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  3. Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid perox...

    Authors: Xīn Gào, Yan Zhang, Barbara Burwinkel, Yang Xuan, Bernd Holleczek, Hermann Brenner and Ben Schöttker

    Citation: Clinical Epigenetics 2019 11:14

    Content type: Research

    Published on:

  4. Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes...

    Authors: Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li and Nicholas D. E. Greene

    Citation: Clinical Epigenetics 2019 11:13

    Content type: Research

    Published on:

  5. Epigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath’s DNA methylation (DN...

    Authors: Elina Sillanpää, Miina Ollikainen, Jaakko Kaprio, Xiaoling Wang, Tuija Leskinen, Urho M. Kujala and Timo Törmäkangas

    Citation: Clinical Epigenetics 2019 11:12

    Content type: Research

    Published on:

  6. The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alteratio...

    Authors: Halina Was, Sylwia K. Krol, Dante Rotili, Antonello Mai, Bartosz Wojtas, Bozena Kaminska and Marta Maleszewska

    Citation: Clinical Epigenetics 2019 11:11

    Content type: Research

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  7. Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation i...

    Authors: Paula Walle, Ville Männistö, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling and Jussi Pihlajamäki

    Citation: Clinical Epigenetics 2019 11:10

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2019 11:47

  8. Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D inv...

    Authors: Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant and Paola B. Arimondo

    Citation: Clinical Epigenetics 2019 11:9

    Content type: Research

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  9. In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic eff...

    Authors: Chao He, Jian Sun, Chao Liu, Yuhang Jiang and Yongqiang Hao

    Citation: Clinical Epigenetics 2019 11:8

    Content type: Research

    Published on:

  10. Ovarian cancer is the deadliest gynecologic malignancy, with a 5-year survival rate of approximately 47%, a number that has remained constant over the past two decades. Early diagnosis improves survival, but u...

    Authors: Sara Moufarrij, Monica Dandapani, Elisa Arthofer, Stephanie Gomez, Aneil Srivastava, Micael Lopez-Acevedo, Alejandro Villagra and Katherine B. Chiappinelli

    Citation: Clinical Epigenetics 2019 11:7

    Content type: Review

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  11. Age-related macular degeneration (AMD) is a degenerative disorder of the central retina and the foremost cause of blindness. The retinal pigment epithelium (RPE) is a primary site of disease pathogenesis. The ...

    Authors: Louise F. Porter, Neil Saptarshi, Yongxiang Fang, Sonika Rathi, Anneke I. den Hollander, Eiko K. de Jong, Simon J. Clark, Paul N. Bishop, Timothy W. Olsen, Triantafillos Liloglou, Venkata R. M. Chavali and Luminita Paraoan

    Citation: Clinical Epigenetics 2019 11:6

    Content type: Research

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  12. Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mort...

    Authors: Jessica S. Jarmasz, Hannah Stirton, James R. Davie and Marc R. Del Bigio

    Citation: Clinical Epigenetics 2019 11:5

    Content type: Research

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  13. Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me ha...

    Authors: Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz and Steven A. Johnsen

    Citation: Clinical Epigenetics 2019 11:4

    Content type: Research

    Published on:

  14. The term pseudohypoparathyroidism (PHP) describes disorders derived from resistance to the parathyroid hormone. Albright hereditary osteodystrophy (AHO) is a disorder with several physical features that can oc...

    Authors: F. M. Elli, L. deSanctis, M.A. Maffini, P. Bordogna, D. Tessaris, A. Pirelli, M. Arosio, A. Linglart and G. Mantovani

    Citation: Clinical Epigenetics 2019 11:3

    Content type: Research

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  15. Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randoml...

    Authors: Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A. Pantaleo…

    Citation: Clinical Epigenetics 2019 11:2

    Content type: Research

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  16. DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine ...

    Authors: Richa Gupta, Jenny van Dongen, Yu Fu, Abdel Abdellaoui, Rachel F. Tyndale, Vidya Velagapudi, Dorret I. Boomsma, Tellervo Korhonen, Jaakko Kaprio, Anu Loukola and Miina Ollikainen

    Citation: Clinical Epigenetics 2019 11:1

    Content type: Research

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  17. There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neu...

    Authors: Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan and Chia-Ron Yang

    Citation: Clinical Epigenetics 2018 10:162

    Content type: Research

    Published on:

  18. Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...

