Bruix J, Boix L, Sala M, Llovet JM: Focus on hepatocellular carcinoma. Cancer Cell. 2004, 5: 215-219. 10.1016/S1535-6108(04)00058-3.
Article
CAS
PubMed
Google Scholar
Dufour JF, Johnson P: Liver cancer: from molecular pathogenesis to new therapies: summary of the EASL single topic conference. J Hepatol. 2010, 52: 296-304. 10.1016/j.jhep.2009.11.010.
Article
CAS
PubMed
Google Scholar
Tischoff I, Tannapfel A: DNA methylation in hepatocellular carcinoma. World J Gastroenterol. 2008, 14: 1741-1748. 10.3748/wjg.14.1741.
Article
CAS
PubMed
PubMed Central
Google Scholar
Parkin DM, Bray FI, Devesa SS: Cancer burden in the year. The global picture. Eur J Cancer . 2001, 37 (Suppl 8): S4-S66.
Article
PubMed
Google Scholar
Zucman-Rossi J, Laurent-Puig P: Genetic diversity of hepatocellular carcinomas and its potential impact on targeted therapies. Pharmacogenomics. 2007, 8: 997-1003. 10.2217/14622416.8.8.997.
Article
CAS
PubMed
Google Scholar
Gehring AJ, Ho ZZ, Tan AT, Aung MO, Lee KH, Tan KC, Lim SG, Bertoletti A: Profile of tumor antigen–specific CD8 T cells in patients with hepatitis B virus–related hepatocellular carcinoma. Gastroenterology. 2009, 137: 682-690. 10.1053/j.gastro.2009.04.045.
Article
CAS
PubMed
Google Scholar
Huang J, Wang Y, Guo Y, Sun S: Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology. 2010, 52: 60-70. 10.1002/hep.23660.
Article
CAS
PubMed
Google Scholar
Vivekanandan P, Daniel HD, Kannangai R, Martinez-Murillo F, Torbenson M: Hepatitis B virus replication induces methylation of both host and viral DNA. J Virol. 2010, 84: 4321-4329. 10.1128/JVI.02280-09.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wei X, Xiang T, Ren G, Tan C, Liu R, Xu X, Wu Z: miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. Cell Signal. 2013, 25: 439-446. 10.1016/j.cellsig.2012.10.013.
Article
CAS
PubMed
Google Scholar
Letelier P, Brebi P, Tapia O, Roa JC: DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer. Clin Epigenetics. 2012, 4: 11-10.1186/1868-7083-4-11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, Natsume A, Goto Y, Ito M, Murakami H, Osada H, Zhang J, Issa JP, Sekido Y: Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis. 2008, 29: 1901-1910. 10.1093/carcin/bgn170.
Article
CAS
PubMed
Google Scholar
Hernandez-Vargas H, Lambert MP, Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z: Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinicalpredictors. PLoS One. 2010, 5: e9749-10.1371/journal.pone.0009749.
Article
PubMed
PubMed Central
Google Scholar
Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH: Identification of novel methylation markers in hepatocellular carcinoma using a methylationarray. J Korean Med Sci. 2010, 25: 1152-1159. 10.3346/jkms.2010.25.8.1152.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ammerpohl O, Pratschke J, Schafmayer C, Haake A, Faber W, von Kampen O, Brosch M, Sipos B, von Schönfels W, Balschun K, Röcken C, Arlt A, Schniewind B, Grauholm J, Kalthoff H, Neuhaus P, Stickel F, Schreiber S, Becker T, Siebert R, Hampe J: Distinct DNA methylation patterns in cirrhotic liverand hepatocellular carcinoma. Int J Cancer. 2011, 130: 1319-1328.
Article
PubMed
Google Scholar
Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM: Genome-wide DNA Methylation Profiles in Hepatocellular Carcinoma. Hepatology. 2012, 55: 1799-1808. 10.1002/hep.25569.
Article
CAS
PubMed
PubMed Central
Google Scholar
Um TH, Kim H, Oh BK, Kim MS, Kim KS, Jung G, Park YN: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. J Hepatol. 2011, 54: 939-947. 10.1016/j.jhep.2010.08.021.
Article
CAS
PubMed
Google Scholar
Ren N, Qin LX, Tu H, Liu YK, Zhang BH, Tang ZY: Quantitative analysis of circulating DNA level in plasma from patients with hepatocellular carcinoma and its potential clinical value. J Fudan Univ Med Sci. 2005, 32: 134-138.
CAS
Google Scholar
Zhai R, Zhao Y, Su L, Cassidy L, Liu G, Christini DC: Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and barrett esophagus. Neoplasia. 2012, 14: 29-33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G: DNA methylationdirectly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet. 2011, 20: 4299-4310. 10.1093/hmg/ddr356.
Article
CAS
PubMed
PubMed Central
Google Scholar
Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP: The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009, 41: 178-186. 10.1038/ng.298.
Article
CAS
PubMed
PubMed Central
Google Scholar
Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ, Feinberg AP: Differential methylation of tissue- and cancer-specific CpG island shores distinguishes humaninduced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet. 2009, 41: 1350-1353. 10.1038/ng.471.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin. 2011, 61: 69-90. 10.3322/caac.20107.
