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  1. Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been increasingly identified to be associated with tumor...

    Authors: Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang and Liang Tao
    Citation: Clinical Epigenetics 2022 14:138
  2. Aberrant epigenetic modifications such as DNA methylation may contribute to the pathogenesis of DR. We aimed at elucidating the role of novel DNA methylation modifications in diabetic retinopathy (DR) in patie...

    Authors: Shaopeng Yang, Xiao Guo, Weijing Cheng, Ishith Seth, Gabriella Bulloch, Yifan Chen, Xianwen Shang, Zhuoting Zhu, Wenyong Huang and Wei Wang
    Citation: Clinical Epigenetics 2022 14:137
  3. Identifying blood-based DNA methylation patterns is a minimally invasive way to detect biomarkers in predicting age, characteristics of certain diseases and conditions, as well as responses to immunotherapies....

    Authors: Emily Tang, John K. Wiencke, Gayathri Warrier, Helen Hansen, Lucie McCoy, Terri Rice, Paige M. Bracci, Margaret Wrensch, Jennie W. Taylor, Jennifer L. Clarke, Devin C. Koestler, Lucas A. Salas, Brock C. Christensen, Karl T. Kelsey and Annette M. Molinaro
    Citation: Clinical Epigenetics 2022 14:136
  4. Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in brea...

    Authors: Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang and Ze-fang Ren
    Citation: Clinical Epigenetics 2022 14:135
  5. Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied ...

    Authors: Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs Jr., Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:134
  6. Penile cancer is one of the most aggressive male tumors. Although it is preventable, the main etiologic causes are lifestyle behaviors and viral infection, such as human papillomavirus (HPV). Long-term epigene...

    Authors: Renan da Silva Santos, Carlos Gustavo Hirth, Daniel Pascoalino Pinheiro, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Manoel Odorico de Moraes Filho, Arlindo de Alencar Araripe Moura, Marcos Venício Alves Lima, Claudia do Ó Pessoa and Cristiana Libardi Miranda Furtado
    Citation: Clinical Epigenetics 2022 14:133
  7. The associations between blood lipids and DNA methylation have been investigated in epigenome-wide association studies mainly among European ancestry populations. Several studies have explored the direction of...

    Authors: Zhiyu Wu, Lu Chen, Xuanming Hong, Jiahui Si, Weihua Cao, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Yu Guo…
    Citation: Clinical Epigenetics 2022 14:132
  8. Epigenetics exerts a vital role in the onset and development of renal cell carcinoma (RCC). Mounting evidence has shed light on the significance of human immune system in response to tumor infiltrating T cells...

    Authors: Shu-cheng Liu, Li-bo Chen, Ping-feng Chen, Meng-long Huang, Tian-pei Liu, Jun Peng and Xin-sheng Lu
    Citation: Clinical Epigenetics 2022 14:131
  9. Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA...

    Authors: Hannah R. Elliott, Kimberley Burrows, Josine L. Min, Therese Tillin, Dan Mason, John Wright, Gillian Santorelli, George Davey Smith, Deborah A. Lawlor, Alun D. Hughes, Nishi Chaturvedi and Caroline L. Relton
    Citation: Clinical Epigenetics 2022 14:130
  10. Alterations in the epigenome are a risk factor in multiple disease states. We have demonstrated in the past that disruption of the epigenome during early pregnancy or periconception, as demonstrated by altered...

    Authors: Andrey V. Dolinko, Bryant M. Schultz, Jayashri Ghosh, Charikleia Kalliora, Monica Mainigi, Christos Coutifaris, Carmen Sapienza and Suneeta Senapati
    Citation: Clinical Epigenetics 2022 14:129
  11. Cri du chat (also called 5p deletion, or monosomy 5p) syndrome is a genetic disease caused by deletions of various lengths in the short (p) arm of chromosome 5. Genetic analysis and phenotyping have been used ...

    Authors: Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl and Arne Søraas
    Citation: Clinical Epigenetics 2022 14:128
  12. Arteriovenous malformation (AVM) is a tangle of arteries and veins, rupture of which can result in catastrophic hemorrhage in vulnerable sites such as the brain. Cerebral AVM is associated with a high mortalit...