    Authors: Cavin K. Ward-Caviness, Golareh Agha, Brian H. Chen, Liliane Pfeiffer, Rory Wilson, Petra Wolf, Christian Gieger, Joel Schwartz, Pantel S. Vokonas, Lifang Hou, Allan C. Just, Stefania Bandinelli, Dena G. Hernandez, Andrew B. Singleton, Holger Prokisch, Thomas Meitinger…

    Citation: Clinical Epigenetics 2018 10:161

    Content type: Research

    Published on:

  19. Psoriasis (Ps) is a common chronic inflammatory skin disease. The keratinocytes of psoriatic skin defy normal apoptosis and exhibit active cell proliferation. Aberrant DNA methylation (DNAm) has been suggested...

    Authors: Changbing Shen, Leilei Wen, Randy Ko, Jing Gao, Xue Shen, Xianbo Zuo, Liangdan Sun, Yi-Hsiang Hsu, Xuejun Zhang, Yong Cui, Meng Wang and Fusheng Zhou

    Citation: Clinical Epigenetics 2018 10:160

    Content type: Short report

    Published on:

  20. Epigenetic age acceleration (an older methylation age compared to chronological age) correlates strongly with various age-related morbidities and mortality. Chronic systemic inflammation is thought to be a hal...

    Authors: Anna J. Stevenson, Daniel L. McCartney, Sarah E. Harris, Adele M. Taylor, Paul Redmond, John M. Starr, Qian Zhang, Allan F. McRae, Naomi R. Wray, Tara L. Spires-Jones, Barry W. McColl, Andrew M. McIntosh, Ian J. Deary and Riccardo E. Marioni

    Citation: Clinical Epigenetics 2018 10:159

    Content type: Research

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  21. Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. H...

    Authors: Qiumei Yao, Gareth J. Morgan and Chor Sang Chim

    Citation: Clinical Epigenetics 2018 10:158

    Content type: Letter to the Editor

    Published on:

  22. Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication d...

    Authors: Xin Sun, Vijesh Vaghjiani, W. Samantha N. Jayasekara, Jason E. Cain and Justin C. St. John

    Citation: Clinical Epigenetics 2018 10:157

    Content type: Research

    Published on:

  23. Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence ...

    Authors: Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth and Janis Klovins

    Citation: Clinical Epigenetics 2018 10:156

    Content type: Research

    Published on:

  24. The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their immune-related outcomes, inc...

    Authors: Xinyu Zhang, Ying Hu, Bradley E. Aouizerat, Gang Peng, Vincent C. Marconi, Michael J. Corley, Todd Hulgan, Kendall J. Bryant, Hongyu Zhao, John H. Krystal, Amy C. Justice and Ke Xu

    Citation: Clinical Epigenetics 2018 10:155

    Content type: Research

    Published on:

  25. The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown.

    Authors: Yue Hu, Mingrui Dai, Yayuan Zheng, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu and Xianghui Yu

    Citation: Clinical Epigenetics 2018 10:154

    Content type: Research

    Published on:

  26. B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targ...

    Authors: Rui Deng, Peng Zhang, Weizhen Liu, Xiangyu Zeng, Xianxiong Ma, Liang Shi, Tao Wang, Yuping Yin, Weilong Chang, Pei Zhang, Guobin Wang and Kaixiong Tao

    Citation: Clinical Epigenetics 2018 10:153

    Content type: Research

    Published on:

  27. Lung macrophages are major participants in the pulmonary innate immune response. In the cystic fibrosis (CF) lung, the inability of lung macrophages to successfully regulate the exaggerated inflammatory respon...

    Authors: Youdinghuan Chen, David A. Armstrong, Lucas A. Salas, Haley F. Hazlett, Amanda B. Nymon, John A. Dessaint, Daniel S. Aridgides, Diane L. Mellinger, Xiaoying Liu, Brock C. Christensen and Alix Ashare

    Citation: Clinical Epigenetics 2018 10:152

    Content type: Research

    Published on:

  28. Upon publication of the original article [1], it was noticed that the Figure captions of Figs. 2 and 3 were incorrectly given. The correct Figure captions are given below.

    Authors: Nikolay Kondratyev, Arkady Golov, Margarita Alfimova, Tatiana Lezheiko and Vera Golimbet

    Citation: Clinical Epigenetics 2018 10:151

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2018 10:130

  29. Imprinted genes are regulated by DNA methylation at imprinting-associated differentially methylated regions (iDMRs). Abnormal expression of imprinted genes is implicated in imprinting disorders and tumors. In ...

    Authors: Hidenori Hidaka, Ken Higashimoto, Saori Aoki, Hiroyuki Mishima, Chisa Hayashida, Toshiyuki Maeda, Yasuo Koga, Hitomi Yatsuki, Keiichiro Joh, Hirokazu Noshiro, Ryuichi Iwakiri, Atsushi Kawaguchi, Koh-ichiro Yoshiura, Kazuma Fujimoto and Hidenobu Soejima

    Citation: Clinical Epigenetics 2018 10:150

    Content type: Research

    Published on:

  30. Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is characterized by axonal degeneration and gliosis. Although the causes of MS remain unknown, gene dysregul...

    Authors: Xuan Yang, Yuzhang Wu, Bei Zhang and Bing Ni

    Citation: Clinical Epigenetics 2018 10:149

    Content type: Review

    Published on:

  31. Increased lower body fat is associated with reduced cardiometabolic risk. The molecular basis for depot-specific differences in gluteofemoral (GF) compared with abdominal (A) subcutaneous adipocyte function is...

    Authors: Adeline Divoux, Katalin Sandor, Dora Bojcsuk, Amlan Talukder, Xiaoman Li, Balint L. Balint, Timothy F. Osborne and Steven R. Smith

    Citation: Clinical Epigenetics 2018 10:148

    Content type: Research

    Published on:

  32. Prevention of unnecessary biopsies and overtreatment of indolent disease remains a challenge in the management of prostate cancer. Novel non-invasive tests that can identify clinically significant (intermediat...

    Authors: Fang Zhao, Ekaterina Olkhov-Mitsel, Shivani Kamdar, Renu Jeyapala, Julia Garcia, Rachel Hurst, Marcelino Yazbek Hanna, Robert Mills, Alexandra V. Tuzova, Eve O’Reilly, Sarah Kelly, Colin Cooper, Daniel Brewer, Antoinette S. Perry, Jeremy Clark, Neil Fleshner…

    Citation: Clinical Epigenetics 2018 10:147

    Content type: Research

    Published on:

  33. Recent studies demonstrated that changes in DNA methylation (DNAm) and inactivation of two imprinted genes (MKRN3 and DLK1) alter the onset of female puberty. We aimed to investigate the association of DNAm profi...

    Authors: Danielle S. Bessa, Mariana Maschietto, Carlos Francisco Aylwin, Ana P. M. Canton, Vinicius N. Brito, Delanie B. Macedo, Marina Cunha-Silva, Heloísa M. C. Palhares, Elisabete A. M. R. de Resende, Maria de Fátima Borges, Berenice B. Mendonca, Irene Netchine, Ana C. V. Krepischi, Alejandro Lomniczi, Sergio R. Ojeda and Ana Claudia Latronico

    Citation: Clinical Epigenetics 2018 10:146

    Content type: Research

    Published on:

  35. DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This mechanism is largely unstudied in papillary thyro...

    Authors: Isabella Maria Dias Payão Ortiz, Mateus Camargo Barros-Filho, Mariana Bisarro dos Reis, Caroline Moraes Beltrami, Fabio Albuquerque Marchi, Hellen Kuasne, Luísa Matos do Canto, Julia Bette Homem de Mello, Cecilie Abildgaard, Clóvis Antônio Lopes Pinto, Luiz Paulo Kowalski and Silvia Regina Rogatto

    Citation: Clinical Epigenetics 2018 10:144

    Content type: Research

    Published on:

  36. The introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation (ChIP) from formalin-fixed paraffin-embedded (FFPE) tissues, has extended the a...

    Authors: Stefano Amatori, Giuseppe Persico, Claudio Paolicelli, Roman Hillje, Nora Sahnane, Francesco Corini, Daniela Furlan, Lucilla Luzi, Saverio Minucci, Marco Giorgio, Pier Giuseppe Pelicci and Mirco Fanelli

    Citation: Clinical Epigenetics 2018 10:143

    Content type: Methodology

    Published on:

  37. Ovarian cancer is the most fatal tumor of the female reproductive system and the fifth leading cause of cancer death among women in the USA. The prognosis is poor due to the lack of biomarkers for treatment op...

    Authors: Wenna Guo, Liucun Zhu, Minghao Yu, Rui Zhu, Qihan Chen and Qiang Wang

    Citation: Clinical Epigenetics 2018 10:142

    Content type: Research

    Published on:

  38. Altered methylation patterns are driving forces in colorectal carcinogenesis. The serrated adenocarcinoma (SAC) and sporadic colorectal carcinoma showing histological and molecular features of microsatellite i...

