Skip to main content

Articles

Page 10 of 37

  2. DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across...

    Authors: Rebecca Shepherd, Ingrid Bretherton, Ken Pang, Toby Mansell, Anna Czajko, Bowon Kim, Amanda Vlahos, Jeffrey D. Zajac, Richard Saffery, Ada Cheung and Boris Novakovic
    Citation: Clinical Epigenetics 2022 14:24
    Content type: Research Published on:

  3. Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often confounded by cell-type heterogeneity.

    Authors: Alok K. Maity, Timothy C. Stone, Vanessa Ward, Amy P. Webster, Zhen Yang, Aine Hogan, Hazel McBain, Margaraet Duku, Kai Man Alexander Ho, Paul Wolfson, David G. Graham, Stephan Beck, Andrew E. Teschendorff and Laurence B. Lovat
    Citation: Clinical Epigenetics 2022 14:23
    Content type: Research Published on:

  4. Multiple studies have reported the prognostic impact of DNA methylation changes in acute myeloid leukemia (AML). However, these epigenetic markers have not been thoroughly validated and therefore are still not...

    Authors: Šárka Šestáková, Ela Cerovská, Cyril Šálek, Dávid Kundrát, Ivana Ježíšková, Adam Folta, Jiří Mayer, Zdeněk Ráčil, Petr Cetkovský and Hana Remešová
    Citation: Clinical Epigenetics 2022 14:22
    Content type: Research Published on:

  5. Genome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we investigated cancer-related molecular changes dete...

    Authors: Natascia Marino, Rana German, Ram Podicheti, Douglas B. Rusch, Pam Rockey, Jie Huang, George E. Sandusky, Constance J. Temm, Sandra Althouse, Kenneth P. Nephew, Harikrishna Nakshatri, Jun Liu, Ashley Vode, Sha Cao and Anna Maria V. Storniolo
    Citation: Clinical Epigenetics 2022 14:21
    Content type: Research Published on:

  6. Although kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and non-immune-mediated complications. Current biomarkers of post-transplant compli...

    Authors: Iacopo Cristoferi, Tommaso Antonio Giacon, Karin Boer, Myrthe van Baardwijk, Flavia Neri, Manuela Campisi, Hendrikus J. A. N. Kimenai, Marian C. Clahsen - van Groningen, Sofia Pavanello, Lucrezia Furian and Robert C. Minnee
    Citation: Clinical Epigenetics 2022 14:20
    Content type: Review Published on:

  7. The development of accurate urinary biomarkers for non-invasive and cost-effective detection of primary and recurrent bladder tumours is recognized as one of the major clinical needs in bladder cancer diagnostics

    Authors: Anouk E. Hentschel, Irene J. Beijert, Judith Bosschieter, Paul C. Kauer, André N. Vis, Birgit I. Lissenberg-Witte, R. Jeroen A. van Moorselaar, Renske D. M. Steenbergen and Jakko A. Nieuwenhuijzen
    Citation: Clinical Epigenetics 2022 14:19
    Content type: Research Published on:

  8. Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due to suboptimal accuracy. Herein, we...

    Authors: Shang Chen, Yanqi Yu, Tao Li, Weimei Ruan, Jun Wang, Quanzhou Peng, Yingdian Yu, Tianfeng Cao, Wenyuan Xue, Xin Liu, Zhiwei Chen, Jiang Yu and Jian-Bing Fan
    Citation: Clinical Epigenetics 2022 14:18
    Content type: Research Published on:

  10. GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and...

    Authors: Tao Gao, John T. Wilkins, Yinan Zheng, Brian T. Joyce, David R. Jacobs Jr., Pamela J. Schreiner, Steve Horvath, Philip Greenland, Donald Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:16
    Content type: Research Published on:

  11. Lung cancer is one of most common cancers worldwide, with a 5-year survival rate of less than 20%, which is mainly due to late-stage diagnosis. Noninvasive methods using 5-hydroxymethylation of cytosine (5hmC)...