    Authors: Jaya Mary Thomas, Dhakshmi Sasankan, Mathew Abraham, Sumi Surendran, Chandrasekharan C. Kartha and Arumugam Rajavelu
    Citation: Clinical Epigenetics 2022 14:127
  13. 5-Hydroxymethylcytosine (5hmC), an important DNA epigenetic modification, plays a vital role in tumorigenesis, progression and prognosis in many cancers. Diffuse large B cell lymphoma (DLBCL) can involve almos...

    Authors: Ye Shen, Jinping Ou, Bo He, Jinmin Yang, Huihui Liu, Lihong Wang, Bingjie Wang, Liang Gao, Chengqi Yi, Jinying Peng and Xinan Cen
    Citation: Clinical Epigenetics 2022 14:126
  14. Phthalates and bisphenols are non-persistent endocrine disrupting chemicals that are ubiquitously present in our environment and may have long-lasting health effects following fetal exposure. A potential mecha...

    Authors: Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix and Leonardo Trasande
    Citation: Clinical Epigenetics 2022 14:125
  15. The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in ...

    Authors: Natalia Cullell, Carolina Soriano-Tárraga, Cristina Gallego-Fábrega, Jara Cárcel-Márquez, Elena Muiño, Laia Llucià-Carol, Miquel Lledós, Manel Esteller, Manuel Castro de Moura, Joan Montaner, Anna Rosell, Pilar Delgado, Joan Martí-Fábregas, Jerzy Krupinski, Jaume Roquer, Jordi Jiménez-Conde…
    Citation: Clinical Epigenetics 2022 14:124
  16. High-altitude (HA, 2500 m) hypoxic exposure evokes a multitude of physiological processes. The hypoxia-sensing genes though influence transcriptional output in disease susceptibility; the exact regulatory mech...

    Authors: Kavita Sharma, Aastha Mishra, Himanshu Singh, Tashi Thinlas and M. A. Qadar Pasha
    Citation: Clinical Epigenetics 2022 14:123
  17. DNA methylation-regulated genes have been demonstrated as the crucial participants in the occurrence of coronary heart disease (CHD). The machine learning based on DNA methylation-regulated genes has tremendou...

    Authors: Xiaokang Zhang, Chen Wang, Dingdong He, Yating Cheng, Li Yu, Daoxi Qi, Boyu Li and Fang Zheng
    Citation: Clinical Epigenetics 2022 14:122
  18. Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD). DNAm surrogate of exposures predict...

    Authors: Andrea Cappozzo, Cathal McCrory, Oliver Robinson, Anna Freni Sterrantino, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Licia Iacoviello, Fulvio Ricceri, Sabina Sieri, Paolo Chiodini, Gareth J. McKay, Amy Jayne McKnight, Frank Kee, Ian S. Young…
    Citation: Clinical Epigenetics 2022 14:121
  19. There has been extensive scrutiny of cancer driving mutations within the exome (especially amino acid altering mutations) as these are more likely to have a clear impact on protein functions, and thus on cell ...

    Authors: Michael Pudjihartono, Jo K. Perry, Cris Print, Justin M. O’Sullivan and William Schierding
    Citation: Clinical Epigenetics 2022 14:120
  20. Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi…
    Citation: Clinical Epigenetics 2022 14:119

    The original article was published in Clinical Epigenetics 2019 11:68

  21. Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed to...

    Authors: Peilong Li, Shibiao Liu, Lutao Du, Ghazal Mohseni, Yi Zhang and Chuanxin Wang
    Citation: Clinical Epigenetics 2022 14:118
  22. DNA 5-hydroxymethylcytosine (5hmC) is produced by dynamic 5mC oxidation process contributing to tissue specification, and loss of 5hmC has been reported in multiple cancers including genitourinary cancers. How...

    Authors: Jie Qi, Yue Shi, Yezhen Tan, Qi Zhang, Jianye Zhang, Jilu Wang, Cong Huang and Weimin Ci
    Citation: Clinical Epigenetics 2022 14:117
  23. Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identif...

