LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

Table 2 Multiple linear regression analysis predicting metabolic syndrome (MetS)-related phenotypes while including LINE-1 methylation level ( LINE-1 %meth) in the predictive model

Dependent variables	*LINE-1*%meth
Dependent variables	N	β (95% CI)^model	P value
Waist circumference (cm)	180	-0.51 (-1.33 to 0.32)^A	0.23
Fasting glucose (mmol/l)	179	-0.04 (-0.08 to -0.01)^B	0.03
Triglycerides (mmol/l)	179	0.01 (-0.04 to 0.06)^B	0.64
High-density lipoprotein-cholesterol (mmol/l)	179	0.01 (-0.003 to 0.03)^B	0.13
Systolic blood pressure (mmHg)	180	-0.71 (-1.55 to 0.13)^B	0.10
Diastolic blood pressure (mmHg)	180	-0.65 (-1.26 to -0.05)^B	0.03
MetS (n)	184	-0.04 (-0.06 to -0.01)^A	0.004

Only coefficients (β), 95% confidence intervals (95% CI) and P values accounted for by the independent variable LINE-1%meth levels are shown in the table. The coefficient β corresponds to the change in the dependent variable per unit change in LINE-1%meth, given that all the other variables in the model remain constant.
Model A: LINE-1%meth, age, sex and smoking.
Model B: LINE-1%meth, age, sex, smoking and waist circumference.

ISSN: 1868-7083