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  1. Content type: Research

    Drawing the epigenome landscape of Alzheimer’s disease (AD) still remains a challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD, we profiled genome-wide DNA methylation lev...

    Authors: Miren Altuna, Amaya Urdánoz-Casado, Javier Sánchez-Ruiz de Gordoa, María V. Zelaya, Alberto Labarga, Julie M. J. Lepesant, Miren Roldán, Idoia Blanco-Luquin, Álvaro Perdones, Rosa Larumbe, Ivonne Jericó, Carmen Echavarri, Iván Méndez-López, Luisa Di Stefano and Maite Mendioroz

    Citation: Clinical Epigenetics 2019 11:91

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  2. Content type: Research

    Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresen...

    Authors: Cheng Liu, Lochlan J. Fennell, Mark L. Bettington, Neal I. Walker, Joel Dwine, Barbara A. Leggett and Vicki L. J. Whitehall

    Citation: Clinical Epigenetics 2019 11:90

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  3. Content type: Research

    Cardiac disease modelling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) requires thorough insight into cardiac cell type differentiation processes. However, current methods to dis...

    Authors: Kirstin Hoff, Marta Lemme, Anne-Karin Kahlert, Kerstin Runde, Enrique Audain, Dorit Schuster, Jens Scheewe, Tim Attmann, Thomas Pickardt, Almuth Caliebe, Reiner Siebert, Hans-Heiner Kramer, Hendrik Milting, Arne Hansen, Ole Ammerpohl and Marc-Phillip Hitz

    Citation: Clinical Epigenetics 2019 11:89

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  4. Content type: Research

    To evaluate the association of early-life exposure to the Chinese Great Famine (1959–1961) with DNA methylation in IGF2 and its subsequent influence on blood lipid levels in late adulthood among participants of t...

    Authors: Luqi Shen, Changwei Li, Zhenghe Wang, Ruiyuan Zhang, Ye Shen, Toni Miles, Jingkai Wei and Zhiyong Zou

    Citation: Clinical Epigenetics 2019 11:88

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  5. Content type: Research

    Numerous studies have demonstrated that DNA methylation levels in the aryl hydrocarbon receptor repressor (AHRR) gene measured in cord blood are significantly associated with prenatal tobacco smoke exposure and c...

    Authors: Matthew A. Bergens, Gary S. Pittman, Isabel J. B. Thompson, Michelle R. Campbell, Xuting Wang, Cathrine Hoyo and Douglas A. Bell

    Citation: Clinical Epigenetics 2019 11:87

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  6. Content type: Research

    Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA m...

    Authors: Lara Kular, Maria Needhamsen, Milena Z. Adzemovic, Tatiana Kramarova, David Gomez-Cabrero, Ewoud Ewing, Eliane Piket, Jesper Tegnér, Stephan Beck, Fredrik Piehl, Lou Brundin and Maja Jagodic

    Citation: Clinical Epigenetics 2019 11:86

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  7. Content type: Research

    Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitu...

    Authors: Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng and Shiow-Lin Pan

    Citation: Clinical Epigenetics 2019 11:85

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  8. Content type: Research

    Hypertension is one of primary clinical presentations of pre-eclampsia. The occurrence and progress of hypertension are closely related to vascular dysfunction. However, information is limited regarding the pa...

    Authors: Qinqin Gao, Xiaorong Fan, Ting Xu, Huan Li, Yun He, Yuxian Yang, Jie Chen, Hongmei Ding, Jianying Tao and Zhice Xu

    Citation: Clinical Epigenetics 2019 11:84

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  9. Content type: Research

    Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting altera...

    Authors: Tobias Wiechmann, Simone Röh, Susann Sauer, Darina Czamara, Janine Arloth, Maik Ködel, Madita Beintner, Lisanne Knop, Andreas Menke, Elisabeth B. Binder and Nadine Provençal

    Citation: Clinical Epigenetics 2019 11:83

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  10. Content type: Review

    The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of thei...

    Authors: Annalisa Roberti, Adolfo F. Valdes, Ramón Torrecillas, Mario F. Fraga and Agustin F. Fernandez

    Citation: Clinical Epigenetics 2019 11:81

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  11. Content type: Research

    DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyse...

