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Cancer Epigenetics - Solid Tumors

Section information

Section Editors : Maria Berdasco and Carmen Jeronimo 

Associate Editors : Nita Ahuja, Tiziana Bonaldi (histones), Rene Cortese, James Flanagan (cervical/ovarian), Mario Fraga, Michéle Hoffmann (prostate), Bozena Kaminska (gliomas), Gwen Lomberk, Arpad Patai (colorectal/GI cancers), Qian Tao, Raul Urrutia, Stefan Wiemann (breast), Keishi Yamashita

The development of genome-wide techniques has rapidly improved the comprehensive knowledge of epigenetic alterations in cancer. Currently, a vast number of genes and their associated molecular pathways that show epigenetic differences between normal and tumoral cells have been identified, emphasizing the crucial role of epigenetic factors in cancer etiology and progression.  This section publishes original epigenetic research focused on the identification of epigenetic biomarkers associated with cancer diagnosis or tumor progression. Manuscripts on epigenetic biomarkers leading to a better definition of therapy response are also accepted (pharmacoepigenetics). Submissions on reports from human clinical trials providing insights on the clinical application of epigenetic biomarkers are welcomed.

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  1. Glial cells in the central nervous system play a key role in neuroinflammation and subsequent central sensitization to pain. They are therefore involved in the development of persistent pain. One of the main s...

    Authors: Dario Kringel, Mari A. Kaunisto, Eija Kalso and Jörn Lötsch
    Citation: Clinical Epigenetics 2019 11:167
  2. Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules wh...

    Authors: Dörte Nitschkowski, Sebastian Marwitz, Sousana A. Kotanidou, Martin Reck, Christian Kugler, Klaus F. Rabe, Ole Ammerpohl and Torsten Goldmann
    Citation: Clinical Epigenetics 2019 11:157
  3. Aberrant DNA methylation is involved in gastric carcinogenesis and may serve as a useful biomarker in the diagnosis and detection of gastric cancer (GC) recurrence.

    Authors: Wen-Liang Fang, Ming-Huang Chen, Kuo-Hung Huang, Shih-Ching Chang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu and Yi-Ming Shyr
    Citation: Clinical Epigenetics 2019 11:154
  4. Men often undergo repeat prostate biopsies because of suspicion of missed cancer. We assessed if (i) methylation of selected genes in prostate tissue vary with aging and (ii) methylation alterations in repeat ...

    Authors: Valentina Fiano, Daniela Zugna, Chiara Grasso, Morena Trevisan, Luisa Delsedime, Luca Molinaro, Paola Cassoni, Mauro Papotti, Franco Merletti, Olof Akre, Andreas Pettersson, Laura De Marco and Lorenzo Richiardi
    Citation: Clinical Epigenetics 2019 11:152
  5. The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not progress to aggressive stages, may be ...

    Authors: Reka Toth, Heiko Schiffmann, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Sören Weidemann, Patrick Lebok, Christoph Fraune, Sarah Minner, Thorsten Schlomm, Guido Sauter, Christoph Plass, Yassen Assenov, Ronald Simon, Jan Meiners and Clarissa Gerhäuser
    Citation: Clinical Epigenetics 2019 11:148
  6. Current diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, resulting in overdiagnosis and overtreatment of clinically insignificant tumors. Thus, to improve the management of PC, novel bi...

    Authors: Maibritt Nørgaard, Christa Haldrup, Marianne Trier Bjerre, Søren Høyer, Benedicte Ulhøi, Michael Borre and Karina D. Sørensen
    Citation: Clinical Epigenetics 2019 11:147
  7. The two most common repetitive elements (REs) in humans, long interspersed nuclear element-1 (LINE-1) and Alu element (Alu), have been linked to various cancers. Hepatitis C virus (HCV) may cause hepatocellula...

    Authors: Yinan Zheng, Ryan A. Hlady, Brian T. Joyce, Keith D. Robertson, Chunyan He, Drew R. Nannini, Warren A. Kibbe, Chad J. Achenbach, Robert L. Murphy, Lewis R. Roberts and Lifang Hou
    Citation: Clinical Epigenetics 2019 11:145
  8. Vigilant management of women with high-risk human papillomavirus (hrHPV) is necessary in cancer screening programs. To this end, we evaluated the performance of S5 (targeting DNA methylation in HPV16, HPV18, H...