    Authors: Cora Palanca-Ballester, David Hervas, Maria Villalba, Teresa Valdes-Sanchez, Diana Garcia, Maria Isabel Alcoriza-Balaguer, Marta Benet, Raquel Martinez-Tomas, Andres Briones-Gomez, Jose Galbis-Caravajal, Alfonso Calvo, Oscar Juan, Agustin Lahoz, Enrique Cases and Juan Sandoval
    Citation: Clinical Epigenetics 2022 14:116
  24. Cystoscopy is the gold standard for bladder cancer detection, but is costly, invasive and has imperfect diagnostic accuracy. We aimed to identify novel and accurate DNA methylation biomarkers for non-invasive ...

    Authors: Heidi Dietrichson Pharo, Marine Jeanmougin, Eirill Ager-Wick, Hege Marie Vedeld, Anne Klara Sørbø, Christina Dahl, Louise Katrine Larsen, Hilde Honne, Sara Brandt-Winge, May-Britt Five, Sara Monteiro-Reis, Rui Henrique, Carmen Jeronimo, Kenneth Steven, Rolf Wahlqvist, Per Guldberg…
    Citation: Clinical Epigenetics 2022 14:115
  25. DNA methylation (DNAm) is considered a plausible pathway through which genetic and environmental factors may influence the development of allergies. However, causality has yet to be determined as it is unknown...

    Authors: Anna Kilanowski, Simon Kebede Merid, Sarina Abrishamcar, Dakotah Feil, Elisabeth Thiering, Melanie Waldenberger, Erik Melén, Annette Peters, Marie Standl and Anke Hüls
    Citation: Clinical Epigenetics 2022 14:114
  26. Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place the important epigenetic mark 5-methyl-2’-deoxycytidine by methylating 2’-deoxycytidine (...

    Authors: Tina Aumer, Constanze B. Gremmelmaier, Leander S. Runtsch, Johannes C. Pforr, G. Nur Yeşiltaç, Stefanie Kaiser and Franziska R. Traube
    Citation: Clinical Epigenetics 2022 14:113
  27. Despite clinical relevance of immunological activation due to histone leakage into the serum following cardiac surgery, long-term data describing their longitudinal dynamic are lacking. Therefore, this study e...

    Authors: Krzysztof Laudanski, Da Liu, Jihane Hajj, Danyal Ghani and Wilson Y. Szeto
    Citation: Clinical Epigenetics 2022 14:112
  28. The novel long noncoding RNA MEF2C-AS1 has been identified to play suppressor roles during tumorigenesis. DNA methylation has a regulatory effect on gene expression in cancer initiation and progression. However, ...

    Authors: Sangni Qian, Shujuan Lin, Xin Xu, Hao Bai, Aibuta Yeerken, Xiaojiang Ying, Zhenjun Li, Xinglin Fei, Jinhua Yang, Mengling Tang, Jianbing Wang, Mingjuan Jin and Kun Chen
    Citation: Clinical Epigenetics 2022 14:111
  29. Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigenetic research and technologies on medicine and society. There is growing...

    Authors: Charles Dupras, Terese Knoppers, Nicole Palmour, Elisabeth Beauchamp, Stamatina Liosi, Reiner Siebert, Alison May Berner, Stephan Beck, Ian Charest and Yann Joly
    Citation: Clinical Epigenetics 2022 14:110
  30. Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Accumulating evidence suggests that imbalanced Treg/Th17 ratio acce...

    Authors: Cong Zeng, Ting-ting Cheng, Xia Ma, Yi Liu, Juan Hua, Xu Chen, Shi-yu Wang and Ya-jing Xu
    Citation: Clinical Epigenetics 2022 14:109
  31. The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is altered in patients with eating and weight disorders, and a variant of the oxytocin receptor...

    Authors: Katrin Elisabeth Giel, Kathrin Schag, Elisabeth Johanna Leehr, Isabelle Mack, Lea-Sarah Schuster, Ariane Wiegand, Stephan Zipfel, Manfred Hallschmid and Vanessa Nieratschker
    Citation: Clinical Epigenetics 2022 14:108
  32. Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved through research advancing on: pore efficiency, creating mechanisms to control DNA transloca...

