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  1. Intrauterine growth restriction (IUGR), which refers to reduced fetal growth in the context of placental insufficiency, is etiologically heterogeneous. IUGR is associated not only with perinatal morbidity and ...

    Authors: Maian Roifman, Sanaa Choufani, Andrei L. Turinsky, Sascha Drewlo, Sarah Keating, Michael Brudno, John Kingdom and Rosanna Weksberg
    Citation: Clinical Epigenetics 2016 8:70
    Content type: Research Published on:

  2. The overgrowth-associated Beckwith-Wiedemann syndrome (BWS) and the undergrowth-associated Silver-Russell syndrome (SRS) are characterized by heterogeneous molecular defects affecting a large imprinted gene cl...

    Authors: Susanne Eriksen Boonen, Andrea Freschi, Rikke Christensen, Federica Maria Valente, Dorte Launholt Lildballe, Lucia Perone, Orazio Palumbo, Massimo Carella, Niels Uldbjerg, Angela Sparago, Andrea Riccio and Flavia Cerrato
    Citation: Clinical Epigenetics 2016 8:69
    Content type: Short report Published on:

  3. Aberrant DNA methylation has been identified as a key molecular event regulating the pathogenesis of myelodysplastic syndromes (MDS); myeloid neoplasms with an inherent risk of transformation to acute myeloid ...

    Authors: Seongseok Yun, Nicole D. Vincelette, Ivo Abraham, Keith D. Robertson, Martin E. Fernandez-Zapico and Mrinal M. Patnaik
    Citation: Clinical Epigenetics 2016 8:68
    Content type: Review Published on:

  4. Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2–8 % of all pregnancies. Although children born to women with preeclampsia h...

    Authors: Masako Suzuki, Ryo Maekawa, Nicole E. Patterson, David M. Reynolds, Brent R. Calder, Sandra E. Reznik, Hye J. Heo, Francine Hughes Einstein and John M. Greally
    Citation: Clinical Epigenetics 2016 8:67
    Content type: Research Published on:

  5. Opportunistic screening in hospitals is widely used to effectively reduce the incidence rate of cervical cancer in China and other developing countries. This study aimed to identify clinical risk factor algori...

    Authors: Yu-Ligh Liou, Tao-Lan Zhang, Tian Yan, Ching-Tung Yeh, Ya-Nan Kang, Lanqin Cao, Nayiyuan Wu, Chi-Feng Chang, Huei-Jen Wang, Carolyn Yen, Tang-Yuan Chu, Yi Zhang, Yu Zhang and Honghao Zhou
    Citation: Clinical Epigenetics 2016 8:66
    Content type: Case study Published on:

  6. Crohn’s disease (CD) is a chronic inflammatory disorder belonging to the inflammatory bowel diseases (IBD). CD affects distinct parts of the gastrointestinal tract, leading to symptoms including diarrhea, feve...

    Authors: Andrew Y. F. Li Yim, Nicolette W. Duijvis, Jing Zhao, Wouter J. de Jonge, Geert R. A. M. D’Haens, Marcel M. A. M. Mannens, Adri N. P. M. Mul, Anje A. te Velde and Peter Henneman
    Citation: Clinical Epigenetics 2016 8:65
    Content type: Research Published on:

  7. Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages ...

    Authors: Laura Perna, Yan Zhang, Ute Mons, Bernd Holleczek, Kai-Uwe Saum and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:64
    Content type: Research Published on:

  9. When assembled in multiprotein polycomb repressive complexes (PRCs), highly evolutionary conserved polycomb group (PcG) proteins epigenetically control gene activity. Although the composition of PRCs may vary ...

    Authors: Koraljka Gall Trošelj, Renata Novak Kujundzic and Djurdjica Ugarkovic
    Citation: Clinical Epigenetics 2016 8:55
    Content type: Review Published on:

  10. Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, ...

    Authors: Yong Wang, Fei Li, Guowei Zhang, Lihua Kang and Huaijin Guan
    Citation: Clinical Epigenetics 2016 8:62
    Content type: Research Published on:

  12. Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferatio...

    Authors: Vincenzo Carafa, Dante Rotili, Mariantonietta Forgione, Francesca Cuomo, Enrica Serretiello, Gebremedhin Solomon Hailu, Elina Jarho, Maija Lahtela-Kakkonen, Antonello Mai and Lucia Altucci
    Citation: Clinical Epigenetics 2016 8:61
    Content type: Review Published on:

  14. The quantification of global DNA methylation has been established in epigenetic screening. As more practicable alternatives to the HPLC-based gold standard, the methylation analysis of CpG islands in repeatabl...