    Authors: Rubí Hernández-López, Attila T. Lorincz, Leticia Torres-Ibarra, Caroline Reuter, Dorota Scibior-Bentkowska, Rhian Warman, Belinda Nedjai, Indira Mendiola-Pastrana, Leith León-Maldonado, Berenice Rivera-Paredez, Paula Ramírez-Palacios, Eduardo Lazcano-Ponce, Jack Cuzick and Jorge Salmerón
    Citation: Clinical Epigenetics 2019 11:140
  9. Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorde...

    Authors: Oxana Bereshchenko, Oriana Lo Re, Fedor Nikulenkov, Sara Flamini, Jana Kotaskova, Tommaso Mazza, Marguerite-Marie Le Pannérer, Marcus Buschbeck, Cesarina Giallongo, Giuseppe Palumbo, Giovanni Li Volti, Valerio Pazienza, Libor Cervinek, Carlo Riccardi, Lumir Krejci, Sarka Pospisilova…
    Citation: Clinical Epigenetics 2019 11:121
  10. Cervical cancer screening by combined cytology and HPV test has reduced the incidence of cervical cancer, but cytological screening lacks a higher sensitivity while HPV testing possesses a lower specificity. M...

    Authors: Xinlin Jiao, Siying Zhang, Jun Jiao, Teng Zhang, Wenjie Qu, Guy Mutangala Muloye, Beihua Kong, Qing Zhang and Baoxia Cui
    Citation: Clinical Epigenetics 2019 11:120
  11. Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atyp...

    Authors: Malgorzata Pienkowska, Sanaa Choufani, Andrei L. Turinsky, Tanya Guha, Diana M. Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard J. Gilbertson, Jonathan L. Finlay, Nada Jabado, Christian Thomas…
    Citation: Clinical Epigenetics 2019 11:117

    The Correction to this article has been published in Clinical Epigenetics 2019 11:144

  12. Significant numbers of prostate cancer (PCa) patients experience tumour upstaging and upgrading in surgical specimens that cause serious problems in timely and proper selection of the treatment strategy. This ...

    Authors: Arnas Bakavicius, Kristina Daniunaite, Kristina Zukauskaite, Marija Barisiene, Sonata Jarmalaite and Feliksas Jankevicius
    Citation: Clinical Epigenetics 2019 11:115
  13. Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more general...

    Authors: Euan J. Rodger, Aniruddha Chatterjee, Peter A. Stockwell and Michael R. Eccles
    Citation: Clinical Epigenetics 2019 11:114
  14. Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- and γ-PCDH. The expression of this cluster consists of a complex mechanism involving DNA hub...

    Authors: Ana Florencia Vega-Benedetti, Eleonora Loi, Loredana Moi, Sylvain Blois, Antonio Fadda, Manila Antonelli, Antonella Arcella, Manuela Badiali, Felice Giangaspero, Isabella Morra, Amedeo Columbano, Angelo Restivo, Luigi Zorcolo, Viviana Gismondi, Liliana Varesco, Sara Erika Bellomo…
    Citation: Clinical Epigenetics 2019 11:100
  15. Prostate cancer (PC) is a commonly diagnosed malignancy in males, especially in the western hemisphere. The extensive use of multiple biomarkers plays an important role in the diagnosis and prognosis of PC. Ho...

    Authors: Xin Li, Wanfeng Zhang, Jing Song, Xianqin Zhang, Longke Ran and Yunfeng He
    Citation: Clinical Epigenetics 2019 11:99
  16. Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide, and deciphering underlying molecular mechanism is essential. The loss of monoubiquitinated histone H2B (H2Bub1) was corre...

    Authors: Deborah Schneider, Robert Lorenz Chua, Nicole Molitor, Feda H. Hamdan, Eva Maria Rettenmeier, Evangelos Prokakis, Vivek Kumar Mishra, Vijayalakshmi Kari, Florian Wegwitz, Steven A. Johnsen and Robyn Laura Kosinsky
    Citation: Clinical Epigenetics 2019 11:98
  17. ARID1A (AT-rich interactive domain-containing protein 1A) is a subunit of the BAF chromatin remodeling complex and plays roles in transcriptional regulation and DNA damage response. Mutations in ARID1A that lead ...

