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  1. Prenatal growth restriction and low birth weight have been linked to long-term alterations of health, presumably via adaptive modifications of the epigenome. Recent studies indicate a plasticity of the 11p15 e...

    Authors: Felix Schreiner, Bettina Gohlke, Sonja Stutte, Peter Bartmann, Kurt Hecher, Johannes Oldenburg, Osman El-Maarri and Joachim Woelfle
    Citation: Clinical Epigenetics 2014 6:6
  2. Adenomatous polyposis coli (APC) has been reported to be a candidate tumor suppressor in many cancers. However, the diagnostic role of APC promoter methylation in non-small cell lung cancer (NSCLC) remains unclea...

    Authors: Shicheng Guo, Lixing Tan, Weilin Pu, Junjie Wu, Kuan Xu, Jinhui Wu, Qiang Li, Yanyun Ma, Jibin Xu, Li Jin and Jiucun Wang
    Citation: Clinical Epigenetics 2014 6:5
  3. DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet the greatest increase in smoking is occur...

    Authors: Hannah R Elliott, Therese Tillin, Wendy L McArdle, Karen Ho, Aparna Duggirala, Tim M Frayling, George Davey Smith, Alun D Hughes, Nish Chaturvedi and Caroline L Relton
    Citation: Clinical Epigenetics 2014 6:4
  4. The Editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 5 (2013).

    Authors: Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2014 6:3
  5. In 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether deci...

    Authors: David J Stewart, Maria I Nunez, Jaroslav Jelinek, David Hong, Sanjay Gupta, Jean-Pierre Issa, Ignacio I Wistuba and Razelle Kurzrock
    Citation: Clinical Epigenetics 2014 6:2
  6. The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.

    Authors: Melkaye G Melka, Benjamin I Laufer, Patrick McDonald, Christina A Castellani, Nagalingam Rajakumar, Richard O’Reilly and Shiva M Singh
    Citation: Clinical Epigenetics 2014 6:1
  7. Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth disorder associated with abnormalities in 11p15.5 imprinted genes. The most common cause is loss of methylation (epimutation) at the imprinting cont...

    Authors: Louise Tee, Derek HK Lim, Renuka P Dias, Marie-Odile Baudement, Amy A Slater, Gail Kirby, Tom Hancocks, Helen Stewart, Carol Hardy, Fiona Macdonald and Eamonn R Maher
    Citation: Clinical Epigenetics 2013 5:23
  8. Asthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs, rs20541 and rs1800925, of the IL-13 gene (IL13) hav...

    Authors: Veeresh K Patil, John W Holloway, Hongmei Zhang, Nelis Soto-Ramirez, Susan Ewart, S Hasan Arshad and Wilfried Karmaus
    Citation: Clinical Epigenetics 2013 5:22
  9. Prospective studies have shown that low levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) are associated with the risk of type 2 diabetes. In the present study, we investigated DNA m...

    Authors: Tianwei Gu, Harvest F Gu, Agneta Hilding, Louise K Sjöholm, Claes-Göran Östenson, Tomas J Ekström and Kerstin Brismar
    Citation: Clinical Epigenetics 2013 5:21
  10. Insulin-like growth factor-binding protein 7 (IGFBP-7) is able to interact with insulin-like growth factor 1 (IGF-1) as well as insulin. Previous studies have suggested that serum IGFBP-7 levels may be associa...

    Authors: Harvest F Gu, Tianwei Gu, Agneta Hilding, Yiming Zhu, Lars Kärvestedt, Claes-Göran Östenson, Maode Lai, Masahiko Kutsukake, Jan Frystyk, Kazuhiro Tamura and Kerstin Brismar
    Citation: Clinical Epigenetics 2013 5:20
  11. Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is cor...

    Authors: Robert A Philibert, Steven R H Beach, Man-Kit Lei and Gene H Brody
    Citation: Clinical Epigenetics 2013 5:19
  12. Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses ...

