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  1. Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP,...

    Authors: Azadeh Houshmand-Oeregaard, Ninna S. Hansen, Line Hjort, Louise Kelstrup, Christa Broholm, Elisabeth R. Mathiesen, Tine D. Clausen, Peter Damm and Allan Vaag
    Citation: Clinical Epigenetics 2017 9:37
    Content type: Research Published on:

  2. Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatic...

    Authors: Pelayo G. de Lena, Abel Paz-Gallardo, Jesús M. Paramio and Ramón García-Escudero
    Citation: Clinical Epigenetics 2017 9:36
    Content type: Research Published on:

  3. Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leadi...

    Authors: Ken Declerck, Sylvie Remy, Christine Wohlfahrt-Veje, Katharina M. Main, Guy Van Camp, Greet Schoeters, Wim Vanden Berghe and Helle R. Andersen
    Citation: Clinical Epigenetics 2017 9:35
    Content type: Research Published on:

  5. DNA methylation is the most studied epigenetic modification due to its role in regulating gene expression, and its involvement in the pathogenesis of cancer and several diseases upon aberrations in methylation...

    Authors: Teresia Kling, Anna Wenger, Stephan Beck and Helena Carén
    Citation: Clinical Epigenetics 2017 9:33
    Content type: Short report Published on:

  7. Determining the role of DNA methylation in various biological processes is dependent on the accurate representation of often highly complex patterns. Accurate representation is dependent on unbiased PCR amplif...

    Authors: Ida L. M. Candiloro, Thomas Mikeska and Alexander Dobrovic
    Citation: Clinical Epigenetics 2017 9:31
    Content type: Methodology Published on:

  8. Dysregulation in post-translational modifications of histones and their modifiers are now well-recognized as a hallmark of cancer and can be used as biomarkers and potential therapeutic targets for disease pro...

    Authors: Divya Reddy, Bharat Khade, Riddhi Pandya and Sanjay Gupta
    Citation: Clinical Epigenetics 2017 9:30
    Content type: Methodology Published on:

  9. Genetics explains a small proportion of variance in body mass index at the population level. Epigenetics, commonly measured by gene methylation, holds promise for understanding obesity risk factors and mechani...

    Authors: Jocelyn Dunstan, Joseph P. Bressler, Timothy H. Moran, Jonathan S. Pollak, Annemarie G. Hirsch, Lisa Bailey-Davis, Thomas A. Glass and Brian S. Schwartz
    Citation: Clinical Epigenetics 2017 9:29
    Content type: Research Published on:

  10. Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene r...

    Authors: Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen and Thomas Haaf
    Citation: Clinical Epigenetics 2017 9:28
    Content type: Research Published on:

  11. Authors: Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, Félix Recillas-Targa, Patricia Ostrosky-Wegman, Diego Arenas Aranda and Luis Benítez-Bribiesca
    Citation: Clinical Epigenetics 2017 9:27
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2016 8:1

  12. Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tu...

    Authors: Andrea J. Savio, Miralem Mrkonjic, Mathieu Lemire, Steven Gallinger, Julia A. Knight and Bharat Bapat
    Citation: Clinical Epigenetics 2017 9:26
    Content type: Research Published on:

  13. Conventional tubular adenomas are frequently detected in patients undergoing average risk screening colonoscopy and are over-represented in patients who will develop colorectal cancer (CRC). Whether features o...

    Authors: Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari and Joshua Melson
    Citation: Clinical Epigenetics 2017 9:25
    Content type: Research Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:76

  14. Colorectal cancer (CRC) is the third most common cancer worldwide. If detected at an early stage, prognosis is good. Despite increasing evidence for the benefits of implemented screening programs, such as scre...

    Authors: Jonathan Alexander Heiss and Hermann Brenner
    Citation: Clinical Epigenetics 2017 9:24
    Content type: Research Published on:

  16. MiRNA expression markers are well characterized in colorectal cancer (CRC), but less is known about miRNA expression profiles in colorectal adenomas. Genome-wide miRNA and mRNA expression analyses were conduct...

    Authors: Zsófia Brigitta Nagy, Barnabás Wichmann, Alexandra Kalmár, Orsolya Galamb, Barbara Kinga Barták, Sándor Spisák, Zsolt Tulassay and Béla Molnár
    Citation: Clinical Epigenetics 2017 9:22
    Content type: Research Published on:

  17. Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de...

