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  1. PLCD1, located at 3p22, encodes an enzyme that mediates cellular metabolism and homeostasis, intracellular signal transduction and movement. PLCD1 plays a pivotal role in tumor suppression of several types of can...

    Authors: Jianlian Xie, Jun Zhou, Jiliang Xia, Ying Zeng, Guo Huang, Weihong Zeng, Tingyu Fan, Lili Li, Xi Zeng and Qian Tao
    Citation: Clinical Epigenetics 2023 15:30
  2. Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. Whil...

    Authors: Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem…
    Citation: Clinical Epigenetics 2023 15:28
  3. miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives. ...

    Authors: Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli…
    Citation: Clinical Epigenetics 2023 15:27
  4. Early detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC). Here, we developed new candidate CpG site biomarkers for CRC and evaluate...

    Authors: Yuguang Shen, Dongyang Wang, Tianli Yuan, Hongsheng Fang, Chen Zhu, Juan Qin, Xiaojing Xu, Cheng Zhang, Jiahua Liu, Yuanruohan Zhang, Zhoujin Wen, Jian Tang and Zheng Wang
    Citation: Clinical Epigenetics 2023 15:26
  5. Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African Americans. Despite this, African Americans are dramatically underrepr...

    Authors: Peter C. Allen, Sarah Smith, Robert C. Wilson, Jena R. Wirth, Nathan H. Wilson, DeAnna Baker Frost, Jonathan Flume, Gary S. Gilkeson, Melissa A. Cunningham, Carl D. Langefeld, Devin M. Absher and Paula S. Ramos
    Citation: Clinical Epigenetics 2023 15:25
  6. Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above 90%. However, advanced-stage disease accounts for most case...

    Authors: Simone Karlsson Terp, Malene Pontoppidan Stoico, Karen Dybkær and Inge Søkilde Pedersen
    Citation: Clinical Epigenetics 2023 15:24
  7. Insulin resistance (IR) is a well-established factor for breast cancer (BC) risk in postmenopausal women, but the interrelated molecular pathways on the methylome are not explicitly described. We conducted a p...

    Authors: Su Yon Jung, Parveen Bhatti and Matteo Pellegrini
    Citation: Clinical Epigenetics 2023 15:23
  8. N7-methylguanosine (m7G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in...

    Authors: Chaoqun Ma, Dingyuan Tu, Qiang Xu, Yan Wu, Xiaowei Song, Zhifu Guo and Xianxian Zhao
    Citation: Clinical Epigenetics 2023 15:22
  9. Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Altho...

    Authors: Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Vanessa D. de Mello and Jussi Pihlajamäki
    Citation: Clinical Epigenetics 2023 15:21
  10. Pregnancy in women with multiple sclerosis (wwMS) is associated with a reduction of long-term disability progression. The mechanism that drives this effect is unknown, but converging evidence suggests a role f...

    Authors: Maria Pia Campagna, Alexandre Xavier, Jim Stankovich, Vicki E. Maltby, Mark Slee, Wei Z. Yeh, Trevor Kilpatrick, Rodney J. Scott, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney A. Lea and Vilija G. Jokubaitis
    Citation: Clinical Epigenetics 2023 15:20
  11. Natural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and limited therapeutic options. Therefore, there is an urgent need to ex...

    Authors: Jinghong Chen, Zhixiang Zuo, Yan Gao, Xiaosai Yao, Peiyong Guan, Yali Wang, Zhimei Li, Zhilong Liu, Jing Han Hong, Peng Deng, Jason Yongsheng Chan, Daryl Ming Zhe Cheah, Jingquan Lim, Kelila Xin Ye Chai, Burton Kuan Hui Chia, Jane Wan Lu Pang…
    Citation: Clinical Epigenetics 2023 15:19
  12. Oncogenic overexpression of integrin-β7 (ITGB7) in cases of high-risk multiple myeloma (MM) was reported to promote enhanced interactions between neoplastic plasma-B cells and stromal cells to develop cell-adhesi...

    Authors: Samrat Roy Choudhury, Stephanie D. Byrum, Duah Alkam, Cody Ashby, Fenghuang Zhan, Alan J. Tackett and Frits Van Rhee
    Citation: Clinical Epigenetics 2023 15:18
  13. People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...

