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Citation: Clinical Epigenetics 2024 16:59
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DNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites
Alzheimer’s disease (AD) prevalence is twice as high in non-Hispanic Blacks (NHBs) as in non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant methylation at imprint control...
Citation: Clinical Epigenetics 2024 16:58 -
Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression
Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has...
Citation: Clinical Epigenetics 2024 16:57 -
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as a means to identify women at risk of developi...
Citation: Clinical Epigenetics 2024 16:56 -
DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
CSLCs(Cancer stem cell-like cells), which are central to tumorigenesis, are intrinsically influenced by epigenetic modifications. This study aimed to elucidate the underlying mechanism involving the DNMT1/miR-...
Citation: Clinical Epigenetics 2024 16:55 -
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes, ranging from pluripotency and development to carcinogenesis...
Citation: Clinical Epigenetics 2024 16:54 -
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging...
Citation: Clinical Epigenetics 2024 16:53 -
Epigenetics in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate pathological mechanisms of DCM cause diastolic dysfunction, follo...
Citation: Clinical Epigenetics 2024 16:52 -
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and curious. While selenium has shown promise in reducing cancer risks through supplementatio...
Citation: Clinical Epigenetics 2024 16:51 -
Nucleosome reorganisation in breast cancer tissues
Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understanding these changes is important to elucidate fundamental aspects of cancer. It is also ...
Citation: Clinical Epigenetics 2024 16:50 -
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complicati...
Citation: Clinical Epigenetics 2024 16:49 -
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells hav...
Citation: Clinical Epigenetics 2024 16:48 -
Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles
The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most commo...
Citation: Clinical Epigenetics 2024 16:47 -
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typicall...
Citation: Clinical Epigenetics 2024 16:46 -
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obt...
Citation: Clinical Epigenetics 2024 16:45 -
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance betwe...
Citation: Clinical Epigenetics 2024 16:44 -
Correction: Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
Citation: Clinical Epigenetics 2024 16:43 -
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, pro...
Citation: Clinical Epigenetics 2024 16:42 -
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly a...
Citation: Clinical Epigenetics 2024 16:41 -
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx), attributable to promoter hypermethylation. Long noncoding RNA genes (lncGs) play pivo...
Citation: Clinical Epigenetics 2024 16:40 -
Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications
Alzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the developme...
Citation: Clinical Epigenetics 2024 16:39 -
An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD
Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this quest...
Citation: Clinical Epigenetics 2024 16:38 -
Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
The recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in health and diseases. This study used COVID-19 as a disease model to investi...
Citation: Clinical Epigenetics 2024 16:37 -
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide approach, we aimed to investigate DNA methylation changes occurring secondary ...
Citation: Clinical Epigenetics 2024 16:36 -
Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age
We previously reported in the “Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function” randomized clinical trial (RCT) that vitamin C (500 mg/day) supplementation to pregnant smokers...
Citation: Clinical Epigenetics 2024 16:35 -
Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Cell-free DNA (cfDNA) contains a large amount of molecular information that can be used for multi-cancer early detection (MCED), including changes in epigenetic status of cfDNA, such as cfDNA fragmentation pro...
Citation: Clinical Epigenetics 2024 16:34 -
Reduced representative methylome profiling of cell-free DNA for breast cancer detection
Whole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome profiling (RRMP), which employs restriction enzyme for depletion of A...
Citation: Clinical Epigenetics 2024 16:33 -
Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging
People living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less susceptible to AIDS-related complications, they remain highly vulnerable to non-communica...
Citation: Clinical Epigenetics 2024 16:32 -
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may im...
Citation: Clinical Epigenetics 2024 16:31 -
Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury
Spinal cord injury (SCI) is a severe neurological disorder that causes neurological impairment and disability. Neural stem/progenitor cells (NS/PCs) derived from induced pluripotent stem cells (iPSCs) represen...
Citation: Clinical Epigenetics 2024 16:30 -
Epigenome-wide association study of dietary fatty acid intake
Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often r...
Citation: Clinical Epigenetics 2024 16:29 -
Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspec...
