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  1. 5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloi...

    Authors: Metin Karahoca and Richard L Momparler
    Citation: Clinical Epigenetics 2013 5:3
  2. Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite i...

    Authors: Eddy H van Roon, Arnoud Boot, Ashwin A Dihal, Robert F Ernst, Tom van Wezel, Hans Morreau and Judith M Boer
    Citation: Clinical Epigenetics 2013 5:2
  3. The occurrence of asthma is weakly explained by known genetic variants. Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add to the explanation of asthma. However, no etiological mode...

    Authors: Nelís Soto-Ramírez, Syed Hasan Arshad, John W Holloway, Hongmei Zhang, Eric Schauberger, Susan Ewart, Veeresh Patil and Wilfried Karmaus
    Citation: Clinical Epigenetics 2013 5:1
  4. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol in insulin target tissues. In people with type 2 diabetes, skeletal muscle (SkM) 11βHSD1 is upregul...

    Authors: Warrick J Inder, Varuni R Obeyesekere, Christina Jang and Richard Saffery
    Citation: Clinical Epigenetics 2012 4:24
  5. The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models...

    Authors: Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari and Serena D’Souza
    Citation: Clinical Epigenetics 2012 4:23
  6. Studying DNA methylation profiles in detail should be the first step in epigenetic research. Although sodium bisulfite modification of genomic DNA is the gold standard method for DNA methylation analysis, this...

    Authors: Miki Bundo, Fumiko Sunaga, Junko Ueda, Kiyoto Kasai, Tadafumi Kato and Kazuya Iwamoto
    Citation: Clinical Epigenetics 2012 4:22
  7. The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA me...

    Authors: Rae-Chi Huang, John C Galati, Sally Burrows, Lawrence J Beilin, Xin Li, Craig E Pennell, JAM van Eekelen, Trevor A Mori, Leon A Adams and Jeffrey M Craig
    Citation: Clinical Epigenetics 2012 4:21
  8. Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune rheumatic disease of largely unknown cause. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with autoimmun...

    Authors: Justine A Ellis, Jane E Munro, Raul A Chavez, Lavinia Gordon, Jihoon E Joo, Jonathan D Akikusa, Roger C Allen, Anne-Louise Ponsonby, Jeffrey M Craig and Richard Saffery
    Citation: Clinical Epigenetics 2012 4:20
  9. Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain...

    Authors: Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller and Alexander G Haslberger
    Citation: Clinical Epigenetics 2012 4:19
  10. Vibration-induced white finger disease (VWF), also known as hand-arm vibration syndrome, is a secondary form of Raynaud’s disease, affecting the blood vessels and nerves. So far, little is known about the path...

    Authors: Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian L Dransfeld, Stephan Letzel and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2012 4:18
  11. Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined t...

    Authors: Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Katharine Hammond and Kari Nadeau
    Citation: Clinical Epigenetics 2012 4:17
  12. MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies t...

    Authors: Mansi A Parasramka, W Mohaiza Dashwood, Rong Wang, Hassaan H Saeed, David E Williams, Emily Ho and Roderick H Dashwood
    Citation: Clinical Epigenetics 2012 4:16
  13. Silver-Russell syndrome (SRS) is characterized by severe intrauterine and postnatal growth failure and frequent body asymmetry. Half of the patients with SRS carry a DNA hypomethylation of the imprinting cente...

    Authors: Kai Kannenberg, Karin Weber, Cathrin Binder, Christina Urban, Hans-Joachim Kirschner and Gerhard Binder
    Citation: Clinical Epigenetics 2012 4:15
  14. A wet nurse can be used if a baby’s natural mother is unable or chooses not to breastfeed her infant. The practice of using wet nurses is ancient and common to many cultures.

    Authors: Hasan Ozkan, Funda Tuzun, Abdullah Kumral and Nuray Duman
    Citation: Clinical Epigenetics 2012 4:14
  15. Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigen...

    Authors: Karla Bennemann, Oliver Galm, Stefan Wilop, Claudia Schubert, Tim H Brümmendorf and Edgar Jost
    Citation: Clinical Epigenetics 2012 4:12
  16. Epigenetic mechanisms may be involved in the regulation of genes found to be differentially expressed in the visceral adipose tissue (VAT) of severely obese subjects with (MetS+) versus without (MetS-) metabol...

    Authors: Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho and Marie-Claude Vohl
    Citation: Clinical Epigenetics 2012 4:10
  17. It has been suggested that inactivation of p14ARF, a tumor suppressor central to regulating p53 protein stability through interaction with the MDM2 oncoprotein, abrogates p53 activity in human tumors retaining th...

