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  1. Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity m...

    Authors: Ji-Qing Chen, Lucas A. Salas, John K. Wiencke, Devin C. Koestler, Annette M. Molinaro, Angeline S. Andrew, John D. Seigne, Margaret R. Karagas, Karl T. Kelsey and Brock C. Christensen
    Citation: Clinical Epigenetics 2022 14:14
  2. Heart failure with preserved ejection fraction (HFpEF), affected collectively by genetic and environmental factors, is the common subtype of chronic heart failure. Although the available risk assessment method...

    Authors: Xuetong Zhao, Yang Sui, Xiuyan Ruan, Xinyue Wang, Kunlun He, Wei Dong, Hongzhu Qu and Xiangdong Fang
    Citation: Clinical Epigenetics 2022 14:11
  3. DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclero...

    Authors: Farah Ammous, Wei Zhao, Lisha Lin, Scott M. Ratliff, Thomas H. Mosley, Lawrence F. Bielak, Xiang Zhou, Patricia A. Peyser, Sharon L. R. Kardia and Jennifer A. Smith
    Citation: Clinical Epigenetics 2022 14:10
  4. DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, n...

    Authors: Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard and Maria Pino-Yanes
    Citation: Clinical Epigenetics 2022 14:9
  5. Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the hos...

    Authors: Boghuma K. Titanji, Marta Gwinn, Vincent C. Marconi and Yan V. Sun
    Citation: Clinical Epigenetics 2022 14:8
  6. Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resista...

    Authors: Garyfallia Pantelaiou-Prokaki, Iga Mieczkowska, Geske E. Schmidt, Sonja Fritzsche, Evangelos Prokakis, Julia Gallwas and Florian Wegwitz
    Citation: Clinical Epigenetics 2022 14:7
  7. The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk...

    Authors: Elie Antoun, Prachand Issarapu, Chiara di Gravio, Smeeta Shrestha, Modupeh Betts, Ayden Saffari, Sirazul A. Sahariah, Alagu Sankareswaran, Manisha Arumalla, Andrew M. Prentice, Caroline H. D. Fall, Matt J. Silver, Giriraj R. Chandak and Karen A. Lillycrop
    Citation: Clinical Epigenetics 2022 14:6
  8. Type II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late t...

    Authors: Melanie R. Müller, Aaron Burmeister, Margaretha A. Skowron, Alexa Stephan, Felix Bremmer, Gamal A. Wakileh, Patrick Petzsch, Karl Köhrer, Peter Albers and Daniel Nettersheim
    Citation: Clinical Epigenetics 2022 14:5
  9. High-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origi...

    Authors: Jaqueline Loaeza-Loaeza, Berenice Illades-Aguiar, Oscar del Moral-Hernández, Yaneth Castro-Coronel, Marco A. Leyva-Vázquez, Roberto Dircio-Maldonado, Julio Ortiz-Ortiz and Daniel Hernández-Sotelo
    Citation: Clinical Epigenetics 2022 14:4
  10. DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical ...

    Authors: Chaoyuan Kuang, Yongseok Park, Ryan C. Augustin, Yan Lin, Douglas J. Hartman, Lindsey Seigh, Reetesh K. Pai, Weijing Sun, Nathan Bahary, James Ohr, John C. Rhee, Stanley M. Marks, H. Scott Beasley, Yongli Shuai, James G. Herman, Hassane M. Zarour…
    Citation: Clinical Epigenetics 2022 14:3
  11. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop ...

    Authors: Jiewen Zhang, Junkui Shang, Fengyu Wang, Xuejing Huo, Ruihua Sun, Zhixia Ren, Wan Wang, Miaomiao Yang, Gai Li, Dandan Gao, Ruijie Liu, Pingping Bai, Shuyi Wang, Yanliang Wang and Xi Yan
    Citation: Clinical Epigenetics 2022 14:2
  12. Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age accel...

