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  1. Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretro...

    Authors: Kateřina Trejbalová, Denisa Kovářová, Jana Blažková, Ladislav Machala, David Jilich, Jan Weber, Dana Kučerová, Ondřej Vencálek, Ivan Hirsch and Jiří Hejnar
    Citation: Clinical Epigenetics 2016 8:19
  2. The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in Volume 7 (2015).

    Authors: Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2016 8:18
  3. We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer in an ethnically diverse group of patients in the Breast Cancer Care in Chi...

    Authors: Elizaveta V. Benevolenskaya, Abul B. M. M. K. Islam, Habibul Ahsan, Muhammad G. Kibriya, Farzana Jasmine, Ben Wolff, Umaima Al-Alem, Elizabeth Wiley, Andre Kajdacsy-Balla, Virgilia Macias and Garth H. Rauscher
    Citation: Clinical Epigenetics 2016 8:17
  4. While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that ab...

    Authors: Pier-Luc Clermont, Francesco Crea, Yan Ting Chiang, Dong Lin, Amy Zhang, James Z. L. Wang, Abhijit Parolia, Rebecca Wu, Hui Xue, Yuwei Wang, Jiarui Ding, Kelsie L. Thu, Wan L. Lam, Sohrab P. Shah, Colin C. Collins, Yuzhuo Wang…
    Citation: Clinical Epigenetics 2016 8:16
  5. Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The molecular pathways associated with...

    Authors: Sarah Brasa, Arne Mueller, Sébastien Jacquemont, Florian Hahne, Izabela Rozenberg, Thomas Peters, Yunsheng He, Christine McCormack, Fabrizio Gasparini, Salah-Dine Chibout, Olivier Grenet, Jonathan Moggs, Baltazar Gomez-Mancilla and Rémi Terranova
    Citation: Clinical Epigenetics 2016 8:15
  6. The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chro...

    Authors: Zhe Zhang, Lihua Shi, Noor Dawany, Judith Kelsen, Michelle A. Petri and Kathleen E. Sullivan
    Citation: Clinical Epigenetics 2016 8:14
  7. The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changi...

    Authors: Wadha A. Al Muftah, Mashael Al-Shafai, Shaza B. Zaghlool, Alessia Visconti, Pei-Chien Tsai, Pankaj Kumar, Tim Spector, Jordana Bell, Mario Falchi and Karsten Suhre
    Citation: Clinical Epigenetics 2016 8:13
  8. Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methyl...

    Authors: Ting Li-Tempel, Mauro F. Larra, Estelle Sandt, Sophie B. Mériaux, Andrea B. Schote, Hartmut Schächinger, Claude P. Muller and Jonathan D. Turner
    Citation: Clinical Epigenetics 2016 8:12
  9. Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal growth. DNA methylation is an epigenetic mechanism which involv...

    Authors: Aamod R. Nawathe, Mark Christian, Sung Hye Kim, Mark Johnson, Makrina D. Savvidou and Vasso Terzidou
    Citation: Clinical Epigenetics 2016 8:11
  10. Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients is hampered by clinical and molecular diagnostic overlaps. The European Conso...

    Authors: Anne Rochtus, Alejandro Martin-Trujillo, Benedetta Izzi, Francesca Elli, Intza Garin, Agnes Linglart, Giovanna Mantovani, Guiomar Perez de Nanclares, Suzanne Thiele, Brigitte Decallonne, Chris Van Geet, David Monk and Kathleen Freson
    Citation: Clinical Epigenetics 2016 8:10
  11. 5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has ...

    Authors: Yuji Huang, Guanghui Wang, Zhonglin Liang, Yili Yang, Long Cui and Chen-Ying Liu
    Citation: Clinical Epigenetics 2016 8:9
  12. Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are impo...

    Authors: Lauren E. McCullough, Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy and Cathrine Hoyo
    Citation: Clinical Epigenetics 2016 8:8
  13. A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in bl...

    Authors: Leonie Roos, Jenny van Dongen, Christopher G. Bell, Andrea Burri, Panos Deloukas, Dorret I. Boomsma, Tim D. Spector and Jordana T. Bell
    Citation: Clinical Epigenetics 2016 8:7
  14. There is growing interest in the hypertriglyceridemic waist (HTGW) phenotype, defined as high waist circumference (≥95 cm in males and ≥80 cm in females) combined with high serum triglyceride concentration (≥2...