    Authors: Yujie He, Lot D. de Witte, Lotte C. Houtepen, Danny M. Nispeling, Zhida Xu, Qiong Yu, Yaqin Yu, Elly M. Hol, René S. Kahn and Marco P. Boks

    Citation: Clinical Epigenetics 2019 11:80

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  12. Content type: Review

    Circadian rhythms orchestrate crucial physiological functions and behavioral aspects around a day in almost all living forms. The circadian clock is a time tracking system that permits organisms to predict and...

    Authors: Ignacio Pacheco-Bernal, Fernando Becerril-Pérez and Lorena Aguilar-Arnal

    Citation: Clinical Epigenetics 2019 11:79

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  13. Content type: Review

    Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the ...

    Authors: Simin Tang, Jun Zhou, Huan Jing, Meijuan Liao, Sen Lin, Zhenxing Huang, Teng Huang, Jiying Zhong and HanbingWang

    Citation: Clinical Epigenetics 2019 11:78

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  14. Content type: Research

    TP53 is frequently mutated across various tissue types of cancers. In normal cells, long interspersed nuclear element-1 (LINE-1, L1) is mostly repressed by DNA methylation in its 5′ untranslated region but is act...

    Authors: Yun-Joo Shin, Younghoon Kim, Xianyu Wen, Nam-Yun Cho, Sun Lee, Woo Ho Kim and Gyeong Hoon Kang

    Citation: Clinical Epigenetics 2019 11:77

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  15. Content type: Research

    To identify novel epigenetic signatures that could provide predictive information that is complementary to promoter methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene for predicting ...

    Authors: An-An Yin, Ya-Long He, Amandine Etcheverry, Yu-He Liu, Marc Aubry, Jill Barnholtz-Sloan, Bo-Lin Liu, Jean Mosser, Zi-Fan Lu and Xiang Zhang

    Citation: Clinical Epigenetics 2019 11:76

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  16. Content type: Research

    Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a predicted transcription factor with potential role in hematopoietic development. Recent evidence linked low methylation level of ZBTB12 exon1 to myoc...

    Authors: Fabrizia Noro, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello and Benedetta Izzi

    Citation: Clinical Epigenetics 2019 11:74

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  17. Content type: Research

    Obstetric complications have long been retrospectively associated with a wide range of short- and long-term health consequences, including neurodevelopmental alterations such as those observed in schizophrenia...

    Authors: Helena Palma-Gudiel, Elisenda Eixarch, Fátima Crispi, Sebastián Morán, Anthony S. Zannas and Lourdes Fañanás

    Citation: Clinical Epigenetics 2019 11:73

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  18. Content type: Research

    Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apopto...

    Authors: Yun Huang, Aiguo Ren, Linlin Wang, Lei Jin, Shanshan Lin, Zhiwen Li and Jasmine A. McDonald

    Citation: Clinical Epigenetics 2019 11:72

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  19. Content type: Research

    miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic mi...

    Authors: Zhenhai Li, Kwan Yeung Wong, George A. Calin, Wee-Joo Chng, Godfrey Chi-fung Chan and Chor Sang Chim

    Citation: Clinical Epigenetics 2019 11:71

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  20. Content type: Research

    Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvem...

    Authors: Takeshi Niinuma, Hiroshi Kitajima, Masahiro Kai, Eiichiro Yamamoto, Akira Yorozu, Kazuya Ishiguro, Hajime Sasaki, Gota Sudo, Mutsumi Toyota, Tomo Hatahira, Reo Maruyama, Takashi Tokino, Hiroshi Nakase, Tamotsu Sugai and Hiromu Suzuki

    Citation: Clinical Epigenetics 2019 11:70

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  21. Content type: Research

    DNA methylation is associated with cancer, metabolic, neurological, and autoimmune disorders. Hypomethylation of aryl hydrocarbon receptor repressor (AHRR) especially at cg05575921 is associated with smoking a...

    Authors: Disline Manli Tantoh, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Chin Lin, Hou-Wei Chu, Pei-Hsin Chen, Shu-Yi Hsu, Wen-Hsiu Liu, Chen-Chang Ho, Chia-Chi Lung, Ming-Fang Wu, Yi-Ching Liaw, Tonmoy Debnath and Yung-Po Liaw

    Citation: Clinical Epigenetics 2019 11:69

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  22. Content type: Research

    DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enha...

    Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi…

    Citation: Clinical Epigenetics 2019 11:68

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  23. Content type: Research

    Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the ...

    Authors: Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende…

    Citation: Clinical Epigenetics 2019 11:67

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  24. Content type: Research

    It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, ...

    Authors: Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemaker, Nick Orr, Katarzyna Tomczyk…

    Citation: Clinical Epigenetics 2019 11:66

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  25. Content type: Research

    Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quanti...

    Authors: Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger and Gabriela Aust

    Citation: Clinical Epigenetics 2019 11:65

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  26. Content type: Research

    ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation...

    Authors: Eric G. Bend, Erfan Aref-Eshghi, David B. Everman, R. Curtis Rogers, Sara S. Cathey, Eloise J. Prijoles, Michael J. Lyons, Heather Davis, Katie Clarkson, Karen W. Gripp, Dong Li, Elizabeth Bhoj, Elaine Zackai, Paul Mark, Hakon Hakonarson, Laurie A. Demmer…

    Citation: Clinical Epigenetics 2019 11:64

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  27. Content type: Research

    Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosi...

    Authors: Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou and Song-Mei Liu

    Citation: Clinical Epigenetics 2019 11:63

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  28. Content type: Review

    Ageing is one of the principal risk factors for many chronic diseases. However, there is considerable between-person variation in the rate of ageing and individual differences in their susceptibility to diseas...

    Authors: Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Michael E. Ernst and Joanne Ryan

    Citation: Clinical Epigenetics 2019 11:62

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  29. Content type: Research

    Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing t...

    Authors: Pooja Sagvekar, Pankaj Kumar, Vijay Mangoli, Sadhana Desai and Srabani Mukherjee

    Citation: Clinical Epigenetics 2019 11:61

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  30. Content type: Research

    Congenital malformations associated with maternal uniparental disomy of chromosome 16, upd(16)mat, resemble those observed in newborns with the lethal developmental lung disease, alveolar capillary dysplasia w...

    Authors: Katharina V. Schulze, Przemyslaw Szafranski, Harry Lesmana, Robert J. Hopkin, Aaron Hamvas, Jennifer A. Wambach, Marwan Shinawi, Gladys Zapata, Claudia M. B. Carvalho, Qian Liu, Justyna A. Karolak, James R. Lupski, Neil A. Hanchard and Paweł Stankiewicz

    Citation: Clinical Epigenetics 2019 11:60

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  31. Content type: Research

    Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood b...

    Authors: Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic II, Christine A. Iacobuzio-Donahue…

    Citation: Clinical Epigenetics 2019 11:59

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  32. Content type: Research

    Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predic...

    Authors: Paula S. Ramos, Kip D. Zimmerman, Sandra Haddad, Carl D. Langefeld, Thomas A. Medsger Jr and Carol A. Feghali-Bostwick

    Citation: Clinical Epigenetics 2019 11:58

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  33. Content type: Methodology

    There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We inves...

    Authors: F. Perrier, V. Viallon, S. Ambatipudi, A. Ghantous, C. Cuenin, H. Hernandez-Vargas, V. Chajès, L. Baglietto, M. Matejcic, H. Moreno-Macias, T. Kühn, H. Boeing, A. Karakatsani, A. Kotanidou, A. Trichopoulou, S. Sieri…

    Citation: Clinical Epigenetics 2019 11:57

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  34. Content type: Research

    Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with c...

    Authors: Andres Cardenas, Sabrina Faleschini, Andrea Cortes Hidalgo, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Dawn L. DeMeo, Augusto A. Litonjua, Alexander Neumann, Janine F. Felix, Vincent W. V. Jaddoe, Hanan El Marroun, Henning Tiemeier, Emily Oken, Marie-France Hivert and Heather H. Burris

    Citation: Clinical Epigenetics 2019 11:56

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  35. Content type: Review

    Epigenetics is defined as the science that studies the modifications of gene expression that are not owed to mutations or changes in the genetic sequence. Recently, strong evidences are pinpointing toward a so...