    Authors: Yohannis Wondwosen Ahmed, Berhan Ababaw Alemu, Sisay Addisu Bekele, Solomon Tebeje Gizaw, Muluken Fekadie Zerihun, Endriyas Kelta Wabalo, Maria Degef Teklemariam, Tsehayneh Kelemu Mihrete, Endris Yibru Hanurry, Tensae Gebru Amogne, Assaye Desalegne Gebrehiwot, Tamirat Nida Berga, Ebsitu Abate Haile, Dessiet Oma Edo and Bizuwork Derebew Alemu
    Citation: Clinical Epigenetics 2022 14:107
  33. Hepatocellular carcinoma (HCC) is one of the most common primary liver malignancies worldwide. The long-term prognosis for HCC remains extremely poor, with drug resistance being the major underlying cause of r...

    Authors: Yu-Chin Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Po-Shuan Huang, Chia-Jung Liao, Yu-Syuan Liou, Chiao-Chun Lin, Chia-Jung Yu, Chau-Ting Yeh, Ya-Hui Huang and Kwang-Huei Lin
    Citation: Clinical Epigenetics 2022 14:106
  34. Maternal air pollutants exposure is associated with a number of adverse pregnancy outcomes, including recurrent spontaneous abortion (RSA). However, the underlying mechanisms are still unknown. The present stu...

    Authors: Weiqiang Zhu, Yan Gu, Min Li, Zhaofeng Zhang, Junwei Liu, Yanyan Mao, Qianxi Zhu, Lin Zhao, Yupei Shen, Fujia Chen, Lingjin Xia, Lin He and Jing Du
    Citation: Clinical Epigenetics 2022 14:105
  35. Familial adenomatous polyposis (FAP) is an inherited colorectal cancer (CRC) syndrome resulting from germ line mutations in the adenomatous polyposis coli (APC) gene. While FAP accounts for less than 1% of all CR...

    Authors: Matthew A. Devall, Stephen Eaton, Mourad Wagdy Ali, Christopher H. Dampier, Daniel Weisenberger, Steven M. Powell, Li Li and Graham Casey
    Citation: Clinical Epigenetics 2022 14:104
  36. DNA methylation in the human genome is established and maintained by DNA methyltransferases (DNMTs). DNMT isoforms show differential expression by cell lineage and during development, but much remains to be el...

    Authors: Chanachai Sae-Lee, Timothy M. Barrow, Elena Colicino, Si Ho Choi, Yoana Rabanal-Ruiz, Daniel Green, Viktor I. Korolchuk, John C. Mathers and Hyang-Min Byun
    Citation: Clinical Epigenetics 2022 14:103
  37. Noninvasive diagnostic markers that are capable of distinguishing patients with colorectal cancer (CRC) from healthy individuals or patients with other cancer types are lacking. We report the discovery and val...

    Authors: Dapeng Li, Lei Zhang, Jinming Fu, Hao Huang, Yanlong Liu, Lin Zhu, Hongru Sun, Simin Sun, Ding Zhang, Tian Tian, Fan Wang, Fulan Hu, Xiaolin Peng, Gairui Li, Liyuan Zhao, Ting Zheng…
    Citation: Clinical Epigenetics 2022 14:102
  38. Vascular smooth muscle cell (VSMC) phenotype switching is critical for neointima formation, which is the major cause of restenosis after stenting or coronary artery bypass grafting. However, the epigenetic mec...

    Authors: Yi He, Xin Yi, Zihao Zhang, Hanshen Luo, Rui Li, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Wenlin Cheng, Ding-Sheng Jiang, Fang Zhao and Xiang Wei
    Citation: Clinical Epigenetics 2022 14:101
  39. CpG methylation levels can help to explain inter-individual differences in phenotypic traits. Few studies have explored whether identifying probe subsets based on their biological and statistical properties ca...

