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  1. Research

    Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

    Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by placental mitochondria. The biological mechanisms by which thyroid hormones exer...

    Bram G. Janssen, Hyang-Min Byun, Harry A. Roels, Wilfried Gyselaers, Joris Penders, Andrea A. Baccarelli and Tim S. Nawrot

    Clinical Epigenetics 2017 9:66

    Published on: 21 June 2017

  2. Research

    Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

    Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be ...

    Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R. Jezioro, David Z. Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P. Perera, Andrew G. Rundle, Matthew S. Perzanowski, Steven N. Chillrud and Rachel L. Miller

    Clinical Epigenetics 2017 9:65

    Published on: 13 June 2017

  3. Research

    Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer

    This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 ex...

    Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Yuki Misawa, Shiori Endo, Masato Mima, Hideya Kawasaki, Thomas E. Carey and Takeharu Kanazawa

    Clinical Epigenetics 2017 9:64

    Published on: 12 June 2017

  4. Research

    Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A

    Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, co...

    Andrea Halaburková, Rastislav Jendželovský, Ján Kovaľ, Zdenko Herceg, Peter Fedoročko and Akram Ghantous

    Clinical Epigenetics 2017 9:62

    Published on: 8 June 2017

  5. Research

    Distinct DNA methylation profiles in subtypes of orofacial cleft

    Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environm...

    Gemma C. Sharp, Karen Ho, Amy Davies, Evie Stergiakouli, Kerry Humphries, Wendy McArdle, Jonathan Sandy, George Davey Smith, Sarah J. Lewis and Caroline L. Relton

    Clinical Epigenetics 2017 9:63

    Published on: 8 June 2017

  6. Research

    Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

    Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not bee...

    Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R. Jezioro, Matthew Perzanowski, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller

    Clinical Epigenetics 2017 9:61

    Published on: 2 June 2017

  7. Research

    ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer

    Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby...

    Antje M. Richter, Steffen Kiehl, Nicole Köger, Janina Breuer, Thorsten Stiewe and Reinhard H. Dammann

    Clinical Epigenetics 2017 9:60

    Published on: 2 June 2017

  8. Research

    Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

    Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LIN...

    Carlo Furlan, Jerry Polesel, Luigi Barzan, Giovanni Franchin, Sandro Sulfaro, Salvatore Romeo, Francesca Colizzi, Aurora Rizzo, Vittorio Baggio, Vittorio Giacomarra, Angelo Paolo Dei Tos, Paolo Boscolo-Rizzo, Emanuela Vaccher, Riccardo Dolcetti, Luca Sigalotti and Elisabetta Fratta

    Clinical Epigenetics 2017 9:58

    Published on: 30 May 2017

  9. Research

    Pulmonary microRNA profiling: implications in upper lobe predominant lung disease

    Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulm...

    David A. Armstrong, Amanda B. Nymon, Carol S. Ringelberg, Corina Lesseur, Haley F. Hazlett, Louisa Howard, Carmen J. Marsit and Alix Ashare

    Clinical Epigenetics 2017 9:56

    Published on: 30 May 2017

  10. Research

    Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia

    In chronic lymphocytic leukemia (CLL), epigenomic and genomic studies have expanded the existing knowledge about the disease biology and led to the identification of potential biomarkers relevant for implement...

    Lata Rani, Nitin Mathur, Ritu Gupta, Ajay Gogia, Gurvinder Kaur, Jaspreet Kaur Dhanjal, Durai Sundar, Lalit Kumar and Atul Sharma

    Clinical Epigenetics 2017 9:57

    Published on: 30 May 2017

  11. Research

    Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa

    Two molecular pathways promote the development of colorectal cancer (CRC). One is termed “microsatellite stable” (MSS) whereas the other is characterized by “microsatellite instability” (MSI or MIN). In additi...

    Tamotsu Sugai, Masakazu Yoshida, Makoto Eizuka, Noriyuki Uesugii, Wataru Habano, Kouki Otsuka, Akira Sasaki, Eiichiro Yamamoto, Takayuki Matsumoto and Hiromu Suzuki

    Clinical Epigenetics 2017 9:55

    Published on: 18 May 2017

  12. Research

    Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer

    Colonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure. However, certain limitatio...

