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Table 3 Logistic regression analysis evaluating the association between LINE-1 methylation level ( LINE-1 %meth) quartiles and metabolic syndrome (MetS) risk

From: LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

LINE-1%meth quartiles MetS-,n = 98 MetS+,n = 86 Wald’sχ2 = 12.3,P = 0.007a, OR (95% CL) P value
Q1: 67.3% to 73.8% 21 (0.22) 25 (0.29) 4.37 (1.59 to 12.02) 0.004
Q2: 73.8% to 75.0% 19 (0.19) 27 (0.31) 4.76 (1.76 to 12.90) 0.002
Q3: 75.0% to 77.3% 28 (0.29) 18 (0.21) 1.82 (0.70 to 4.71) 0.22
Q4: 77.3% to 85.0% 30 (0.31) 16 (0.18) 1.00 -
  1. Odds ratios and P values computed by the logistic regression analysis were obtained while including potential confounding factors in the model, namely age, sex and smoking. The fourth LINE-1%meth quartile (Q4) was set as the reference group.
  2. aCorresponds to the Wald’s χ2 and P value for the effect of LINE-1%meth quartiles. For the whole model, Wald’s χ2 = 14.0 and P value = 0.03.
  3. CL = Wald’s confidence limits.