    Authors: Verena Laura Banszerus, Maximilian König, Ulf Landmesser, Valentin Max Vetter and Ilja Demuth
    Citation: Clinical Epigenetics 2023 15:16
  14. N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP .....

    Authors: Jake Shortt, Peter Galettis, Chan Y. Cheah, Joanne Davis, Mandy Ludford-Menting, Emma K. Link, Jennifer H. Martin, Rachel Koldej and David Ritchie
    Citation: Clinical Epigenetics 2023 15:15
  15. Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methyl...

    Authors: Xiaonan Wang, Wancui Zhu, Qian Long, Enni Chen, Haohui Sun, Xiaodi Li, Hailin Xu, Weizhao Li, Pei Dong, Liru He, Miao Chen and Wuguo Deng
    Citation: Clinical Epigenetics 2023 15:14
  16. Collagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression pattern and the function of COL12A1 in intrahepatic cholangiocarcinoma (iCCA) remain unknown....

    Authors: Zengwei Tang, Yuan Yang, Qi Zhang and Tingbo Liang
    Citation: Clinical Epigenetics 2023 15:13

    The Correction to this article has been published in Clinical Epigenetics 2023 15:46

  17. Histone methylation modification plays an irreplaceable role in the wheezing diseases. The aim of this study was to explore whether azithromycin (AZM) attenuates post-inflammatory wheezing through inhibiting h...

    Authors: Shuqi Wu, Xiaochun Tian, Qian Mao and Chang Peng
    Citation: Clinical Epigenetics 2023 15:12
  18. Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be...

    Authors: Jee Yeon Kim, Jaroslav Jelinek, Young Ho Lee, Dae Hyun Kim, Keunsoo Kang, Su Hyun Ryu, Hye Rin Moon, Kwangjo Cho, Seo Hee Rha, Jae Kwan Cha, Jean-Pierre J. Issa and Jei Kim
    Citation: Clinical Epigenetics 2023 15:11
  19. Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc finger transcription factor superfamily, which consists of hundreds of members that play critical roles in all steps of tumorigenesis.

    Authors: Bin Li, Baoqing Ren, Gang Ma, Fenglin Cai, Pengliang Wang, Yi Zeng, Yong Liu, Li Zhang, Yang Yang, Han Liang, Rupeng Zhang and Jingyu Deng
    Citation: Clinical Epigenetics 2023 15:10
  20. In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adve...

    Authors: Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey and Ellen Anckaert
    Citation: Clinical Epigenetics 2023 15:9
  21. Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric c...

    Authors: Ines Verlinden, Grégoire Coppens, Ilse Vanhorebeek, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe
    Citation: Clinical Epigenetics 2023 15:8
  22. Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose...

    Authors: Aurora Taira, Kimmo Palin, Anna Kuosmanen, Niko Välimäki, Outi Kuittinen, Outi Kuismin, Eevi Kaasinen, Kristiina Rajamäki and Lauri A. Aaltonen
    Citation: Clinical Epigenetics 2023 15:7
  23. Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease areas with several approved therapies marketed, primarily for cancer. Despite the over...

    Authors: Taylor Feehley, Charles W. O’Donnell, John Mendlein, Mahesh Karande and Thomas McCauley
    Citation: Clinical Epigenetics 2023 15:6
  24. Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. While ...

    Authors: Donovan Chan, Kathleen Oros Klein, Antoni Riera-Escamilla, Csilla Krausz, Cristian O’Flaherty, Peter Chan, Bernard Robaire and Jacquetta M. Trasler
    Citation: Clinical Epigenetics 2023 15:5
  25. To explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated the genetic and DNA methylation profile...

    Authors: Fenglei Yu, Xiaojie Huang, Danting Zhou, Zhenyu Zhao, Fang Wu, Banglun Qian, Qiang Wang, Juan Chen, Qingchun Liang, Yi Jiang, Qi Ding, Qiongzhi He, Jingqun Tang, Xiang Wang, Wenliang Liu and Chen Chen
    Citation: Clinical Epigenetics 2023 15:4
  26. Authors: Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carrillo-de Santa Pau…
    Citation: Clinical Epigenetics 2023 15:3

    The original article was published in Clinical Epigenetics 2022 14:148

  27. Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis meth...

    Authors: Ping Guo, Hailing Zheng, Yihan Li, Yuntong Li, Yue Xiao, Jin Zheng, Xingqiang Zhu, Huan Xu, Zhi He, Qian Zhang, Jinchun Chen, Mingshan Qiu, Min Jiang, Pingguo Liu and Hongliang Chen
    Citation: Clinical Epigenetics 2023 15:2
  28. Depression is a multifactorial disorder representing a significant public health burden. Previous studies have linked multiple single nucleotide polymorphisms with depressive phenotypes and suicidal behavior. ...

    Authors: Aleksandr V. Sokolov, Diana-Maria Manu, Didi O. T. Nordberg, Adrian D. E. Boström, Jussi Jokinen and Helgi B. Schiöth
    Citation: Clinical Epigenetics 2023 15:1
  29. Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of which is associated with significant pulmonary, cardiovascular, and neurologic complicati...

    Authors: Matthew A. Fischer, Douglas J. Chapski, Elizabeth Soehalim, Dennis J. Montoya, Tristan Grogan, Matteo Pellegrini, Hua Cai, Richard J. Shemin and Thomas M. Vondriska
    Citation: Clinical Epigenetics 2022 14:195
  30. The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental interactions are involved. Moreover, the lack of prognostic biomarkers make...

    Authors: Maria Pia Campagna, Alexandre Xavier, Rodney A. Lea, Jim Stankovich, Vicki E. Maltby, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney J. Scott and Vilija G. Jokubaitis
    Citation: Clinical Epigenetics 2022 14:194
  31. Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...

    Authors: Kristin Fritsche, Francesco Boccellato, Philipp Schlaermann, Max Koeppel, Christian Denecke, Alexander Link, Peter Malfertheiner, Ivo Gut, Thomas F. Meyer and Hilmar Berger
    Citation: Clinical Epigenetics 2022 14:193
  32. Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...

    Authors: Meng-Nan Yang, Rong Huang, Tao Zheng, Yu Dong, Wen-Juan Wang, Ya-Jie Xu, Vrati Mehra, Guang-Di Zhou, Xin Liu, Hua He, Fang Fang, Fei Li, Jian-Gao Fan, Jun Zhang, Fengxiu Ouyang, Laurent Briollais…
    Citation: Clinical Epigenetics 2022 14:192
  33. Stroke is the leading cause of mortality in China. DNA methylation has essential roles in multiple diseases, but its association with stroke was barely studied. We hereby explored the association between blood...

    Authors: Chunlan Liu, Mengxia Li, Qiming Yin, Yao Fan, Chong Shen and Rongxi Yang
    Citation: Clinical Epigenetics 2022 14:191

    The Correction to this article has been published in Clinical Epigenetics 2023 15:141

  34. Parental imprinting is an epigenetic mechanism that leads to monoallelic expression of a subset of genes depending on their parental origin. Imprinting disorders (IDs), caused by disturbances of imprinted gene...

    Authors: A. Pham, C. Selenou, E. Giabicani, V. Fontaine, S. Marteau, F. Brioude, L. David, D. Mitanchez, M. L. Sobrier and I. Netchine
    Citation: Clinical Epigenetics 2022 14:190
  35. High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic conditions. Among the molecular potential mechanisms underlying this relationship, DNA methyl...

    Authors: Fabrizia Noro, Federica Santonastaso, Annalisa Marotta, Marialaura Bonaccio, Sabatino Orlandi, Alfonsina Tirozzi, Simona Costanzo, Amalia De Curtis, Francesco Gianfagna, Augusto Di Castelnuovo, Furio Brighenti, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi…
    Citation: Clinical Epigenetics 2022 14:189
  36. DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns an...

    Authors: Ricardo Martins-Ferreira, Bárbara Leal, João Chaves, Laura Ciudad, Raquel Samões, António Martins da Silva, Paulo Pinho Costa and Esteban Ballestar
    Citation: Clinical Epigenetics 2022 14:188
  37. BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for the prediction of non-resp...

    Authors: Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert and Helge Frieling
    Citation: Clinical Epigenetics 2022 14:187
  38. To assess the genetic and epigenetic effects promoted by Bisphenol A (BPA) exposure in adolescent males from the Spanish INMA-Granada birth cohort, and in human cells.