    Authors: Manju Mamtani, Hemant Kulkarni, Thomas D. Dyer, Harald H. H. Göring, Jennifer L. Neary, Shelley A. Cole, Jack W. Kent, Satish Kumar, David C. Glahn, Michael C. Mahaney, Anthony G. Comuzzie, Laura Almasy, Joanne E. Curran, Ravindranath Duggirala, John Blangero and Melanie A. Carless
    Citation: Clinical Epigenetics 2016 8:6
  15. Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate the...

    Authors: Rosie May Walker, Andrea Nikie Christoforou, Daniel L. McCartney, Stewart W. Morris, Nicholas A. Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H. R. Blackwood, Andrew Mark McIntosh, David John Porteous and Kathryn Louise Evans
    Citation: Clinical Epigenetics 2016 8:5
  16. Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of correspon...

    Authors: Yanshuo Han, Fadwa Tanios, Christian Reeps, Jian Zhang, Kristina Schwamborn, Hans-Henning Eckstein, Alma Zernecke and Jaroslav Pelisek
    Citation: Clinical Epigenetics 2016 8:3
  17. Alterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cycl...

    Authors: Merli Saare, Vijayachitra Modhukur, Marina Suhorutshenko, Balaji Rajashekar, Kadri Rekker, Deniss Sõritsa, Helle Karro, Pille Soplepmann, Andrei Sõritsa, Cecilia M. Lindgren, Nilufer Rahmioglu, Alexander Drong, Christian M. Becker, Krina T. Zondervan, Andres Salumets and Maire Peters
    Citation: Clinical Epigenetics 2016 8:2
  18. Retinoblastoma is a malignant tumor of the retina in children <5 years of age and occurs after two mutations in the RB1 gene. The first mutation (M1) is germinal and confers predisposition to the hereditary type,...

    Authors: Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, Félix Recillas-Targa, Patricia Ostrosky-Wegman, Diego Arenas Aranda and Luis Benítez-Bribiesca
    Citation: Clinical Epigenetics 2016 8:1

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:27

  19. DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Ther...

    Authors: Simonetta Guarrera, Giovanni Fiorito, N. Charlotte Onland-Moret, Alessia Russo, Claudia Agnoli, Alessandra Allione, Cornelia Di Gaetano, Amalia Mattiello, Fulvio Ricceri, Paolo Chiodini, Silvia Polidoro, Graziella Frasca, Monique W. M. Verschuren, Jolanda M. A. Boer, Licia Iacoviello, Yvonne T. van der Schouw…
    Citation: Clinical Epigenetics 2015 7:133
  20. Pancreatic ductal adenocarcinoma (PDAC) remains a highly chemoresistant tumor entity for which no reliable molecular targets exist to predict or influence the success of chemotherapy. Recently, we identified a...

    Authors: Sameer Abdallah Dhayat, Baha Abdeen, Gabriele Köhler, Norbert Senninger, Jörg Haier and Wolf Arif Mardin
    Citation: Clinical Epigenetics 2015 7:132
  21. Aberrant DNA methylation has been widely investigated in sporadic colorectal carcinomas (CRCs), and extensive work has been performed to characterize different methylation profiles of CRC. Less information is ...

    Authors: Nora Sahnane, Francesca Magnoli, Barbara Bernasconi, Maria Grazia Tibiletti, Chiara Romualdi, Monica Pedroni, Maurizio Ponz de Leon, Giulia Magnani, Luca Reggiani-Bonetti, Lucio Bertario, Stefano Signoroni, Carlo Capella, Fausto Sessa and Daniela Furlan
    Citation: Clinical Epigenetics 2015 7:131
  22. Asthma is the most common chronic inflammatory disorder in children. The aetiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factor...

    Authors: Therese M. Murphy, Chloe C. Y. Wong, Louise Arseneault, Joe Burrage, Ruby Macdonald, Eilis Hannon, Helen L. Fisher, Antony Ambler, Terrie E. Moffitt, Avshalom Caspi and Jonathan Mill
    Citation: Clinical Epigenetics 2015 7:130
  23. Primary pulmonary enteric adenocarcinoma (PEAC) is defined as a pulmonary adenocarcinoma with a predominant component of intestinal differentiation and tumor cells positive for at least one intestinal marker. ...

    Authors: Ingrid Garajová, Niccola Funel, Michelangelo Fiorentino, Valentina Agostini, Manuela Ferracin, Massimo Negrini, Giovanni Luca Frassineti, Giampaolo Gavelli, Adam Enver Frampton, Guido Biasco and Elisa Giovannetti
    Citation: Clinical Epigenetics 2015 7:129
  24. About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not ye...

