Articles
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Citation: Clinical Epigenetics 2016 8:84
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Tobacco smoking differently influences cell types of the innate and adaptive immune system—indications from CpG site methylation
Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association of tobacco smoking with epigenetic cha...
Citation: Clinical Epigenetics 2016 8:83 -
Increased global placental DNA methylation levels are associated with gestational diabetes
Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. It is known that GDM is associated with an altered placental function and changes in placental gene regulation. More recent st...
Citation: Clinical Epigenetics 2016 8:82 -
Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots
In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases potentially mediated through lasting effects on the epigenome. As the epigeno...
Citation: Clinical Epigenetics 2016 8:81 -
Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma
Epigenetic events mediated by methylation and histone modifications have been associated with the development of metastasis in patients with uveal melanoma. The role of epigenetic events mediated by microRNA (...
Citation: Clinical Epigenetics 2016 8:80 -
Combinatorial epigenetic therapy in diffuse large B cell lymphoma pre-clinical models and patients
Refractory and/or relapsed diffuse large B cell lymphoma (RR-DLBCL) patients are incurable with conventional chemotherapy due to the aggressiveness and the chemorefractory state of these tumors. DNA hypermethy...
Citation: Clinical Epigenetics 2016 8:79 -
Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain
Vascular malformations are developmental congenital abnormalities of the vascular system which may involve any segment of the vascular tree such as capillaries, veins, arteries, or lymphatics. Arteriovenous ma...
Citation: Clinical Epigenetics 2016 8:78 -
Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes
Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skelet...
Citation: Clinical Epigenetics 2016 8:77 -
Studying epigenetic complexes and their inhibitors with the proteomics toolbox
Some epigenetic modifier proteins have become validated clinical targets. With a few small molecule inhibitors already approved by national health administrations and many more in the pharmaceutical industry p...
Citation: Clinical Epigenetics 2016 8:76 -
Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas
DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be f...
Citation: Clinical Epigenetics 2016 8:74 -
Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses
Human methylome mapping in health and disease states has largely relied on Illumina Human Methylation 450k array (450k array) technology. Accompanying this has been the necessary evolution of analysis pipeline...
Citation: Clinical Epigenetics 2016 8:75 -
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment
Aberrant patterns of DNA methylation are abundant in cancer, and epigenetic pathways are increasingly being targeted in cancer drug treatment. Genetic components of the folate-mediated one-carbon metabolism pa...
Citation: Clinical Epigenetics 2016 8:73 -
PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to prote...
Citation: Clinical Epigenetics 2016 8:72 -
A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers
The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy b...
Citation: Clinical Epigenetics 2016 8:71 -
Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction
Intrauterine growth restriction (IUGR), which refers to reduced fetal growth in the context of placental insufficiency, is etiologically heterogeneous. IUGR is associated not only with perinatal morbidity and ...
Citation: Clinical Epigenetics 2016 8:70 -
Two maternal duplications involving the CDKN1C gene are associated with contrasting growth phenotypes
The overgrowth-associated Beckwith-Wiedemann syndrome (BWS) and the undergrowth-associated Silver-Russell syndrome (SRS) are characterized by heterogeneous molecular defects affecting a large imprinted gene cl...
Citation: Clinical Epigenetics 2016 8:69 -
Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials
Aberrant DNA methylation has been identified as a key molecular event regulating the pathogenesis of myelodysplastic syndromes (MDS); myeloid neoplasms with an inherent risk of transformation to acute myeloid ...
Citation: Clinical Epigenetics 2016 8:68 -
Amnion as a surrogate tissue reporter of the effects of maternal preeclampsia on the fetus
Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2–8 % of all pregnancies. Although children born to women with preeclampsia h...
Citation: Clinical Epigenetics 2016 8:67 -
Combined clinical and genetic testing algorithm for cervical cancer diagnosis
Opportunistic screening in hospitals is widely used to effectively reduce the incidence rate of cervical cancer in China and other developing countries. This study aimed to identify clinical risk factor algori...
Citation: Clinical Epigenetics 2016 8:66 -
Peripheral blood methylation profiling of female Crohn’s disease patients
Crohn’s disease (CD) is a chronic inflammatory disorder belonging to the inflammatory bowel diseases (IBD). CD affects distinct parts of the gastrointestinal tract, leading to symptoms including diarrhea, feve...
Citation: Clinical Epigenetics 2016 8:65 -
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages ...
Citation: Clinical Epigenetics 2016 8:64 -
Erratum to: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer
Citation: Clinical Epigenetics 2016 8:63 -
Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background
When assembled in multiprotein polycomb repressive complexes (PRCs), highly evolutionary conserved polycomb group (PcG) proteins epigenetically control gene activity. Although the composition of PRCs may vary ...
Citation: Clinical Epigenetics 2016 8:55 -
Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation
Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, ...
