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  1. Vascular endothelial growth factor A (VEGF-A) is a chemokine that induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis. It is ...

    Authors: Vesna Gorenjak, Dwaine R. Vance, Sébastien Dade, Maria G. Stathopoulou, Lauren Doherty, Ting Xie, Helena Murray, Christine Masson, John Lamont, Peter Fitzgerald and Sophie Visvikis-Siest

    Citation: Clinical Epigenetics 2020 12:79

    Content type: Research

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  2. Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal gr...

    Authors: Fasil Tekola-Ayele, Xuehuo Zeng, Marion Ouidir, Tsegaselassie Workalemahu, Cuilin Zhang, Fabien Delahaye and Ronald Wapner

    Citation: Clinical Epigenetics 2020 12:78

    Content type: Research

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  3. This study aimed to determine the epigenetic biomarkers of diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). This retrospective study is based on the Shanghai Xinjing community preven...

    Authors: Tao Li, Yi Xu, Yongyong Shi, Jianhua Chen, Senlin Lin, Jianfeng Zhu, Xian Xu, Lina Lu and Haidong Zou

    Citation: Clinical Epigenetics 2020 12:77

    Content type: Research

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  4. A long-term opioid use has been associated with hypermethylation of the opioid receptor mu 1 (OPRM1) promoter. Very little is currently known about the early epigenetic response to therapeutic opioids. Here, we e...

    Authors: Jose Vladimir Sandoval-Sierra, Francisco I. Salgado García, Jeffrey H. Brooks, Karen J. Derefinko and Khyobeni Mozhui

    Citation: Clinical Epigenetics 2020 12:76

    Content type: Research

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  5. Epigenetic abnormalities caused by superovulation have recently attracted increasing attention. Superovulation with exogenous hormones may prevent oocytes from establishing an appropriate epigenetic state, and...

    Authors: Ying Huo, Zhi Qiang Yan, Peng Yuan, Meng Qin, Ying Kuo, Rong Li, Li Ying Yan, Huai Liang Feng and Jie Qiao

    Citation: Clinical Epigenetics 2020 12:75

    Content type: Research

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  6. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...

    Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nuša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom

    Citation: Clinical Epigenetics 2020 12:74

    Content type: Research

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  7. Increasing evidence has suggested that epigenetic and metabolic alterations in cancer cells are highly intertwined. As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transc...

    Authors: Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li and Lixiang Xue

    Citation: Clinical Epigenetics 2020 12:72

    Content type: Review

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  8. Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples usin...

    Authors: Rulong Shen, Tong Cheng, Chuanliang Xu, Rex C. Yung, Jiandong Bao, Xing Li, Hongyu Yu, Shaohua Lu, Huixiong Xu, Hongxun Wu, Jian Zhou, Wenbo Bu, Xiaonan Wang, Han Si, Panying Shi, Pengcheng Zhao…

    Citation: Clinical Epigenetics 2020 12:71

    Content type: Methodology

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  9. Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnorma...

    Authors: Manon Lernoux, Michael Schnekenburger, Hélène Losson, Koen Vermeulen, Hyunggu Hahn, Déborah Gérard, Jin-Young Lee, Aloran Mazumder, Muneer Ahamed, Christo Christov, Dong-Wook Kim, Mario Dicato, Guy Bormans, Byung Woo Han and Marc Diederich

    Citation: Clinical Epigenetics 2020 12:69

    Content type: Research

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  10. Adipogenesis, the process whereby preadipocytes differentiate into mature adipocytes, is crucial for maintaining metabolic homeostasis. Cholesterol-lowering statins increase type 2 diabetes (T2D) risk possibly...

    Authors: Amna Khamis, Raphael Boutry, Mickaël Canouil, Sumi Mathew, Stephane Lobbens, Hutokshi Crouch, Toby Andrew, Amar Abderrahmani, Filippo Tamanini and Philippe Froguel

    Citation: Clinical Epigenetics 2020 12:68

    Content type: Research

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  11. Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis, prognosis, and recurrence prediction of colore...

    Authors: Shih-Ching Chang, Phui-Ly Liew, Muhamad Ansar, Shih-Yun Lin, Sheng-Chao Wang, Chin-Sheng Hung, Jian-Yu Chen, Shikha Jain and Ruo-Kai Lin

    Citation: Clinical Epigenetics 2020 12:67

    Content type: Research

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  12. Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying t...

