Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009, 120: 1640-1645. 10.1161/CIRCULATIONAHA.109.192644.
Article
CAS
PubMed
Google Scholar
Mathieu P, Lemieux I, Despres JP: Obesity, inflammation, and cardiovascular risk. Clin Pharmacol Ther. 2010, 87: 407-416. 10.1038/clpt.2009.311.
Article
CAS
PubMed
Google Scholar
Pajunen P, Kotronen A, Korpi-Hyovalti E, Keinanen-Kiukaanniemi S, Oksa H, Niskanen L, Saaristo T, Saltevo JT, Sundvall J, Vanhala M, Uusitupa M, Peltonen M: Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey. BMC Publ Health. 2011, 11: 754-10.1186/1471-2458-11-754.
Article
Google Scholar
Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie ME, Messier V, Sladek R, Rabasa-Lhoret R: Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond). 2011, 35: 971-981. 10.1038/ijo.2010.216.
Article
CAS
Google Scholar
Bluher M: Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes. 2009, 117: 241-250. 10.1055/s-0029-1192044.
Article
CAS
PubMed
Google Scholar
Bluher M: The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol. 2010, 21: 38-43. 10.1097/MOL.0b013e3283346ccc.
Article
PubMed
Google Scholar
Bouchard L, Tchernof A, Deshaies Y, Marceau S, Lescelleur O, Biron S, Vohl MC: ZFP36: a promising candidate gene for obesity-related metabolic complications identified by converging genomics. Obes Surg. 2007, 17: 372-382. 10.1007/s11695-007-9067-5.
Article
PubMed
Google Scholar
Hardy OT, Perugini RA, Nicoloro SM, Gallagher-Dorval K, Puri V, Straubhaar J, Czech MP: Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis. 2011, 7: 60-67. 10.1016/j.soard.2010.05.013.
Article
PubMed Central
PubMed
Google Scholar
Klimcakova E, Roussel B, Kovacova Z, Kovacikova M, Siklova-Vitkova M, Combes M, Hejnova J, Decaunes P, Maoret JJ, Vedral T, Viguerie N, Bourlier V, Bouloumie A, Stich V, Langin D: Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat. Diabetologia. 2011, 54: 876-887. 10.1007/s00125-010-2014-3.
Article
CAS
PubMed
Google Scholar
Delisle H: Programming of chronic disease by impaired fetal nutrition: evidence and implications for policy and intervention strategies. Report of the Department of Nutrition for Health and Development, Department of Noncommunicable Disease Prevention and Health Promotion. 2002, Geneva: World Health Organization
Google Scholar
McMillen IC, Robinson JS: Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005, 85: 571-633. 10.1152/physrev.00053.2003.
Article
CAS
PubMed
Google Scholar
Symonds ME, Sebert SP, Hyatt MA, Budge H: Nutritional programming of the metabolic syndrome. Nat Rev Endocrinol. 2009, 5: 604-610. 10.1038/nrendo.2009.195.
Article
CAS
PubMed
Google Scholar
Fall CH: Evidence for the intra-uterine programming of adiposity in later life. Ann Hum Biol. 2011, 38: 410-428. 10.3109/03014460.2011.592513.
Article
PubMed Central
PubMed
Google Scholar
Muhlhausler B, Smith SR: Early-life origins of metabolic dysfunction: role of the adipocyte. Trends Endocrinol Metab. 2009, 20: 51-57. 10.1016/j.tem.2008.10.006.
Article
CAS
PubMed
Google Scholar
Bruce KD, Cagampang FR: Epigenetic priming of the metabolic syndrome. Toxicol Mech Methods. 2011, 21: 353-361. 10.3109/15376516.2011.559370.
Article
CAS
PubMed
Google Scholar
Campion J, Milagro FI, Martinez JA: Individuality and epigenetics in obesity. Obes Rev. 2009, 10: 383-392. 10.1111/j.1467-789X.2009.00595.x.
Article
CAS
PubMed
Google Scholar
Relton CL, Davey SG: Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med. 2010, 7: e1000356-10.1371/journal.pmed.1000356.
Article
PubMed Central
PubMed
Google Scholar
Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, Yang AS, Vokonas P, Lissowska J, Fustinoni S, Pesatori AC, Bonzini M, Apostoli P, Costa G, Bertazzi PA, Chow WH, Schwartz J, Baccarelli A: Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol. 2010, 41: 126-139.