    Jean-François Rahier, Anne Druez, Laurence Faugeras, Jean-Paul Martinet, Myriam Géhénot, Eléonore Josseaux, Marielle Herzog, Jake Micallef, Fabienne George, Monique Delos, Thierry De Ronde, Abdenor Badaoui and Lionel D’Hondt

    Clinical Epigenetics 2017 9:53

    Published on: 15 May 2017

  13. Short report

    Genetic heterogeneity of patients with suspected Silver-Russell syndrome: genome-wide copy number analysis in 82 patients without imprinting defects

    Silver-Russell syndrome (SRS) is a rare congenital disorder characterized by pre- and postnatal growth failure and dysmorphic features. Recently, pathogenic copy number variations (PCNVs) and imprinting defect...

    Takanobu Inoue, Akie Nakamura, Tomoko Fuke, Kazuki Yamazawa, Shinichiro Sano, Keiko Matsubara, Seiji Mizuno, Yoshika Matsukura, Chie Harashima, Tatsuji Hasegawa, Hisakazu Nakajima, Kumi Tsumura, Zenro Kizaki, Akira Oka, Tsutomu Ogata, Maki Fukami…

    Clinical Epigenetics 2017 9:52

    Published on: 15 May 2017

  14. Short report

    Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease

    Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial ...

    Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Keiko Naruse, Shigeki Yokota, Hiroyuki Asano, Tatsuaki Matsubara and Mitsuhiro Yokota

    Clinical Epigenetics 2017 9:54

    Published on: 15 May 2017

  15. Letter to the Editor

    Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression

    Targeting checkpoint inhibitors using monoclonal antibodies results in significantly better outcome of cancer patients compared to conventional chemotherapy. However, the current companion diagnostics to predi...

    Sebastian Marwitz, Swetlana Scheufele, Sven Perner, Martin Reck, Ole Ammerpohl and Torsten Goldmann

    Clinical Epigenetics 2017 9:51

    Published on: 11 May 2017

  16. Short report

    Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth

    A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may p...

    Polina Girchenko, Jari Lahti, Darina Czamara, Anna K. Knight, Meaghan J. Jones, Anna Suarez, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Michael S. Kobor, Alicia K. Smith, Elisabeth B. Binder and Katri Räikkönen

    Clinical Epigenetics 2017 9:49

    Published on: 8 May 2017

  17. Short report

    Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

    DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylat...

    Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon and Katie Lunnon

    Clinical Epigenetics 2017 9:47

    Published on: 3 May 2017

  18. Research

    Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

    Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These mechanisms, including DNA methylation, influence ...

    Donia Macartney-Coxson, Miles C. Benton, Ray Blick, Richard S. Stubbs, Ronald D. Hagan and Michael A. Langston

    Clinical Epigenetics 2017 9:48

    Published on: 3 May 2017

  19. Research

    The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases

    The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine...

    Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous, George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas and William M. Grady

    Clinical Epigenetics 2017 9:46

    Published on: 2 May 2017

  20. Research

    Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas

    Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regula...

    Caroline Moraes Beltrami, Mariana Bisarro dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski and Silvia Regina Rogatto

    Clinical Epigenetics 2017 9:45

    Published on: 2 May 2017

  21. Research

    Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation

    Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigene...

    Bénédicte L. Tremblay, Frédéric Guénard, Iwona Rudkowska, Simone Lemieux, Patrick Couture and Marie-Claude Vohl

    Clinical Epigenetics 2017 9:43

    Published on: 26 April 2017

  22. Research

    Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

    Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription ...

    J. Song, I. H. Heijink, L. E. M. Kistemaker, M. Reinders-Luinge, W. Kooistra, J. A. Noordhoek, R. Gosens, C. A. Brandsma, W. Timens, P. S. Hiemstra, M. G. Rots and M. N. Hylkema

    Clinical Epigenetics 2017 9:42

    Published on: 24 April 2017

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