Skip to main content

Advertisement

Cancer epigenetics and diagnostics

Section information

Section Editors : Carmen Jeronimo and Maria Berdasco

Associate Editors : Nita Ahuja, James Chim (haematological-based cancers only); Jim Davie, James Flanagan, Mario Fraga, Michéle Hoffmann, Bozena Kaminska (gliomas), Gwen Lomberk, Graham K Packham, Arpad Patai (colorectal/GI cancers), Qian Tao, Raul Urrutia, Keishi Yamashita

The development of genome-wide techniques has rapidly improved the comprehensive knowledge of epigenetic alterations in cancer. Currently, a vast number of genes and their associated molecular pathways that show epigenetic differences between normal and tumoral cells have been identified, emphasizing the crucial role of epigenetic factors in cancer etiology and progression.  This section publishes original epigenetic research focused on the identification of epigenetic biomarkers associated with cancer diagnosis or tumor progression. Manuscripts on epigenetic biomarkers leading to a better definition of therapy response are also accepted (pharmacoepigenetics). Submissions on reports from human clinical trials providing insights on the clinical application of epigenetic biomarkers are welcomed.

Page 5 of 5

  1. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogen...

    Authors: Olga Aprelikova, Kenny Chen, Lara H. El Touny, Constance Brignatz-Guittard, Justin Han, Tinghu Qiu, Howard H. Yang, Maxwell P. Lee, Min Zhu and Jeffrey E. Green

    Citation: Clinical Epigenetics 2016 8:38

    Content type: Research

    Published on:

  2. Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional stat...

    Authors: Duo Chen, Xianyu Wen, Young Seok Song, Ye-Young Rhee, Tae Hun Lee, Nam Yun Cho, Sae-Won Han, Tae-You Kim and Gyeong Hoon Kang

    Citation: Clinical Epigenetics 2016 8:36

    Content type: Research

    Published on:

  3. Circulating hypermethylated RASSF1A could be a novel and potential useful marker for monitoring patients with metastatic breast cancer. Technical obstacles include fragmentation of the circulating DNA, fluctuatio...

    Authors: Søren Kristiansen, Dorte Nielsen and György Sölétormos

    Citation: Clinical Epigenetics 2016 8:35

    Content type: Methodology

    Published on:

  4. Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. ...

    Authors: Quan-Yi Zhao, Pin-Ji Lei, Xiaoran Zhang, Jun-Yi Zheng, Hui-Yi Wang, Jiao Zhao, Yi-Ming Li, Mei Ye, Lianyun Li, Gang Wei and Min Wu

    Citation: Clinical Epigenetics 2016 8:34

    Content type: Research

    Published on:

  5. An abundant class of intronic microRNAs (miRNAs) undergoes atypical Drosha-independent biogenesis in which the spliceosome governs the excision of hairpin miRNA precursors, called mirtrons. Although nearly 500...

    Authors: Stasė Butkytė, Laurynas Čiupas, Eglė Jakubauskienė, Laurynas Vilys, Paulius Mocevicius, Arvydas Kanopka and Giedrius Vilkaitis

    Citation: Clinical Epigenetics 2016 8:33

    Content type: Research

    Published on:

  6. Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethy...

    Authors: Shivani N. Kamdar, Linh T. Ho, Ken J. Kron, Ruth Isserlin, Theodorus van der Kwast, Alexandre R. Zlotta, Neil E. Fleshner, Gary Bader and Bharati Bapat

    Citation: Clinical Epigenetics 2016 8:32

    Content type: Research

    Published on:

  7. Primary hyperparathyroidism is characterized by enlarged parathyroid glands due to an adenoma (80–85 %) or multiglandular disease (~15 %) causing hypersecretion of parathyroid hormone (PTH) and generally hyper...

    Authors: Elham Barazeghi, Anthony J. Gill, Stan Sidhu, Olov Norlén, Roberto Dina, F. Fausto Palazzo, Per Hellman, Peter Stålberg and Gunnar Westin

    Citation: Clinical Epigenetics 2016 8:31

    Content type: Research

    Published on:

  8. Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both hig...

    Authors: A. Boers, R. Wang, R. W. van Leeuwen, H. G. Klip, G. H. de Bock, H. Hollema, W. van Criekinge, T. de Meyer, S. Denil, A. G J. van der Zee, E. Schuuring and G. B. A. Wisman

    Citation: Clinical Epigenetics 2016 8:29

    Content type: Research

    Published on:

  9. A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20–25 nucleotides) non-coding ...

    Authors: Franz Zehentmayr, Cornelia Hauser-Kronberger, Barbara Zellinger, Falk Hlubek, Claudia Schuster, Ulrich Bodenhofer, Gerd Fastner, Heinz Deutschmann, Philipp Steininger, Roland Reitsamer, Thorsten Fischer and Felix Sedlmayer

    Citation: Clinical Epigenetics 2016 8:28

    Content type: Research

    Published on:

  10. Methylation-sensitive restriction enzymes—polymerase chain reaction (MSRE-PCR) has been used in epigenetic research to identify genome-wide and gene-specific DNA methylation. Currently, epigenome-wide discover...

