Retraction Note: Hypermethylation of the 5′ CpG island of the p14ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression
Clinical Epigenetics volume 15, Article number: 88 (2023)
Retraction note: Clinical Epigenetics 2012, 4:9 http://www.clinicalepigeneticsjournal.com/content/4/1/9
The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding similarities among different parts of the methylation PCR gel image in Fig. 1B. Specifically, the two lanes representing the second Tumor (T) sample and the positive control (CTL+) appear highly similar. In addition, the unmethylated (U) lane of the CTL+ group appears to be repeated multiple times in the negative control (H2O) group.
The authors have provided some of the raw data used to produce this image, which confirmed that the image was a composite, and have been unable to sufficiently justify the similarity between the T and CTL+ groups.
The Editor-in-Chief therefore no longer has confidence in the presented data. Christine Nyiraneza, Christine Sempoux, Alex Kartheuser and Karin Dahan do not agree to this retraction. The Publisher has not been able to obtain a current email address for Roger Detry.
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Nyiraneza, C., Sempoux, C., Detry, R. et al. Retraction Note: Hypermethylation of the 5′ CpG island of the p14ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression. Clin Epigenet 15, 88 (2023). https://doi.org/10.1186/s13148-023-01504-x