    Authors: Rhona A. Beynon, Suzanne M. Ingle, Ryan Langdon, Margaret May, Andy Ness, Richard M. Martin, Matthew Suderman, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Tim Waterboer, Michael Pawlita, Caroline Relton, George Davey Smith and Rebecca C. Richmond
    Citation: Clinical Epigenetics 2022 14:1
  13. Circulating tumor DNA (ctDNA) is a promising diagnostic and prognostic marker for many cancers and has been actively investigated in recent years. Previous studies have already demonstrated the potential use o...

    Authors: Wu-Hao Lin, Jian Xiao, Zi-Yi Ye, Da-Liang Wei, Xiao-Hui Zhai, Rui-Hua Xu, Zhao-Lei Zeng and Hui-Yan Luo
    Citation: Clinical Epigenetics 2021 13:232
  14. The role of breastfeeding in modulating epigenetic factors has been suggested as a possible mechanism conferring its benefits on child development but it lacks evidence. Using extensive DNA methylation data fr...

    Authors: Laurent Briollais, Denis Rustand, Catherine Allard, Yanyan Wu, Jingxiong Xu, Samyukta Govinda Rajan, Marie-France Hivert, Myriam Doyon, Luigi Bouchard, Patrick O. McGowan, Steven Matthews and Steven Lye
    Citation: Clinical Epigenetics 2021 13:231
  15. Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DN...

    Authors: Whitney L. Do, Steve Nguyen, Jie Yao, Xiuqing Guo, Eric A. Whitsel, Ellen Demerath, Jerome I. Rotter, Stephen S. Rich, Leslie Lange, Jingzhong Ding, David Van Den Berg, Yongmei Liu, Anne E. Justice, Weihua Guan, Steve Horvath, Themistocles L. Assimes…
    Citation: Clinical Epigenetics 2021 13:230
  16. The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to ...

    Authors: Fenglong Bie, He Tian, Nan Sun, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Yue Peng, Guangyu Bai, Bolun Zhou and Shugeng Gao
    Citation: Clinical Epigenetics 2021 13:229
  17. Dysregulation of fibroblast growth factor receptor (FGFR) signaling pathway has been observed in head and neck squamous cell carcinoma (HNSCC) and is a promising therapeutic target for selective tyrosine kinase i...

    Authors: Yilin Bao, Jennis Gabrielpillai, Jörn Dietrich, Romina Zarbl, Sebastian Strieth, Friederike Schröck and Dimo Dietrich
    Citation: Clinical Epigenetics 2021 13:228
  18. Women with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease ...

    Authors: Emily W. Harville, Pashupati P. Mishra, Mika Kähönen, Emma Raitoharju, Saara Marttila, Olli Raitakari and Terho Lehtimäki
    Citation: Clinical Epigenetics 2021 13:227
  19. Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient’s response to NAC are needed to individualise therapy and a...

    Authors: Braydon Meyer, Samuel Clifton, Warwick Locke, Phuc-Loi Luu, Qian Du, Dilys Lam, Nicola J. Armstrong, Beena Kumar, Niantao Deng, Kate Harvey, Alex Swarbrick, Vinod Ganju, Susan J. Clark, Ruth Pidsley and Clare Stirzaker
    Citation: Clinical Epigenetics 2021 13:226
  20. Deregulated methylation of tumor suppressor genes is a hallmark event in colorectal cancer (CRC) carcinogenesis. UNC5 receptors, down-regulated in various human malignancies due to epigenetic alterations, have be...

    Authors: Dong Dong, Runshi Zhang, Jie Shao, Aimin Zhang, Yichao Wang, Yunli Zhou and Yueguo Li
    Citation: Clinical Epigenetics 2021 13:225
  21. Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese br...

    Authors: Jamaji C. Nwanaji-Enwerem, Felicia Fei-Lei Chung, Lars Van der Laan, Alexei Novoloaca, Cyrille Cuenin, Harriet Johansson, Bernardo Bonanni, Alan E. Hubbard, Martyn T. Smith, Sheri J. Hartman, Andres Cardenas, Dorothy D. Sears and Zdenko Herceg
    Citation: Clinical Epigenetics 2021 13:224
  22. Patients with severe acute pancreatitis (SAP) have a high mortality, thus early diagnosis and interventions are critical for improving survival. However, conventional tests are limited in acute pancreatitis (A...

