Skip to main content

Articles

Page 20 of 22

  1. Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is cor...

    Authors: Robert A Philibert, Steven R H Beach, Man-Kit Lei and Gene H Brody

    Citation: Clinical Epigenetics 2013 5:19

    Content type: Research

    Published on:

  2. Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses ...

    Authors: Carmen J Marsit, Devin C Koestler, Debra Watson-Smith, Charlotte M Boney, James F Padbury and Francois Luks

    Citation: Clinical Epigenetics 2013 5:18

    Content type: Research

    Published on:

  3. A remarkable correspondence exists between the cytogenetic locations of the known fragile sites and frequently reported sites of hypermethylation. The best-known features of fragile sites are sequence motifs t...

    Authors: Steven S Smith

    Citation: Clinical Epigenetics 2013 5:17

    Content type: Hypothesis

    Published on:

  4. Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation...

    Authors: Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif and Eamonn R Maher

    Citation: Clinical Epigenetics 2013 5:16

    Content type: Research

    Published on:

  5. Epidemiological evidence indicates yet unknown epigenetic mechanisms underlying a propensity for overweight and type 2 diabetes. We analyzed the extent of methylation at lysine 4 and lysine 9 of histone H3 in ...

    Authors: Åsa Jufvas, Simon Sjödin, Kim Lundqvist, Risul Amin, Alexander V Vener and Peter Strålfors

    Citation: Clinical Epigenetics 2013 5:15

    Content type: Research

    Published on:

  6. Authors: Athar Aziz, E Joanna Baxter, Carol Edwards, Clara Yujing Cheong, Mitsuteru Ito, Anthony Bench, Rebecca Kelley, Yvonne Silber, Philip A Beer, Keefe Chng, Marilyn B Renfree, Kirsten McEwen, Dionne Gray, Jyoti Nangalia, Ghulam J Mufti, Eva Hellstrom-Lindberg…

    Citation: Clinical Epigenetics 2013 5(Suppl 1):S5

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  7. Authors: Gabriella Ficz, Timothy A Hore, Fatima Santos, Heather J Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu-Lee Paul, Jörn Walter, Simon J Cook, Simon Andrews, Miguel R Branco and Wolf Reik

    Citation: Clinical Epigenetics 2013 5(Suppl 1):S2

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  8. Prenatal alcohol exposure is known to result in fetal alcohol spectrum disorders, a continuum of physiological, behavioural, and cognitive phenotypes that include increased risk for anxiety and learning-associ...

    Authors: Randa L Stringer, Benjamin I Laufer, Morgan L Kleiber and Shiva M Singh

    Citation: Clinical Epigenetics 2013 5:14

    Content type: Short report

    Published on:

  9. A large proportion of patients with acute myeloid leukemia (AML) are not fit for intensive and potentially curative therapy due to advanced age or comorbidity. Previous studies have demonstrated that a subset ...

    Authors: Hanne Fredly, Elisabeth Ersvær, Astrid Olsnes Kittang, Galina Tsykunova, Bjørn Tore Gjertsen and Øystein Bruserud

    Citation: Clinical Epigenetics 2013 5:13

    Content type: Research

    Published on:

  10. Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histon...

    Authors: Hanne Fredly, Bjørn Tore Gjertsen and Øystein Bruserud

    Citation: Clinical Epigenetics 2013 5:12

    Content type: Review

    Published on:

  11. The NAD-dependent protein deacetylase SIRT1 has a wide range of different targets, which may be regulated either directly through deacetylation and thus potentially altering their activity or localization or i...

    Authors: Judith Katto, Nicole Engel, Wasim Abbas, Georges Herbein and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2013 5:11

    Content type: Research

    Published on:

  12. Sirtuin 1 (Sirt1) is a nuclear enzyme from the class III histone deacetylases that modulates gene expression and is involved in bone and cartilage remodeling. The goal of our study was to evaluate Sirt1 activi...