    Authors: Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring and Jörn Lötsch
    Citation: Clinical Epigenetics 2016 8:60
    Content type: Methodology Published on:

  17. Prenatal maternal stress (PNMS) is an important programming factor of postnatal immunity. We tested here the hypothesis that DNA methylation of genes in the NF-κB signaling pathway in T cells mediates the effe...

    Authors: Lei Cao-Lei, Franz Veru, Guillaume Elgbeili, Moshe Szyf, David P. Laplante and Suzanne King
    Citation: Clinical Epigenetics 2016 8:54
    Content type: Research Published on:

  18. The tumor-specific microregional effects of the anticancer agent RRx-001, a novel epigenetic-based radio/chemosensitizer with nitrogen oxide-donating properties in phase II clinical trials, were investigated w...

    Authors: Bryan Oronsky, Jan Scicinski, Pedro Cabrales and Andrew Minchinton
    Citation: Clinical Epigenetics 2016 8:53
    Content type: Research Published on:

  19. Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi...

    Authors: Anna Starnawska, Ditte Demontis, Andrew McQuillin, Niamh L. O’Brien, Nicklas H. Staunstrup, Ole Mors, Anders L. Nielsen, Anders D. Børglum and Mette Nyegaard
    Citation: Clinical Epigenetics 2016 8:52
    Content type: Short report Published on:

  20. Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishme...

    Authors: Adelheid Soubry, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price and Susan K. Murphy
    Citation: Clinical Epigenetics 2016 8:51
    Content type: Research Published on:

  21. Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm of childhood whose clinical heterogeneity is only poorly represented by gene sequence alterations. It was previously shown that aberrant...

    Authors: Silvia Fluhr, Melanie Boerries, Hauke Busch, Aikaterini Symeonidi, Tania Witte, Daniel B Lipka, Oliver Mücke, Peter Nöllke, Christopher Felix Krombholz, Charlotte M Niemeyer, Christoph Plass and Christian Flotho
    Citation: Clinical Epigenetics 2016 8:50
    Content type: Short report Published on:

  22. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are ...

    Authors: Olivier J. Switzeny, Markus Christmann, Mirjam Renovanz, Alf Giese, Clemens Sommer and Bernd Kaina
    Citation: Clinical Epigenetics 2016 8:49
    Content type: Research Published on:

  23. Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants and environmental cues influenc...

    Authors: Müjdat Zeybel, Sezgin Vatansever, Timothy Hardy, Ayşegül Akder Sarı, Fulya Cakalağaoğlu, Arzu Avcı, Gemma Louise Zeybel, Serçin Karahüseyinoğlu, Matthew Bashton, John C. Mathers, Belkıs Ünsal and Jelena Mann
    Citation: Clinical Epigenetics 2016 8:48
    Content type: Research Published on:

  24. Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally important genes from defined parental alleles. The regulation of imprinted g...

    Authors: Florian Bohne, David Langer, Ursula Martiné, Claudia S. Eider, Regina Cencic, Matthias Begemann, Miriam Elbracht, Luzie Bülow, Thomas Eggermann, Ulrich Zechner, Jerry Pelletier, Bernhard Ulrich Zabel, Thorsten Enklaar and Dirk Prawitt
    Citation: Clinical Epigenetics 2016 8:47
    Content type: Research Published on:

  25. 5-Azacytidine (5-AZA), a DNA methyl transferase inhibitor, is a clinically used epigenetic drug for cancer therapy. Recently, we have shown that 5-AZA upregulates ten-eleven translocation (TET) protein express...

    Authors: Sahar Olsadat Sajadian, Chaturvedula Tripura, Fazel Sahraneshin Samani, Marc Ruoss, Steven Dooley, Hossein Baharvand and Andreas K. Nussler
    Citation: Clinical Epigenetics 2016 8:46
    Content type: Research Published on:

  26. The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic methods to improve accuracy and reproducibility of the interpretation of r...