    Authors: Ram Vinay Pandey, Walter Pulverer, Rainer Kallmeyer, Gabriel Beikircher, Stephan Pabinger, Albert Kriegner and Andreas Weinhäusel

    Citation: Clinical Epigenetics 2016 8:26

    Content type: Methodology

    Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:84

  11. Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explana...

    Authors: Min Jia, Xu Gao, Yan Zhang, Michael Hoffmeister and Hermann Brenner

    Citation: Clinical Epigenetics 2016 8:25

    Content type: Review

    Published on:

  12. Cytology remains the gold standard for the detection of malignant cells in ascites. However, its sensitivity is limited. The aim of this study was to evaluate DNA methylation biomarkers for the differential di...

    Authors: Maria Jung, Svenja Pützer, Heidrun Gevensleben, Sebastian Meller, Glen Kristiansen and Dimo Dietrich

    Citation: Clinical Epigenetics 2016 8:24

    Content type: Research

    Published on:

  13. We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer in an ethnically diverse group of patients in the Breast Cancer Care in Chi...

    Authors: Elizaveta V. Benevolenskaya, Abul B. M. M. K. Islam, Habibul Ahsan, Muhammad G. Kibriya, Farzana Jasmine, Ben Wolff, Umaima Al-Alem, Elizabeth Wiley, Andre Kajdacsy-Balla, Virgilia Macias and Garth H. Rauscher

    Citation: Clinical Epigenetics 2016 8:17

    Content type: Research

    Published on:

  14. While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that ab...

    Authors: Pier-Luc Clermont, Francesco Crea, Yan Ting Chiang, Dong Lin, Amy Zhang, James Z. L. Wang, Abhijit Parolia, Rebecca Wu, Hui Xue, Yuwei Wang, Jiarui Ding, Kelsie L. Thu, Wan L. Lam, Sohrab P. Shah, Colin C. Collins, Yuzhuo Wang…

    Citation: Clinical Epigenetics 2016 8:16

    Content type: Research

    Published on:

  15. 5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has ...

    Authors: Yuji Huang, Guanghui Wang, Zhonglin Liang, Yili Yang, Long Cui and Chen-Ying Liu

    Citation: Clinical Epigenetics 2016 8:9

    Content type: Letter to the Editor

    Published on:

  16. A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in bl...

    Authors: Leonie Roos, Jenny van Dongen, Christopher G. Bell, Andrea Burri, Panos Deloukas, Dorret I. Boomsma, Tim D. Spector and Jordana T. Bell

    Citation: Clinical Epigenetics 2016 8:7

    Content type: Research

    Published on:

  17. Retinoblastoma is a malignant tumor of the retina in children <5 years of age and occurs after two mutations in the RB1 gene. The first mutation (M1) is germinal and confers predisposition to the hereditary type,...

    Authors: Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, Félix Recillas-Targa, Patricia Ostrosky-Wegman, Diego Arenas Aranda and Luis Benítez-Bribiesca

    Citation: Clinical Epigenetics 2016 8:1

    Content type: Research

    Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:27

  18. Pancreatic ductal adenocarcinoma (PDAC) remains a highly chemoresistant tumor entity for which no reliable molecular targets exist to predict or influence the success of chemotherapy. Recently, we identified a...

    Authors: Sameer Abdallah Dhayat, Baha Abdeen, Gabriele Köhler, Norbert Senninger, Jörg Haier and Wolf Arif Mardin

    Citation: Clinical Epigenetics 2015 7:132

    Content type: Research

    Published on:

  19. Aberrant DNA methylation has been widely investigated in sporadic colorectal carcinomas (CRCs), and extensive work has been performed to characterize different methylation profiles of CRC. Less information is ...

    Authors: Nora Sahnane, Francesca Magnoli, Barbara Bernasconi, Maria Grazia Tibiletti, Chiara Romualdi, Monica Pedroni, Maurizio Ponz de Leon, Giulia Magnani, Luca Reggiani-Bonetti, Lucio Bertario, Stefano Signoroni, Carlo Capella, Fausto Sessa and Daniela Furlan

    Citation: Clinical Epigenetics 2015 7:131

    Content type: Research

    Published on:

  20. Primary pulmonary enteric adenocarcinoma (PEAC) is defined as a pulmonary adenocarcinoma with a predominant component of intestinal differentiation and tumor cells positive for at least one intestinal marker. ...

