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  1. Research

    LINE-1 is preferentially hypomethylated within adenomatous polyps in the presence of synchronous colorectal cancer

    Conventional tubular adenomas are frequently detected in patients undergoing average risk screening colonoscopy and are over-represented in patients who will develop colorectal cancer (CRC). Whether features o...

    Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari and Joshua Melson

    Clinical Epigenetics 2017 9:25

    Published on: 9 March 2017

  2. Research

    The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer

    Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tu...

    Andrea J. Savio, Miralem Mrkonjic, Mathieu Lemire, Steven Gallinger, Julia A. Knight and Bharat Bapat

    Clinical Epigenetics 2017 9:26

    Published on: 9 March 2017

  3. Research

    Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens

    MiRNA expression markers are well characterized in colorectal cancer (CRC), but less is known about miRNA expression profiles in colorectal adenomas. Genome-wide miRNA and mRNA expression analyses were conduct...

    Zsófia Brigitta Nagy, Barnabás Wichmann, Alexandra Kalmár, Orsolya Galamb, Barbara Kinga Barták, Sándor Spisák, Zsolt Tulassay and Béla Molnár

    Clinical Epigenetics 2017 9:22

    Published on: 14 February 2017

  4. Research

    DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

    Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contributi...

    Milena Magalhães, Isabelle Rivals, Mireille Claustres, Jessica Varilh, Mélodie Thomasset, Anne Bergougnoux, Laurent Mely, Sylvie Leroy, Harriet Corvol, Loïc Guillot, Marlène Murris, Emmanuelle Beyne, Davide Caimmi, Isabelle Vachier, Raphaël Chiron and Albertina De Sario

    Clinical Epigenetics 2017 9:19

    Published on: 14 February 2017

  5. Research

    Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals

    Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an in...

    Tapio Nevalainen, Laura Kananen, Saara Marttila, Juulia Jylhävä, Nina Mononen, Mika Kähönen, Olli T. Raitakari, Antti Hervonen, Marja Jylhä, Terho Lehtimäki and Mikko Hurme

    Clinical Epigenetics 2017 9:20

    Published on: 14 February 2017

  6. Research

    Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

    Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de...

    Abhay Raina, Xiaoping Zhao, Megan L. Grove, Jan Bressler, Rebecca F. Gottesman, Weihua Guan, James S. Pankow, Eric Boerwinkle, Thomas H. Mosley and Myriam Fornage

    Clinical Epigenetics 2017 9:21

    Published on: 14 February 2017

  7. Review

    Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

    Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the cancer cell mic...

    Mark E. Issa, Farnaz Sedigheh Takhsha, Chandra Sekhar Chirumamilla, Claudina Perez-Novo, Wim Vanden Berghe and Muriel Cuendet

    Clinical Epigenetics 2017 9:17

    Published on: 10 February 2017

  8. Research

    Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

    DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of trig...

    Kim V. E. Braun, Klodian Dhana, Paul S. de Vries, Trudy Voortman, Joyce B. J. van Meurs, Andre G. Uitterlinden, Albert Hofman, Frank B. Hu, Oscar H. Franco and Abbas Dehghan

    Clinical Epigenetics 2017 9:15

    Published on: 7 February 2017

  9. Research

    Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

    Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspr...

    Sara Pauwels, Manosij Ghosh, Radu Corneliu Duca, Bram Bekaert, Kathleen Freson, Inge Huybrechts, Sabine A. S. Langie, Gudrun Koppen, Roland Devlieger and Lode Godderis

    Clinical Epigenetics 2017 9:16

    Published on: 7 February 2017

  10. Research

    Genome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India

    Oral squamous cell carcinoma (OSCC) is one of the common malignancies in Southeast Asia. Epigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers. Considering the varied env...

    Baidehi Basu, Joyeeta Chakraborty, Aditi Chandra, Atul Katarkar, Jadav Ritesh Kumar Baldevbhai, Debjit Dhar Chowdhury, Jay Gopal Ray, Keya Chaudhuri and Raghunath Chatterjee

    Clinical Epigenetics 2017 9:13

    Published on: 3 February 2017

  11. Research

    Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival

    Differentially methylated regions (DMRs) within DNA isolated from whole blood can be used to estimate the proportions of circulating leukocyte subtypes. We use the term “immunomethylomics” to describe the appl...

    John K. Wiencke, Devin C. Koestler, Lucas A. Salas, Joseph L. Wiemels, Ritu P. Roy, Helen M. Hansen, Terri Rice, Lucie S. McCoy, Paige M. Bracci, Annette M. Molinaro, Karl T. Kelsey, Margaret R. Wrensch and Brock C. Christensen

    Clinical Epigenetics 2017 9:10

    Published on: 2 February 2017

  12. Research

    PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma

    Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation...

    Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck and Dimo Dietrich

    Clinical Epigenetics 2017 9:12

    Published on: 2 February 2017

  13. Research

    UroMark—a urinary biomarker assay for the detection of bladder cancer

    Bladder cancer (BC) is one of the most common cancers in the western world and ranks as the most expensive to manage, due to the need for cystoscopic examination. BC shows frequent changes in DNA methylation, ...

    Andrew Feber, Pawan Dhami, Liqin Dong, Patricia de Winter, Wei Shen Tan, Mónica Martínez-Fernández, Dirk S. Paul, Antony Hynes-Allen, Sheida Rezaee, Pratik Gurung, Simon Rodney, Ahmed Mehmood, Felipe Villacampa, Federico de la Rosa, Charles Jameson, Kar Keung Cheng…

    Clinical Epigenetics 2017 9:8

    Published on: 31 January 2017

  14. Research

    CDH22 hypermethylation is an independent prognostic biomarker in breast cancer

    Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in colorec...

    Esperanza Martín-Sánchez, Saioa Mendaza, Ane Ulazia-Garmendia, Iñaki Monreal-Santesteban, Alicia Córdoba, Francisco Vicente-García, Idoia Blanco-Luquin, Susana De La Cruz, Ana Aramendia and David Guerrero-Setas

    Clinical Epigenetics 2017 9:7

    Published on: 24 January 2017

  15. Research

    Epigenome-wide association study of DNA methylation in panic disorder

    Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility ...

    Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, Yoshiya Kawamura, Miki Bundo, Kazuya Iwamoto, Mamoru Tochigi, Kiyoto Kasai, Hisanobu Kaiya, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga and Tsukasa Sasaki

    Clinical Epigenetics 2017 9:6

    Published on: 21 January 2017

  16. Short report

    The epigenomic basis of common diseases

    A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.

    Euan J. Rodger and Aniruddha Chatterjee

    Clinical Epigenetics 2017 9:5

    Published on: 19 January 2017

  17. Research

    The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

    RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macropha...

    Hongjuan Zhao, Shoucheng Ning, Rosalie Nolley, Jan Scicinski, Bryan Oronsky, Susan J. Knox and Donna M. Peehl

    Clinical Epigenetics 2017 9:4

    Published on: 19 January 2017

  18. Letter to the Editor

    Combining omics data to identify genes associated with allergic rhinitis

    Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association stu...

    Andréanne Morin, Michel Laviolette, Tomi Pastinen, Louis-Philippe Boulet and Catherine Laprise

    Clinical Epigenetics 2017 9:3

    Published on: 18 January 2017

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