Citation: Clinical Epigenetics 2024 16:28 -
Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression
Chronological and biological age correlate with DNA methylation levels at specific sites in the genome. Linear combinations of multiple methylation sites, termed epigenetic clocks, can inform us the chronologi...
Citation: Clinical Epigenetics 2024 16:27 -
Molecular map of disulfidptosis-related genes in lung adenocarcinoma: the perspective toward immune microenvironment and prognosis
Disulfidptosis is a recently discovered form of programmed cell death that could impact cancer development. Nevertheless, the prognostic significance of disulfidptosis-related genes (DRGs) in lung adenocarcino...
Citation: Clinical Epigenetics 2024 16:26 -
Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel
Cancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different tissues and cancer types enable the ident...
Citation: Clinical Epigenetics 2024 16:25 -
The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications
DNA methylation is a pivotal epigenetic modification that affects gene expression. Tumor immune microenvironment (TIME) comprises diverse immune cells and stromal components, creating a complex landscape that ...
Citation: Clinical Epigenetics 2024 16:24 -
Correction: A transgenic mice model of retinopathy of cblG‑type inherited disorder of one‑carbon metabolism highlights epigenome‑wide alterations related to cone photoreceptor cells development and retinal metabolism
Citation: Clinical Epigenetics 2024 16:23 -
Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DN...
Citation: Clinical Epigenetics 2024 16:22 -
Per-cell histone acetylation is associated with terminal differentiation in human T cells
Epigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However, efforts to investigate underlying epigenetic mechanisms that control T c...
Citation: Clinical Epigenetics 2024 16:21 -
Epigenetics of prenatal stress in humans: the current research landscape
Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible process how these adverse environmen...
Citation: Clinical Epigenetics 2024 16:20 -
Identification of DNA methylation biomarkers for evaluating cardiovascular disease risk from epigenome profiles altered by low-dose ionizing radiation
Environmental exposure, medical diagnostic and therapeutic applications, and industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation (< 100 mGy). C...
Citation: Clinical Epigenetics 2024 16:19 -
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteo...
Citation: Clinical Epigenetics 2024 16:18 -
MethScore as a new comprehensive DNA methylation-based value refining the prognosis in acute myeloid leukemia
Changes in DNA methylation are common events in the pathogenesis of acute myeloid leukemia (AML) and have been repeatedly reported as associated with prognosis. However, studies integrating these numerous and ...
Citation: Clinical Epigenetics 2024 16:17 -
The predictive value of BTG1 for the response of newly diagnosed acute myeloid leukemia to decitabine
Decitabine has been widely used to treat acute myeloid leukemia (AML); however as AML is a heterogeneous disease, not all patients benefit from decitabine. This study aimed to identify markers for predicting t...
Citation: Clinical Epigenetics 2024 16:16 -
Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function
DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics change in asthma, we used publicly available DNAm (asthmatics, n ...
Citation: Clinical Epigenetics 2024 16:15 -
YAP represses intestinal inflammation through epigenetic silencing of JMJD3
Epigenetics plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Some studies have reported that YAP is involved in inflammatory response and can regulate target genes through epige...
Citation: Clinical Epigenetics 2024 16:14 -
Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essen...
Citation: Clinical Epigenetics 2024 16:13 -
Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter r...
Citation: Clinical Epigenetics 2024 16:12 -
EBV DNA methylation profiles and its application in distinguishing nasopharyngeal carcinoma and nasal NK/T-cell lymphoma
As an oncovirus, EBV is associated with multiple cancers, including solid tumors and hematological malignancies. EBV methylation plays an important role in regulating tumor occurrence. However, the EBV methyla...
Citation: Clinical Epigenetics 2024 16:11 -
Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis
Metastasis is the primary cause of recurrence and death in patients with papillary thyroid carcinoma (PTC). LncRNA ACTA2-AS1, a long non-coding RNA, acts as a tumor suppressor in multiple types of human malign...
Citation: Clinical Epigenetics 2024 16:10
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- ISSN: 1868-7083 (electronic)