    Authors: Abhay Raina, Xiaoping Zhao, Megan L. Grove, Jan Bressler, Rebecca F. Gottesman, Weihua Guan, James S. Pankow, Eric Boerwinkle, Thomas H. Mosley and Myriam Fornage
    Citation: Clinical Epigenetics 2017 9:21
    Content type: Research Published on:

  18. Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an in...

    Authors: Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Nina Mononen, Mika Kähönen, Olli T. Raitakari, Antti Hervonen, Marja Jylhä, Terho Lehtimäki and Mikko Hurme
    Citation: Clinical Epigenetics 2017 9:20
    Content type: Research Published on:

  19. Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contributi...

    Authors: Milena Magalhães, Isabelle Rivals, Mireille Claustres, Jessica Varilh, Mélodie Thomasset, Anne Bergougnoux, Laurent Mely, Sylvie Leroy, Harriet Corvol, Loïc Guillot, Marlène Murris, Emmanuelle Beyne, Davide Caimmi, Isabelle Vachier, Raphaël Chiron and Albertina De Sario
    Citation: Clinical Epigenetics 2017 9:19
    Content type: Research Published on:

  20. Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcyto...

    Authors: Ashley Ramsawhook, Lara Lewis, Beth Coyle and Alexey Ruzov
    Citation: Clinical Epigenetics 2017 9:18
    Content type: Short report Published on:

  21. Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the cancer cell mic...

    Authors: Mark E. Issa, Farnaz Sedigheh Takhsha, Chandra Sekhar Chirumamilla, Claudina Perez-Novo, Wim Vanden Berghe and Muriel Cuendet
    Citation: Clinical Epigenetics 2017 9:17
    Content type: Review Published on:

  22. Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspr...

    Authors: Sara Pauwels, Manosij Ghosh, Radu Corneliu Duca, Bram Bekaert, Kathleen Freson, Inge Huybrechts, Sabine A. S. Langie, Gudrun Koppen, Roland Devlieger and Lode Godderis
    Citation: Clinical Epigenetics 2017 9:16
    Content type: Research Published on:

  23. DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of trig...

    Authors: Kim V. E. Braun, Klodian Dhana, Paul S. de Vries, Trudy Voortman, Joyce B. J. van Meurs, Andre G. Uitterlinden, Albert Hofman, Frank B. Hu, Oscar H. Franco and Abbas Dehghan
    Citation: Clinical Epigenetics 2017 9:15
    Content type: Research Published on:

  24. We analyzed placental DNA methylation levels at repeated sequences (LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fer...

    Authors: Jayashri Ghosh, Christos Coutifaris, Carmen Sapienza and Monica Mainigi
    Citation: Clinical Epigenetics 2017 9:14
    Content type: Research Published on:

  25. Oral squamous cell carcinoma (OSCC) is one of the common malignancies in Southeast Asia. Epigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers. Considering the varied env...

    Authors: Baidehi Basu, Joyeeta Chakraborty, Aditi Chandra, Atul Katarkar, Jadav Ritesh Kumar Baldevbhai, Debjit Dhar Chowdhury, Jay Gopal Ray, Keya Chaudhuri and Raghunath Chatterjee
    Citation: Clinical Epigenetics 2017 9:13
    Content type: Research Published on:

  26. Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation...

    Authors: Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck and Dimo Dietrich
    Citation: Clinical Epigenetics 2017 9:12
    Content type: Research Published on:

  27. Population based epigenetic association studies of disease and exposures are becoming more common with the availability of economical genome-wide technologies for interrogation of the methylome, such as the Il...

    Authors: Rachel D. Edgar, Meaghan J. Jones, Wendy P. Robinson and Michael S. Kobor
    Citation: Clinical Epigenetics 2017 9:11
    Content type: Methodology Published on:

  28. Differentially methylated regions (DMRs) within DNA isolated from whole blood can be used to estimate the proportions of circulating leukocyte subtypes. We use the term “immunomethylomics” to describe the appl...

    Authors: John K. Wiencke, Devin C. Koestler, Lucas A. Salas, Joseph L. Wiemels, Ritu P. Roy, Helen M. Hansen, Terri Rice, Lucie S. McCoy, Paige M. Bracci, Annette M. Molinaro, Karl T. Kelsey, Margaret R. Wrensch and Brock C. Christensen
    Citation: Clinical Epigenetics 2017 9:10
    Content type: Research Published on:

  29. There is a growing interest in simple molecular biomarkers for biological aging. Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be combined into epigenetic age predictors to est...