    Authors: Carmen J Marsit, Devin C Koestler, Debra Watson-Smith, Charlotte M Boney, James F Padbury and Francois Luks
    Citation: Clinical Epigenetics 2013 5:18
  13. A remarkable correspondence exists between the cytogenetic locations of the known fragile sites and frequently reported sites of hypermethylation. The best-known features of fragile sites are sequence motifs t...

    Authors: Steven S Smith
    Citation: Clinical Epigenetics 2013 5:17
  14. Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation...

    Authors: Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif and Eamonn R Maher
    Citation: Clinical Epigenetics 2013 5:16
  15. Epidemiological evidence indicates yet unknown epigenetic mechanisms underlying a propensity for overweight and type 2 diabetes. We analyzed the extent of methylation at lysine 4 and lysine 9 of histone H3 in ...

    Authors: Åsa Jufvas, Simon Sjödin, Kim Lundqvist, Risul Amin, Alexander V Vener and Peter Strålfors
    Citation: Clinical Epigenetics 2013 5:15
  16. Authors: Athar Aziz, E Joanna Baxter, Carol Edwards, Clara Yujing Cheong, Mitsuteru Ito, Anthony Bench, Rebecca Kelley, Yvonne Silber, Philip A Beer, Keefe Chng, Marilyn B Renfree, Kirsten McEwen, Dionne Gray, Jyoti Nangalia, Ghulam J Mufti, Eva Hellstrom-Lindberg…
    Citation: Clinical Epigenetics 2013 5(Suppl 1):S5

    This article is part of a Supplement: Volume 5 Supplement 1

  17. Authors: Gabriella Ficz, Timothy A Hore, Fatima Santos, Heather J Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu-Lee Paul, Jörn Walter, Simon J Cook, Simon Andrews, Miguel R Branco and Wolf Reik
    Citation: Clinical Epigenetics 2013 5(Suppl 1):S2

    This article is part of a Supplement: Volume 5 Supplement 1

  18. Prenatal alcohol exposure is known to result in fetal alcohol spectrum disorders, a continuum of physiological, behavioural, and cognitive phenotypes that include increased risk for anxiety and learning-associ...

    Authors: Randa L Stringer, Benjamin I Laufer, Morgan L Kleiber and Shiva M Singh
    Citation: Clinical Epigenetics 2013 5:14
  19. A large proportion of patients with acute myeloid leukemia (AML) are not fit for intensive and potentially curative therapy due to advanced age or comorbidity. Previous studies have demonstrated that a subset ...

    Authors: Hanne Fredly, Elisabeth Ersvær, Astrid Olsnes Kittang, Galina Tsykunova, Bjørn Tore Gjertsen and Øystein Bruserud
    Citation: Clinical Epigenetics 2013 5:13
  20. Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histon...

    Authors: Hanne Fredly, Bjørn Tore Gjertsen and Øystein Bruserud
    Citation: Clinical Epigenetics 2013 5:12
  21. The NAD-dependent protein deacetylase SIRT1 has a wide range of different targets, which may be regulated either directly through deacetylation and thus potentially altering their activity or localization or i...

    Authors: Judith Katto, Nicole Engel, Wasim Abbas, Georges Herbein and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2013 5:11
  22. Sirtuin 1 (Sirt1) is a nuclear enzyme from the class III histone deacetylases that modulates gene expression and is involved in bone and cartilage remodeling. The goal of our study was to evaluate Sirt1 activi...

    Authors: Daniel Wendling, Wasim Abbas, Marie Godfrin-Valnet, Xavier Guillot, Kashif Aziz Khan, Jean-Pierre Cedoz, Lucile Baud, Clément Prati and Georges Herbein
    Citation: Clinical Epigenetics 2013 5:10
  23. Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhance tumorigenesis via D...

    Authors: Mathilde Cheray, Romain Pacaud, Arulraj Nadaradjane, François M Vallette and Pierre-François Cartron
    Citation: Clinical Epigenetics 2013 5:9
  24. Epidemiological studies demonstrate that foetal growth restriction and low birth weight affect long-term health. Derangements in tissue-specific epigenetic programming of foetal and placental tissues are a sug...