Article
PubMed
Google Scholar
Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, Germanidis G, Flaherty JF, Schall RA, Bornstein JD, Kitrinos KM, Subramanian GM, McHutchison JG, Heathcote EJ: Regression of cirrhosis during treatment with tenofovirdisoproxilfumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2012, 381: 468-475.
Article
PubMed
Google Scholar
Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R: Induction of tumors in mice by genomic hypomethylation. Science. 2003, 300: 489-492. 10.1126/science.1083558.
Article
CAS
PubMed
Google Scholar
Rakyan VK, Hildmann T, Novik KL, Lewin J, Tost J, Cox AV, Andrews TD, Howe KL, Otto T, Olek A, Fischer J, Gut IG, Berlin K, Beck S: DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol. 2004, 2: e405-10.1371/journal.pbio.0020405.
Article
PubMed
PubMed Central
Google Scholar
Sung WK, Lu Y, Lee CWH, Zhang D, Ronaghi M, Lee CG: Deregulated Direct Targets of the Hepatitis B Virus (HBV)Protein, HBx, Identified through Chromatin Immunoprecipitation and Expression Microarray Profiling. J Biol Chem. 2009, 284: 21941-21954. 10.1074/jbc.M109.014563.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tao R, Li J, Xin J, Wu J, Guo J, Zhang L, Jiang L, Zhang W, Yang Z, Li L: Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma. PLoS One. 2011, 6: e19862-10.1371/journal.pone.0019862.
Article
CAS
PubMed
PubMed Central
Google Scholar
Maria ND, Manno M, Villa E: Sex hormones and liver cancer. Mol Cell Endocrinol. 2002, 193: 59-63. 10.1016/S0303-7207(02)00096-5.
Article
PubMed
Google Scholar
Fisel P, Kruck S, Winter S, Bedke J, Hennenlotter J, Nies AT, Scharpf M, Fend F, Stenzl A, Schwab M, Schaeffeler E: DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome. Clin Cancer Res. 2013, 19: 5170-5181. 10.1158/1078-0432.CCR-13-1180.
Article
CAS
PubMed
Google Scholar
Nigam SK, Bush KT, Bhatnagar V: Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007, 3: 443-448.
Article
CAS
PubMed
Google Scholar
Burckhardt G, Burckhardt BC: In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Drug Transporters. 2011, Berlin Heidelberg: Springer, 29-104.
Chapter
Google Scholar
Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W: Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. Biochim Biophys Acta. 2004, 1676: 203-209. 10.1016/j.bbaexp.2003.11.011.
Article
CAS
PubMed
Google Scholar
Wang T, Wang XG, Xu JH, Wu XP, Qiu HL, Yi H, Li WX: Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway. J Cell Mol Med. 2012, 16: 1134-1145. 10.1111/j.1582-4934.2011.01388.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nygren AO, Dean J, Jensen TJ, Kruse S, Kwong W, Boom D, Ehrich M: Quantification of Fetal DNA by Use of Methylation-Based DNA Discrimination. Clin Chem. 2010, 56: 1627-1635. 10.1373/clinchem.2010.146290.
Article
CAS
PubMed
Google Scholar
Yu J, Zhang H, Ma Z, Lu W, Wang Y, Zhu JD: Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res. 2003, 13: 319-333. 10.1038/sj.cr.7290177.
Article
CAS
PubMed
Google Scholar
Doleshal M, Magotra AA, Choudhury B, Cannon BD, Labourier E, Szafranska AE: Evaluation and validation of total RNA extraction methods for MicroRNA expression analyses in formalin-fixed. Paraffin-embedded tissue J Mol Diagn. 2008, 10: 203-211.
Article
CAS
PubMed
Google Scholar
Zhao Y, Guo S, Sun J, Huang Z, Zhu T, Zhang H, Gu J, He Y, Wang W, Ma K, Wang J, Yu J: Methylcap-Seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population. PLoS One. 2012, 7: e35175-10.1371/journal.pone.0035175.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li H, Durbin R: Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009, 25: 1754-1760. 10.1093/bioinformatics/btp324.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kuhn RM, Haussler D, Kent WJ: The UCSC genome browser and associated tools. Brief Bioinform. 2013, 14: 144-161. 10.1093/bib/bbs038.
Article
CAS
PubMed
Google Scholar
Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS: Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008, 9: R137-10.1186/gb-2008-9-9-r137.
Article
PubMed
PubMed Central
Google Scholar
Lan X, Adams C, Landers M, Dudas M, Krissinger D, Marnellos G, Bonneville R, Xu M, Wang J, Huang TH, Meredith G, Jin VX: High resolution detection and analysis of CpG inucleotides methylation using MBD-Seq technology. PLoS One. 2011, 6: e22226-10.1371/journal.pone.0022226.
Article
CAS
PubMed
PubMed Central
Google Scholar
Quinlan AR, Hall IM: BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010, 26: 841-842. 10.1093/bioinformatics/btq033.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lacopetta B, Grieu F, Philips M, Ruszkiewicz A, Moore J, Minamoto T, Kawakami K: Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. Cancer Sci. 2007, 98: 454-1460.
Google Scholar