Article
PubMed Central
PubMed
Google Scholar
Nelson HH, Marsit CJ, Kelsey KT: Global methylation in exposure biology and translational medical science. Environ Health Perspect. 2011, 119: 1528-1533. 10.1289/ehp.1103423.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C: Initial sequencing and analysis of the human genome. Nature. 2001, 409: 860-921. 10.1038/35057062.
Article
CAS
PubMed
Google Scholar
Sunami E, de MM, Vu A, Turner RR, Hoon DS: LINE-1 hypomethylation during primary colon cancer progression. PLoS One. 2011, 6: e18884-10.1371/journal.pone.0018884.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhu ZZ, Sparrow D, Hou L, Tarantini L, Bollati V, Litonjua AA, Zanobetti A, Vokonas P, Wright RO, Baccarelli A, Schwartz J: Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control. 2011, 22: 437-447. 10.1007/s10552-010-9715-2.
Article
PubMed Central
PubMed
Google Scholar
Baccarelli A, Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L, Sparrow D, Vokonas P, Schwartz J: Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology. 2010, 21: 819-828. 10.1097/EDE.0b013e3181f20457.
Article
PubMed Central
PubMed
Google Scholar
Pearce MS, McConnell JC, Potter C, Barrett LM, Parker L, Mathers JC, Relton CL: Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles. Int J Epidemiol. 2012, 41: 210-217. 10.1093/ije/dys020.
Article
PubMed Central
PubMed
Google Scholar
Cash HL, McGarvey ST, Houseman EA, Marsit CJ, Hawley NL, Lambert-Messerlian GM, Viali S, Tuitele J, Kelsey KT: Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics. 2011, 6: 1257-1264. 10.4161/epi.6.10.17728.
Article
PubMed Central
CAS
PubMed
Google Scholar
Marceau P, Hould FS, Simard S, Lebel S, Bourque RA, Potvin M, Biron S: Biliopancreatic diversion with duodenal switch. World J Surg. 1998, 22: 947-954. 10.1007/s002689900498.
Article
CAS
PubMed
Google Scholar
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003, 26 (Suppl 1): S5-S20.
Google Scholar
Vohl MC, Houde A, Lebel S, Hould FS, Marceau P: Effects of the peroxisome proliferator-activated receptor-gamma co-activator-1 Gly482Ser variant on features of the metabolic syndrome. Mol Genet Metab. 2005, 86: 300-306. 10.1016/j.ymgme.2005.07.002.
Article
CAS
PubMed
Google Scholar
Vohl MC, Sladek R, Robitaille J, Gurd S, Marceau P, Richard D, Hudson TJ, Tchernof A: A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men. Obes Res. 2004, 12: 1217-1222. 10.1038/oby.2004.153.
Article
CAS
PubMed
Google Scholar
Alberti KG, Zimmet P, Shaw J: Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006, 23: 469-480.
Article
CAS
PubMed
Google Scholar
Expert Panel on Detection EaToHBCiA: Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001, 285: 2486-2497. 10.1001/jama.285.19.2486.
Article
Google Scholar
England R, Pettersson M: Pyro Q-CpG: quantitative analysis of methylation in multiple CpG sites by pyrosequencing. Nature Methods. 2005, 2: 10.1038.
Google Scholar
Turcot V, Bouchard L, Faucher G, Tchernof A, Deshaies Y, Perusse L, Belisle A, Marceau S, Biron S, Lescelleur O, Biertho L, Vohl MC: DPP4 gene DNA methylation in the omentum is associated with its gene expression and plasma lipid profile in severe obesity. Obesity (Silver Spring). 2011, 19: 388-395. 10.1038/oby.2010.198.
Article
CAS
Google Scholar
Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC: Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One. 2010, 5: e13730-10.1371/journal.pone.0013730.
Article
PubMed Central
PubMed
Google Scholar
Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP: A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 2004, 32: e38-10.1093/nar/gnh032.
Article
PubMed Central
PubMed
Google Scholar
Baccarelli A, Tarantini L, Wright RO, Bollati V, Litonjua AA, Zanobetti A, Sparrow D, Vokonas P, Schwartz J: Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study. Epigenetics. 2010, 5: 222-228. 10.4161/epi.5.3.11377.
Article
CAS
PubMed
Google Scholar
Choi JY, James SR, Link PA, McCann SE, Hong CC, Davis W, Nesline MK, Ambrosone CB, Karpf AR: Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis. 2009, 30: 1889-1897. 10.1093/carcin/bgp143.
Article
PubMed Central
CAS
PubMed
Google Scholar
Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM: DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics. 2011, 6: 828-837. 10.4161/epi.6.7.16500.