    Authors: Jee Yeon Kim, Bong-Geun Choi, Jaroslav Jelinek, Dae Hyun Kim, Seo Hyun Lee, Kwangjo Cho, Seo Hee Rha, Young Ho Lee, Hyo Sun Jin, Dae-Kyoung Choi, Geun-Eun Kim, Sun U. Kwon, Junha Hwang, Jae Kwan Cha, Sukhoon Lee, Jean-Pierre J. Issa…

    Citation: Clinical Epigenetics 2020 12:66

    Content type: Research

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  13. Assessing long-term health effects from a potentially harmful environment is challenging. Endocrine-disrupting compounds (EDCs) have become omnipresent in our environment. Individuals may or may not experience...

    Authors: Olivia Van Cauwenbergh, Alessandra Di Serafino, Jan Tytgat and Adelheid Soubry

    Citation: Clinical Epigenetics 2020 12:65

    Content type: Review

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  14. Preimplantation embryos experience profound resetting of epigenetic information inherited from the gametes. Genome-wide analysis at single-base resolution has shown similarities but also species differences be...

    Authors: Elena Ivanova, Sebastian Canovas, Soledad Garcia-Martínez, Raquel Romar, Jordana S. Lopes, Dimitrios Rizos, Maria J. Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey and Pilar Coy

    Citation: Clinical Epigenetics 2020 12:64

    Content type: Research

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    The Correction to this article has been published in Clinical Epigenetics 2020 12:96

  15. Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder caused by disturbances of the chromosomal region 11p15.5. The most frequent molecular finding in BWS is loss of methylation (LOM) of the Imprinting C...

    Authors: Carla Eßinger, Stephanie Karch, Ute Moog, György Fekete, Anna Lengyel, Eva Pinti, Thomas Eggermann and Matthias Begemann

    Citation: Clinical Epigenetics 2020 12:63

    Content type: Research

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  16. How to best triage human papillomavirus (HPV) positive women remains controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the long-term risk stratification for triaging HPV 16...

    Authors: Li Dong, Li Zhang, Shang-Ying Hu, Rui-Mei Feng, Xue-Lian Zhao, Qian Zhang, Qin-Jing Pan, Xun Zhang, You-Lin Qiao and Fang-Hui Zhao

    Citation: Clinical Epigenetics 2020 12:62

    Content type: Research

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  17. In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation...

    Authors: Elsa Leitão, Sara Di Persio, Sandra Laurentino, Marius Wöste, Martin Dugas, Sabine Kliesch, Nina Neuhaus and Bernhard Horsthemke

    Citation: Clinical Epigenetics 2020 12:61

    Content type: Research

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    The Letter to the Editor to this article has been published in Clinical Epigenetics 2020 12:172

  18. Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical va...

    Authors: Edwina H. Yeung, Weihua Guan, Xuehuo Zeng, Lucas A. Salas, Sunni L. Mumford, Paula de Prado Bert, Evelien R. van Meel, Anni Malmberg, Jordi Sunyer, Liesbeth Duijts, Janine F. Felix, Darina Czamara, Esa Hämäläinen, Elisabeth B. Binder, Katri Räikkönen, Jari Lahti…

    Citation: Clinical Epigenetics 2020 12:60

    Content type: Research

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  19. DNA methylation (DNAm) variation is an established predictor for several traits. In the context of oropharyngeal cancer (OPC), where 5-year survival is ~ 65%, DNA methylation may act as a prognostic biomarker....

    Authors: Ryan J. Langdon, Rhona A. Beynon, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Richard M. Martin, Andy R. Ness, Michael Pawlita, Tim Waterboer, Caroline Relton, Steven J. Thomas and Rebecca C. Richmond

    Citation: Clinical Epigenetics 2020 12:58

    Content type: Research

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  20. Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we co...

    Authors: Yuan-Yuan Gu, Guan-Nan Zhou, Qing Wang, Jing-Xin Ding and Ke-Qin Hua

    Citation: Clinical Epigenetics 2020 12:57

    Content type: Research

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  21. Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are ...

    Authors: Jian Fan, Jun Li, Shicheng Guo, Chengcheng Tao, Haikun Zhang, Wenjing Wang, Ying Zhang, Dake Zhang, Shigang Ding and Changqing Zeng

    Citation: Clinical Epigenetics 2020 12:56

    Content type: Research

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  22. Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation...

    Authors: Rosalind Tang, Laura D. Howe, Matthew Suderman, Caroline L. Relton, Andrew A. Crawford and Lotte C. Houtepen

    Citation: Clinical Epigenetics 2020 12:55

    Content type: Research

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  23. The genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as many T-cell genes, with a strong MHC associati...

    Authors: R. Pitaksalee, A. N. Burska, S. Ajaib, J. Rogers, R. Parmar, K. Mydlova, X. Xie, A. Droop, J. S. Nijjar, P. Chambers, P. Emery, R. Hodgett, I. B. McInnes and F. Ponchel

    Citation: Clinical Epigenetics 2020 12:54

    Content type: Research

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  24. Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated tha...

    Authors: Carolina Serena, Monica Millan, Miriam Ejarque, Alfonso Saera-Vila, Elsa Maymó-Masip, Catalina Núñez-Roa, Diandra Monfort-Ferré, Margarida Terrón-Puig, Michelle Bautista, Margarita Menacho, Marc Martí, Eloy Espin, Joan Vendrell and Sonia Fernández-Veledo

    Citation: Clinical Epigenetics 2020 12:53

    Content type: Research

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  25. Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-...

    Authors: Delnaz Roshandel, Zhuo Chen, Angelo J. Canty, Shelley B. Bull, Rama Natarajan and Andrew D. Paterson

    Citation: Clinical Epigenetics 2020 12:52

    Content type: Research

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  26. DNA methylation is associated with body mass index (BMI), but it is not clear if methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we explore the causal nature and predictive ...

    Authors: Zoe E. Reed, Matthew J. Suderman, Caroline L. Relton, Oliver S. P. Davis and Gibran Hemani

    Citation: Clinical Epigenetics 2020 12:50

    Content type: Research

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  27. DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-qu...

    Authors: Anne Seeboth, Daniel L. McCartney, Yunzhang Wang, Robert F. Hillary, Anna J. Stevenson, Rosie M. Walker, Archie Campbell, Kathryn L. Evans, Andrew M. McIntosh, Sara Hägg, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2020 12:49

    Content type: Research

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  28. Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts...

    Authors: Mitchell G. Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A. Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A. Taylor, Gail P. Risbridger and Susan J. Clark

    Citation: Clinical Epigenetics 2020 12:48

    Content type: Research

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  29. Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the pr...

    Authors: Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo and Dianshuai Gao

    Citation: Clinical Epigenetics 2020 12:47

    Content type: Research

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  30. Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).

    Authors: Mark W. Logue, Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, Filomene G. Morrison, Zhenwei Zhou, Yuanchao Zheng, Alicia K. Smith, Nikolaos P. Daskalakis, Andrew Ratanatharathorn, Monica Uddin, Caroline M. Nievergelt, Allison E. Ashley-Koch, Dewleen G. Baker, Jean C. Beckham, Melanie E. Garrett…

    Citation: Clinical Epigenetics 2020 12:46

    Content type: Research

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  31. DNA methylation (DNAm) age has been widely accepted as an epigenetic biomarker for biological aging. Emerging evidence suggests that DNAm age can be tissue-specific and female breast tissue ages faster than ot...

    Authors: James R. Castle, Nan Lin, Jinpeng Liu, Anna Maria V. Storniolo, Aditi Shendre, Lifang Hou, Steve Horvath, Yunlong Liu, Chi Wang and Chunyan He

    Citation: Clinical Epigenetics 2020 12:45

    Content type: Research

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  32. Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neigh...

    Authors: Cavin K. Ward-Caviness, Shirley Pu, Chantel L. Martin, Sandro Galea, Monica Uddin, Derek E. Wildman, Karestan Koenen and Allison E. Aiello

    Citation: Clinical Epigenetics 2020 12:44

    Content type: Research

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  33. Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathoge...

    Authors: Catarina Salgado, Nelleke Gruis, Bastiaan T. Heijmans, Jan Oosting and Remco van Doorn

    Citation: Clinical Epigenetics 2020 12:43

    Content type: Short report

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  34. Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngea...

    Authors: Yu Jiang, Lei Liu, Qin Xiang, Xiaoqian He, Yan Wang, Dishu Zhou, Can Zou, Qian Chen, Mingyu Peng, Jin He, Xianyao Jiang, Tingxiu Xiang and Yucheng Yang

    Citation: Clinical Epigenetics 2020 12:41

    Content type: Research

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  35. We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility in Chinese patients w...

    Authors: Chen Chen, Xiaojie Huang, Wei Yin, Muyun Peng, Fang Wu, Xia Wu, Jingqun Tang, Mingjiu Chen, Xiang Wang, Alicia Hulbert, Malcolm V. Brock, Wenliang Liu, James G. Herman and Fenglei Yu

    Citation: Clinical Epigenetics 2020 12:39

    Content type: Research

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  36. Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 m...

    Authors: Yuqiu Ge, Gaoxiang Ma, Hanting Liu, Yadi Lin, Gang Zhang, Mulong Du, Meilin Wang, Haiyan Chu, Haiyan Zhang and Zhengdong Zhang

    Citation: Clinical Epigenetics 2020 12:37

    Content type: Research

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  37. The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regula...

    Authors: Sam Kint, Wim Trypsteen, Ward De Spiegelaere, Eva Malatinkova, Sabine Kinloch-de Loes, Tim De Meyer, Wim Van Criekinge and Linos Vandekerckhove

    Citation: Clinical Epigenetics 2020 12:36

    Content type: Research

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  38. Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for ob...

    Authors: Heather E. Rizzo, Elia N. Escaname, Nicholas B. Alana, Elizabeth Lavender, Jonathan Gelfond, Roman Fernandez, Matthew A. Hibbs, Jonathan M. King, Nicholas R. Carr and Cynthia L. Blanco

    Citation: Clinical Epigenetics 2020 12:34

    Content type: Research

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  39. While a considerable number of tumor-specific hypermethylated loci have been identified in renal cell cancer (RCC), DNA methylation of loci showing successive increases in normal, tumoral, and metastatic tissu...

    Authors: Jürgen Serth, Inga Peters, Natalia Dubrowinskaja, Christel Reese, Knut Albrecht, Michael Klintschar, Marcel Lafos, Alexander Grote, Albert Becker, Jörg Hennenlotter, Arnulf Stenzl, Hossein Tezval and Markus A. Kuczyk

    Citation: Clinical Epigenetics 2020 12:33

    Content type: Research

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  40. Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues fr...

    Authors: Nur Jury, Sebastian Abarzua, Ivan Diaz, Miguel V. Guerra, Estibaliz Ampuero, Paula Cubillos, Pablo Martinez, Andrea Herrera-Soto, Cristian Arredondo, Fabiola Rojas, Marcia Manterola, Adriana Rojas, Martín Montecino, Lorena Varela-Nallar and Brigitte van Zundert

    Citation: Clinical Epigenetics 2020 12:32

    Content type: Research

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  41. The NuRD (Nucleosome Remodeling and Deacetylation) complex is a repressive complex in gene transcription by modulating chromatin accessibility of target genes to transcription factors and RNA polymerase II. Al...

    Authors: Simin Shao, Haowei Cao, Zhongkun Wang, Dongmei Zhou, Chaoshen Wu, Shu Wang, Dian Xia and Daoyong Zhang

    Citation: Clinical Epigenetics 2020 12:31

    Content type: Research

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  42. The vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain hom...

    Authors: Xiang Wei, Xin Yi, Xue-Hai Zhu and Ding-Sheng Jiang

    Citation: Clinical Epigenetics 2020 12:30

    Content type: Review

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  43. The association between obesity and cardiovascular disease (CVD) is proven, but why some adults with obesity develop CVD while others remain disease-free is poorly understood. Here, we investigated whether mit...

    Authors: Sarah Corsi, Simona Iodice, Luisella Vigna, Akin Cayir, John C. Mathers, Valentina Bollati and Hyang-Min Byun

    Citation: Clinical Epigenetics 2020 12:29

    Content type: Research

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  44. Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epitheli...

    Authors: Eva Galle, Bernard Thienpont, Sarah Cappuyns, Tom Venken, Pieter Busschaert, Matthias Van Haele, Eric Van Cutsem, Tania Roskams, Jos van Pelt, Chris Verslype, Jeroen Dekervel and Diether Lambrechts

    Citation: Clinical Epigenetics 2020 12:27

    Content type: Research

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  45. Radiation is an important therapeutic tool. However, radiotherapy has the potential to promote co-evolution of genetic and epigenetic changes that can drive tumour heterogeneity, formation of radioresistant ce...

    Authors: Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell and Helena Carén

    Citation: Clinical Epigenetics 2020 12:26

    Content type: Research

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  46. Although massive studies have been conducted to investigate the mechanisms of esophageal squamous cell carcinoma (ESCC) carcinogenesis, the understanding of molecular alterations during the malignant transform...

    Authors: Yarui Ma, Siyuan He, Aiai Gao, Ying Zhang, Qing Zhu, Pei Wang, Beibei Yang, Huihui Yin, Yifei Li, Jinge Song, Pinli Yue, Mo Li, Dandan Zhang, Yun Liu, Xiaobing Wang, Mingzhou Guo…

    Citation: Clinical Epigenetics 2020 12:25

    Content type: Research

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