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  2. Weight gain is one of the consequences of estrogen deficiency and constitutes a major health problem. The present study highlights the effects of N-methyl pyrrolidone (NMP) on adipogenesis in osteoporosis indu...

    Authors: Bebeka Gjoksi, Chafik Ghayor, Indranil Bhattacharya, Marcy Zenobi-Wong and Franz E. Weber
    Citation: Clinical Epigenetics 2016 8:42
    Content type: Research Published on:

  3. Authors: Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…
    Citation: Clinical Epigenetics 2016 8:40
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2016 8:23

  4. In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to ret...

    Authors: Mathew A. Sloane, Robyn L. Ward and Luke B. Hesson
    Citation: Clinical Epigenetics 2016 8:39
    Content type: Letter to the Editor Published on:

  5. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogen...

    Authors: Olga Aprelikova, Kenny Chen, Lara H. El Touny, Constance Brignatz-Guittard, Justin Han, Tinghu Qiu, Howard H. Yang, Maxwell P. Lee, Min Zhu and Jeffrey E. Green
    Citation: Clinical Epigenetics 2016 8:38
    Content type: Research Published on:

  6. Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the role that TREM2 plays in sporadic AD is...

    Authors: Naiara Celarain, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Rosa Larumbe, Laura Pulido, Carmen Echavarri and Maite Mendioroz
    Citation: Clinical Epigenetics 2016 8:37
    Content type: Research Published on:

  7. Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional stat...

    Authors: Duo Chen, Xianyu Wen, Young Seok Song, Ye-Young Rhee, Tae Hun Lee, Nam Yun Cho, Sae-Won Han, Tae-You Kim and Gyeong Hoon Kang
    Citation: Clinical Epigenetics 2016 8:36
    Content type: Research Published on:

  8. Circulating hypermethylated RASSF1A could be a novel and potential useful marker for monitoring patients with metastatic breast cancer. Technical obstacles include fragmentation of the circulating DNA, fluctuatio...

    Authors: Søren Kristiansen, Dorte Nielsen and György Sölétormos
    Citation: Clinical Epigenetics 2016 8:35
    Content type: Methodology Published on:

  9. Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. ...

    Authors: Quan-Yi Zhao, Pin-Ji Lei, Xiaoran Zhang, Jun-Yi Zheng, Hui-Yi Wang, Jiao Zhao, Yi-Ming Li, Mei Ye, Lianyun Li, Gang Wei and Min Wu
    Citation: Clinical Epigenetics 2016 8:34
    Content type: Research Published on:

  10. An abundant class of intronic microRNAs (miRNAs) undergoes atypical Drosha-independent biogenesis in which the spliceosome governs the excision of hairpin miRNA precursors, called mirtrons. Although nearly 500...

    Authors: Stasė Butkytė, Laurynas Čiupas, Eglė Jakubauskienė, Laurynas Vilys, Paulius Mocevicius, Arvydas Kanopka and Giedrius Vilkaitis
    Citation: Clinical Epigenetics 2016 8:33
    Content type: Research Published on:

  11. Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethy...

    Authors: Shivani N. Kamdar, Linh T. Ho, Ken J. Kron, Ruth Isserlin, Theodorus van der Kwast, Alexandre R. Zlotta, Neil E. Fleshner, Gary Bader and Bharati Bapat
    Citation: Clinical Epigenetics 2016 8:32
    Content type: Research Published on:

  12. Primary hyperparathyroidism is characterized by enlarged parathyroid glands due to an adenoma (80–85 %) or multiglandular disease (~15 %) causing hypersecretion of parathyroid hormone (PTH) and generally hyper...

    Authors: Elham Barazeghi, Anthony J. Gill, Stan Sidhu, Olov Norlén, Roberto Dina, F. Fausto Palazzo, Per Hellman, Peter Stålberg and Gunnar Westin
    Citation: Clinical Epigenetics 2016 8:31
    Content type: Research Published on:

  13. Fibrosis of the intestine is a common and poorly understood complication of Crohn’s disease (CD) characterized by excessive deposition of extracellular matrix and accompanied by narrowing and obstruction of th...

    Authors: Tammy Sadler, Jeffrey M. Bhasin, Yaomin Xu, Jill Barnholz-Sloan, Yanwen Chen, Angela H. Ting and Eleni Stylianou
    Citation: Clinical Epigenetics 2016 8:30
    Content type: Research Published on:

  14. Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both hig...

