hee Rha, Young Ho Lee, Hyo Sun Jin, Dae-Kyoung Choi, Geun-Eun Kim, Sun U. Kwon, Junha Hwang, Jae Kwan Cha, Sukhoon Lee, Jean-Pierre J. Issa…

    Citation: Clinical Epigenetics 2020 12:66

    Content type: Research

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  28. Assessing long-term health effects from a potentially harmful environment is challenging. Endocrine-disrupting compounds (EDCs) have become omnipresent in our environment. Individuals may or may not experience...

    Authors: Olivia Van Cauwenbergh, Alessandra Di Serafino, Jan Tytgat and Adelheid Soubry

    Citation: Clinical Epigenetics 2020 12:65

    Content type: Review

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  29. Preimplantation embryos experience profound resetting of epigenetic information inherited from the gametes. Genome-wide analysis at single-base resolution has shown similarities but also species differences be...

    Authors: Elena Ivanova, Sebastian Canovas, Soledad Garcia-Martínez, Raquel Romar, Jordana S. Lopes, Dimitrios Rizos, Maria J. Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey and Pilar Coy

    Citation: Clinical Epigenetics 2020 12:64

    Content type: Research

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    The Correction to this article has been published in Clinical Epigenetics 2020 12:96

  30. Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder caused by disturbances of the chromosomal region 11p15.5. The most frequent molecular finding in BWS is loss of methylation (LOM) of the Imprinting C...

    Authors: Carla Eßinger, Stephanie Karch, Ute Moog, György Fekete, Anna Lengyel, Eva Pinti, Thomas Eggermann and Matthias Begemann

    Citation: Clinical Epigenetics 2020 12:63

    Content type: Research

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  31. How to best triage human papillomavirus (HPV) positive women remains controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the long-term risk stratification for triaging HPV 16...

    Authors: Li Dong, Li Zhang, Shang-Ying Hu, Rui-Mei Feng, Xue-Lian Zhao, Qian Zhang, Qin-Jing Pan, Xun Zhang, You-Lin Qiao and Fang-Hui Zhao

    Citation: Clinical Epigenetics 2020 12:62

    Content type: Research

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  32. In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation...

    Authors: Elsa Leitão, Sara Di Persio, Sandra Laurentino, Marius Wöste, Martin Dugas, Sabine Kliesch, Nina Neuhaus and Bernhard Horsthemke

    Citation: Clinical Epigenetics 2020 12:61

    Content type: Research

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  33. Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical va...

    Authors: Edwina H. Yeung, Weihua Guan, Xuehuo Zeng, Lucas A. Salas, Sunni L. Mumford, Paula de Prado Bert, Evelien R. van Meel, Anni Malmberg, Jordi Sunyer, Liesbeth Duijts, Janine F. Felix, Darina Czamara, Esa Hämäläinen, Elisabeth B. Binder, Katri Räikkönen, Jari Lahti…

    Citation: Clinical Epigenetics 2020 12:60

    Content type: Research

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  34. DNA methylation (DNAm) variation is an established predictor for several traits. In the context of oropharyngeal cancer (OPC), where 5-year survival is ~ 65%, DNA methylation may act as a prognostic biomarker....

    Authors: Ryan J. Langdon, Rhona A. Beynon, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Richard M. Martin, Andy R. Ness, Michael Pawlita, Tim Waterboer, Caroline Relton, Steven J. Thomas and Rebecca C. Richmond

    Citation: Clinical Epigenetics 2020 12:58

    Content type: Research

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  35. Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we co...

    Authors: Yuan-Yuan Gu, Guan-Nan Zhou, Qing Wang, Jing-Xin Ding and Ke-Qin Hua

    Citation: Clinical Epigenetics 2020 12:57

    Content type: Research

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  36. Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are ...

    Authors: Jian Fan, Jun Li, Shicheng Guo, Chengcheng Tao, Haikun Zhang, Wenjing Wang, Ying Zhang, Dake Zhang, Shigang Ding and Changqing Zeng

    Citation: Clinical Epigenetics 2020 12:56

    Content type: Research

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  37. Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation...

    Authors: Rosalind Tang, Laura D. Howe, Matthew Suderman, Caroline L. Relton, Andrew A. Crawford and Lotte C. Houtepen

    Citation: Clinical Epigenetics 2020 12:55

    Content type: Research

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  38. The genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as many T-cell genes, with a strong MHC associati...

    Authors: R. Pitaksalee, A. N. Burska, S. Ajaib, J. Rogers, R. Parmar, K. Mydlova, X. Xie, A. Droop, J. S. Nijjar, P. Chambers, P. Emery, R. Hodgett, I. B. McInnes and F. Ponchel

    Citation: Clinical Epigenetics 2020 12:54

    Content type: Research

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  39. Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated tha...

    Authors: Carolina Serena, Monica Millan, Miriam Ejarque, Alfonso Saera-Vila, Elsa Maymó-Masip, Catalina Núñez-Roa, Diandra Monfort-Ferré, Margarida Terrón-Puig, Michelle Bautista, Margarita Menacho, Marc Martí, Eloy Espin, Joan Vendrell and Sonia Fernández-Veledo

    Citation: Clinical Epigenetics 2020 12:53

    Content type: Research

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  40. Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-...

    Authors: Delnaz Roshandel, Zhuo Chen, Angelo J. Canty, Shelley B. Bull, Rama Natarajan and Andrew D. Paterson

    Citation: Clinical Epigenetics 2020 12:52

    Content type: Research

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  41. DNA methylation is associated with body mass index (BMI), but it is not clear if methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we explore the causal nature and predictive ...

    Authors: Zoe E. Reed, Matthew J. Suderman, Caroline L. Relton, Oliver S. P. Davis and Gibran Hemani

    Citation: Clinical Epigenetics 2020 12:50

    Content type: Research

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  42. DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-qu...

    Authors: Anne Seeboth, Daniel L. McCartney, Yunzhang Wang, Robert F. Hillary, Anna J. Stevenson, Rosie M. Walker, Archie Campbell, Kathryn L. Evans, Andrew M. McIntosh, Sara Hägg, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:49

    Content type: Research

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  43. Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts...

    Authors: Mitchell G. Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A. Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A. Taylor, Gail P. Risbridger and Susan J. Clark

    Citation: Clinical Epigenetics 2020 12:48

    Content type: Research

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  44. Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the pr...

    Authors: Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo and Dianshuai Gao

    Citation: Clinical Epigenetics 2020 12:47

    Content type: Research

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  45. Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).

    Authors: Mark W. Logue, Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, Filomene G. Morrison, Zhenwei Zhou, Yuanchao Zheng, Alicia K. Smith, Nikolaos P. Daskalakis, Andrew Ratanatharathorn, Monica Uddin, Caroline M. Nievergelt, Allison E. Ashley-Koch, Dewleen G. Baker, Jean C. Beckham, Melanie E. Garrett…

    Citation: Clinical Epigenetics 2020 12:46

    Content type: Research

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  46. DNA methylation (DNAm) age has been widely accepted as an epigenetic biomarker for biological aging. Emerging evidence suggests that DNAm age can be tissue-specific and female breast tissue ages faster than ot...

    Authors: James R. Castle, Nan Lin, Jinpeng Liu, Anna Maria V. Storniolo, Aditi Shendre, Lifang Hou, Steve Horvath, Yunlong Liu, Chi Wang and Chunyan He

    Citation: Clinical Epigenetics 2020 12:45

    Content type: Research

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