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  1. Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in he...

    Authors: Ilse Vanhorebeek, Grégoire Coppens, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe
    Citation: Clinical Epigenetics 2023 15:116
  2. Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association...

    Authors: Xian Shi, Minghan Qu, Yi Jiang, Ziwei Zhu, Chengguqiu Dai, Minghui Jiang, Lin Ding, Yu Yan, Chaolong Wang, Xiaomin Zhang, Shanshan Cheng and Xingjie Hao
    Citation: Clinical Epigenetics 2023 15:115
  3. DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that ca...

    Authors: Kristine L. Haftorn, Julia Romanowska, Yunsung Lee, Christian M. Page, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur and William R. P. Denault
    Citation: Clinical Epigenetics 2023 15:114
  4. To systematically evaluate the efficacy and safety of FDA-approved isocitrate dehydrogenase (IDH) inhibitors in the treatment of IDH-mutated acute myeloid leukemia (AML).

    Authors: Xiu Chen, Hongyun Xing, Xiaolu Xie, Liqiu Kou, Jun Li and Yaling Li
    Citation: Clinical Epigenetics 2023 15:113
  5. The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persisten...

    Authors: Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zsófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Brossart…
    Citation: Clinical Epigenetics 2023 15:112
  6. Biomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide stu...

    Authors: Katleen Janssens, Isabelle Neefs, Joe Ibrahim, Anne Schepers, Patrick Pauwels, Marc Peeters, Guy Van Camp and Ken Op de Beeck
    Citation: Clinical Epigenetics 2023 15:111
  7. An adverse intrauterine or periconceptional environment, such as hyperglycemia during pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this study, we explored the epige...

    Authors: Teresa Linares-Pineda, Nerea Peña-Montero, Nicolás Fragoso-Bargas, Carolina Gutiérrez-Repiso, Fuensanta Lima-Rubio, María Suarez-Arana, Antonio Sánchez-Pozo, Francisco J. Tinahones, María Molina-Vega, María José Picón-César, Christine Sommer and Sonsoles Morcillo
    Citation: Clinical Epigenetics 2023 15:110
  8. With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use in pregnancy is rapidly increasing. Howev...

    Authors: Lyndsey E. Shorey-Kendrick, Victoria H. J. Roberts, Rahul J. D’Mello, Elinor L. Sullivan, Susan K. Murphy, Owen J. T. Mccarty, Danny J. Schust, Jason C. Hedges, A. J. Mitchell, Jose Juanito D. Terrobias, Charles A. Easley IV, Eliot R. Spindel and Jamie O. Lo
    Citation: Clinical Epigenetics 2023 15:104
  9. Alterations in DNA methylation (DNAm) have been reported to be a mechanism by which bariatric surgeries resulted in considerable metabolic improvements. Previous studies have mostly focused on change in DNAm f...

    Authors: Xiaoxiao Wen, Helena Palma-Gudiel, Guanhong Miao, Mingjing Chen, Zhiguang Huo, Hao Peng, Stephen Anton, Gang Hu, Ricky Brock, Phillip J. Brantley and Jinying Zhao
    Citation: Clinical Epigenetics 2023 15:108
  10. In utero exposure to maternal hyperglycemia has been associated with an increased risk for the development of chronic diseases in later life. These predispositions may be programmed by fetal DNA methylation (D...

    Authors: Amélie Taschereau, Kathrine Thibeault, Catherine Allard, Diana Juvinao-Quintero, Patrice Perron, Sharon M. Lutz, Luigi Bouchard and Marie-France Hivert
    Citation: Clinical Epigenetics 2023 15:107
  11. DNA methylation has previously been associated with ischemic stroke, but the specific genes and their functional roles in ischemic stroke remain to be determined. Here we aimed to identify differentially methy...

    Authors: Hao Peng, Helena Palma-Gudiel, Carolina Soriano-Tarraga, Jordi Jimenez-Conde, Mingzhi Zhang, Yonghong Zhang and Jinying Zhao
    Citation: Clinical Epigenetics 2023 15:106
  12. Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylat...

    Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost and Wolfgang Wagner
    Citation: Clinical Epigenetics 2023 15:105

    The Correction to this article has been published in Clinical Epigenetics 2023 15:117

  13. The Dutch population-based cervical cancer screening programme (PBS) consists of primary high-risk human papilloma virus (hrHPV) testing with cytology as triage test. In addition to cervical scraping by a gene...

    Authors: J. de Waard, A. Bhattacharya, M. T. de Boer, B. M. van Hemel, M. D. Esajas, K. M. Vermeulen, G. H. de Bock, E. Schuuring and G. B. A. Wisman
    Citation: Clinical Epigenetics 2023 15:103
  14. Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These findings offer promisi...

    Authors: Felicia Fei-Lei Chung, Sandra González Maldonado, Amelie Nemc, Liacine Bouaoun, Vincent Cahais, Cyrille Cuenin, Aurelie Salle, Theron Johnson, Bekir Ergüner, Marina Laplana, Paul Datlinger, Jana Jeschke, Elisabete Weiderpass, Vessela Kristensen, Suzette Delaloge, François Fuks…
    Citation: Clinical Epigenetics 2023 15:102
  15. Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, ...

    Authors: Safiya Naina Marikar, Keith Al-Hasani, Ishant Khurana, Harikrishnan Kaipananickal, Jun Okabe, Scott Maxwell and Assam El-Osta
    Citation: Clinical Epigenetics 2023 15:101
  16. The effects of SARS-CoV-2 infection can be more complex and severe in patients with hepatocellular carcinoma (HCC) as compared to other cancers. This is due to several factors, including pre-existing condition...

    Authors: Huiyan Luo, Jixin Chen, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo and Xiongwen Wang
    Citation: Clinical Epigenetics 2023 15:100
  17. Early screening and detection of hepatocellular carcinoma (HCC) can efficiently improve patient prognosis. We aimed to identify a series of hypermethylated DNA markers and develop a blood-based HCC diagnosis p...

    Authors: Yi Bai, Juan Xu, Deqiang Li, Xiaoyu Zhang, Dapeng Chen, Fucun Xie, Longmei Huang, Xiaotian Yu, Haitao Zhao and Yamin Zhang
    Citation: Clinical Epigenetics 2023 15:99
  18. DNA methylation changes, frequent early events in cancer, can modulate the binding of transcription factors. RE1-silencing transcription factor (REST) plays a fundamental role in regulating the expression of n...

    Authors: Ana Florencia Vega-Benedetti, Eleonora Loi, Loredana Moi and Patrizia Zavattari
    Citation: Clinical Epigenetics 2023 15:98
  19. The majority of these existing prognostic models of head and neck squamous cell carcinoma (HNSCC) have unsatisfactory prediction accuracy since they solely utilize demographic and clinical information. Leverag...

    Authors: Ziang Xu, Xinlei Chen, Xiaomeng Song, Xinxin Kong, Jiajin Chen, Yunjie Song, Maojie Xue, Lin Qiu, Mingzhu Geng, Changyue Xue, Wei Zhang and Ruyang Zhang
    Citation: Clinical Epigenetics 2023 15:97
  20. Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing ...

    Authors: Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood and Marie Hudson
    Citation: Clinical Epigenetics 2023 15:96
  21. MLH1 epimutation is characterised by constitutional monoallelic MLH1 promoter hypermethylation, which can cause colorectal cancer (CRC). Tumour molecular profiles of MLH1 epimutation CRCs were used to classify ge...

    Authors: Jihoon E. Joo, Khalid Mahmood, Romy Walker, Peter Georgeson, Ida Candiloro, Mark Clendenning, Julia Como, Sharelle Joseland, Susan Preston, Lise Graversen, Mathilda Wilding, Michael Field, Michelle Lemon, Janette Wakeling, Helen Marfan, Rachel Susman…
    Citation: Clinical Epigenetics 2023 15:95
  22. Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genom...

    Authors: Mayuri Inchanalkar, Sumana Srivatsa, Srikant Ambatipudi, Priyanka G. Bhosale, Asawari Patil, Alejandro A. Schäffer, Niko Beerenwinkel and Manoj B. Mahimkar
    Citation: Clinical Epigenetics 2023 15:93
  23. Epigenetic dysregulation is essential to the tumorigenesis of oral squamous cell carcinoma (OSCC). SET and MYND domain-containing protein 3 (SMYD3), a histone lysine methyltransferase, is implicated in gene tr...

