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  1. Glucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of cytokine signaling (SOCS) 1 methylation has been shown to be associated w...

    Authors: Feng Li, Ying Zhang, Zhao-Hui Wang, Shuai Gao, Yu-Chen Fan and Kai Wang
    Citation: Clinical Epigenetics 2023 15:79
  2. Our previous study suggested that assisted reproductive technology (ART) may be a possible risk factor for the development of epimutation-mediated imprinting disorders (epi-IDs) for mothers aged ≥ 30 years. Ho...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Akie Nakamura, Shinichiro Sano, Takanobu Inoue, Sayaka Kawashima, Tomoko Fuke, Kazuki Yamazawa, Maki Fukami, Tsutomu Ogata and Masayo Kagami
    Citation: Clinical Epigenetics 2023 15:78
  3. Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including g...

    Authors: Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang, Fenglin Cai, Hui Liu, Jing Zhang, Han Liang, Yongzhan Nie and Jingyu Deng
    Citation: Clinical Epigenetics 2023 15:77
  4. The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in wome...

    Authors: Giulia Sgueglia, Salvatore Longobardi, Domenico Valerio, Maria Rosaria Campitiello, Nicola Colacurci, Cinzia Di Pietro, Rosalia Battaglia, Thomas D’Hooghe, Lucia Altucci and Carmela Dell’Aversana
    Citation: Clinical Epigenetics 2023 15:76
  5. Although most patients with diffuse large B-cell lymphoma (DLBCL) achieve complete remission after first-line rituximab-containing immunochemotherapy, up to 40% of patients relapse and require salvage therapy....

    Authors: Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Youngil Koh, Dong-Yeop Shin, Tae Kon Kim, Ja Min Byun, Sung-Soo Yoon and Junshik Hong
    Citation: Clinical Epigenetics 2023 15:75
  6. Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histon...

    Authors: Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt and Nilofer S. Azad
    Citation: Clinical Epigenetics 2023 15:74
  7. Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to expl...

    Authors: Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman and Pilar Blancafort
    Citation: Clinical Epigenetics 2023 15:73
  8. Chromatin regulators (CRs) are critical epigenetic modifiers and have been reported to play critical roles during the progression of various tumors, but their role in lung adenocarcinoma (LUAD) has not been co...

    Authors: Yongbiao Huang, Lingyan Xiao, Motuma Yigezu Daba, Duo Xu, Yuan Wang, Long Li, Qian Li, Bo Liu, Wan Qin, Huixian Zhang and Xianglin Yuan
    Citation: Clinical Epigenetics 2023 15:72
  9. Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...

    Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho and Keith D. Robertson
    Citation: Clinical Epigenetics 2023 15:71
  10. Individuals who are socioeconomically disadvantaged are at increased risk for aging-related diseases and perform less well on tests of cognitive function. The weathering hypothesis proposes that these disparit...

    Authors: L. Raffington, T. Schwaba, M. Aikins, D. Richter, G. G. Wagner, K. P. Harden, D. W. Belsky and E. M. Tucker-Drob
    Citation: Clinical Epigenetics 2023 15:70
  11. Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of le...

    Authors: Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler and Karl T. Kelsey
    Citation: Clinical Epigenetics 2023 15:69
  12. Disadvantaged socioeconomic position (SEP), including lower educational attainment and household income, may influence cancer risk and outcomes. We hypothesized that DNA methylation could function as an interm...

    Authors: Jianhong Chen, Mark D. Long, Sirinapa Sribenja, Sung Jun Ma, Li Yan, Qiang Hu, Song Liu, Thaer Khoury, Chi-Chen Hong, Elisa Bandera, Anurag K. Singh, Elizabeth A. Repasky, Elizabeth G. Bouchard, Michael Higgins, Christine B. Ambrosone and Song Yao
    Citation: Clinical Epigenetics 2023 15:68
  13. Shortened lifespans are associated with having Attention Deficit Hyperactivity Disorder (ADHD), which is likely mediated by related behavioral and sociodemographic factors that are also associated with acceler...

    Authors: Thalida E. Arpawong, Eric T. Klopack, Jung Ki Kim and Eileen M. Crimmins
    Citation: Clinical Epigenetics 2023 15:67
  14. The placenta is a temporary organ that is essential for supporting mammalian embryo and fetal development. Understanding the molecular mechanisms underlying trophoblast differentiation and placental function m...