    Authors: Robert F. Hillary, Daniel L. McCartney, Allan F. McRae, Archie Campbell, Rosie M. Walker, Caroline Hayward, Steve Horvath, David J. Porteous, Kathryn L. Evans and Riccardo E. Marioni
    Citation: Clinical Epigenetics 2022 14:100
  40. Clear cell renal cell carcinoma (ccRCC) is the most common and highly heterogeneous subtype of renal cell carcinoma. Dysregulated basal cell adhesion molecule (BCAM) gene is associated with poor prognosis in vari...

    Authors: Junjie Zhao, Jiayu Liang, Yang Yang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Xu Hu, Junru Chen, Sha Zhu, Yuchao Ni, Yaowen Zhang, Jindong Dai, Zhipeng Wang, Zilin Wang, Yuhao Zeng, Jin Yao…
    Citation: Clinical Epigenetics 2022 14:99
  41. Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which ...

    Authors: Jeries Abu-Hanna, Jigisha A. Patel, Evangelos Anastasakis, Richard Cohen, Lucie H. Clapp, Marilena Loizidou and Mohammad M. R. Eddama
    Citation: Clinical Epigenetics 2022 14:98
  42. Interferon gamma (IFNγ) is a pro-inflammatory cytokine that directly activates the JAK/STAT pathway. However, the temporal dynamics of chromatin remodeling and transcriptional activation initiated by IFNγ have...

    Authors: Simon J. Hogg, Olga Motorna, Conor J. Kearney, Emily B. Derrick, Imran G. House, Izabela Todorovski, Madison J. Kelly, Magnus Zethoven, Kenneth D. Bromberg, Albert Lai, Paul A. Beavis, Jake Shortt, Ricky W. Johnstone and Stephin J. Vervoort
    Citation: Clinical Epigenetics 2022 14:96
  43. Modern epigenetics emerged about 40 years ago. Since then, the field has rapidly grown. Unfortunately, this development has been accompanied by certain misconceptions and methodological shortcomings. A profoun...

    Authors: Bernhard Horsthemke
    Citation: Clinical Epigenetics 2022 14:95
  44. We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fiftee...

    Authors: Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Anish Adhikari, Rachel Vancavage, Harold A. Singer, Reid S. Alisch and Ariel Jaitovich
    Citation: Clinical Epigenetics 2022 14:94
  45. With the rapid development of next-generation sequencing (NGS) technologies, researchers are making efforts to reveal the genomic landscape of multiple myeloma (MM). However, the clinical significance of many ...

    Authors: Lina Zhang, Run Zhang, Jing Wang, Ying Chen, Chun Qiao, Qinglin Shi, Yuanyuan Jin, Xuxing Shen, Jianyong Li and Lijuan Chen
    Citation: Clinical Epigenetics 2022 14:93
  46. SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and functions as a tumor suppressor. However, the mechanisms underlying the in...

    Authors: Yang Li, Baike Liu, Xiaonan Yin, Zhiyuan Jiang, Chao Fang, Na Chen, Bo Zhang, Lei Dai and Yuan Yin
    Citation: Clinical Epigenetics 2022 14:92
  47. Native Hawaiians are disproportionately affected by type 2 diabetes mellitus (DM), a chronic metabolic, non-communicable disease characterized by hyperglycemia and systemic inflammation. Unrelenting systemic i...

    Authors: Christian K. Dye, Michael J. Corley, Claire Ing, Annette Lum-Jones, Dongmei Li, Marjorie K. L. M. Mau and Alika K. Maunakea
    Citation: Clinical Epigenetics 2022 14:91
  48. Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention strategies in women are not as effective as in men. By comparison, the Early versus La...

    Authors: James R. Hilser, Jaana A. Hartiala, Intira Sriprasert, Naoko Kono, Zhiheng Cai, Roksana Karim, Joseph DeYoung, Wendy J. Mack, Howard N. Hodis and Hooman Allayee
    Citation: Clinical Epigenetics 2022 14:90
  49. Several reports have provided crucial evidence in animal models that epigenetic modifications, such as DNA methylation, may be involved in psychostimulant-induced stable changes at the cellular level in the br...

    Authors: Kaili Anier, Kelli Somelar, Külli Jaako, Margret Alttoa, Kerli Sikk, Raul Kokassaar, Kai Kisand and Anti Kalda
    Citation: Clinical Epigenetics 2022 14:89