    Authors: Milan S. Geybels, Joshi J. Alumkal, Manuel Luedeke, Antje Rinckleb, Shanshan Zhao, Irene M. Shui, Marina Bibikova, Brandy Klotzle, Piet A. van den Brandt, Elaine A. Ostrander, Jian-Bing Fan, Ziding Feng, Christiane Maier and Janet L. Stanford
    Citation: Clinical Epigenetics 2015 7:128
  25. Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observed in cutaneous lymphomas represents a proof of principle that similar results may be obtained i...

    Authors: Clara Nervi, Elisabetta De Marinis and Giovanni Codacci-Pisanelli
    Citation: Clinical Epigenetics 2015 7:127
  26. While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...

    Authors: Yang Gao, Allison Jones, Peter A. Fasching, Matthias Ruebner, Matthias W. Beckmann, Martin Widschwendter and Andrew E. Teschendorff
    Citation: Clinical Epigenetics 2015 7:126

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:63

  27. There are currently no screening tests in routine use for oral and pharyngeal cancer beyond visual inspection and palpation, which are provided on an opportunistic basis, indicating a need for development of n...

    Authors: Scott M. Langevin, Melissa Eliot, Rondi A. Butler, Agnes Cheong, Xiang Zhang, Michael D. McClean, Devin C. Koestler and Karl T. Kelsey
    Citation: Clinical Epigenetics 2015 7:125
  28. ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADA...

    Authors: Sergio Alonso, Beatriz González, Tatiana Ruiz-Larroya, Mercedes Durán Domínguez, Takaharu Kato, Akihiro Matsunaga, Koichi Suzuki, Alex Y. Strongin, Pepita Gimènez-Bonafé and Manuel Perucho
    Citation: Clinical Epigenetics 2015 7:124
  29. Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years...

    Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine
    Citation: Clinical Epigenetics 2015 7:123

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:27

  30. Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. Th...

    Authors: Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison and Bernhard T. Baune
    Citation: Clinical Epigenetics 2015 7:122
  31. Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during ea...

    Authors: Dieuwertje E. G. Kok, Rosalie A. M. Dhonukshe-Rutten, Carolien Lute, Sandra G. Heil, André G. Uitterlinden, Nathalie van der Velde, Joyce B. J. van Meurs, Natasja M. van Schoor, Guido J. E. J. Hooiveld, Lisette C. P. G. M. de Groot, Ellen Kampman and Wilma T. Steegenga
    Citation: Clinical Epigenetics 2015 7:121
  32. The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and fem...

    Authors: Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta and Ivana Antonucci
    Citation: Clinical Epigenetics 2015 7:120
  33. The Response Evaluation Criteria in Solid Tumors (RECIST) guideline and Common Terminology Criteria for Adverse Events (CTCAE) criteria are used to assess chemotherapy efficiency and toxicity in patients with ...

    Authors: Hong Wang, Bingfeng Zhang, Dan Chen, Wenying Xia, Jiexin Zhang, Fang Wang, Jian Xu, Yan Zhang, Meijuan Zhang, Lixia Zhang, Yachun Lu, Yan Geng, Peijun Huang, Puwen Huang, Hong Wang and Shiyang Pan
    Citation: Clinical Epigenetics 2015 7:119
  34. Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particula...

    Authors: Vicki E. Maltby, Moira C. Graves, Rodney A. Lea, Miles C. Benton, Katherine A. Sanders, Lotti Tajouri, Rodney J. Scott and Jeannette Lechner-Scott
    Citation: Clinical Epigenetics 2015 7:118
  35. Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, signifi...

    Authors: Cheng Zhang, Jiang F. Zhong, Andres Stucky, Xue-Lian Chen, Michael F. Press and Xi Zhang
    Citation: Clinical Epigenetics 2015 7:117
  36. Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classific...

    Authors: Tanja Božić, Qiong Lin, Joana Frobel, Stefan Wilop, Melanie Hoffmann, Carsten Müller-Tidow, Tim H. Brümmendorf, Edgar Jost and Wolfgang Wagner
    Citation: Clinical Epigenetics 2015 7:116
  37. Peroxisome proliferator-activated receptor gamma (PPAR-γ) has been demonstrated to be involved in anti-inflammatory reactions, but its role in acute-on-chronic hepatitis B liver failure (ACHBLF) is unclear. Th...

