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Research
Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findi...
Clinical Epigenetics 2017 9:79
Published on: 3 August 2017
Review
Systemic lupus erythematosus (SLE) is a chronic relapsing–remitting autoimmune disease with highly heterogeneous phenotypes. Biomarkers with high sensitivity and specificity are useful for early diagnosis as w...
Clinical Epigenetics 2017 9:78
Published on: 2 August 2017
Research
Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate th...
Clinical Epigenetics 2017 9:77
Published on: 2 August 2017
Erratum
Clinical Epigenetics 2017 9:76
Published on: 27 July 2017
The original article was published in Clinical Epigenetics 2017 9:25
Methodology
Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the ...
Clinical Epigenetics 2017 9:75
Published on: 25 July 2017
Research
Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12...
Clinical Epigenetics 2017 9:74
Published on: 24 July 2017
Research
Most DNA cancer methylation markers are based on the transcriptional regulation of the promoter-gene relationship. Recently, the importance of long-range interactions between distal CpGs and target genes has b...
Clinical Epigenetics 2017 9:73
Published on: 24 July 2017
Research
The aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopatholog...
Clinical Epigenetics 2017 9:72
Published on: 21 July 2017
Research
Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA...
Clinical Epigenetics 2017 9:71
Published on: 18 July 2017
Methodology
The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic ma...
Clinical Epigenetics 2017 9:70
Published on: 14 July 2017
Methodology
Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could not only represent useful biomarkers but also suggest possible targetable ...
Clinical Epigenetics 2017 9:69
Published on: 11 July 2017
Research
The BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critic...
Clinical Epigenetics 2017 9:68
Published on: 30 June 2017
Review
Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and ...
Clinical Epigenetics 2017 9:67
Published on: 29 June 2017
Research
Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...
Clinical Epigenetics 2017 9:66
Published on: 21 June 2017
Research
Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...
Clinical Epigenetics 2017 9:65
Published on: 13 June 2017
Research
This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 ex...
Clinical Epigenetics 2017 9:64
Published on: 12 June 2017
Research
Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environm...
Clinical Epigenetics 2017 9:63
Published on: 8 June 2017
Research
Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, co...
Clinical Epigenetics 2017 9:62
Published on: 8 June 2017
Research
Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby...
Clinical Epigenetics 2017 9:60
Published on: 2 June 2017
Research
Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not bee...
Clinical Epigenetics 2017 9:61
Published on: 2 June 2017
Research
In chronic lymphocytic leukemia (CLL), epigenomic and genomic studies have expanded the existing knowledge about the disease biology and led to the identification of potential biomarkers relevant for implement...
Clinical Epigenetics 2017 9:57
Published on: 30 May 2017
Review
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for c...
Clinical Epigenetics 2017 9:59
Published on: 30 May 2017
Research
Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulm...
Clinical Epigenetics 2017 9:56
Published on: 30 May 2017
Research
Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LIN...
Clinical Epigenetics 2017 9:58
Published on: 30 May 2017
Research
Two molecular pathways promote the development of colorectal cancer (CRC). One is termed “microsatellite stable” (MSS) whereas the other is characterized by “microsatellite instability” (MSI or MIN). In additi...
Clinical Epigenetics 2017 9:55
Published on: 18 May 2017