    Authors: A. Boers, R. Wang, R. W. van Leeuwen, H. G. Klip, G. H. de Bock, H. Hollema, W. van Criekinge, T. de Meyer, S. Denil, A. G J. van der Zee, E. Schuuring and G. B. A. Wisman
    Citation: Clinical Epigenetics 2016 8:29
    Content type: Research Published on:

  15. A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20–25 nucleotides) non-coding ...

    Authors: Franz Zehentmayr, Cornelia Hauser-Kronberger, Barbara Zellinger, Falk Hlubek, Claudia Schuster, Ulrich Bodenhofer, Gerd Fastner, Heinz Deutschmann, Philipp Steininger, Roland Reitsamer, Thorsten Fischer and Felix Sedlmayer
    Citation: Clinical Epigenetics 2016 8:28
    Content type: Research Published on:

  16. Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine
    Citation: Clinical Epigenetics 2016 8:27
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2015 7:123

  17. Methylation-sensitive restriction enzymes—polymerase chain reaction (MSRE-PCR) has been used in epigenetic research to identify genome-wide and gene-specific DNA methylation. Currently, epigenome-wide discover...

    Authors: Ram Vinay Pandey, Walter Pulverer, Rainer Kallmeyer, Gabriel Beikircher, Stephan Pabinger, Albert Kriegner and Andreas Weinhäusel
    Citation: Clinical Epigenetics 2016 8:26
    Content type: Methodology Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:84

  18. Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explana...

    Authors: Min Jia, Xu Gao, Yan Zhang, Michael Hoffmeister and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:25
    Content type: Review Published on:

  19. Cytology remains the gold standard for the detection of malignant cells in ascites. However, its sensitivity is limited. The aim of this study was to evaluate DNA methylation biomarkers for the differential di...

    Authors: Maria Jung, Svenja Pützer, Heidrun Gevensleben, Sebastian Meller, Glen Kristiansen and Dimo Dietrich
    Citation: Clinical Epigenetics 2016 8:24
    Content type: Research Published on:

  20. Multiple (epi)genetic defects affecting the expression of the imprinted genes within the 11p15.5 chromosomal region underlie Silver–Russell (SRS) and Beckwith–Wiedemann (BWS) syndromes. The molecular diagnosis...

    Authors: Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…
    Citation: Clinical Epigenetics 2016 8:23
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:40

  21. Maternal obesity impacts fetal growth and pregnancy outcomes. To counteract the deleterious effects of obesity on fertility and pregnancy issue, preconceptional weight loss is recommended to obese women. Wheth...

    Authors: Polina E. Panchenko, Sarah Voisin, Mélanie Jouin, Luc Jouneau, Audrey Prézelin, Simon Lecoutre, Christophe Breton, Hélène Jammes, Claudine Junien and Anne Gabory
    Citation: Clinical Epigenetics 2016 8:22
    Content type: Research Published on:

  22. The epigenetic clock, in particular epigenetic pre-aging quantified by the so-called DNA methylation age acceleration, has recently been suggested to closely correlate with a variety of disease phenotypes. The...

    Authors: Lutz Philipp Breitling, Kai-Uwe Saum, Laura Perna, Ben Schöttker, Bernd Holleczek and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:21
    Content type: Research Published on:

  23. Tobacco smoking is a major cause of chronic disease worldwide. Smoking may induce cellular and molecular changes including epigenetic modification, with both short-term and long-term modification patterns that...

    Authors: Daniella Klebaner, Yunfeng Huang, Qin Hui, Jacquelyn Y. Taylor, Jack Goldberg, Viola Vaccarino and Yan V. Sun
    Citation: Clinical Epigenetics 2016 8:20
    Content type: Research Published on:

  24. Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretro...

    Authors: Kateřina Trejbalová, Denisa Kovářová, Jana Blažková, Ladislav Machala, David Jilich, Jan Weber, Dana Kučerová, Ondřej Vencálek, Ivan Hirsch and Jiří Hejnar
    Citation: Clinical Epigenetics 2016 8:19
    Content type: Research Published on:

  25. The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in Volume 7 (2015).

    Authors: Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2016 8:18
    Content type: Reviewer acknowledgement Published on:

  26. We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer in an ethnically diverse group of patients in the Breast Cancer Care in Chi...

    Authors: Elizaveta V. Benevolenskaya, Abul B. M. M. K. Islam, Habibul Ahsan, Muhammad G. Kibriya, Farzana Jasmine, Ben Wolff, Umaima Al-Alem, Elizabeth Wiley, Andre Kajdacsy-Balla, Virgilia Macias and Garth H. Rauscher
    Citation: Clinical Epigenetics 2016 8:17
    Content type: Research Published on:

  27. While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that ab...

    Authors: Pier-Luc Clermont, Francesco Crea, Yan Ting Chiang, Dong Lin, Amy Zhang, James Z. L. Wang, Abhijit Parolia, Rebecca Wu, Hui Xue, Yuwei Wang, Jiarui Ding, Kelsie L. Thu, Wan L. Lam, Sohrab P. Shah, Colin C. Collins, Yuzhuo Wang…
    Citation: Clinical Epigenetics 2016 8:16
    Content type: Research Published on:

  28. Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The molecular pathways associated with...