    Authors: Xinlei Hu, Kai Luo, Hui Shi, Xiaoqin Yan, Ruichen Huang, Bi Zhao, Jun Zhang, Dan Xie and Wei Zhang
    Citation: Clinical Epigenetics 2022 14:15
    Content type: Research Published on:

  12. Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity m...

    Authors: Ji-Qing Chen, Lucas A. Salas, John K. Wiencke, Devin C. Koestler, Annette M. Molinaro, Angeline S. Andrew, John D. Seigne, Margaret R. Karagas, Karl T. Kelsey and Brock C. Christensen
    Citation: Clinical Epigenetics 2022 14:14
    Content type: Research Published on:

  13. Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits and are characterized by troubling and functionally disabling somatic...

    Authors: Johannes Achenbach, Mathias Rhein, Alexander Glahn, Helge Frieling and Matthias Karst
    Citation: Clinical Epigenetics 2022 14:13
    Content type: Research Published on:

  14. Prenatal alcohol exposure (PAE) is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing ...

    Authors: Mitchell Bestry, Martyn Symons, Alexander Larcombe, Evelyne Muggli, Jeffrey M. Craig, Delyse Hutchinson, Jane Halliday and David Martino
    Citation: Clinical Epigenetics 2022 14:12
    Content type: Review Published on:

  15. Heart failure with preserved ejection fraction (HFpEF), affected collectively by genetic and environmental factors, is the common subtype of chronic heart failure. Although the available risk assessment method...

    Authors: Xuetong Zhao, Yang Sui, Xiuyan Ruan, Xinyue Wang, Kunlun He, Wei Dong, Hongzhu Qu and Xiangdong Fang
    Citation: Clinical Epigenetics 2022 14:11
    Content type: Research Published on:

  16. DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclero...

    Authors: Farah Ammous, Wei Zhao, Lisha Lin, Scott M. Ratliff, Thomas H. Mosley, Lawrence F. Bielak, Xiang Zhou, Patricia A. Peyser, Sharon L. R. Kardia and Jennifer A. Smith
    Citation: Clinical Epigenetics 2022 14:10
    Content type: Research Published on:

  17. DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, n...

    Authors: Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard and Maria Pino-Yanes
    Citation: Clinical Epigenetics 2022 14:9
    Content type: Research Published on:

  18. Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the hos...

    Authors: Boghuma K. Titanji, Marta Gwinn, Vincent C. Marconi and Yan V. Sun
    Citation: Clinical Epigenetics 2022 14:8
    Content type: Review Published on:

  19. Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resista...

    Authors: Garyfallia Pantelaiou-Prokaki, Iga Mieczkowska, Geske E. Schmidt, Sonja Fritzsche, Evangelos Prokakis, Julia Gallwas and Florian Wegwitz
    Citation: Clinical Epigenetics 2022 14:7
    Content type: Research Published on:

  20. The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk...

    Authors: Elie Antoun, Prachand Issarapu, Chiara di Gravio, Smeeta Shrestha, Modupeh Betts, Ayden Saffari, Sirazul A. Sahariah, Alagu Sankareswaran, Manisha Arumalla, Andrew M. Prentice, Caroline H. D. Fall, Matt J. Silver, Giriraj R. Chandak and Karen A. Lillycrop
    Citation: Clinical Epigenetics 2022 14:6
    Content type: Research Published on:

  21. Type II germ cell tumors (GCT) are the most common solid cancers in males of age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving high cure rates, but also leading to late t...

    Authors: Melanie R. Müller, Aaron Burmeister, Margaretha A. Skowron, Alexa Stephan, Felix Bremmer, Gamal A. Wakileh, Patrick Petzsch, Karl Köhrer, Peter Albers and Daniel Nettersheim
    Citation: Clinical Epigenetics 2022 14:5
    Content type: Research Published on:

  22. High-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its development. Abnormal DNA methylation has an important role in the origi...