    Authors: Hong-Wei Sun, Sheng-Jie Dai, Hong-Ru Kong, Jie-Xiang Fan, Fang-Yuan Yang, Ju-Qing Dai, Yue-Peng Jin, Guan-Zhen Yu, Bi-Cheng Chen and Ke-Qing Shi
    Citation: Clinical Epigenetics 2021 13:223
  23. Examining immunity-related DNA methylation alterations in blood could help elucidate the role of the immune response in lung cancer etiology and aid in discovering factors that are key to lung cancer developme...

    Authors: Naisi Zhao, Mengyuan Ruan, Devin C. Koestler, Jiayun Lu, Lucas A. Salas, Karl T. Kelsey, Elizabeth A. Platz and Dominique S. Michaud
    Citation: Clinical Epigenetics 2021 13:222
  24. Socioeconomic position (SEP) is a major determinant of health across the life course. Yet, little is known about the biological mechanisms explaining this relationship. One possibility widely pursued in the sc...

    Authors: Janine Cerutti, Alexandre A. Lussier, Yiwen Zhu, Jiaxuan Liu and Erin C. Dunn
    Citation: Clinical Epigenetics 2021 13:221
  25. Early lung cancer detection remains a clinical challenge for standard diagnostic biopsies due to insufficient tumor morphological evidence. As epigenetic alterations precede morphological changes, expression a...

    Authors: Jian Zhou, Tong Cheng, Xing Li, Jie Hu, Encheng Li, Ming Ding, Rulong Shen, John P. Pineda, Chun Li, Shaohua Lu, Hongyu Yu, Jiayuan Sun, Wenbin Huang, Xiaonan Wang, Han Si, Panying Shi…
    Citation: Clinical Epigenetics 2021 13:220
  26. One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, ...

    Authors: Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Kozo Tanno, Makoto Sasaki and Atsushi Shimizu
    Citation: Clinical Epigenetics 2021 13:219
  27. Colon cancer (CC) is treatable if detected in its early stages. Improved CC detection assays that are highly sensitive, specific, and available at point of care are needed. In this study, we systematically sel...

    Authors: Romy A. M. Klein Kranenbarg, Abdul Hussain Vali, Jan N. M. IJzermans, Thomas R. Pisanic II, Tza-Huei Wang, Nilofer Azad, Saraswati Sukumar and Mary Jo Fackler
    Citation: Clinical Epigenetics 2021 13:218
  28. Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study (EWAS) in patients with MFS aiming at ide...

    Authors: Mitzi M. van Andel, Maarten Groenink, Maarten P. van den Berg, Janneke Timmermans, Arthur J. H. A. Scholte, Barbara J. M. Mulder, Aeilko H. Zwinderman and Vivian de Waard
    Citation: Clinical Epigenetics 2021 13:217
  29. Illumina DNA methylation arrays are high-throughput platforms for cost-effective genome-wide profiling of individual CpGs. Experimental and technical factors introduce appreciable measurement variation, some o...

    Authors: Zongli Xu, Liang Niu and Jack A. Taylor
    Citation: Clinical Epigenetics 2021 13:216
  30. Smoking is a major causal risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and is the main preventable cause of deaths in the world. The components of ci...

    Authors: Ying Mao, Peng Huang, Yan Wang, Maiqiu Wang, Ming D. Li and Zhongli Yang
    Citation: Clinical Epigenetics 2021 13:215
  31. The aetiology and pathophysiology of complex diseases are driven by the interaction between genetic and environmental factors. The variability in risk and outcomes in these diseases are incompletely explained ...

    Authors: Maria Pia Campagna, Alexandre Xavier, Jeannette Lechner-Scott, Vicky Maltby, Rodney J. Scott, Helmut Butzkueven, Vilija G. Jokubaitis and Rodney A. Lea
    Citation: Clinical Epigenetics 2021 13:214
  32. Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in adrenocortical adenomas. The present study aims to e...