    Authors: Sarah Brasa, Arne Mueller, Sébastien Jacquemont, Florian Hahne, Izabela Rozenberg, Thomas Peters, Yunsheng He, Christine McCormack, Fabrizio Gasparini, Salah-Dine Chibout, Olivier Grenet, Jonathan Moggs, Baltazar Gomez-Mancilla and Rémi Terranova
    Citation: Clinical Epigenetics 2016 8:15
    Content type: Research Published on:

  29. The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chro...

    Authors: Zhe Zhang, Lihua Shi, Noor Dawany, Judith Kelsen, Michelle A. Petri and Kathleen E. Sullivan
    Citation: Clinical Epigenetics 2016 8:14
    Content type: Research Published on:

  30. The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changi...

    Authors: Wadha A. Al Muftah, Mashael Al-Shafai, Shaza B. Zaghlool, Alessia Visconti, Pei-Chien Tsai, Pankaj Kumar, Tim Spector, Jordana Bell, Mario Falchi and Karsten Suhre
    Citation: Clinical Epigenetics 2016 8:13
    Content type: Research Published on:

  31. Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methyl...

    Authors: Ting Li-Tempel, Mauro F. Larra, Estelle Sandt, Sophie B. Mériaux, Andrea B. Schote, Hartmut Schächinger, Claude P. Muller and Jonathan D. Turner
    Citation: Clinical Epigenetics 2016 8:12
    Content type: Research Published on:

  32. Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal growth. DNA methylation is an epigenetic mechanism which involv...

    Authors: Aamod R. Nawathe, Mark Christian, Sung Hye Kim, Mark Johnson, Makrina D. Savvidou and Vasso Terzidou
    Citation: Clinical Epigenetics 2016 8:11
    Content type: Research Published on:

  33. Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients is hampered by clinical and molecular diagnostic overlaps. The European Conso...

    Authors: Anne Rochtus, Alejandro Martin-Trujillo, Benedetta Izzi, Francesca Elli, Intza Garin, Agnes Linglart, Giovanna Mantovani, Guiomar Perez de Nanclares, Suzanne Thiele, Brigitte Decallonne, Chris Van Geet, David Monk and Kathleen Freson
    Citation: Clinical Epigenetics 2016 8:10
    Content type: Research Published on:

  34. 5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has ...

    Authors: Yuji Huang, Guanghui Wang, Zhonglin Liang, Yili Yang, Long Cui and Chen-Ying Liu
    Citation: Clinical Epigenetics 2016 8:9
    Content type: Letter to the Editor Published on:

  35. Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are impo...

    Authors: Lauren E. McCullough, Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy and Cathrine Hoyo
    Citation: Clinical Epigenetics 2016 8:8
    Content type: Research Published on:

  36. A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in bl...

    Authors: Leonie Roos, Jenny van Dongen, Christopher G. Bell, Andrea Burri, Panos Deloukas, Dorret I. Boomsma, Tim D. Spector and Jordana T. Bell
    Citation: Clinical Epigenetics 2016 8:7
    Content type: Research Published on:

  37. There is growing interest in the hypertriglyceridemic waist (HTGW) phenotype, defined as high waist circumference (≥95 cm in males and ≥80 cm in females) combined with high serum triglyceride concentration (≥2...

    Authors: Manju Mamtani, Hemant Kulkarni, Thomas D. Dyer, Harald H. H. Göring, Jennifer L. Neary, Shelley A. Cole, Jack W. Kent, Satish Kumar, David C. Glahn, Michael C. Mahaney, Anthony G. Comuzzie, Laura Almasy, Joanne E. Curran, Ravindranath Duggirala, John Blangero and Melanie A. Carless
    Citation: Clinical Epigenetics 2016 8:6
    Content type: Research Published on:

  38. Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate the...

    Authors: Rosie May Walker, Andrea Nikie Christoforou, Daniel L. McCartney, Stewart W. Morris, Nicholas A. Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H. R. Blackwood, Andrew Mark McIntosh, David John Porteous and Kathryn Louise Evans
    Citation: Clinical Epigenetics 2016 8:5
    Content type: Research Published on:

  40. Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of correspon...

