Articles
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Citation: Clinical Epigenetics 2022 14:25
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Gender-affirming hormone therapy induces specific DNA methylation changes in blood
DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across...
Citation: Clinical Epigenetics 2022 14:24 -
Novel epigenetic network biomarkers for early detection of esophageal cancer
Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often confounded by cell-type heterogeneity.
Citation: Clinical Epigenetics 2022 14:23 -
A validation study of potential prognostic DNA methylation biomarkers in patients with acute myeloid leukemia using a custom DNA methylation sequencing panel
Multiple studies have reported the prognostic impact of DNA methylation changes in acute myeloid leukemia (AML). However, these epigenetic markers have not been thoroughly validated and therefore are still not...
Citation: Clinical Epigenetics 2022 14:22 -
Aberrant epigenetic and transcriptional events associated with breast cancer risk
Genome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we investigated cancer-related molecular changes dete...
Citation: Clinical Epigenetics 2022 14:21 -
The applications of DNA methylation as a biomarker in kidney transplantation: a systematic review
Although kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and non-immune-mediated complications. Current biomarkers of post-transplant compli...
Citation: Clinical Epigenetics 2022 14:20 -
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation
The development of accurate urinary biomarkers for non-invasive and cost-effective detection of primary and recurrent bladder tumours is recognized as one of the major clinical needs in bladder cancer diagnostics
Citation: Clinical Epigenetics 2022 14:19 -
A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer
Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due to suboptimal accuracy. Herein, we...
Citation: Clinical Epigenetics 2022 14:18 -
Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling
Citation: Clinical Epigenetics 2022 14:17 -
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and...
Citation: Clinical Epigenetics 2022 14:16 -
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer
Lung cancer is one of most common cancers worldwide, with a 5-year survival rate of less than 20%, which is mainly due to late-stage diagnosis. Noninvasive methods using 5-hydroxymethylation of cytosine (5hmC)...
Citation: Clinical Epigenetics 2022 14:15 -
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes
Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity m...
Citation: Clinical Epigenetics 2022 14:14 -
Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain
Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits and are characterized by troubling and functionally disabling somatic...
Citation: Clinical Epigenetics 2022 14:13 -
Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence
Prenatal alcohol exposure (PAE) is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing ...
Citation: Clinical Epigenetics 2022 14:12 -
A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features
Heart failure with preserved ejection fraction (HFpEF), affected collectively by genetic and environmental factors, is the common subtype of chronic heart failure. Although the available risk assessment method...
Citation: Clinical Epigenetics 2022 14:11 -
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)
DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclero...
Citation: Clinical Epigenetics 2022 14:10 -
Epigenome-wide association study of lung function in Latino children and youth with asthma
DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, n...
Citation: Clinical Epigenetics 2022 14:9 -
Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the hos...
Citation: Clinical Epigenetics 2022 14:8 -
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer
Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resista...
Citation: Clinical Epigenetics 2022 14:7 -
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study
The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk...
Citation: Clinical Epigenetics 2022 14:6 -
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights
Type II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late t...
Citation: Clinical Epigenetics 2022 14:5 -
The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer
High-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origi...
Citation: Clinical Epigenetics 2022 14:4 -
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis
DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical ...
Citation: Clinical Epigenetics 2022 14:3 -
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop ...
Citation: Clinical Epigenetics 2022 14:2 -
Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer
Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age accel...
Citation: Clinical Epigenetics 2022 14:1 -
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer
Circulating tumor DNA (ctDNA) is a promising diagnostic and prognostic marker for many cancers and has been actively investigated in recent years. Previous studies have already demonstrated the potential use o...
Citation: Clinical Epigenetics 2021 13:232 -
DNA methylation mediates the association between breastfeeding and early-life growth trajectories
The role of breastfeeding in modulating epigenetic factors has been suggested as a possible mechanism conferring its benefits on child development but it lacks evidence. Using extensive DNA methylation data fr...
Citation: Clinical Epigenetics 2021 13:231 -
Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes
Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DN...
Citation: Clinical Epigenetics 2021 13:230 -
Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians
The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to ...