    Authors: José García-Solano, María C. Turpin, Daniel Torres-Moreno, Francisco Huertas-López, Anne Tuomisto, Markus J. Mäkinen, Ana Conesa and Pablo Conesa-Zamora

    Citation: Clinical Epigenetics 2018 10:141

    Content type: Research

    Published on:

    The Data Descriptor to this article has been published in Scientific Data 2019 6:255

  40. In the present study, we investigated the molecular mechanisms underlying the pro-apoptotic effects of quercetin (Qu) by evaluating the effect of Qu treatment on DNA methylation and posttranslational histone m...

    Authors: Marisa Claudia Alvarez, Victor Maso, Cristiane Okuda Torello, Karla Priscilla Ferro and Sara Teresinha Olalla Saad

    Citation: Clinical Epigenetics 2018 10:139

    Content type: Research

    Published on:

  41. Cancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases. We hypothesize that cancer treatments could lead t...

    Authors: Sara Daniel, Vibe Nylander, Lars R. Ingerslev, Ling Zhong, Odile Fabre, Briana Clifford, Karen Johnston, Richard J. Cohn, Romain Barres and David Simar

    Citation: Clinical Epigenetics 2018 10:138

    Content type: Research

    Published on:

  43. We have previously evaluated the efficacy of the CRF1 receptor antagonist GSK561679 in female PTSD patients. While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger sy...

    Authors: Julius C. Pape, Tania Carrillo-Roa, Barbara O. Rothbaum, Charles B. Nemeroff, Darina Czamara, Anthony S. Zannas, Dan Iosifescu, Sanjay J. Mathew, Thomas C. Neylan, Helen S. Mayberg, Boadie W. Dunlop and Elisabeth B. Binder

    Citation: Clinical Epigenetics 2018 10:136

    Content type: Research

    Published on:

  44. Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes...

    Authors: Lien-Hung Huang, Ho-Chang Kuo, Cheng-Tsung Pan, Yeong-Shin Lin, Ying-Hsien Huang and Sung-Chou Li

    Citation: Clinical Epigenetics 2018 10:135

    Content type: Research

    Published on:

  45. Male infertility is a complex disease caused by a combination of genetic, environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed as a possible mechanism compromising male ferti...

    Authors: Qiuqin Tang, Feng Pan, Jing Yang, Ziqiang Fu, Yiwen Lu, Xian Wu, Xiumei Han, Minjian Chen, Chuncheng Lu, Yankai Xia, Xinru Wang and Wei Wu

    Citation: Clinical Epigenetics 2018 10:134

    Content type: Research

    Published on:

  46. Accelerated age-associated DNA methylation changes in males may explain the earlier onset of age-related diseases (e.g., cardiovascular disease (CVD)) and thus contribute to sexually dimorphic morbidity and li...

    Authors: Fu-Hui Xiao, Xiao-Qiong Chen, Yong-Han He and Qing-Peng Kong

    Citation: Clinical Epigenetics 2018 10:133

    Content type: Short report

    Published on:

  47. Prostate cancer (PCa) is one of the most common cancers among men worldwide. Current screening methods for PCa display limited sensitivity and specificity, not stratifying for disease aggressiveness. Hence, de...

    Authors: Catarina Moreira-Barbosa, Daniela Barros-Silva, Pedro Costa-Pinheiro, Jorge Torres-Ferreira, Vera Constâncio, Rui Freitas, Jorge Oliveira, Luís Antunes, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2018 10:132

    Content type: Research

    Published on:

  48. Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperg...

    Authors: Raffael Ott, Jens H. Stupin, Kerstin Melchior, Karen Schellong, Thomas Ziska, Joachim W. Dudenhausen, Wolfgang Henrich, Rebecca C. Rancourt and Andreas Plagemann

    Citation: Clinical Epigenetics 2018 10:131

    Content type: Research

    Published on:

  49. Methylation of DNA is associated with a variety of biological processes. With whole-genome studies of DNA methylation, it became possible to determine a set of genomic sites where DNA methylation is associated...

    Authors: Nikolay Kondratyev, Arkady Golov, Margarita Alfimova, Tatiana Lezheiko and Vera Golimbet

    Citation: Clinical Epigenetics 2018 10:130

    Content type: Methodology

    Published on:

    The Correction to this article has been published in Clinical Epigenetics 2018 10:151

  50. In this letter, we respond to and discuss the recent publication by Al-Moghrabi et al.: Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters. We discuss their finding...

    Authors: Per Eystein Lønning and Stian Knappskog

    Citation: Clinical Epigenetics 2018 10:128

    Content type: Letter to the Editor

    Published on:

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Clinical Epigenetics

ISSN: 1868-7083

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