    Authors: Yanshuo Han, Fadwa Tanios, Christian Reeps, Jian Zhang, Kristina Schwamborn, Hans-Henning Eckstein, Alma Zernecke and Jaroslav Pelisek
    Citation: Clinical Epigenetics 2016 8:3
    Content type: Research Published on:

  41. Alterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cycl...

    Authors: Merli Saare, Vijayachitra Modhukur, Marina Suhorutshenko, Balaji Rajashekar, Kadri Rekker, Deniss Sõritsa, Helle Karro, Pille Soplepmann, Andrei Sõritsa, Cecilia M. Lindgren, Nilufer Rahmioglu, Alexander Drong, Christian M. Becker, Krina T. Zondervan, Andres Salumets and Maire Peters
    Citation: Clinical Epigenetics 2016 8:2
    Content type: Research Published on:

  42. Retinoblastoma is a malignant tumor of the retina in children <5 years of age and occurs after two mutations in the RB1 gene. The first mutation (M1) is germinal and confers predisposition to the hereditary type,...

    Authors: Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, Félix Recillas-Targa, Patricia Ostrosky-Wegman, Diego Arenas Aranda and Luis Benítez-Bribiesca
    Citation: Clinical Epigenetics 2016 8:1
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:27

  43. DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Ther...

    Authors: Simonetta Guarrera, Giovanni Fiorito, N. Charlotte Onland-Moret, Alessia Russo, Claudia Agnoli, Alessandra Allione, Cornelia Di Gaetano, Amalia Mattiello, Fulvio Ricceri, Paolo Chiodini, Silvia Polidoro, Graziella Frasca, Monique W. M. Verschuren, Jolanda M. A. Boer, Licia Iacoviello, Yvonne T. van der Schouw…
    Citation: Clinical Epigenetics 2015 7:133
    Content type: Research Published on:

  44. Pancreatic ductal adenocarcinoma (PDAC) remains a highly chemoresistant tumor entity for which no reliable molecular targets exist to predict or influence the success of chemotherapy. Recently, we identified a...

    Authors: Sameer Abdallah Dhayat, Baha Abdeen, Gabriele Köhler, Norbert Senninger, Jörg Haier and Wolf Arif Mardin
    Citation: Clinical Epigenetics 2015 7:132
    Content type: Research Published on:

  45. Aberrant DNA methylation has been widely investigated in sporadic colorectal carcinomas (CRCs), and extensive work has been performed to characterize different methylation profiles of CRC. Less information is ...

    Authors: Nora Sahnane, Francesca Magnoli, Barbara Bernasconi, Maria Grazia Tibiletti, Chiara Romualdi, Monica Pedroni, Maurizio Ponz de Leon, Giulia Magnani, Luca Reggiani-Bonetti, Lucio Bertario, Stefano Signoroni, Carlo Capella, Fausto Sessa and Daniela Furlan
    Citation: Clinical Epigenetics 2015 7:131
    Content type: Research Published on:

  46. Asthma is the most common chronic inflammatory disorder in children. The aetiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factor...

    Authors: Therese M. Murphy, Chloe C. Y. Wong, Louise Arseneault, Joe Burrage, Ruby Macdonald, Eilis Hannon, Helen L. Fisher, Antony Ambler, Terrie E. Moffitt, Avshalom Caspi and Jonathan Mill
    Citation: Clinical Epigenetics 2015 7:130
    Content type: Research Published on:

  47. Primary pulmonary enteric adenocarcinoma (PEAC) is defined as a pulmonary adenocarcinoma with a predominant component of intestinal differentiation and tumor cells positive for at least one intestinal marker. ...

    Authors: Ingrid Garajová, Niccola Funel, Michelangelo Fiorentino, Valentina Agostini, Manuela Ferracin, Massimo Negrini, Giovanni Luca Frassineti, Giampaolo Gavelli, Adam Enver Frampton, Guido Biasco and Elisa Giovannetti
    Citation: Clinical Epigenetics 2015 7:129
    Content type: Short report Published on:

  48. About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not ye...

    Authors: Milan S. Geybels, Joshi J. Alumkal, Manuel Luedeke, Antje Rinckleb, Shanshan Zhao, Irene M. Shui, Marina Bibikova, Brandy Klotzle, Piet A. van den Brandt, Elaine A. Ostrander, Jian-Bing Fan, Ziding Feng, Christiane Maier and Janet L. Stanford
    Citation: Clinical Epigenetics 2015 7:128
    Content type: Research Published on:

  49. Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observed in cutaneous lymphomas represents a proof of principle that similar results may be obtained i...

    Authors: Clara Nervi, Elisabetta De Marinis and Giovanni Codacci-Pisanelli
    Citation: Clinical Epigenetics 2015 7:127
    Content type: Review Published on:

  50. While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...

    Authors: Yang Gao, Allison Jones, Peter A. Fasching, Matthias Ruebner, Matthias W. Beckmann, Martin Widschwendter and Andrew E. Teschendorff
    Citation: Clinical Epigenetics 2015 7:126
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:63

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Clinical Epigenetics

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