    Authors: Zeina Nehme, Sébastien Pasquereau and Georges Herbein

    Citation: Clinical Epigenetics 2019 11:55

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  36. Content type: Research

    Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifical...

    Authors: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner and Bharati Bapat

    Citation: Clinical Epigenetics 2019 11:54

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  37. Content type: Research

    Beckwith-Wiedemann syndrome (BWS) is caused due to the disturbance of imprinted genes at chromosome 11p15. The molecular confirmation of this syndrome is possible in approximately 85% of the cases, whereas in ...

    Authors: I. M. Krzyzewska, M. Alders, S. M. Maas, J. Bliek, A. Venema, P. Henneman, F. I. Rezwan, K. v. d. Lip, A. N. Mul, D. J. G. Mackay and M. M. A. M. Mannens

    Citation: Clinical Epigenetics 2019 11:53

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  38. Content type: Research

    Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distingu...

    Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove and Katie Lunnon

    Citation: Clinical Epigenetics 2019 11:52

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  39. Content type: Research

    Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is signifi...

    Authors: Yoon Dae Han, Tae Jeong Oh, Tae-Ha Chung, Hui Won Jang, Youn Nam Kim, Sungwhan An and Nam Kyu Kim

    Citation: Clinical Epigenetics 2019 11:51

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  40. Content type: Research

    The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evide...

    Authors: Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z. Ratajczak and Gabriela Schneider

    Citation: Clinical Epigenetics 2019 11:50

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  41. Content type: Research

    Major challenges in understanding the functional consequences of genetic risk factors for human disease are which tissues and cell types are affected and the limited availability of suitable tissue. The aim of...

    Authors: Sally Mortlock, Restuadi Restuadi, Rupert Levien, Jane E. Girling, Sarah J. Holdsworth-Carson, Martin Healey, Zhihong Zhu, Ting Qi, Yang Wu, Samuel W. Lukowski, Peter A. W. Rogers, Jian Yang, Allan F. McRae, Jenny N. Fung and Grant W. Montgomery

    Citation: Clinical Epigenetics 2019 11:49

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  42. Content type: Research

    Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific i...

    Authors: Qing-Lan Li, Dan-Ya Wang, Lin-Gao Ju, Jie Yao, Chuan Gao, Pin-Ji Lei, Lian-Yun Li, Xiao-Lu Zhao and Min Wu

    Citation: Clinical Epigenetics 2019 11:48

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  43. Content type: Correction

    Following publication of the original article [1], the author reported the title of this article has been misspelled.

    Authors: Paula Walle, Ville Männistö, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling and Jussi Pihlajamäki

    Citation: Clinical Epigenetics 2019 11:47

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    The original article was published in Clinical Epigenetics 2019 11:10

  44. Content type: Research

    Both SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The ...

    Authors: Disline Manli Tantoh, Ming-Fang Wu, Chien-Chang Ho, Chia-Chi Lung, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Shu-Yi Hsu, Pei-Hsin Chen, Chin Lin, Hou-Wei Chu, Yi-Ching Liaw and Yung-Po Liaw

    Citation: Clinical Epigenetics 2019 11:46

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  45. Content type: Research

    Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we char...

    Authors: Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A. Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G. Mohile, Christine B. Ambrosone, Song Liu and Michelle C. Janelsins

    Citation: Clinical Epigenetics 2019 11:45

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  46. Content type: Research

    Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory f...

    Authors: Pei Du, Keqin Gao, Yu Cao, Shuang Yang, Yang Wang, Ren Guo, Ming Zhao and Sujie Jia

    Citation: Clinical Epigenetics 2019 11:44

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  47. Content type: Short report

    The human chromosome 14q32.2 imprinted region harbors the primary MEG3/DLK1:IG-differentially methylated region (DMR) and secondary MEG3:TSS-DMR. The MEG3:TSS-DMR can remain unmethylated only in the presence of u...

    Authors: Masayo Kagami, Atsuhiro Yanagisawa, Miyuki Ota, Kentaro Matsuoka, Akie Nakamura, Keiko Matsubara, Kazuhiko Nakabayashi, Shuji Takada, Maki Fukami and Tsutomu Ogata

    Citation: Clinical Epigenetics 2019 11:42

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