    Authors: Chuan Wang, Yujing Sun, Xiaofei Yin, Ruoqi Feng, Ruiying Feng, Mingyue Xu, Kai Liang, Ruxing Zhao, Gangli Gu, Xuewen Jiang, Peng Su, Xiaofang Zhang and Jinbo Liu
    Citation: Clinical Epigenetics 2021 13:213
  33. Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce gene...

    Authors: Youssef Siblini, Céline Chéry, Pierre Rouyer, Jérémie Raso, Amélia Julien, Sébastien Hergalant, Aurélie François, Lina Bezdetnaya, Guillaume Vogin, Jean-Louis Guéant and Abderrahim Oussalah
    Citation: Clinical Epigenetics 2021 13:212
  34. Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated ...

    Authors: U. Schagdarsurengin, C. Luo, H. Slanina, D. Sheridan, S. Füssel, N. Böğürcü-Seidel, S. Gattenloehner, G. B. Baretton, L. C. Hofbauer, F. Wagenlehner and T. Dansranjav
    Citation: Clinical Epigenetics 2021 13:211
  35. The thymic microenvironment is mainly comprised of thymic epithelial cells, the cytokines, exosomes, surface molecules, and hormones from the cells, and plays a vital role in the development, differentiation, ...

    Authors: Cexun Hu, Keyu Zhang, Feng Jiang, Hui Wang and Qixiang Shao
    Citation: Clinical Epigenetics 2021 13:210
  36. Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...

    Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Brent A. Coull, Andrea A. Baccarelli, Robert O. Wright, Chitra Amarasiriwardena, Diane R. Gold, Emily Oken, Marie-France Hivert and Andres Cardenas
    Citation: Clinical Epigenetics 2021 13:208
  37. A shift in the proportions of blood immune cells is a hallmark of cancer development. Here, we investigated whether methylation-derived immune cell type ratios and methylation-derived neutrophil-to-lymphocyte ...

    Authors: Mehdi Manoochehri, Thomas Hielscher, Nasim Borhani, Clarissa Gerhäuser, Olivia Fletcher, Anthony J. Swerdlow, Yon-Dschun Ko, Hiltrud Brauch, Thomas Brüning and Ute Hamann
    Citation: Clinical Epigenetics 2021 13:207
  38. DNA methylation (DNAm) performs excellently in the discrimination of current and former smokers from never smokers, where AUCs > 0.9 are regularly reported using a single CpG site (cg05575921; AHRR). However, the...

    Authors: Ryan J. Langdon, Paul Yousefi, Caroline L. Relton and Matthew J. Suderman
    Citation: Clinical Epigenetics 2021 13:206
  39. Hypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of early-life exposures and the development of cardiovascular risk facto...

    Authors: Giulietta S. Monasso, Vincent W. V. Jaddoe, Leanne K. Küpers and Janine F. Felix
    Citation: Clinical Epigenetics 2021 13:205
  40. GGC repeat expansions in NOTCH2NLC are associated with neuronal intranuclear inclusion disease. Very recently, asymptomatic carriers with NOTCH2NLC repeat expansions were reported. In these asymptomatic individua...

    Authors: Hiromi Fukuda, Daisuke Yamaguchi, Kristofor Nyquist, Yasushi Yabuki, Satoko Miyatake, Yuri Uchiyama, Kohei Hamanaka, Ken Saida, Eriko Koshimizu, Naomi Tsuchida, Atsushi Fujita, Satomi Mitsuhashi, Kazuyuki Ohbo, Yuki Satake, Jun Sone, Hiroshi Doi…
    Citation: Clinical Epigenetics 2021 13:204
  41. In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammat...