    Authors: Yan Zhang, Jan Hapala, Hermann Brenner and Wolfgang Wagner
    Citation: Clinical Epigenetics 2017 9:9
    Content type: Short Report Published on:

  30. Bladder cancer (BC) is one of the most common cancers in the western world and ranks as the most expensive to manage, due to the need for cystoscopic examination. BC shows frequent changes in DNA methylation, ...

    Authors: Andrew Feber, Pawan Dhami, Liqin Dong, Patricia de Winter, Wei Shen Tan, Mónica Martínez-Fernández, Dirk S. Paul, Antony Hynes-Allen, Sheida Rezaee, Pratik Gurung, Simon Rodney, Ahmed Mehmood, Felipe Villacampa, Federico de la Rosa, Charles Jameson, Kar Keung Cheng…
    Citation: Clinical Epigenetics 2017 9:8
    Content type: Research Published on:

  31. Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in colorec...

    Authors: Esperanza Martín-Sánchez, Saioa Mendaza, Ane Ulazia-Garmendia, Iñaki Monreal-Santesteban, Alicia Córdoba, Francisco Vicente-García, Idoia Blanco-Luquin, Susana De La Cruz, Ana Aramendia and David Guerrero-Setas
    Citation: Clinical Epigenetics 2017 9:7
    Content type: Research Published on:

  32. Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility ...

    Authors: Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, Yoshiya Kawamura, Miki Bundo, Kazuya Iwamoto, Mamoru Tochigi, Kiyoto Kasai, Hisanobu Kaiya, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga and Tsukasa Sasaki
    Citation: Clinical Epigenetics 2017 9:6
    Content type: Research Published on:

  33. A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.

    Authors: Euan J. Rodger and Aniruddha Chatterjee
    Citation: Clinical Epigenetics 2017 9:5
    Content type: Short report Published on:

  34. RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macropha...

    Authors: Hongjuan Zhao, Shoucheng Ning, Rosalie Nolley, Jan Scicinski, Bryan Oronsky, Susan J. Knox and Donna M. Peehl
    Citation: Clinical Epigenetics 2017 9:4
    Content type: Research Published on:

  35. Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association stu...

    Authors: Andréanne Morin, Michel Laviolette, Tomi Pastinen, Louis-Philippe Boulet and Catherine Laprise
    Citation: Clinical Epigenetics 2017 9:3
    Content type: Letter to the Editor Published on:

  36. The study of DNA methylation in development and disease has ‘exploded’ as a field in recent years, with three major classes of measurement now routine. These encompass (i) locus-specific, (ii) genome-scale/wid...

    Authors: Regan Vryer and Richard Saffery
    Citation: Clinical Epigenetics 2017 9:2
    Content type: Letter to the Editor Published on:

  37. Formalin-fixed, paraffin-embedded (FFPE) tissues are important resources for profiling DNA methylation changes and for studying a variety of diseases. However, formalin fixation introduces inter-strand crossli...

    Authors: Xianyu Wen, Seorin Jeong, Younghoon Kim, Jeong Mo Bae, Nam Yun Cho, Jung Ho Kim and Gyeong Hoon Kang
    Citation: Clinical Epigenetics 2017 9:1
    Content type: Research Published on:

  38. Biliary tract carcinoma (BTC) is a fatal malignancy which aggressiveness contrasts sharply with its relatively mild and late clinical presentation. Novel molecular markers for early diagnosis and precise treat...

    Authors: V. Branchi, P. Schaefer, A. Semaan, A. Kania, P. Lingohr, J. C. Kalff, N. Schäfer, G. Kristiansen, D. Dietrich and H. Matthaei
    Citation: Clinical Epigenetics 2016 8:133
    Content type: Research Published on:

  39. Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries, characterized by a heterogeneous clinical course. Although genetic studies have identified chromosomal aberr...

    Authors: Michaël Van Damme, Emerence Crompot, Nathalie Meuleman, Marie Maerevoet, Philippe Mineur, Dominique Bron, Laurence Lagneaux and Basile Stamatopoulos
    Citation: Clinical Epigenetics 2016 8:132
    Content type: Research Published on:

  40. Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and altered keratinocyte differentiation and inflammation and is caused by the interplay of genetic and environmen...