Citation: Clinical Epigenetics 2016 8:62 -
Histone acetyltransferases: challenges in targeting bi-substrate enzymes
Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have ...
Citation: Clinical Epigenetics 2016 8:59 -
Sirtuin functions and modulation: from chemistry to the clinic
Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferatio...
Citation: Clinical Epigenetics 2016 8:61 -
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
The term epigenetics is defined as heritable changes in gene expression that are not due to alterations of the DNA sequence. In the last years, it has become more and more evident that dysregulated epigenetic ...
Citation: Clinical Epigenetics 2016 8:57 -
Disagreement between two common biomarkers of global DNA methylation
The quantification of global DNA methylation has been established in epigenetic screening. As more practicable alternatives to the HPLC-based gold standard, the methylation analysis of CpG islands in repeatabl...
Citation: Clinical Epigenetics 2016 8:60 -
Epigenetic drugs: from chemistry via biology to medicine and back
Citation: Clinical Epigenetics 2016 8:56 -
MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
Methyl CpG binding protein 2 (MeCP2) is a highly abundant chromosomal protein within the brain. It is hence not surprising that perturbations in its genome-wide distribution, and at particular loci within this...
Citation: Clinical Epigenetics 2016 8:58 -
DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm
Prenatal maternal stress (PNMS) is an important programming factor of postnatal immunity. We tested here the hypothesis that DNA methylation of genes in the NF-κB signaling pathway in T cells mediates the effe...
Citation: Clinical Epigenetics 2016 8:54 -
RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors
The tumor-specific microregional effects of the anticancer agent RRx-001, a novel epigenetic-based radio/chemosensitizer with nitrogen oxide-donating properties in phase II clinical trials, were investigated w...
Citation: Clinical Epigenetics 2016 8:53 -
Hypomethylation of FAM63B in bipolar disorder patients
Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi...
Citation: Clinical Epigenetics 2016 8:52 -
Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study
Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishme...
Citation: Clinical Epigenetics 2016 8:51 -
CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm of childhood whose clinical heterogeneity is only poorly represented by gene sequence alterations. It was previously shown that aberrant...
Citation: Clinical Epigenetics 2016 8:50 -
MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are ...
Citation: Clinical Epigenetics 2016 8:49 -
DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease
Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants and environmental cues influenc...
Citation: Clinical Epigenetics 2016 8:48 -
Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation
Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally important genes from defined parental alleles. The regulation of imprinted g...
Citation: Clinical Epigenetics 2016 8:47 -
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7
5-Azacytidine (5-AZA), a DNA methyl transferase inhibitor, is a clinically used epigenetic drug for cancer therapy. Recently, we have shown that 5-AZA upregulates ten-eleven translocation (TET) protein express...
Citation: Clinical Epigenetics 2016 8:46 -
Establishing an analytic pipeline for genome-wide DNA methylation
The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic methods to improve accuracy and reproducibility of the interpretation of r...
Citation: Clinical Epigenetics 2016 8:45 -
Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome
Already since the 1990s, promoter CpG island methylation markers have been considered promising diagnostic, prognostic, and predictive cancer biomarkers. However, so far, only a limited number of DNA methylati...
Citation: Clinical Epigenetics 2016 8:44 -
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accu...
Citation: Clinical Epigenetics 2016 8:43 -
The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model
Weight gain is one of the consequences of estrogen deficiency and constitutes a major health problem. The present study highlights the effects of N-methyl pyrrolidone (NMP) on adipogenesis in osteoporosis indu...
Citation: Clinical Epigenetics 2016 8:42 -
Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma
Related to genetic alteration, frequent promoter hypermethylation is also a contributing factor in the development of human cancers. Recently, we discovered numerous novel genes that were aberrantly methylated...
Citation: Clinical Epigenetics 2016 8:41 -
Erratum to: A multi-method approach to the molecular diagnosis of overt and borderline 11p15.5 defects underlying Silver–Russell and Beckwith–Wiedemann syndromes
Citation: Clinical Epigenetics 2016 8:40 -
Defining the criteria for identifying constitutional epimutations
In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to ret...
Citation: Clinical Epigenetics 2016 8:39 -
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis
Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogen...
Citation: Clinical Epigenetics 2016 8:38 -
TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus
Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is...
Citation: Clinical Epigenetics 2016 8:37 -
Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients
Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional stat...
Citation: Clinical Epigenetics 2016 8:36 -
Detection and monitoring of hypermethylated RASSF1A in serum from patients with metastatic breast cancer
Circulating hypermethylated RASSF1A could be a novel and potential useful marker for monitoring patients with metastatic breast cancer. Technical obstacles include fragmentation of the circulating DNA, fluctuatio...
Citation: Clinical Epigenetics 2016 8:35
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- ISSN: 1868-7083 (electronic)