    Authors: Sara Vasconcelos, Carla Caniçais, Susana M. Chuva de Sousa Lopes, C. Joana Marques and Sofia Dória
    Citation: Clinical Epigenetics 2023 15:66
  15. The detection of peritoneal metastasis (PM) is limited by current imaging tools. In this prospective study, we aimed to evaluate the sensitivity and specificity of peritoneal cell-free DNA (cfDNA) for diagnosi...

    Authors: Zixu Yuan, Wenle Chen, Duo Liu, Qiyuan Qin, William M. Grady, Alessandro Fichera, Huaiming Wang, Ting Hou, Xinze Lv, Chanhe Li, Hui Wang and Jian Cai
    Citation: Clinical Epigenetics 2023 15:65
  16. Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract which seriously endangers the health of human beings worldwide. Transcriptomic deregulation by epigenetic mechanisms plays ...

    Authors: Siyuan Weng, Minghao Li, Jinhai Deng, Hui Xu, Yuqing Ren, Zhaokai Zhou, Libo Wang, Yuyuan Zhang, Zhe Xing, Lifeng Li, Zaoqu Liu and Xinwei Han
    Citation: Clinical Epigenetics 2023 15:64
  17. Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The...

    Authors: Marcos Quintela, David W. James, Agne Pociute, Lydia Powell, Kadie Edwards, Zoe Coombes, Jetzabel Garcia, Neil Garton, Nagindra Das, Kerryn Lutchman-Singh, Lavinia Margarit, Amy L. Beynon, Inmaculada Rioja, Rab K. Prinjha, Nicola R. Harker, Deyarina Gonzalez…
    Citation: Clinical Epigenetics 2023 15:63
  18. Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment. The aim of this study was to e...

    Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert and Andres Cardenas
    Citation: Clinical Epigenetics 2023 15:62
  19. Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships betw...

    Authors: Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash and Tanika N. Kelly
    Citation: Clinical Epigenetics 2023 15:61
  20. Lung adenocarcinoma (LUAD) has a high incidence and recurrence rate. N6-methyladenosine (m6A) modification of RNA has become a promising epigenetic marker in tumors. The dysregulation of both RNA m6A levels and m

    Authors: Yili Ping, Jingjuan Huang, Jichao Zhu, Zujun Sun, Anquan Shang, Chen Chen, Wenfang Liu and Dong Li
    Citation: Clinical Epigenetics 2023 15:60
  21. In utero exposure to diabetes has been shown to contribute to preterm birth, though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic variations established in utero may be ...

    Authors: Guoying Wang, Richard Xu, Boyang Zhang, Xiumei Hong, Tami R. Bartell, Colleen Pearson, Liming Liang and Xiaobin Wang
    Citation: Clinical Epigenetics 2023 15:59
  22. Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy prior to gonadotoxic treatments such as ca...

    Authors: Joana B. Serrano, Nils C. Tabeling, Cindy M. de Winter-Korver, Saskia K. M. van Daalen, Ans M. M. van Pelt and Callista L. Mulder
    Citation: Clinical Epigenetics 2023 15:58
  23. The incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of CRC research. Early and frequent DNA methylation tends to occur in cance...

    Authors: Qin Xiang, Dishu Zhou, Xinni Xiang, Xin Le, Chaoqun Deng, Ran Sun, Chunhong Li, Huayang Pang, Jin He, Zeze Zheng, Jun Tang, Weiyan Peng, Xi Peng, Xiaoqian He, Fan Wu, Jingfu Qiu…
    Citation: Clinical Epigenetics 2023 15:57
  24. Cardiovascular disease (CVD) is the leading cause of death worldwide and considered one of the most environmentally driven diseases. The role of DNA methylation in response to the individual exposure for the d...

    Authors: Mykhailo Krolevets, Vincent ten Cate, Jürgen H. Prochaska, Andreas Schulz, Steffen Rapp, Stefan Tenzer, Miguel A. Andrade-Navarro, Steve Horvath, Christof Niehrs and Philipp S. Wild
    Citation: Clinical Epigenetics 2023 15:56
  25. Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted age and chronological age, in relation to somatic genomic features in paired cancer and norma...

    Authors: Hela Koka, Clara Bodelon, Steve Horvath, Priscilla Ming Yi Lee, Difei Wang, Lei Song, Tongwu Zhang, Amber N. Hurson, Jennifer Lyn Guida, Bin Zhu, Maeve Bailey-Whyte, Feng Wang, Cherry Wu, Koon Ho Tsang, Yee-Kei Tsoi, W. C. Chan…
    Citation: Clinical Epigenetics 2023 15:55
  26. DNA methylation is a form of epigenetic modification that regulates gene expression. However, there are limited data on the comprehensive analysis of DNA methylation regulated gene mutations (DMRGM) in acute m...

    Authors: Xiaoyan Xu, Hong Wang, Haohao Han, Yifang Yao, Xueqian Li, Jiaqian Qi, Chengsen Cai, Meng Zhou, Yaqiong Tang, Tingting Pan, Ziyan Zhang, Jingyi Yang, Depei Wu and Yue Han
    Citation: Clinical Epigenetics 2023 15:54
  27. The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algo...

    Authors: A. Mongelli, S. Panunzi, M. Nesta, M. Gottardi Zamperla, S. Atlante, V. Barbi, V. Mongiardini, F. Ferraro, S. De Martino, L. Cis, A. Re, S. Maltese, T. Bachetti, M. T. La Rovere, F. Martelli, M. Pesce…
    Citation: Clinical Epigenetics 2023 15:53
  28. DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with ...

    Authors: Jiahui Si, Lu Chen, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Iona Y. Millwood, Robin G. Walters, Ling Yang, Yiping Chen, Huaidong Du, Shixian Feng, Xiaoming Yang, Daniel Avery, Junshi Chen, Zhengming Chen…
    Citation: Clinical Epigenetics 2023 15:52
  29. The mother–child inheritance of DNA methylation (DNAm) variations could contribute to the inheritance of disease susceptibility across generations. However, no study has investigated patterns of mother–child a...

    Authors: Jie Hu, Xin Xu, Jun Li, Yu Jiang, Xiumei Hong, Kathryn M. Rexrode, Guoying Wang, Frank B. Hu, Hongmei Zhang, Wilfried J. Karmaus, Xiaobin Wang and Liming Liang
    Citation: Clinical Epigenetics 2023 15:51
  30. In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerat...

    Authors: Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith and Subra Kugathasan
    Citation: Clinical Epigenetics 2023 15:50
  31. Per- and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to degradation and ubiquitous in our environments. PFAS may impact the developing epigenome, but current human evidence is limited to...

    Authors: Rebekah L. Petroff, Raymond G. Cavalcante, Elizabeth S. Langen, Dana C. Dolinoy, Vasantha Padmanabhan and Jaclyn M. Goodrich
    Citation: Clinical Epigenetics 2023 15:49
  32. Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed...

    Authors: Vicky A. Cameron, Gregory T. Jones, L. John Horwood, Anna P. Pilbrow, Julia Martin, Chris Frampton, Wendy T. Ip, Richard W. Troughton, Charlotte Greer, Jun Yang, Michael J. Epton, Sarah L. Harris and Brian A. Darlow
    Citation: Clinical Epigenetics 2023 15:47
  33. Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including ...

    Authors: Claudio Peter D’Incal, Kirsten Esther Van Rossem, Kevin De Man, Anthony Konings, Anke Van Dijck, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Illana Gozes, Wim Vanden Berghe and R. Frank Kooy
    Citation: Clinical Epigenetics 2023 15:45
  34. Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechan...

    Authors: Meng Qin, Wei Chen, Lingyue Hua, Yan Meng, Jing Wang, Hanna Li, Rui Yang, Liying Yan and Jie Qiao
    Citation: Clinical Epigenetics 2023 15:44
  35. Epigenetic modifications are involved in the remodeling of the tumor microenvironment (TME) and the regulation of immune response. Nonetheless, the role of histone H4 methylation (H4M) modification in the TME ...

    Authors: Linyuan Yu, Tao Ji, Wei Liao, Yuyan Xu, Yinghao Fang, Qing Zhu, Jianmin Nie and Dinghua Yang
    Citation: Clinical Epigenetics 2023 15:43
  36. Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity t...

    Authors: Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik and Kent Søe
    Citation: Clinical Epigenetics 2023 15:42
  37. The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes. These probe types exhibit different technical char...

    Authors: H. Welsh, C. M. P. F. Batalha, W. Li, K. L. Mpye, N. C. Souza-Pinto, M. S. Naslavsky and E. J. Parra
    Citation: Clinical Epigenetics 2023 15:41
  38. Molecular analyses have shown that tumours diagnosed as supratentorial primitive neuro-ectodermal tumours of the central nervous system (CNS-PNETs) in the past represent a heterogenous group of rare childhood ...

