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Aging and Development Epigenetics

Section information

Section Editor: Akihiro Umezawa

Associate Editors: Sara Hägg, Monika Puzianowska-Kuznicka, Koichiro Nishino, Wolfgang Wagner

This section features innovative discoveries that focus on the epigenetics of aging and development brought about through in vivo, in vitro, and clinical studies. Recent findings have shed light on the important role of epigenetics in development and growing evidence supports its link to aging as well. Reports on epigenetics of prenatal and postnatal development such as imprinting genes and gene silencing of maternal or paternal alleles also affect the phenotype/rate of aging after birth are considered. This section aims to publish original works that elucidate the underlying mechanisms and links between development and aging. Resource papers and basic science papers detailing biomarkers of these interdisciplinary fields can be considered if they are significant findings within the field. We ask that epigenetic raw data sets be deposited into public data bases.

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  1. Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2–8 % of all pregnancies. Although children born to women with preeclampsia h...

    Authors: Masako Suzuki, Ryo Maekawa, Nicole E. Patterson, David M. Reynolds, Brent R. Calder, Sandra E. Reznik, Hye J. Heo, Francine Hughes Einstein and John M. Greally
    Citation: Clinical Epigenetics 2016 8:67
  2. Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages ...

    Authors: Laura Perna, Yan Zhang, Ute Mons, Bernd Holleczek, Kai-Uwe Saum and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:64
  3. Multiple (epi)genetic defects affecting the expression of the imprinted genes within the 11p15.5 chromosomal region underlie Silver–Russell (SRS) and Beckwith–Wiedemann (BWS) syndromes. The molecular diagnosis...

    Authors: Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…
    Citation: Clinical Epigenetics 2016 8:23

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:40

  4. The epigenetic clock, in particular epigenetic pre-aging quantified by the so-called DNA methylation age acceleration, has recently been suggested to closely correlate with a variety of disease phenotypes. The...

    Authors: Lutz Philipp Breitling, Kai-Uwe Saum, Laura Perna, Ben Schöttker, Bernd Holleczek and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:21
  5. Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients is hampered by clinical and molecular diagnostic overlaps. The European Conso...

    Authors: Anne Rochtus, Alejandro Martin-Trujillo, Benedetta Izzi, Francesca Elli, Intza Garin, Agnes Linglart, Giovanna Mantovani, Guiomar Perez de Nanclares, Suzanne Thiele, Brigitte Decallonne, Chris Van Geet, David Monk and Kathleen Freson
    Citation: Clinical Epigenetics 2016 8:10
  6. Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years...

    Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine
    Citation: Clinical Epigenetics 2015 7:123

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:27

  7. The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and fem...

    Authors: Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta and Ivana Antonucci
    Citation: Clinical Epigenetics 2015 7:120
  8. Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes...

    Authors: Daniel Nätt, Ingela Johansson, Tomas Faresjö, Johnny Ludvigsson and Annika Thorsell
    Citation: Clinical Epigenetics 2015 7:91
  9. 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate o...

    Authors: Keiko Matsubara, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Maki Fukami, Tsutomu Ogata and Kazuki Yamazawa
    Citation: Clinical Epigenetics 2015 7:90
  10. Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes li...

    Authors: Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman and Patricia Fauque
    Citation: Clinical Epigenetics 2015 7:87
  11. Deleterious effects of prenatal tobacco smoking on fetal growth and newborn weight are well-established. One of the proposed mechanisms underlying this relationship is alterations in epigenetic programming. We...

    Authors: Marieke I. Bouwland-Both, Nina H. van Mil, Catharina P. Tolhoek, Lisette Stolk, Paul H. C. Eilers, Michael M. P. J. Verbiest, Bastiaan T. Heijmans, André G. Uitterlinden, Albert Hofman, Marinus H. van Ijzendoorn, Liesbeth Duijts, Johan C. de Jongste, Henning Tiemeier, Eric A. P. Steegers, Vincent W. V. Jaddoe and Régine P. M. Steegers-Theunissen
    Citation: Clinical Epigenetics 2015 7:83
  12. Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be se...

    Authors: Alexandra M. Binder, Jessica LaRocca, Corina Lesseur, Carmen J. Marsit and Karin B. Michels
    Citation: Clinical Epigenetics 2015 7:79