    Authors: Madhobi Sen, Xin Wang, Feda H. Hamdan, Jacobe Rapp, Jessica Eggert, Robyn Laura Kosinsky, Florian Wegwitz, Ana Patricia Kutschat, Fereshteh S. Younesi, Jochen Gaedcke, Marian Grade, Elisabeth Hessmann, Argyris Papantonis, Philipp Strӧbel and Steven A. Johnsen
    Citation: Clinical Epigenetics 2019 11:92
  18. Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresen...

    Authors: Cheng Liu, Lochlan J. Fennell, Mark L. Bettington, Neal I. Walker, Joel Dwine, Barbara A. Leggett and Vicki L. J. Whitehall
    Citation: Clinical Epigenetics 2019 11:90
  19. TP53 is frequently mutated across various tissue types of cancers. In normal cells, long interspersed nuclear element-1 (LINE-1, L1) is mostly repressed by DNA methylation in its 5′ untranslated region but is act...

    Authors: Yun-Joo Shin, Younghoon Kim, Xianyu Wen, Nam-Yun Cho, Sun Lee, Woo Ho Kim and Gyeong Hoon Kang
    Citation: Clinical Epigenetics 2019 11:77
  20. To identify novel epigenetic signatures that could provide predictive information that is complementary to promoter methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene for predicting ...

    Authors: An-An Yin, Ya-Long He, Amandine Etcheverry, Yu-He Liu, Marc Aubry, Jill Barnholtz-Sloan, Bo-Lin Liu, Jean Mosser, Zi-Fan Lu and Xiang Zhang
    Citation: Clinical Epigenetics 2019 11:76
  21. miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic mi...

    Authors: Zhenhai Li, Kwan Yeung Wong, George A. Calin, Wee-Joo Chng, Godfrey Chi-fung Chan and Chor Sang Chim
    Citation: Clinical Epigenetics 2019 11:71
  22. Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvem...

    Authors: Takeshi Niinuma, Hiroshi Kitajima, Masahiro Kai, Eiichiro Yamamoto, Akira Yorozu, Kazuya Ishiguro, Hajime Sasaki, Gota Sudo, Mutsumi Toyota, Tomo Hatahira, Reo Maruyama, Takashi Tokino, Hiroshi Nakase, Tamotsu Sugai and Hiromu Suzuki
    Citation: Clinical Epigenetics 2019 11:70
  23. DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enha...

    Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi…
    Citation: Clinical Epigenetics 2019 11:68

    The Correction to this article has been published in Clinical Epigenetics 2022 14:119

  24. Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the ...

    Authors: Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende…
    Citation: Clinical Epigenetics 2019 11:67
  25. It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, ...

    Authors: Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemaker, Nick Orr, Katarzyna Tomczyk…
    Citation: Clinical Epigenetics 2019 11:66
  26. Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quanti...

    Authors: Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger and Gabriela Aust
    Citation: Clinical Epigenetics 2019 11:65
  27. Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood b...

    Authors: Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic II, Christine A. Iacobuzio-Donahue…
    Citation: Clinical Epigenetics 2019 11:59
  28. Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifical...

    Authors: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner and Bharati Bapat
    Citation: Clinical Epigenetics 2019 11:54
  29. Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is signifi...

    Authors: Yoon Dae Han, Tae Jeong Oh, Tae-Ha Chung, Hui Won Jang, Youn Nam Kim, Sungwhan An and Nam Kyu Kim
    Citation: Clinical Epigenetics 2019 11:51
  30. The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evide...

    Authors: Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z. Ratajczak and Gabriela Schneider
    Citation: Clinical Epigenetics 2019 11:50
  31. Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific i...

    Authors: Qing-Lan Li, Dan-Ya Wang, Lin-Gao Ju, Jie Yao, Chuan Gao, Pin-Ji Lei, Lian-Yun Li, Xiao-Lu Zhao and Min Wu
    Citation: Clinical Epigenetics 2019 11:48
  32. Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we char...

    Authors: Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A. Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G. Mohile, Christine B. Ambrosone, Song Liu and Michelle C. Janelsins
    Citation: Clinical Epigenetics 2019 11:45
  33. Epigenetic alternation is a common contributing factor to neoplastic transformation. Although previous studies have reported a cluster of aberrant promoter methylation changes associated with silencing of tumo...