    Authors: Elizabeth Schepke, Maja Löfgren, Torsten Pietsch, Teresia Kling, Claes Nordborg, Thomas Olsson Bontell, Stefan Holm, Anders Öberg, Per Nyman, Marie Eliasson-Hofvander, Magnus Sabel, Birgitta Lannering and Helena Carén
    Citation: Clinical Epigenetics 2023 15:40
  39. Advances in understanding of cancer biology, genomics, epigenomics, and immunology have resulted in development of several therapeutic options that expand cancer care beyond traditional chemotherapy or radioth...

    Authors: Allison C. Rosenthal, Javier L. Munoz and J. C. Villasboas
    Citation: Clinical Epigenetics 2023 15:39
  40. Hypertension is a crucial risk factor for developing cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP)...

    Authors: Weijing Wang, Jie Yao, Weilong Li, Yili Wu, Haiping Duan, Chunsheng Xu, Xiaocao Tian, Shuxia Li, Qihua Tan and Dongfeng Zhang
    Citation: Clinical Epigenetics 2023 15:38
  41. Despite its inconsistent response rate, decitabine, a demethylating agent, is often used as a non-intensive alternative therapeutic agent for acute myeloid leukemia (AML). It has been reported that relapsed/re...

    Authors: Shujiao He, Yan Li, Xuanren Shi, Lei Wang, Diya Cai, Jingfeng Zhou and Li Yu
    Citation: Clinical Epigenetics 2023 15:37
  42. Selenium, an essential trace element, has previously been investigated as a pro-apoptotic and DNA demethylation agent. It sensitizes the response to chemotherapy in patients who were refractory to cytotoxic ag...

    Authors: Lok Seng Chan, Johnson Liu, Molly S. C. Li, Lili Li, Qian Tao and Tony S. K. Mok
    Citation: Clinical Epigenetics 2023 15:36
  43. Imprinting disorders (ImpDis) comprise diseases which are caused by aberrant regulation of monoallelically and parent-of-origin-dependent expressed genes. A characteristic molecular change in ImpDis patients i...

    Authors: Larissa Bilo, Eguzkine Ochoa, Sunwoo Lee, Daniela Dey, Ingo Kurth, Florian Kraft, Fay Rodger, France Docquier, Ana Toribio, Leonardo Bottolo, Gerhard Binder, György Fekete, Miriam Elbracht, Eamonn R. Maher, Matthias Begemann and Thomas Eggermann
    Citation: Clinical Epigenetics 2023 15:35
  44. A growing body of research has emphasized 5-hydroxymethylcytosine (5hmC) as an important epigenetic mark. High-resolution methods to detect 5hmC require high sequencing depth and are therefore expensive. Many ...

    Authors: Jaywon Lee, Dongin Lee, Hwang-Phill Kim, Tae-You Kim and Duhee Bang
    Citation: Clinical Epigenetics 2023 15:34
  45. Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion ...

    Authors: Abner T. Apsley, Laura Etzel, Waylon J. Hastings, Christine C. Heim, Jennie G. Noll, Kieran J. O’Donnell, Hannah M. C. Schreier, Chad E. Shenk, Qiaofeng Ye and Idan Shalev
    Citation: Clinical Epigenetics 2023 15:33
  46. DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed E...

    Authors: Qian Dong, Cheng Chen, Nan Song, Na Qin, Noel-Marie Plonski, Emily R. Finch, Kyla Shelton, John Easton, Heather Mulder, Emily Plyer, Geoffrey Neale, Emily Walker, Qian Li, I-Chan Huang, Jinghui Zhang, Hui Wang…
    Citation: Clinical Epigenetics 2023 15:32
  47. Exposure to indoor air pollution during pregnancy has been linked to neurodevelopmental delay in toddlers. Epigenetic modification, particularly DNA methylation (DNAm), may explain this link. In this study, we...

    Authors: Dakotah Feil, Sarina Abrishamcar, Grace M. Christensen, Aneesa Vanker, Nastassja Koen, Anna Kilanowski, Nadia Hoffman, Catherine J. Wedderburn, Kirsten A. Donald, Michael S. Kobor, Heather J. Zar, Dan J. Stein and Anke Hüls
    Citation: Clinical Epigenetics 2023 15:31
  48. Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Seve...

    Authors: Adria-Jaume Roura, Paulina Szadkowska, Katarzyna Poleszak, Michal J. Dabrowski, Aleksandra Ellert-Miklaszewska, Kamil Wojnicki, Iwona A. Ciechomska, Karolina Stepniak, Bozena Kaminska and Bartosz Wojtas
    Citation: Clinical Epigenetics 2023 15:29