    Authors: Zongcheng Yang, Fen Liu, Zongkai Li, Nianping Liu, Xinfeng Yao, Yu Zhou, Liyu Zhang, Pan Jiang, Honghong Liu, Lingming Kong, Chuandong Lang, Xin Xu, Jihui Jia, Takahito Nakajima, Wenchao Gu, Lixin Zheng…
    Citation: Clinical Epigenetics 2023 15:92
  24. Idiopathic non-clonal cytopenia (ICUS) and clonal cytopenia (CCUS) are common in the elderly population. While these entities have similar clinical presentations with peripheral blood cytopenia and less than 1...

    Authors: Katja Kaastrup, Linn Gillberg, Stine U. Mikkelsen, Andreas D. Ørskov, Claudia Schöllkopf, Bo K. Mortensen, Bo Porse, Jakob W. Hansen and Kirsten Grønbæk
    Citation: Clinical Epigenetics 2023 15:91
  25. Tobacco smoking alters the DNA methylation profiles of immune cells which may underpin some of the pathogenesis of smoking-associated diseases. To link smoking-driven epigenetic effects in specific immune cell...

    Authors: Xuting Wang, Michelle R. Campbell, Hye-Youn Cho, Gary S. Pittman, Suzanne N. Martos and Douglas A. Bell
    Citation: Clinical Epigenetics 2023 15:90
  26. Targeting the epigenome of cancerous diseases represents an innovative approach, and the DNA methylation inhibitor decitabine is recommended for the treatment of hematological malignancies. Although epigenetic...

    Authors: Zijiao Tang, Lu Liu and Jürgen Borlak
    Citation: Clinical Epigenetics 2023 15:89
  27. Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has ...

    Authors: Chien-Yu Lin, Hui-Ling Lee, Ching-Way Chen, Chikang Wang, Fung-Chang Sung and Ta-Chen Su
    Citation: Clinical Epigenetics 2023 15:87
  28. Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect the host tissue ce...

    Authors: Kailu Liu, Xi He, Jingyu Huang, Simin Yu, Meiting Cui, Mengya Gao, Li Liu, Yu Qian, Ying Xie, Miao Hui, Yanli Hong and Xiaowei Nie
    Citation: Clinical Epigenetics 2023 15:86
  29. Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic modification provides a potential link to gene expression cha...

    Authors: Yu-Yao Wu, Yan-Ming Xu and Andy T. Y. Lau
    Citation: Clinical Epigenetics 2023 15:85
  30. Higher exposure to traffic-related air pollution (TRAP) is related to lower fertility, with specific adverse effects on the ovary. Folic acid may attenuate these effects. Our goal was to explore the relation o...

    Authors: Audrey J. Gaskins, Robert B. Hood, Jennifer B. Ford, Russ Hauser, Anna K. Knight, Alicia K. Smith and Todd M. Everson
    Citation: Clinical Epigenetics 2023 15:84
  31. Integration of retroviruses into the host genome can impair the genomic and epigenomic integrity of the cell. As a defense mechanism, epigenetic modifications on the proviral DNA repress retroviral sequences i...

    Authors: Ayellet Tal, Jose David Aguilera, Igor Bren, Carmit Strauss and Sharon Schlesinger
    Citation: Clinical Epigenetics 2023 15:83
  32. Children conceived through assisted reproduction are at an increased risk for growth and genomic imprinting disorders, often linked to DNA methylation defects. It has been suggested that assisted reproductive ...

    Authors: Sophia Rahimi, Xiaojian Shao, Donovan Chan, Josée Martel, Anick Bérard, William D. Fraser, Marie-Michelle Simon, Tony Kwan, Guillaume Bourque and Jacquetta Trasler
    Citation: Clinical Epigenetics 2023 15:82
  33. Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related D...

    Authors: Drew R. Nannini, Rene Cortese, Peter Egwom, Senthilnathan Palaniyandi and Gerhard C. Hildebrandt
    Citation: Clinical Epigenetics 2023 15:81
  34. Glucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of cytokine signaling (SOCS) 1 methylation has been shown to be associated w...