    Authors: Jaqueline Loaeza-Loaeza, Berenice Illades-Aguiar, Oscar del Moral-Hernández, Yaneth Castro-Coronel, Marco A. Leyva-Vázquez, Roberto Dircio-Maldonado, Julio Ortiz-Ortiz and Daniel Hernández-Sotelo
    Citation: Clinical Epigenetics 2022 14:4
    Content type: Research Published on:

  23. DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical ...

    Authors: Chaoyuan Kuang, Yongseok Park, Ryan C. Augustin, Yan Lin, Douglas J. Hartman, Lindsey Seigh, Reetesh K. Pai, Weijing Sun, Nathan Bahary, James Ohr, John C. Rhee, Stanley M. Marks, H. Scott Beasley, Yongli Shuai, James G. Herman, Hassane M. Zarour…
    Citation: Clinical Epigenetics 2022 14:3
    Content type: Research Published on:

  24. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop ...

    Authors: Jiewen Zhang, Junkui Shang, Fengyu Wang, Xuejing Huo, Ruihua Sun, Zhixia Ren, Wan Wang, Miaomiao Yang, Gai Li, Dandan Gao, Ruijie Liu, Pingping Bai, Shuyi Wang, Yanliang Wang and Xi Yan
    Citation: Clinical Epigenetics 2022 14:2
    Content type: Research Published on:

  25. Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age accel...

    Authors: Rhona A. Beynon, Suzanne M. Ingle, Ryan Langdon, Margaret May, Andy Ness, Richard M. Martin, Matthew Suderman, Kate Ingarfield, Riccardo E. Marioni, Daniel L. McCartney, Tim Waterboer, Michael Pawlita, Caroline Relton, George Davey Smith and Rebecca C. Richmond
    Citation: Clinical Epigenetics 2022 14:1
    Content type: Research Published on:

  26. Circulating tumor DNA (ctDNA) is a promising diagnostic and prognostic marker for many cancers and has been actively investigated in recent years. Previous studies have already demonstrated the potential use o...

    Authors: Wu-Hao Lin, Jian Xiao, Zi-Yi Ye, Da-Liang Wei, Xiao-Hui Zhai, Rui-Hua Xu, Zhao-Lei Zeng and Hui-Yan Luo
    Citation: Clinical Epigenetics 2021 13:232
    Content type: Research Published on:

  27. The role of breastfeeding in modulating epigenetic factors has been suggested as a possible mechanism conferring its benefits on child development but it lacks evidence. Using extensive DNA methylation data fr...

    Authors: Laurent Briollais, Denis Rustand, Catherine Allard, Yanyan Wu, Jingxiong Xu, Samyukta Govinda Rajan, Marie-France Hivert, Myriam Doyon, Luigi Bouchard, Patrick O. McGowan, Steven Matthews and Steven Lye
    Citation: Clinical Epigenetics 2021 13:231
    Content type: Research Published on:

  28. Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DN...

    Authors: Whitney L. Do, Steve Nguyen, Jie Yao, Xiuqing Guo, Eric A. Whitsel, Ellen Demerath, Jerome I. Rotter, Stephen S. Rich, Leslie Lange, Jingzhong Ding, David Van Den Berg, Yongmei Liu, Anne E. Justice, Weihua Guan, Steve Horvath, Themistocles L. Assimes…
    Citation: Clinical Epigenetics 2021 13:230
    Content type: Research Published on:

  29. The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to ...

    Authors: Fenglong Bie, He Tian, Nan Sun, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Yue Peng, Guangyu Bai, Bolun Zhou and Shugeng Gao
    Citation: Clinical Epigenetics 2021 13:229
    Content type: Research Published on:

  30. Dysregulation of fibroblast growth factor receptor (FGFR) signaling pathway has been observed in head and neck squamous cell carcinoma (HNSCC) and is a promising therapeutic target for selective tyrosine kinase i...

    Authors: Yilin Bao, Jennis Gabrielpillai, Jörn Dietrich, Romina Zarbl, Sebastian Strieth, Friederike Schröck and Dimo Dietrich
    Citation: Clinical Epigenetics 2021 13:228
    Content type: Research Published on:

  31. Women with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease ...

    Authors: Emily W. Harville, Pashupati P. Mishra, Mika Kähönen, Emma Raitoharju, Saara Marttila, Olli Raitakari and Terho Lehtimäki
    Citation: Clinical Epigenetics 2021 13:227
    Content type: Research Published on:

  32. Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient’s response to NAC are needed to individualise therapy and a...

    Authors: Braydon Meyer, Samuel Clifton, Warwick Locke, Phuc-Loi Luu, Qian Du, Dilys Lam, Nicola J. Armstrong, Beena Kumar, Niantao Deng, Kate Harvey, Alex Swarbrick, Vinod Ganju, Susan J. Clark, Ruth Pidsley and Clare Stirzaker
    Citation: Clinical Epigenetics 2021 13:226
    Content type: Short report Published on:

  33. Deregulated methylation of tumor suppressor genes is a hallmark event in colorectal cancer (CRC) carcinogenesis. UNC5 receptors, down-regulated in various human malignancies due to epigenetic alterations, have be...

    Authors: Dong Dong, Runshi Zhang, Jie Shao, Aimin Zhang, Yichao Wang, Yunli Zhou and Yueguo Li
    Citation: Clinical Epigenetics 2021 13:225
    Content type: Research Published on:

  34. Metformin and weight loss relationships with epigenetic age measures—biological aging biomarkers—remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese br...

    Authors: Jamaji C. Nwanaji-Enwerem, Felicia Fei-Lei Chung, Lars Van der Laan, Alexei Novoloaca, Cyrille Cuenin, Harriet Johansson, Bernardo Bonanni, Alan E. Hubbard, Martyn T. Smith, Sheri J. Hartman, Andres Cardenas, Dorothy D. Sears and Zdenko Herceg
    Citation: Clinical Epigenetics 2021 13:224
    Content type: Short report Published on:

  35. Patients with severe acute pancreatitis (SAP) have a high mortality, thus early diagnosis and interventions are critical for improving survival. However, conventional tests are limited in acute pancreatitis (A...

    Authors: Hong-Wei Sun, Sheng-Jie Dai, Hong-Ru Kong, Jie-Xiang Fan, Fang-Yuan Yang, Ju-Qing Dai, Yue-Peng Jin, Guan-Zhen Yu, Bi-Cheng Chen and Ke-Qing Shi
    Citation: Clinical Epigenetics 2021 13:223
    Content type: Research Published on:

  36. Examining immunity-related DNA methylation alterations in blood could help elucidate the role of the immune response in lung cancer etiology and aid in discovering factors that are key to lung cancer developme...

    Authors: Naisi Zhao, Mengyuan Ruan, Devin C. Koestler, Jiayun Lu, Lucas A. Salas, Karl T. Kelsey, Elizabeth A. Platz and Dominique S. Michaud
    Citation: Clinical Epigenetics 2021 13:222
    Content type: Research Published on:

  37. Socioeconomic position (SEP) is a major determinant of health across the life course. Yet, little is known about the biological mechanisms explaining this relationship. One possibility widely pursued in the sc...

    Authors: Janine Cerutti, Alexandre A. Lussier, Yiwen Zhu, Jiaxuan Liu and Erin C. Dunn
    Citation: Clinical Epigenetics 2021 13:221
    Content type: Review Published on:

  38. Early lung cancer detection remains a clinical challenge for standard diagnostic biopsies due to insufficient tumor morphological evidence. As epigenetic alterations precede morphological changes, expression a...

    Authors: Jian Zhou, Tong Cheng, Xing Li, Jie Hu, Encheng Li, Ming Ding, Rulong Shen, John P. Pineda, Chun Li, Shaohua Lu, Hongyu Yu, Jiayuan Sun, Wenbin Huang, Xiaonan Wang, Han Si, Panying Shi…
    Citation: Clinical Epigenetics 2021 13:220
    Content type: Research Published on:

  39. One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, ...

    Authors: Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Kozo Tanno, Makoto Sasaki and Atsushi Shimizu
    Citation: Clinical Epigenetics 2021 13:219
    Content type: Research Published on:

  40. Colon cancer (CC) is treatable if detected in its early stages. Improved CC detection assays that are highly sensitive, specific, and available at point of care are needed. In this study, we systematically sel...

    Authors: Romy A. M. Klein Kranenbarg, Abdul Hussain Vali, Jan N. M. IJzermans, Thomas R. Pisanic II, Tza-Huei Wang, Nilofer Azad, Saraswati Sukumar and Mary Jo Fackler
    Citation: Clinical Epigenetics 2021 13:218
    Content type: Research Published on:

  41. Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study (EWAS) in patients with MFS aiming at ide...

    Authors: Mitzi M. van Andel, Maarten Groenink, Maarten P. van den Berg, Janneke Timmermans, Arthur J. H. A. Scholte, Barbara J. M. Mulder, Aeilko H. Zwinderman and Vivian de Waard
    Citation: Clinical Epigenetics 2021 13:217
    Content type: Research Published on:

  42. Illumina DNA methylation arrays are high-throughput platforms for cost-effective genome-wide profiling of individual CpGs. Experimental and technical factors introduce appreciable measurement variation, some o...

    Authors: Zongli Xu, Liang Niu and Jack A. Taylor
    Citation: Clinical Epigenetics 2021 13:216
    Content type: Research Published on:

  43. Smoking is a major causal risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and is the main preventable cause of deaths in the world. The components of ci...

    Authors: Ying Mao, Peng Huang, Yan Wang, Maiqiu Wang, Ming D. Li and Zhongli Yang
    Citation: Clinical Epigenetics 2021 13:215
    Content type: Research Published on:

  44. The aetiology and pathophysiology of complex diseases are driven by the interaction between genetic and environmental factors. The variability in risk and outcomes in these diseases are incompletely explained ...

    Authors: Maria Pia Campagna, Alexandre Xavier, Jeannette Lechner-Scott, Vicky Maltby, Rodney J. Scott, Helmut Butzkueven, Vilija G. Jokubaitis and Rodney A. Lea
    Citation: Clinical Epigenetics 2021 13:214
    Content type: Review Published on:

  45. Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in adrenocortical adenomas. The present study aims to e...

    Authors: Chuan Wang, Yujing Sun, Xiaofei Yin, Ruoqi Feng, Ruiying Feng, Mingyue Xu, Kai Liang, Ruxing Zhao, Gangli Gu, Xuewen Jiang, Peng Su, Xiaofang Zhang and Jinbo Liu
    Citation: Clinical Epigenetics 2021 13:213
    Content type: Research Published on:

  46. Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce gene...

    Authors: Youssef Siblini, Céline Chéry, Pierre Rouyer, Jérémie Raso, Amélia Julien, Sébastien Hergalant, Aurélie François, Lina Bezdetnaya, Guillaume Vogin, Jean-Louis Guéant and Abderrahim Oussalah
    Citation: Clinical Epigenetics 2021 13:212
    Content type: Research Published on:

  47. Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated ...

    Authors: U. Schagdarsurengin, C. Luo, H. Slanina, D. Sheridan, S. Füssel, N. Böğürcü-Seidel, S. Gattenloehner, G. B. Baretton, L. C. Hofbauer, F. Wagenlehner and T. Dansranjav
    Citation: Clinical Epigenetics 2021 13:211
    Content type: Research Published on:

  48. The thymic microenvironment is mainly comprised of thymic epithelial cells, the cytokines, exosomes, surface molecules, and hormones from the cells, and plays a vital role in the development, differentiation, ...

    Authors: Cexun Hu, Keyu Zhang, Feng Jiang, Hui Wang and Qixiang Shao
    Citation: Clinical Epigenetics 2021 13:210
    Content type: Review Published on:

  50. Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...

    Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Brent A. Coull, Andrea A. Baccarelli, Robert O. Wright, Chitra Amarasiriwardena, Diane R. Gold, Emily Oken, Marie-France Hivert and Andres Cardenas
    Citation: Clinical Epigenetics 2021 13:208
    Content type: Research Published on:
Submit manuscript

Follow

  • ISSN: 1868-7083 (electronic)

Clinical Epigenetics

ISSN: 1868-7083

Contact us