    Authors: Emilie Herzog, Jubby Galvez, Anton Roks, Lisette Stolk, Michael Verbiest, Paul Eilers, Jan Cornelissen, Eric Steegers and Régine Steegers-Theunissen
    Citation: Clinical Epigenetics 2013 5:8
  25. DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMT...

    Authors: Kathrin Kullmann, Mustafa Deryal, Mei Fang Ong, Werner Schmidt and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2013 5:7
  26. Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of...

    Authors: Deepali P Sundrani, Umakar S Reddy, Asmita A Joshi, Savita S Mehendale, Preeti M Chavan-Gautam, Anandwardhan A Hardikar, Giriraj R Chandak and Sadhana R Joshi
    Citation: Clinical Epigenetics 2013 5:6
  27. The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 4 (2012).

    Authors: Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2013 5:4
  28. 5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloi...

    Authors: Metin Karahoca and Richard L Momparler
    Citation: Clinical Epigenetics 2013 5:3
  29. Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite i...

    Authors: Eddy H van Roon, Arnoud Boot, Ashwin A Dihal, Robert F Ernst, Tom van Wezel, Hans Morreau and Judith M Boer
    Citation: Clinical Epigenetics 2013 5:2
  30. The occurrence of asthma is weakly explained by known genetic variants. Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add to the explanation of asthma. However, no etiological mode...

    Authors: Nelís Soto-Ramírez, Syed Hasan Arshad, John W Holloway, Hongmei Zhang, Eric Schauberger, Susan Ewart, Veeresh Patil and Wilfried Karmaus
    Citation: Clinical Epigenetics 2013 5:1
  31. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol in insulin target tissues. In people with type 2 diabetes, skeletal muscle (SkM) 11βHSD1 is upregul...

    Authors: Warrick J Inder, Varuni R Obeyesekere, Christina Jang and Richard Saffery
    Citation: Clinical Epigenetics 2012 4:24
  32. The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models...

    Authors: Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari and Serena D’Souza
    Citation: Clinical Epigenetics 2012 4:23
  33. Studying DNA methylation profiles in detail should be the first step in epigenetic research. Although sodium bisulfite modification of genomic DNA is the gold standard method for DNA methylation analysis, this...

    Authors: Miki Bundo, Fumiko Sunaga, Junko Ueda, Kiyoto Kasai, Tadafumi Kato and Kazuya Iwamoto
    Citation: Clinical Epigenetics 2012 4:22
  34. The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA me...

    Authors: Rae-Chi Huang, John C Galati, Sally Burrows, Lawrence J Beilin, Xin Li, Craig E Pennell, JAM van Eekelen, Trevor A Mori, Leon A Adams and Jeffrey M Craig
    Citation: Clinical Epigenetics 2012 4:21
  35. Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune rheumatic disease of largely unknown cause. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with autoimmun...

    Authors: Justine A Ellis, Jane E Munro, Raul A Chavez, Lavinia Gordon, Jihoon E Joo, Jonathan D Akikusa, Roger C Allen, Anne-Louise Ponsonby, Jeffrey M Craig and Richard Saffery
    Citation: Clinical Epigenetics 2012 4:20
  36. Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain...

    Authors: Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller and Alexander G Haslberger
    Citation: Clinical Epigenetics 2012 4:19
  37. Vibration-induced white finger disease (VWF), also known as hand-arm vibration syndrome, is a secondary form of Raynaud’s disease, affecting the blood vessels and nerves. So far, little is known about the path...

    Authors: Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian L Dransfeld, Stephan Letzel and Ulrich Mahlknecht
    Citation: Clinical Epigenetics 2012 4:18
  38. Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined t...

    Authors: Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Katharine Hammond and Kari Nadeau
    Citation: Clinical Epigenetics 2012 4:17