    Authors: Feng Li, Ying Zhang, Zhao-Hui Wang, Shuai Gao, Yu-Chen Fan and Kai Wang
    Citation: Clinical Epigenetics 2023 15:79
  35. Our previous study suggested that assisted reproductive technology (ART) may be a possible risk factor for the development of epimutation-mediated imprinting disorders (epi-IDs) for mothers aged ≥ 30 years. Ho...

    Authors: Kaori Hara-Isono, Keiko Matsubara, Akie Nakamura, Shinichiro Sano, Takanobu Inoue, Sayaka Kawashima, Tomoko Fuke, Kazuki Yamazawa, Maki Fukami, Tsutomu Ogata and Masayo Kagami
    Citation: Clinical Epigenetics 2023 15:78
  36. Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including g...

    Authors: Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang, Fenglin Cai, Hui Liu, Jing Zhang, Han Liang, Yongzhan Nie and Jingyu Deng
    Citation: Clinical Epigenetics 2023 15:77
  37. The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in wome...

    Authors: Giulia Sgueglia, Salvatore Longobardi, Domenico Valerio, Maria Rosaria Campitiello, Nicola Colacurci, Cinzia Di Pietro, Rosalia Battaglia, Thomas D’Hooghe, Lucia Altucci and Carmela Dell’Aversana
    Citation: Clinical Epigenetics 2023 15:76
  38. Although most patients with diffuse large B-cell lymphoma (DLBCL) achieve complete remission after first-line rituximab-containing immunochemotherapy, up to 40% of patients relapse and require salvage therapy....

    Authors: Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Youngil Koh, Dong-Yeop Shin, Tae Kon Kim, Ja Min Byun, Sung-Soo Yoon and Junshik Hong
    Citation: Clinical Epigenetics 2023 15:75
  39. Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histon...

    Authors: Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt and Nilofer S. Azad
    Citation: Clinical Epigenetics 2023 15:74
  40. Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to expl...

    Authors: Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman and Pilar Blancafort
    Citation: Clinical Epigenetics 2023 15:73
  41. Chromatin regulators (CRs) are critical epigenetic modifiers and have been reported to play critical roles during the progression of various tumors, but their role in lung adenocarcinoma (LUAD) has not been co...

    Authors: Yongbiao Huang, Lingyan Xiao, Motuma Yigezu Daba, Duo Xu, Yuan Wang, Long Li, Qian Li, Bo Liu, Wan Qin, Huixian Zhang and Xianglin Yuan
    Citation: Clinical Epigenetics 2023 15:72
  42. Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...

    Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho and Keith D. Robertson
    Citation: Clinical Epigenetics 2023 15:71
  43. Individuals who are socioeconomically disadvantaged are at increased risk for aging-related diseases and perform less well on tests of cognitive function. The weathering hypothesis proposes that these disparit...

    Authors: L. Raffington, T. Schwaba, M. Aikins, D. Richter, G. G. Wagner, K. P. Harden, D. W. Belsky and E. M. Tucker-Drob
    Citation: Clinical Epigenetics 2023 15:70
  44. Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of le...

    Authors: Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler and Karl T. Kelsey
    Citation: Clinical Epigenetics 2023 15:69
  45. Disadvantaged socioeconomic position (SEP), including lower educational attainment and household income, may influence cancer risk and outcomes. We hypothesized that DNA methylation could function as an interm...

    Authors: Jianhong Chen, Mark D. Long, Sirinapa Sribenja, Sung Jun Ma, Li Yan, Qiang Hu, Song Liu, Thaer Khoury, Chi-Chen Hong, Elisa Bandera, Anurag K. Singh, Elizabeth A. Repasky, Elizabeth G. Bouchard, Michael Higgins, Christine B. Ambrosone and Song Yao
    Citation: Clinical Epigenetics 2023 15:68
  46. Shortened lifespans are associated with having Attention Deficit Hyperactivity Disorder (ADHD), which is likely mediated by related behavioral and sociodemographic factors that are also associated with acceler...

    Authors: Thalida E. Arpawong, Eric T. Klopack, Jung Ki Kim and Eileen M. Crimmins
    Citation: Clinical Epigenetics 2023 15:67