    Authors: Simeng Gu, Shujuan Lin, Ding Ye, Sangni Qian, Danjie Jiang, Xiaocong Zhang, Qilong Li, Jinhua Yang, Xiaojiang Ying, Zhenjun Li, Mengling Tang, Jianbing Wang, Mingjuan Jin and Kun Chen
    Citation: Clinical Epigenetics 2019 11:41
  34. Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct epithelial cell lining. The misdiagnosis of CCA and other biliary diseases may occur due to the similarity of clinical manifestations and blood tests...

    Authors: Wiphawan Wasenang, Ponlatham Chaiyarit, Siriporn Proungvitaya and Temduang Limpaiboon
    Citation: Clinical Epigenetics 2019 11:39
  35. The current prognosis of thymic epithelial tumors (TETs) is according to the World Health Organization (WHO) histologic classification and the Masaoka staging system. These methods of prognosis have certain li...

    Authors: Songlin Li, Yuan Yuan, He Xiao, Jiajia Dai, Yunfei Ye, Qin Zhang, Zhimin Zhang, Yuhan Jiang, Jia Luo, Jing Hu, Chuan Chen and Ge Wang
    Citation: Clinical Epigenetics 2019 11:38
  36. Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) varies between 30 and 40% approximately. To provide further insight into the prediction of pCR,...

    Authors: Begoña Pineda, Angel Diaz-Lagares, José Alejandro Pérez-Fidalgo, Octavio Burgués, Inés González-Barrallo, Ana B. Crujeiras, Juan Sandoval, Manel Esteller, Ana Lluch and Pilar Eroles
    Citation: Clinical Epigenetics 2019 11:33
  37. Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid perox...

    Authors: Xīn Gào, Yan Zhang, Barbara Burwinkel, Yang Xuan, Bernd Holleczek, Hermann Brenner and Ben Schöttker
    Citation: Clinical Epigenetics 2019 11:14
  38. Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D inv...

    Authors: Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant and Paola B. Arimondo
    Citation: Clinical Epigenetics 2019 11:9
  39. Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me ha...

    Authors: Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz and Steven A. Johnsen
    Citation: Clinical Epigenetics 2019 11:4
  40. Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randoml...

    Authors: Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A. Pantaleo…
    Citation: Clinical Epigenetics 2019 11:2
  41. Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. H...

    Authors: Qiumei Yao, Gareth J. Morgan and Chor Sang Chim
    Citation: Clinical Epigenetics 2018 10:158
  42. Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication d...

    Authors: Xin Sun, Vijesh Vaghjiani, W. Samantha N. Jayasekara, Jason E. Cain and Justin C. St. John
    Citation: Clinical Epigenetics 2018 10:157
  43. The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown.

    Authors: Yue Hu, Mingrui Dai, Yayuan Zheng, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu and Xianghui Yu
    Citation: Clinical Epigenetics 2018 10:154
  44. B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targ...

    Authors: Rui Deng, Peng Zhang, Weizhen Liu, Xiangyu Zeng, Xianxiong Ma, Liang Shi, Tao Wang, Yuping Yin, Weilong Chang, Pei Zhang, Guobin Wang and Kaixiong Tao
    Citation: Clinical Epigenetics 2018 10:153
  45. Imprinted genes are regulated by DNA methylation at imprinting-associated differentially methylated regions (iDMRs). Abnormal expression of imprinted genes is implicated in imprinting disorders and tumors. In ...

    Authors: Hidenori Hidaka, Ken Higashimoto, Saori Aoki, Hiroyuki Mishima, Chisa Hayashida, Toshiyuki Maeda, Yasuo Koga, Hitomi Yatsuki, Keiichiro Joh, Hirokazu Noshiro, Ryuichi Iwakiri, Atsushi Kawaguchi, Koh-ichiro Yoshiura, Kazuma Fujimoto and Hidenobu Soejima
    Citation: Clinical Epigenetics 2018 10:150
  46. Prevention of unnecessary biopsies and overtreatment of indolent disease remains a challenge in the management of prostate cancer. Novel non-invasive tests that can identify clinically significant (intermediat...

    Authors: Fang Zhao, Ekaterina Olkhov-Mitsel, Shivani Kamdar, Renu Jeyapala, Julia Garcia, Rachel Hurst, Marcelino Yazbek Hanna, Robert Mills, Alexandra V. Tuzova, Eve O’Reilly, Sarah Kelly, Colin Cooper, Daniel Brewer, Antoinette S. Perry, Jeremy Clark, Neil Fleshner…
    Citation: Clinical Epigenetics 2018 10:147