    Authors: Fusheng Zhou, Changbing Shen, Jingkai Xu, Jing Gao, Xiaodong Zheng, Randy Ko, Jinfa Dou, Yuyan Cheng, Caihong Zhu, Shuangjun Xu, Xianfa Tang, Xianbo Zuo, Xianyong Yin, Yong Cui, Liangdan Sun, Lam C. Tsoi…
    Citation: Clinical Epigenetics 2016 8:131
    Content type: Research Published on:

  41. Epigenetic modifications of the fragile X mental retardation 1 (FMR1) gene locus may impact the risk for reproductive and neurological disorders associated with expanded trinucleotide repeats and methylation stat...

    Authors: Andrew G. Hadd, Stela Filipovic-Sadic, Lili Zhou, Arianna Williams, Gary J. Latham, Elizabeth Berry-Kravis and Deborah A. Hall
    Citation: Clinical Epigenetics 2016 8:130
    Content type: Short report Published on:

  42. Long noncoding RNAs (lncRNAs) are more than 200 nucleotides in length and lack transcriptional ability. The biological function of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. The aim of thi...

    Authors: Cheng-Mei Yang, Tsung-Han Wang, Hung-Chih Chen, Sung-Chou Li, Ming-Chien Lee, Huei-Han Liou, Pei-Feng Liu, Yu-Kai Tseng, Yow-Ling Shiue, Luo-Ping Ger and Kuo-Wang Tsai
    Citation: Clinical Epigenetics 2016 8:129
    Content type: Research Published on:

  43. Maternal cigarette smoking during pregnancy increases the risk of negative health consequences for the exposed child. Epigenetic mechanisms constitute a likely link between the prenatal exposure to maternal ci...

    Authors: Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F. Daugaard, Emil H. Ernst, Rasmus H. Olesen, Linn S. Mamsen, Erik Ernst, Agnete Larsen and Anders L. Nielsen
    Citation: Clinical Epigenetics 2016 8:128
    Content type: Short report Published on:

  44. Newly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer (LC) screening. We aimed to assess the performance of the top hits from previous...

    Authors: Yan Zhang, Magdeldin Elgizouli, Ben Schöttker, Bernd Holleczek, Alexandra Nieters and Hermann Brenner
    Citation: Clinical Epigenetics 2016 8:127
    Content type: Research Published on:

  45. Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus...

    Authors: Qing Zhang, Shu Ding, Huilin Zhang, Hai Long, Haijing Wu, Ming Zhao, Vera Chan, Chak-Sing Lau and Qianjin Lu
    Citation: Clinical Epigenetics 2016 8:126
    Content type: Research Published on:

  46. A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes i...

    Authors: Chandrakumar Sathishkumar, Paramasivam Prabu, Mahalingam Balakumar, Raji Lenin, Durai Prabhu, Ranjith Mohan Anjana, Viswanathan Mohan and Muthuswamy Balasubramanyam
    Citation: Clinical Epigenetics 2016 8:125
    Content type: Research Published on:

  47. Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, m...

    Authors: Shaza B. Zaghlool, Mashael Al-Shafai, Wadha A. Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi and Karsten Suhre
    Citation: Clinical Epigenetics 2016 8:124
    Content type: Research Published on:

  48. We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it ...

    Authors: Tobias Fehlmann, Stefanie Reinheimer, Chunyu Geng, Xiaoshan Su, Snezana Drmanac, Andrei Alexeev, Chunyan Zhang, Christina Backes, Nicole Ludwig, Martin Hart, Dan An, Zhenzhen Zhu, Chongjun Xu, Ao Chen, Ming Ni, Jian Liu…
    Citation: Clinical Epigenetics 2016 8:123
    Content type: Research Published on:

  49. A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational histone modifications, or chromatin structure. These changes of th...

    Authors: René A. M. Dirks, Hendrik G. Stunnenberg and Hendrik Marks
    Citation: Clinical Epigenetics 2016 8:122
    Content type: Review Published on:

  50. Authors: Magdalena Spólnicka, Renata Zbieć Piekarska, Emilia Jaskuła, Grzegorz W. Basak, Renata Jacewicz, Agnieszka Pięta, Żanetta Makowska, Maciej Jedrzejczyk, Agnieszka Wierzbowska, Agnieszka Pluta, Tadeusz Robak, Jarosław Berent, Wojciech Branicki, Wiesław Jędrzejczak, Andrzej Lange and Rafał Płoski
    Citation: Clinical Epigenetics 2016 8:121
    Content type: Erratum Published on:

    The original article was published in Clinical Epigenetics 2016 8:93

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Clinical Epigenetics

ISSN: 1868-7083

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