    Authors: Daniel Wendling, Wasim Abbas, Marie Godfrin-Valnet, Xavier Guillot, Kashif Aziz Khan, Jean-Pierre Cedoz, Lucile Baud, Clément Prati and Georges Herbein

    Citation: Clinical Epigenetics 2013 5:10

    Content type: Research

    Published on:

  13. Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhance tumorigenesis via D...

    Authors: Mathilde Cheray, Romain Pacaud, Arulraj Nadaradjane, François M Vallette and Pierre-François Cartron

    Citation: Clinical Epigenetics 2013 5:9

    Content type: Short report

    Published on:

  14. Epidemiological studies demonstrate that foetal growth restriction and low birth weight affect long-term health. Derangements in tissue-specific epigenetic programming of foetal and placental tissues are a sug...

    Authors: Emilie Herzog, Jubby Galvez, Anton Roks, Lisette Stolk, Michael Verbiest, Paul Eilers, Jan Cornelissen, Eric Steegers and Régine Steegers-Theunissen

    Citation: Clinical Epigenetics 2013 5:8

    Content type: Short report

    Published on:

  15. DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMT...

    Authors: Kathrin Kullmann, Mustafa Deryal, Mei Fang Ong, Werner Schmidt and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2013 5:7

    Content type: Case study

    Published on:

  16. Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of...

    Authors: Deepali P Sundrani, Umakar S Reddy, Asmita A Joshi, Savita S Mehendale, Preeti M Chavan-Gautam, Anandwardhan A Hardikar, Giriraj R Chandak and Sadhana R Joshi

    Citation: Clinical Epigenetics 2013 5:6

    Content type: Research

    Published on:

  17. The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 4 (2012).

    Authors: Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2013 5:4

    Content type: Reviewer Acknowledgement

    Published on:

  18. 5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloi...

    Authors: Metin Karahoca and Richard L Momparler

    Citation: Clinical Epigenetics 2013 5:3

    Content type: Review

    Published on:

  19. Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite i...

    Authors: Eddy H van Roon, Arnoud Boot, Ashwin A Dihal, Robert F Ernst, Tom van Wezel, Hans Morreau and Judith M Boer

    Citation: Clinical Epigenetics 2013 5:2

    Content type: Research

    Published on:

  20. The occurrence of asthma is weakly explained by known genetic variants. Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add to the explanation of asthma. However, no etiological mode...

    Authors: Nelís Soto-Ramírez, Syed Hasan Arshad, John W Holloway, Hongmei Zhang, Eric Schauberger, Susan Ewart, Veeresh Patil and Wilfried Karmaus

    Citation: Clinical Epigenetics 2013 5:1

    Content type: Research

    Published on:

  21. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol in insulin target tissues. In people with type 2 diabetes, skeletal muscle (SkM) 11βHSD1 is upregul...

    Authors: Warrick J Inder, Varuni R Obeyesekere, Christina Jang and Richard Saffery

    Citation: Clinical Epigenetics 2012 4:24

    Content type: Research

    Published on:

  22. The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models...

    Authors: Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari and Serena D’Souza

    Citation: Clinical Epigenetics 2012 4:23

    Content type: Research

    Published on:

  23. Studying DNA methylation profiles in detail should be the first step in epigenetic research. Although sodium bisulfite modification of genomic DNA is the gold standard method for DNA methylation analysis, this...

    Authors: Miki Bundo, Fumiko Sunaga, Junko Ueda, Kiyoto Kasai, Tadafumi Kato and Kazuya Iwamoto

    Citation: Clinical Epigenetics 2012 4:22

    Content type: Methodology

    Published on:

  24. The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA me...

    Authors: Rae-Chi Huang, John C Galati, Sally Burrows, Lawrence J Beilin, Xin Li, Craig E Pennell, JAM van Eekelen, Trevor A Mori, Leon A Adams and Jeffrey M Craig

    Citation: Clinical Epigenetics 2012 4:21

    Content type: Research

    Published on:

  25. Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune rheumatic disease of largely unknown cause. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with autoimmun...