    Authors: Ingrid Garajová, Niccola Funel, Michelangelo Fiorentino, Valentina Agostini, Manuela Ferracin, Massimo Negrini, Giovanni Luca Frassineti, Giampaolo Gavelli, Adam Enver Frampton, Guido Biasco and Elisa Giovannetti

    Citation: Clinical Epigenetics 2015 7:129

    Content type: Short report

    Published on:

  21. About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not ye...

    Authors: Milan S. Geybels, Joshi J. Alumkal, Manuel Luedeke, Antje Rinckleb, Shanshan Zhao, Irene M. Shui, Marina Bibikova, Brandy Klotzle, Piet A. van den Brandt, Elaine A. Ostrander, Jian-Bing Fan, Ziding Feng, Christiane Maier and Janet L. Stanford

    Citation: Clinical Epigenetics 2015 7:128

    Content type: Research

    Published on:

  22. While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...

    Authors: Yang Gao, Allison Jones, Peter A. Fasching, Matthias Ruebner, Matthias W. Beckmann, Martin Widschwendter and Andrew E. Teschendorff

    Citation: Clinical Epigenetics 2015 7:126

    Content type: Research

    Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:63

  23. There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection and palpation, which are provided on an opportunistic basis, indicating a need for development of n...

    Authors: Scott M. Langevin, Melissa Eliot, Rondi A. Butler, Agnes Cheong, Xiang Zhang, Michael D. McClean, Devin C. Koestler and Karl T. Kelsey

    Citation: Clinical Epigenetics 2015 7:125

    Content type: Research

    Published on:

  24. ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADA...

    Authors: Sergio Alonso, Beatriz González, Tatiana Ruiz-Larroya, Mercedes Durán Domínguez, Takaharu Kato, Akihiro Matsunaga, Koichi Suzuki, Alex Y. Strongin, Pepita Gimènez-Bonafé and Manuel Perucho

    Citation: Clinical Epigenetics 2015 7:124

    Content type: Research

    Published on:

  25. The Response Evaluation Criteria in Solid Tumors (RECIST) guideline and Common Terminology Criteria for Adverse Events (CTCAE) criteria are used to assess chemotherapy efficiency and toxicity in patients with ...

    Authors: Hong Wang, Bingfeng Zhang, Dan Chen, Wenying Xia, Jiexin Zhang, Fang Wang, Jian Xu, Yan Zhang, Meijuan Zhang, Lixia Zhang, Yachun Lu, Yan Geng, Peijun Huang, Puwen Huang, Hong Wang and Shiyang Pan

    Citation: Clinical Epigenetics 2015 7:119

    Content type: Research

    Published on:

  26. Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particula...

    Authors: Vicki E. Maltby, Moira C. Graves, Rodney A. Lea, Miles C. Benton, Katherine A. Sanders, Lotti Tajouri, Rodney J. Scott and Jeannette Lechner-Scott

    Citation: Clinical Epigenetics 2015 7:118

    Content type: Short report

    Published on:

  27. Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classific...

    Authors: Tanja Božić, Qiong Lin, Joana Frobel, Stefan Wilop, Melanie Hoffmann, Carsten Müller-Tidow, Tim H. Brümmendorf, Edgar Jost and Wolfgang Wagner

    Citation: Clinical Epigenetics 2015 7:116

    Content type: Short report

    Published on:

  28. Prostate cancer (PC) can be stratified into distinct molecular subtypes based on TMPRSS2-ERG gene fusion status, but its potential prognostic value remains controversial. Likewise, routine clinicopathological fea...

    Authors: Siri H. Strand, Soren Hoyer, Anne-Sofie Lynnerup, Christa Haldrup, Tine Maj Storebjerg, Michael Borre, Torben F. Orntoft and Karina D. Sorensen

    Citation: Clinical Epigenetics 2015 7:111

    Content type: Research

    Published on:

  29. Aberrant DNA methylation at imprinted loci is an important molecular mechanism contributing to several developmental and pathological disorders including cancer. However, knowledge about imprinting defects due...

    Authors: Sumadi Lukman Anwar, Till Krech, Britta Hasemeier, Elisa Schipper, Nora Schweitzer, Arndt Vogel, Hans Kreipe and Ulrich Lehmann

    Citation: Clinical Epigenetics 2015 7:110

    Content type: Research

    Published on:

  30. Long non-coding RNAs (lncRNAs) have been claimed as key molecular players in gene expression regulation, being involved in diverse epigenetic processes. They are aberrantly expressed in various tumors, but the...