    Authors: Shereen Cynthia D’Cruz, Chunxiang Hao, Martin Labussiere, Vicente Mustieles, Carmen Freire, Louis Legoff, Laura Magnaghi-Jaulin, Alicia Olivas-Martinez, Andrea Rodriguez-Carrillo, Christian Jaulin, Arthur David, Mariana F. Fernandez and Fatima Smagulova
    Citation: Clinical Epigenetics 2022 14:186
  39. It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in male reproductive health, including male infertility, impaired semen quality, cryptorchi...

    Authors: Ludwig Stenz, Matthias Beyens, Mark E. Gill, Ariane Paoloni-Giacobino and Christian De Geyter
    Citation: Clinical Epigenetics 2022 14:185
  40. Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro-mo...

    Authors: Yunong Fu, Kaibo Yang, Kunjin Wu, Hai Wang, Qinglin Li, Fengping Zhang, Kun Yang, Qing Yao, Xiaohua Ma, Yujie Deng, Jingyao Zhang, Chang Liu and Kai Qu
    Citation: Clinical Epigenetics 2022 14:184
  41. Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in o...

    Authors: Ellen G. Jarred, Zhipeng Qu, Tesha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing-hua Zhang, Jessica M. Stringer, John Carroll, David K. Gardner, Maarten Van den Buuse, Natalie A. Sims, William T. Gibson, David L. Adelson and Patrick S. Western
    Citation: Clinical Epigenetics 2022 14:183
  42. Chromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-tra...

    Authors: Federica Donnarumma, Valeria Tucci, Concetta Ambrosino, Lucia Altucci and Vincenzo Carafa
    Citation: Clinical Epigenetics 2022 14:182
  43. Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression o...

    Authors: Shuangyan Luo, Huilin Zhang, Yuming Xie, Junke Huang, Danhong Luo and Qing Zhang
    Citation: Clinical Epigenetics 2022 14:181
  44. Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena, including mutations in genes that contro...

    Authors: Luís Alberto de Pádua Covas Lage, Hebert Fabrício Culler, Guilherme Carneiro Barreto, Cadiele Oliana Reichert, Débora Levy, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira
    Citation: Clinical Epigenetics 2022 14:180
  45. Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exp...

    Authors: Kristen Kocher, Surajit Bhattacharya, Matthew S. Bramble, Daniel Okitundu-Luwa, Dieudonne Mumba Ngoyi, Desire Tshala-Katumbay and Eric Vilain
    Citation: Clinical Epigenetics 2022 14:179
  46. Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demonstr...

    Authors: Joana Dias Apolónio, João S. Dias, Mónica Teotónio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H. Zhang, Ricardo Leão, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, José L. Morera, Luis Vicioso, Uri Tabori and Pedro Castelo-Branco
    Citation: Clinical Epigenetics 2022 14:178
  47. The prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation, the best studied epigenetic mark, is related to diabetes risk. Few prosp...

    Authors: Arce Domingo-Relloso, Matthew O. Gribble, Angela L. Riffo-Campos, Karin Haack, Shelley A. Cole, Maria Tellez-Plaza, Jason G. Umans, Amanda M. Fretts, Ying Zhang, M. Daniele Fallin, Ana Navas-Acien and Todd M. Everson
    Citation: Clinical Epigenetics 2022 14:177
  48. Obesity is a multifactorial and chronic condition of growing universal concern. It has recently been reported that bariatric surgery is a more successful treatment for severe obesity than other noninvasive int...

    Authors: Fazlur Rahman Talukdar, David Israel Escobar Marcillo, Ruhina Shirin Laskar, Alexei Novoloaca, Cyrille Cuenin, Paolo Sbraccia, Lorenza Nisticò, Valeria Guglielmi, Tarik Gheit, Massimo Tommasino, Eugenia Dogliotti, Paola Fortini and Zdenko Herceg
    Citation: Clinical Epigenetics 2022 14:176
  49. Host innate immune cells have been identified as key players in the early eradication of Mycobacterium tuberculosis and in the maintenance of an anti-mycobacterial immune memory, which we and others have shown ar...

    Authors: Isabelle Pehrson, Shumaila Sayyab, Jyotirmoy Das, Nina Idh, Jakob Paues, Melissa Méndez-Aranda, César Ugarte-Gil and Maria Lerm
    Citation: Clinical Epigenetics 2022 14:175