    Authors: Justine A Ellis, Jane E Munro, Raul A Chavez, Lavinia Gordon, Jihoon E Joo, Jonathan D Akikusa, Roger C Allen, Anne-Louise Ponsonby, Jeffrey M Craig and Richard Saffery

    Citation: Clinical Epigenetics 2012 4:20

    Content type: Research

    Published on:

  26. Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain...

    Authors: Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller and Alexander G Haslberger

    Citation: Clinical Epigenetics 2012 4:19

    Content type: Research

    Published on:

  27. Vibration-induced white finger disease (VWF), also known as hand-arm vibration syndrome, is a secondary form of Raynaud’s disease, affecting the blood vessels and nerves. So far, little is known about the path...

    Authors: Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian L Dransfeld, Stephan Letzel and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2012 4:18

    Content type: Research

    Published on:

  28. Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined t...

    Authors: Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Katharine Hammond and Kari Nadeau

    Citation: Clinical Epigenetics 2012 4:17

    Content type: Research

    Published on:

  29. MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies t...

    Authors: Mansi A Parasramka, W Mohaiza Dashwood, Rong Wang, Hassaan H Saeed, David E Williams, Emily Ho and Roderick H Dashwood

    Citation: Clinical Epigenetics 2012 4:16

    Content type: Research

    Published on:

  30. Silver-Russell syndrome (SRS) is characterized by severe intrauterine and postnatal growth failure and frequent body asymmetry. Half of the patients with SRS carry a DNA hypomethylation of the imprinting cente...

    Authors: Kai Kannenberg, Karin Weber, Cathrin Binder, Christina Urban, Hans-Joachim Kirschner and Gerhard Binder

    Citation: Clinical Epigenetics 2012 4:15

    Content type: Research

    Published on:

  31. A wet nurse can be used if a baby’s natural mother is unable or chooses not to breastfeed her infant. The practice of using wet nurses is ancient and common to many cultures.

    Authors: Hasan Ozkan, Funda Tuzun, Abdullah Kumral and Nuray Duman

    Citation: Clinical Epigenetics 2012 4:14

    Content type: Hypothesis

    Published on:

  32. Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigen...

    Authors: Karla Bennemann, Oliver Galm, Stefan Wilop, Claudia Schubert, Tim H Brümmendorf and Edgar Jost

    Citation: Clinical Epigenetics 2012 4:12

    Content type: Research

    Published on:

  33. Epigenetic mechanisms may be involved in the regulation of genes found to be differentially expressed in the visceral adipose tissue (VAT) of severely obese subjects with (MetS+) versus without (MetS-) metabol...

    Authors: Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho and Marie-Claude Vohl

    Citation: Clinical Epigenetics 2012 4:10

    Content type: Research

    Published on:

  34. It has been suggested that inactivation of p14ARF, a tumor suppressor central to regulating p53 protein stability through interaction with the MDM2 oncoprotein, abrogates p53 activity in human tumors retaining th...

    Authors: Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser and Karin Dahan

    Citation: Clinical Epigenetics 2012 4:9

    Content type: Research

    Published on:

  35. Birth by cesarean delivery (CD) as opposed to vaginal delivery (VD) is associated with altered health outcomes later in life, including respiratory disorders, allergies and risk of developing type I diabetes. ...

    Authors: Shama Virani, Dana C Dolinoy, Sindhu Halubai, Tamara R Jones, Steve E Domino, Laura S Rozek, Muna S Nahar and Vasantha Padmanabhan

    Citation: Clinical Epigenetics 2012 4:8

    Content type: Research

    Published on:

  36. Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. T...

    Authors: Christina Schleithoff, Susanne Voelter-Mahlknecht, Indra Navina Dahmke and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2012 4:7

    Content type: Review

    Published on:

  37. The number of children ages 6 to 21 in the United States receiving special education services under the autism disability category increased 91% between 2005 to 2010 while the number of children receiving spec...

    Authors: Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga and Richard Deth

    Citation: Clinical Epigenetics 2012 4:6

    Content type: Review

    Published on: