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  1. The myeloproliferative neoplasms (MPNs) are a group of clonal hematological malignancies characterized by a hypercellular bone marrow and a tendency to develop thrombotic complications and to evolve to myelofi...

    Authors: John Mascarenhas, Nitin Roper, Pratima Chaurasia and Ronald Hoffman
    Citation: Clinical Epigenetics 2011 2:50
  2. 5-azacytidine (AZA) has become standard treatment for patients with higher-risk myelodysplastic syndrome (MDS). Response rate is about 50% and response duration is limited. Histone deactylase (HDAC) inhibitors...

    Authors: Andrea Kuendgen, Gesine Bug, Oliver G. Ottmann, Detlef Haase, Julie Schanz, Barbara Hildebrandt, Kathrin Nachtkamp, Judith Neukirchen, Ariane Dienst, Rainer Haas, Ulrich Germing and Norbert Gattermann
    Citation: Clinical Epigenetics 2011 2:31
  3. Fermentation of glucose to lactate in the presence of sufficient oxygen, known as aerobic glycolysis or Warburg effect, is a universal phenotype of cancer cells. Understanding its origin and role in cellular i...

    Authors: Paike Jayadeva Bhat, Lalit Darunte, Venkatesh Kareenhalli, Jaswandi Dandekar and Abhay Kumar
    Citation: Clinical Epigenetics 2011 2:30
  4. Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites suc...

    Authors: Zhi-yi Guo, Xiao-hui Hao, Fei-Fei Tan, Xin Pei, Li-Mei Shang, Xue-lian Jiang and Fang Yang
    Citation: Clinical Epigenetics 2011 2:18
  5. The bioactive vitamin D (VD) metabolite, 1,25-dihydroxyvitamin D3 regulates essential pathways of cellular metabolism and differentiation via its nuclear receptor (VDR). Molecular mechanisms which are known to pl...

    Authors: Heidrun Karlic and Franz Varga
    Citation: Clinical Epigenetics 2011 2:21
  6. Considering psychiatry as a medical discipline, a diagnosis identifying a disorder should lead to an effective therapy. Such presumed causality is the basis of evidence-based psychiatry. We examined the streng...

    Authors: Drozdstoy Stojanov, Jakob Korf, Peter de Jonge and Georgi Popov
    Citation: Clinical Epigenetics 2010 2:14
  7. There exist two paradigms about the nature of cancer. According to the generally accepted one, cancer is a by-product of design limitations of a multi-cellular organism (Greaves, Nat Rev Cancer 7:213–221, 2007...

    Authors: Anatoly V. Lichtenstein
    Citation: Clinical Epigenetics 2010 1:10
  8. Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ...

    Authors: Susanne Voelter-Mahlknecht and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2010 1:8
  9. Histone modifications have widely been implicated in cancer development and progression and are potentially reversible by drug treatments. The N-terminal tails of each histone extend outward through the DNA st...

    Authors: Francesco Paolo Tambaro, Carmela Dell’Aversana, Vincenzo Carafa, Angela Nebbioso, Branka Radic, Felicetto Ferrara and Lucia Altucci
    Citation: Clinical Epigenetics 2010 1:6
  10. This study examined molecular (DNA hypermethylation), clinical, histopathological, demographical, smoking, and alcohol variables to assess diagnosis (early versus late stage) and prognosis (survival) outcomes ...

    Authors: Josena K. Stephen, Kang Mei Chen, Veena Shah, Shaleta Havard, Alissa Kapke, Mei Lu, Michael S. Benninger and Maria J. Worsham
    Citation: Clinical Epigenetics 2010 1:5
  11. The analysis and visualisation of research data in an environment which is most similar to living conditions belong to the most challenging claims of present scientific research endeavours. To date, the effect...

    Authors: Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2010 1:4
  12. Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible fo...

    Authors: Georges Herbein and Daniel Wendling
    Citation: Clinical Epigenetics 2010 1:3
  13. microRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. He...

    Authors: Salma Essa, N. Denzer, U. Mahlknecht, R. Klein, E. M. Collnot and J. Reichrath
    Citation: Clinical Epigenetics 2010 1:1