Article
PubMed Central
CAS
PubMed
Google Scholar
Irahara N, Nosho K, Baba Y, Shima K, Lindeman NI, Hazra A, Schernhammer ES, Hunter DJ, Fuchs CS, Ogino S: Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells. J Mol Diagn. 2010, 12: 177-183. 10.2353/jmoldx.2010.090106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pavicic W, Joensuu EI, Nieminen T, Peltomaki P: LINE-1 hypomethylation in familial and sporadic cancer. J Mol Med (Berl). 2012, 10.1007/s00109-011-0854-z.
Google Scholar
Wilhelm-Benartzi CS, Houseman EA, Maccani MA, Poage GM, Koestler DC, Langevin SM, Gagne LA, Banister C, Padbury JF, Marsit CJ: In utero exposures, infant growth, and DNA methylation of repetitive element and developmentally related genes in human placenta. Environ Health Perspect. 2012, 120: 296-302.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, Jacobs DR, Steffes M, Lee DH: Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environ Health Perspect. 2010, 118: 370-374.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang FF, Cardarelli R, Carroll J, Fulda KG, Kaur M, Gonzalez K, Vishwanatha JK, Santella RM, Morabia A: Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics. 2011, 6: 623-629. 10.4161/epi.6.5.15335.
Article
PubMed Central
CAS
PubMed
Google Scholar
El-Maarri O, Walier M, Behne F, van UJ, Singer H, Diaz-Lacava A, Nusgen N, Niemann B, Watzka M, Reinsberg J, van dV, Wienker T, Stoffel-Wagner B, Schwaab R, Oldenburg J: Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles. PLoS One. 2011, 6: e16252-10.1371/journal.pone.0016252.
Article
PubMed Central
CAS
PubMed
Google Scholar
Singer H, Walier M, Nusgen N, Meesters C, Schreiner F, Woelfle J, Fimmers R, Wienker T, Kalscheuer VM, Becker T, Schwaab R, Oldenburg J, El-Maarri O: Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci. Hum Mol Genet. 2012, 21: 219-235. 10.1093/hmg/ddr456.
Article
PubMed Central
PubMed
Google Scholar
Poage GM, Houseman EA, Christensen BC, Butler RA, Avissar-Whiting M, McClean MD, Waterboer T, Pawlita M, Marsit CJ, Kelsey KT: Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer. Clin Cancer Res. 2011, 17: 3579-3589. 10.1158/1078-0432.CCR-11-0044.
Article
PubMed Central
CAS
PubMed
Google Scholar
Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, Ehrlich M, Laird PW: Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res. 2005, 33: 6823-6836. 10.1093/nar/gki987.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wu HC, Delgado-Cruzata L, Flom JD, Kappil M, Ferris JS, Liao Y, Santella RM, Terry MB: Global methylation profiles in DNA from different blood cell types. Epigenetics. 2011, 6: 76-85. 10.4161/epi.6.1.13391.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kazazian HH, Goodier JL: LINE drive. retrotransposition and genome instability. Cell. 2002, 110: 277-280. 10.1016/S0092-8674(02)00868-1.
Article
CAS
PubMed
Google Scholar
Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T: Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer. 2009, 124: 81-87. 10.1002/ijc.23849.
Article
CAS
PubMed
Google Scholar
Lee DH: Persistent organic pollutants and obesity-related metabolic dysfunction: focusing on type 2 diabetes. Epidemiol Health. 2012, 34: e2012002-
Article
PubMed Central
PubMed
Google Scholar
Ruzzin J, Petersen R, Meugnier E, Madsen L, Lock EJ, Lillefosse H, Ma T, Pesenti S, Sonne SB, Marstrand TT, Malde MK, Du ZY, Chavey C, Fajas L, Lundebye AK, Brand CL, Vidal H, Kristiansen K, Froyland L: Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect. 2010, 118: 465-471.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sell H, Eckel J: Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care. 2010, 13: 366-370. 10.1097/MCO.0b013e32833aab7f.
Article
PubMed
Google Scholar
Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, Leong HX, Glassford A, Caimol M, Kenkel JA, Tedder TF, McLaughlin T, Miklos DB, Dosch HM, Engleman EG: B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011, 17: 610-617. 10.1038/nm.2353.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ulrich CM, Reed MC, Nijhout HF: Modeling folate, one-carbon metabolism, and DNA methylation. Nutr Rev. 2008, 66 (Suppl 1): S27-S30.
Article
PubMed
Google Scholar