    Authors: Michelle L. Wright, Mikhail G. Dozmorov, Aaron R. Wolen, Colleen Jackson-Cook, Angela R. Starkweather, Debra E. Lyon and Timothy P. York
    Citation: Clinical Epigenetics 2016 8:45
    Content type: Review Published on:

  27. Already since the 1990s, promoter CpG island methylation markers have been considered promising diagnostic, prognostic, and predictive cancer biomarkers. However, so far, only a limited number of DNA methylati...

    Authors: Muriel X. G. Draht, Kim M. Smits, Valérie Jooste, Benjamin Tournier, Martijn Vervoort, Chantal Ramaekers, Caroline Chapusot, Matty P. Weijenberg, Manon van Engeland and Veerle Melotte
    Citation: Clinical Epigenetics 2016 8:44
    Content type: Research Published on:

  29. Weight gain is one of the consequences of estrogen deficiency and constitutes a major health problem. The present study highlights the effects of N-methyl pyrrolidone (NMP) on adipogenesis in osteoporosis indu...

    Authors: Bebeka Gjoksi, Chafik Ghayor, Indranil Bhattacharya, Marcy Zenobi-Wong and Franz E. Weber
    Citation: Clinical Epigenetics 2016 8:42
    Content type: Research Published on:

  30. Related to genetic alteration, frequent promoter hypermethylation is also a contributing factor in the development of human cancers. Recently, we discovered numerous novel genes that were aberrantly methylated...

    Authors: Yu-Lueng Shih, Chih-Chi Kuo, Ming-De Yan, Ya-Wen Lin, Chung-Bao Hsieh and Tsai-Yuan Hsieh
    Citation: Clinical Epigenetics 2016 8:41
    Content type: Research Published on:

  31. Authors: Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…
    Citation: Clinical Epigenetics 2016 8:40
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2016 8:23

  32. In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to ret...

    Authors: Mathew A. Sloane, Robyn L. Ward and Luke B. Hesson
    Citation: Clinical Epigenetics 2016 8:39
    Content type: Letter to the Editor Published on:

  33. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogen...

    Authors: Olga Aprelikova, Kenny Chen, Lara H. El Touny, Constance Brignatz-Guittard, Justin Han, Tinghu Qiu, Howard H. Yang, Maxwell P. Lee, Min Zhu and Jeffrey E. Green
    Citation: Clinical Epigenetics 2016 8:38
    Content type: Research Published on:

  34. Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is...

    Authors: Naiara Celarain, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Rosa Larumbe, Laura Pulido, Carmen Echavarri and Maite Mendioroz
    Citation: Clinical Epigenetics 2016 8:37
    Content type: Research Published on:

  35. Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional stat...

    Authors: Duo Chen, Xianyu Wen, Young Seok Song, Ye-Young Rhee, Tae Hun Lee, Nam Yun Cho, Sae-Won Han, Tae-You Kim and Gyeong Hoon Kang
    Citation: Clinical Epigenetics 2016 8:36
    Content type: Research Published on:

  36. Circulating hypermethylated RASSF1A could be a novel and potential useful marker for monitoring patients with metastatic breast cancer. Technical obstacles include fragmentation of the circulating DNA, fluctuatio...

    Authors: Søren Kristiansen, Dorte Nielsen and György Sölétormos
    Citation: Clinical Epigenetics 2016 8:35
    Content type: Methodology Published on:

  37. Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. ...

    Authors: Quan-Yi Zhao, Pin-Ji Lei, Xiaoran Zhang, Jun-Yi Zheng, Hui-Yi Wang, Jiao Zhao, Yi-Ming Li, Mei Ye, Lianyun Li, Gang Wei and Min Wu
    Citation: Clinical Epigenetics 2016 8:34
    Content type: Research Published on:

  38. An abundant class of intronic microRNAs (miRNAs) undergoes atypical Drosha-independent biogenesis in which the spliceosome governs the excision of hairpin miRNA precursors, called mirtrons. Although nearly 500...

    Authors: Stasė Butkytė, Laurynas Čiupas, Eglė Jakubauskienė, Laurynas Vilys, Paulius Mocevicius, Arvydas Kanopka and Giedrius Vilkaitis
    Citation: Clinical Epigenetics 2016 8:33
    Content type: Research Published on:

  39. Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethy...

    Authors: Shivani N. Kamdar, Linh T. Ho, Ken J. Kron, Ruth Isserlin, Theodorus van der Kwast, Alexandre R. Zlotta, Neil E. Fleshner, Gary Bader and Bharati Bapat
    Citation: Clinical Epigenetics 2016 8:32
    Content type: Research Published on:

  40. Primary hyperparathyroidism is characterized by enlarged parathyroid glands due to an adenoma (80–85 %) or multiglandular disease (~15 %) causing hypersecretion of parathyroid hormone (PTH) and generally hyper...