    Authors: Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser and Karin Dahan
    Citation: Clinical Epigenetics 2012 4:9
  18. Birth by cesarean delivery (CD) as opposed to vaginal delivery (VD) is associated with altered health outcomes later in life, including respiratory disorders, allergies and risk of developing type I diabetes. ...

    Authors: Shama Virani, Dana C Dolinoy, Sindhu Halubai, Tamara R Jones, Steve E Domino, Laura S Rozek, Muna S Nahar and Vasantha Padmanabhan
    Citation: Clinical Epigenetics 2012 4:8
  19. Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. T...

    Authors: Christina Schleithoff, Susanne Voelter-Mahlknecht, Indra Navina Dahmke and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2012 4:7
  20. The number of children ages 6 to 21 in the United States receiving special education services under the autism disability category increased 91% between 2005 to 2010 while the number of children receiving spec...

    Authors: Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga and Richard Deth
    Citation: Clinical Epigenetics 2012 4:6
  21. The biological mechanisms responsible for the onset and exacerbation of asthma symptoms in children may involve the epigenetic regulation of inflammatory genes after environmental exposures. Using buccal cells...

    Authors: DZ Torrone, JS Kuriakose, K Moors, H Jiang, MM Niedzwiecki, FF Perera and RL Miller
    Citation: Clinical Epigenetics 2012 4:3
  22. Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in whic...

    Authors: Daman Kumari and Karen Usdin
    Citation: Clinical Epigenetics 2012 4:2
  23. Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins. Although environmental and gene...

    Authors: Takeo Kubota, Kunio Miyake and Takae Hirasawa
    Citation: Clinical Epigenetics 2012 4:1
  24. The influence of epigenetics is evident in many fields of medicine today. This is also true in placentology, where versatile epigenetic mechanisms that regulate expression of genes have shown to have important...

    Authors: L Serman and D Dodig
    Citation: Clinical Epigenetics 2011 3:7
  25. Adenomatous polyposis coli (APC) and Ataxia-telangiectasia-mutated (ATM) gene products have an important role in cell cycle control and maintenance of genomic stability. Our aim was to analyze ATM and APC methyla...

    Authors: Mohammad Ayub Rigi-Ladiz, Dor Mohammad Kordi-Tamandani and Adam Torkamanzehi
    Citation: Clinical Epigenetics 2011 3:6
  26. Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effect...

    Authors: Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood and Emily Ho
    Citation: Clinical Epigenetics 2011 3:3
  27. In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship betwee...

    Authors: A Soubry, SK Murphy, Z Huang, A Murtha, JM Schildkraut, RL Jirtle, F Wang, J Kurtzberg, W Demark-Wahnefried, MR Forman and C Hoyo
    Citation: Clinical Epigenetics 2011 3:2
  28. Epigenetic mechanisms such as DNA hypermethylation and modifications of histone amino acids are known to play an important role in the control of gene expression both in normal human development and tumorigene...

    Authors: Christoph Oing, Edgar Jost, Edgar Dahl, Stefan Wilop, Tim H. Brümmendorf and Oliver Galm
    Citation: Clinical Epigenetics 2011 2:43
  29. Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be determined, it is evident that both genet...

    Authors: Suyin P. Chin, Joanne L. Dickinson and Adele F. Holloway
    Citation: Clinical Epigenetics 2011 2:41
  30. Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studi...

    Authors: Norishige Yamada, Sho Kitamoto, Seiya Yokoyama, Tomofumi Hamada, Masamichi Goto, Hideaki Tsutsumida, Michiyo Higashi and Suguru Yonezawa
    Citation: Clinical Epigenetics 2011 2:37
  31. This review presents an epigenetic view on complex factors leading to development and perception of “genius.” There is increasing evidence which indicates that artistic creativity is influenced by epigenetic p...

    Authors: Heidrun Karlic and Pia Baurek
    Citation: Clinical Epigenetics 2011 2:33
  32. Lymphocytes from the peripheral blood of patients with prostate cancer—the most frequent (noncutaneous) tumor in men—display epigenetic aberrations (altered modes of allelic replication) characteristic of the ...

    Authors: Samuel Cytron, Evgeni Stepnov, Igor Bounkin, Maya Mashevich, Aviva Dotan and Lydia Avivi
    Citation: Clinical Epigenetics 2011 2:29
  33. S100 proteins are small, calcium-binding proteins whose genes are localized in a cluster on human chromosome 1. Through their ability to interact with various protein partners in a calcium-dependent manner, th...

    Authors: Wiesława Leśniak
    Citation: Clinical Epigenetics 2011 2:23
  34. Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapi...

    Authors: Chris J. McNeil, John H. Beattie, M-J Gordon, Lynn P. Pirie and Susan J. Duthie
    Citation: Clinical Epigenetics 2011 2:22