    Authors: Gesa M. Richter, Jochen Kruppa, H. Gencay Keceli, Emel Tuğba Ataman-Duruel, Christian Graetz, Nicole Pischon, Gunar Wagner, Carsten Rendenbach, Yvonne Jockel-Schneider, Orlando Martins, Corinna Bruckmann, Ingmar Staufenbiel, Andre Franke, Rahime M. Nohutcu, Søren Jepsen, Henrik Dommisch…
    Citation: Clinical Epigenetics 2021 13:203
  42. Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one of the main contributing factors. Various tissues display sex differences in DNA methylation; how...

    Authors: Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez-Romero, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Voisin and Nir Eynon
    Citation: Clinical Epigenetics 2021 13:202
  43. Glioblastoma (GBM) is a malignant human brain tumor that has an extremely poor prognosis. Classic mutations such as IDH (isocitrate dehydrogenase) mutations, EGFR (epidermal growth factor receptor) alternations, ...

    Authors: Yin-Cheng Huang, Joseph Chieh-Yu Lai, Pei-Hua Peng, Kuo-Chen Wei and Kou-Juey Wu
    Citation: Clinical Epigenetics 2021 13:201
  44. Depression is a common, complex, and debilitating mental disorder estimated to be under-diagnosed and insufficiently treated in society. Liability to depression is influenced by both genetic and environmental ...

    Authors: Anna Starnawska, Lina Bukowski, Ana Chernomorchenko, Betina Elfving, Heidi Kaastrup Müller, Edwin van den Oord, Karolina Aberg, Jerry Guintivano, Jakob Grove, Ole Mors, Anders D. Børglum, Anders L. Nielsen, Per Qvist and Nicklas Heine Staunstrup
    Citation: Clinical Epigenetics 2021 13:200
  45. Histone modification is an important form of epigenetic regulation. Thereinto, histone methylation is a critical determination of chromatin states, participating in multiple cellular processes. As a conserved ...

    Authors: Chu Xiao, Tao Fan, He Tian, Yujia Zheng, Zheng Zhou, Shuofeng Li, Chunxiang Li and Jie He
    Citation: Clinical Epigenetics 2021 13:199
  46. Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. Recently, DNA methylation-based inference of alcohol consumption from blood wa...

    Authors: Silvana C. E. Maas, Athina Vidaki, Alexander Teumer, Ricardo Costeira, Rory Wilson, Jenny van Dongen, Marian Beekman, Uwe Völker, Hans J. Grabe, Sonja Kunze, Karl-Heinz Ladwig, Joyce B. J. van Meurs, André G. Uitterlinden, Trudy Voortman, Dorret I. Boomsma, P. Eline Slagboom…
    Citation: Clinical Epigenetics 2021 13:198
  47. 5-Hydroxymethylcytosine (5hmC) is a significant DNA epigenetic modification. However, the 5hmC modification alterations in genomic regions encoding long non-coding RNA (lncRNA) and their clinical significance ...

    Authors: Meng Zhou, Ping Hou, Congcong Yan, Lu Chen, Ke Li, Yiran Wang, Jingting Zhao, Jianzhong Su and Jie Sun
    Citation: Clinical Epigenetics 2021 13:197
  48. DNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutat...

    Authors: Teoman Deger, Ruben G. Boers, Vanja de Weerd, Lindsay Angus, Marjolijn M. J. van der Put, Joachim B. Boers, Z. Azmani, Wilfred F. J. van IJcken, Dirk J. Grünhagen, Lisanne F. van Dessel, Martijn P. J. K. Lolkema, Cornelis Verhoef, Stefan Sleijfer, John W. M. Martens, Joost Gribnau and Saskia M. Wilting
    Citation: Clinical Epigenetics 2021 13:196
  49. The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation i...

    Authors: Yuqing Chen, Irfahan Kassam, Suk Hiang Lau, Jaspal S. Kooner, Rory Wilson, Annette Peters, Juliane Winkelmann, John C. Chambers, Vincent T. Chow, Chiea Chuen Khor, Rob M. van Dam, Yik-Ying Teo, Marie Loh and Xueling Sim
    Citation: Clinical Epigenetics 2021 13:195