    Authors: Elham Barazeghi, Anthony J. Gill, Stan Sidhu, Olov Norlén, Roberto Dina, F. Fausto Palazzo, Per Hellman, Peter Stålberg and Gunnar Westin
    Citation: Clinical Epigenetics 2016 8:31
    Content type: Research Published on:

  41. Fibrosis of the intestine is a common and poorly understood complication of Crohn’s disease (CD) characterized by excessive deposition of extracellular matrix and accompanied by narrowing and obstruction of th...

    Authors: Tammy Sadler, Jeffrey M. Bhasin, Yaomin Xu, Jill Barnholz-Sloan, Yanwen Chen, Angela H. Ting and Eleni Stylianou
    Citation: Clinical Epigenetics 2016 8:30
    Content type: Research Published on:

  42. Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both hig...

    Authors: A. Boers, R. Wang, R. W. van Leeuwen, H. G. Klip, G. H. de Bock, H. Hollema, W. van Criekinge, T. de Meyer, S. Denil, A. G J. van der Zee, E. Schuuring and G. B. A. Wisman
    Citation: Clinical Epigenetics 2016 8:29
    Content type: Research Published on:

  43. A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20–25 nucleotides) non-coding ...

    Authors: Franz Zehentmayr, Cornelia Hauser-Kronberger, Barbara Zellinger, Falk Hlubek, Claudia Schuster, Ulrich Bodenhofer, Gerd Fastner, Heinz Deutschmann, Philipp Steininger, Roland Reitsamer, Thorsten Fischer and Felix Sedlmayer
    Citation: Clinical Epigenetics 2016 8:28
    Content type: Research Published on:

  44. Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine
    Citation: Clinical Epigenetics 2016 8:27
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2015 7:123

  45. Methylation-sensitive restriction enzymes—polymerase chain reaction (MSRE-PCR) has been used in epigenetic research to identify genome-wide and gene-specific DNA methylation. Currently, epigenome-wide discover...

    Authors: Ram Vinay Pandey, Walter Pulverer, Rainer Kallmeyer, Gabriel Beikircher, Stephan Pabinger, Albert Kriegner and Andreas Weinhäusel
    Citation: Clinical Epigenetics 2016 8:26
    Content type: Methodology Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:84

  46. Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explana...

    Authors: Min Jia, Xu Gao, Yan Zhang, Michael Hoffmeister and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:25
    Content type: Review Published on:

  47. Cytology remains the gold standard for the detection of malignant cells in ascites. However, its sensitivity is limited. The aim of this study was to evaluate DNA methylation biomarkers for the differential di...

    Authors: Maria Jung, Svenja Pützer, Heidrun Gevensleben, Sebastian Meller, Glen Kristiansen and Dimo Dietrich
    Citation: Clinical Epigenetics 2016 8:24
    Content type: Research Published on:

  48. Multiple (epi)genetic defects affecting the expression of the imprinted genes within the 11p15.5 chromosomal region underlie Silver–Russell (SRS) and Beckwith–Wiedemann (BWS) syndromes. The molecular diagnosis...

    Authors: Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…
    Citation: Clinical Epigenetics 2016 8:23
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:40

  49. Maternal obesity impacts fetal growth and pregnancy outcomes. To counteract the deleterious effects of obesity on fertility and pregnancy issue, preconceptional weight loss is recommended to obese women. Wheth...

    Authors: Polina E. Panchenko, Sarah Voisin, Mélanie Jouin, Luc Jouneau, Audrey Prézelin, Simon Lecoutre, Christophe Breton, Hélène Jammes, Claudine Junien and Anne Gabory
    Citation: Clinical Epigenetics 2016 8:22
    Content type: Research Published on:

  50. The epigenetic clock, in particular epigenetic pre-aging quantified by the so-called DNA methylation age acceleration, has recently been suggested to closely correlate with a variety of disease phenotypes. The...

    Authors: Lutz Philipp Breitling, Kai-Uwe Saum, Laura Perna, Ben Schöttker, Bernd Holleczek and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:21
    Content type: Research Published on:
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Clinical Epigenetics

ISSN: 1868-7083

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