Citation: Clinical Epigenetics 2021 13:229 -
Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors
Dysregulation of fibroblast growth factor receptor (FGFR) signaling pathway has been observed in head and neck squamous cell carcinoma (HNSCC) and is a promising therapeutic target for selective tyrosine kinase i...
Citation: Clinical Epigenetics 2021 13:228 -
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study
Women with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease ...
Citation: Clinical Epigenetics 2021 13:227 -
Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer
Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient’s response to NAC are needed to individualise therapy and a...
Citation: Clinical Epigenetics 2021 13:226 -
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer
Deregulated methylation of tumor suppressor genes is a hallmark event in colorectal cancer (CRC) carcinogenesis. UNC5 receptors, down-regulated in various human malignancies due to epigenetic alterations, have be...
Citation: Clinical Epigenetics 2021 13:225 -
An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors
Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese br...
Citation: Clinical Epigenetics 2021 13:224 -
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles
Patients with severe acute pancreatitis (SAP) have a high mortality, thus early diagnosis and interventions are critical for improving survival. However, conventional tests are limited in acute pancreatitis (A...
Citation: Clinical Epigenetics 2021 13:223 -
Methylation-derived inflammatory measures and lung cancer risk and survival
Examining immunity-related DNA methylation alterations in blood could help elucidate the role of the immune response in lung cancer etiology and aid in discovering factors that are key to lung cancer developme...
Citation: Clinical Epigenetics 2021 13:222 -
Associations between indicators of socioeconomic position and DNA methylation: a scoping review
Socioeconomic position (SEP) is a major determinant of health across the life course. Yet, little is known about the biological mechanisms explaining this relationship. One possibility widely pursued in the sc...
Citation: Clinical Epigenetics 2021 13:221 -
Epigenetic imprinting alterations as effective diagnostic biomarkers for early-stage lung cancer and small pulmonary nodules
Early lung cancer detection remains a clinical challenge for standard diagnostic biopsies due to insufficient tumor morphological evidence. As epigenetic alterations precede morphological changes, expression a...
Citation: Clinical Epigenetics 2021 13:220 -
Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics
One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, ...
Citation: Clinical Epigenetics 2021 13:219 -
High performance methylated DNA markers for detection of colon adenocarcinoma
Colon cancer (CC) is treatable if detected in its early stages. Improved CC detection assays that are highly sensitive, specific, and available at point of care are needed. In this study, we systematically sel...
Citation: Clinical Epigenetics 2021 13:218 -
Genome-wide methylation patterns in Marfan syndrome
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study (EWAS) in patients with MFS aiming at ide...
Citation: Clinical Epigenetics 2021 13:217 -
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines
Illumina DNA methylation arrays are high-throughput platforms for cost-effective genome-wide profiling of individual CpGs. Experimental and technical factors introduce appreciable measurement variation, some o...
Citation: Clinical Epigenetics 2021 13:216 -
Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking
Smoking is a major causal risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and is the main preventable cause of deaths in the world. The components of ci...
Citation: Clinical Epigenetics 2021 13:215 -
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction between genetic and environmental factors. The variability in risk and outcomes in these diseases are incompletely explained ...
Citation: Clinical Epigenetics 2021 13:214 -
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy
Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in adrenocortical adenomas. The present study aims to e...
Citation: Clinical Epigenetics 2021 13:213 -
Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency
Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce gene...
Citation: Clinical Epigenetics 2021 13:212 -
Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature
Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated ...
Citation: Clinical Epigenetics 2021 13:211 -
Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy
The thymic microenvironment is mainly comprised of thymic epithelial cells, the cytokines, exosomes, surface molecules, and hormones from the cells, and plays a vital role in the development, differentiation, ...
Citation: Clinical Epigenetics 2021 13:210 -
Correction to: Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS‑CoV‑2 infectivity
Citation: Clinical Epigenetics 2021 13:209 -
Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals
Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...
Citation: Clinical Epigenetics 2021 13:208
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- ISSN: 1868-7083 (electronic)