    Authors: Mónica Martínez-Fernández, Andrew Feber, Marta Dueñas, Cristina Segovia, Carolina Rubio, Maria Fernandez, Felipe Villacampa, José Duarte, Fernando F. López-Calderón, Ma José Gómez-Rodriguez, Daniel Castellano, Jose L. Rodriguez-Peralto, Federico de la Rosa, Stephan Beck and Jesús M. Paramio

    Citation: Clinical Epigenetics 2015 7:109

    Content type: Short report

    Published on:

  31. Subtelomeric regions dynamically change their epigenetic pattern during development and progression of several malignancies and degenerative disorders. However, DNA methylation of human subtelomeres and their ...

    Authors: Samrat Roy Choudhury, Yi Cui, Jacob R. Milton, Jian Li and Joseph Irudayaraj

    Citation: Clinical Epigenetics 2015 7:107

    Content type: Research

    Published on:

  32. To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and ther...

    Authors: Monika Bauden, Dorian Pamart, Daniel Ansari, Marielle Herzog, Mark Eccleston, Jake Micallef, Bodil Andersson and Roland Andersson

    Citation: Clinical Epigenetics 2015 7:106

    Content type: Research

    Published on:

  33. CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily,...

    Authors: Nilufer Sayar, Gurbet Karahan, Ozlen Konu, Betul Bozkurt, Onder Bozdogan and Isik G. Yulug

    Citation: Clinical Epigenetics 2015 7:104

    Content type: Research

    Published on:

  34. Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5–8.7 % of CRCs. It has been shown that SAC has a worse prognosis and different histological and molecula...

    Authors: Pablo Conesa-Zamora, José García-Solano, María del Carmen Turpin, Patricia Sebastián-León, Daniel Torres-Moreno, Eduardo Estrada, Anne Tuomisto, Jamie Wilce, Markus J. Mäkinen, Miguel Pérez-Guillermo and Ana Conesa

    Citation: Clinical Epigenetics 2015 7:101

    Content type: Research

    Published on:

  35. Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, pro...

    Authors: Kristina Harrison, Gwen Hoad, Paula Scott, Louise Simpson, Graham W. Horgan, Elizabeth Smyth, Steven D. Heys and Paul Haggarty

    Citation: Clinical Epigenetics 2015 7:92

    Content type: Research

    Published on:

  36. DNA methylation (5-methylcytosine (5mC)) patterns are often altered in cancers. Ten-eleven translocation (Tet) proteins oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytos...

    Authors: Maria Eleftheriou, Ana Jimenez Pascual, Lee M. Wheldon, Christina Perry, Abdulkadir Abakir, Arvind Arora, Andrew D. Johnson, Dorothee T. Auer, Ian O. Ellis, Srinivasan Madhusudan and Alexey Ruzov

    Citation: Clinical Epigenetics 2015 7:88

    Content type: Short Report

    Published on:

  37. Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to...

    Authors: Par Bahadur Pun, Yu-Ping Liao, Po-Hsuan Su, Hui-Chen Wang, Yu-Chih Chen, Yaw-Wen Hsu, Rui-Lan Huang, Cheng-Chang Chang and Hung-Cheng Lai

    Citation: Clinical Epigenetics 2015 7:85

    Content type: Research

    Published on:

  38. Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylat...

    Authors: Edward Curry, Ian Green, Nadine Chapman-Rothe, Elham Shamsaei, Sarah Kandil, Fanny L Cherblanc, Luke Payne, Emma Bell, Thota Ganesh, Nitipol Srimongkolpithak, Joachim Caron, Fengling Li, Anthony G. Uren, James P. Snyder, Masoud Vedadi, Matthew J. Fuchter…

    Citation: Clinical Epigenetics 2015 7:84

    Content type: Research

    Published on:

  39. Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to acc...

    Authors: Satu Valo, Sippy Kaur, Ari Ristimäki, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Minna Nyström and Päivi Peltomäki

    Citation: Clinical Epigenetics 2015 7:71

    Content type: Research

    Published on:

  40. Classification of pediatric tumors into biologically defined subtypes is challenging, and multifaceted approaches are needed. For this aim, we developed a diagnostic classifier based on DNA methylation profiles.

    Authors: Anna Danielsson, Szilárd Nemes, Magnus Tisell, Birgitta Lannering, Claes Nordborg, Magnus Sabel and Helena Carén

    Citation: Clinical Epigenetics 2015 7:62

    Content type: Methodology

    Published on:

  41. An important model of hepatocellular carcinoma (HCC) that has been described in southeast Asia includes the transition from chronic hepatitis B infection (CHB) to liver cirrhosis (LC) and, finally, to HCC. The...

    Authors: Yangxing Zhao, Feng Xue, Jinfeng Sun, Shicheng Guo, Hongyu Zhang, Bijun Qiu, Junfeng Geng, Jun Gu, Xiaoyu Zhou, Wei Wang, Zhenfeng Zhang, Ning Tang, Yinghua He, Jian Yu and Qiang Xia

    Citation: Clinical Epigenetics 2014 6:30

    Content type: Research

    Published on:

Advertisement