    Authors: Ze-Hua Zhao, Yu-Chen Fan, Qi Zhao, Cheng-Yun Dou, Xiang-Fen Ji, Jing Zhao, Shuai Gao, Xin-You Li and Kai Wang
    Citation: Clinical Epigenetics 2015 7:115
  38. Many human tumors show aberrant activation of a group of germline-specific genes, termed cancer-germline (CG) genes, several of which appear to exert oncogenic functions. Although activation of CG genes in tum...

    Authors: Julie Cannuyer, Aurélie Van Tongelen, Axelle Loriot and Charles De Smet
    Citation: Clinical Epigenetics 2015 7:114
  39. Active smoking is a major preventable public health problem and an established critical factor for epigenetic modification. In this systematic review, we identified 17 studies addressing the association of act...

    Authors: Xu Gao, Min Jia, Yan Zhang, Lutz Philipp Breitling and Hermann Brenner
    Citation: Clinical Epigenetics 2015 7:113
  40. Epigenetic modulation of gene activity occurs in response to non-genetic factors such as body weight status, physical activity, dietary factors, and environmental toxins. In addition, each of these factors is ...

    Authors: Bidisha Paul, Stephen Barnes, Wendy Demark-Wahnefried, Casey Morrow, Carolina Salvador, Christine Skibola and Trygve O. Tollefsbol
    Citation: Clinical Epigenetics 2015 7:112
  41. Prostate cancer (PC) can be stratified into distinct molecular subtypes based on TMPRSS2-ERG gene fusion status, but its potential prognostic value remains controversial. Likewise, routine clinicopathological fea...

    Authors: Siri H. Strand, Soren Hoyer, Anne-Sofie Lynnerup, Christa Haldrup, Tine Maj Storebjerg, Michael Borre, Torben F. Orntoft and Karina D. Sorensen
    Citation: Clinical Epigenetics 2015 7:111
  42. Aberrant DNA methylation at imprinted loci is an important molecular mechanism contributing to several developmental and pathological disorders including cancer. However, knowledge about imprinting defects due...

    Authors: Sumadi Lukman Anwar, Till Krech, Britta Hasemeier, Elisa Schipper, Nora Schweitzer, Arndt Vogel, Hans Kreipe and Ulrich Lehmann
    Citation: Clinical Epigenetics 2015 7:110
  43. Long non-coding RNAs (lncRNAs) have been claimed as key molecular players in gene expression regulation, being involved in diverse epigenetic processes. They are aberrantly expressed in various tumors, but the...

    Authors: Mónica Martínez-Fernández, Andrew Feber, Marta Dueñas, Cristina Segovia, Carolina Rubio, Maria Fernandez, Felipe Villacampa, José Duarte, Fernando F. López-Calderón, Ma José Gómez-Rodriguez, Daniel Castellano, Jose L. Rodriguez-Peralto, Federico de la Rosa, Stephan Beck and Jesús M. Paramio
    Citation: Clinical Epigenetics 2015 7:109
  44. Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of cognitive impairment in Alzheimer’s disease (AD). Howev...

    Authors: M. Cuadrado-Tejedor, C. Garcia-Barroso, J. Sanzhez-Arias, S. Mederos, O. Rabal, A. Ugarte, R. Franco, M. Pascual-Lucas, V. Segura, G. Perea, J. Oyarzabal and A. Garcia-Osta
    Citation: Clinical Epigenetics 2015 7:108
  45. Subtelomeric regions dynamically change their epigenetic pattern during development and progression of several malignancies and degenerative disorders. However, DNA methylation of human subtelomeres and their ...

    Authors: Samrat Roy Choudhury, Yi Cui, Jacob R. Milton, Jian Li and Joseph Irudayaraj
    Citation: Clinical Epigenetics 2015 7:107
  46. To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and ther...

    Authors: Monika Bauden, Dorian Pamart, Daniel Ansari, Marielle Herzog, Mark Eccleston, Jake Micallef, Bodil Andersson and Roland Andersson
    Citation: Clinical Epigenetics 2015 7:106
  47. Drug metabolizing enzymes (DMEs) exhibit dramatic inter- and intra-individual variability in expression and activity. However, the mechanisms determining this variability have not been fully elucidated. The ai...

    Authors: Wataru Habano, Kohei Kawamura, Natsuki Iizuka, Jun Terashima, Tamotsu Sugai and Shogo Ozawa
    Citation: Clinical Epigenetics 2015 7:105
  48. CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily,...

    Authors: Nilufer Sayar, Gurbet Karahan, Ozlen Konu, Betul Bozkurt, Onder Bozdogan and Isik G. Yulug
    Citation: Clinical Epigenetics 2015 7:104