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  1. Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, m...

    Authors: Shaza B. Zaghlool, Mashael Al-Shafai, Wadha A. Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi and Karsten Suhre
    Citation: Clinical Epigenetics 2016 8:124
  2. We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it ...

    Authors: Tobias Fehlmann, Stefanie Reinheimer, Chunyu Geng, Xiaoshan Su, Snezana Drmanac, Andrei Alexeev, Chunyan Zhang, Christina Backes, Nicole Ludwig, Martin Hart, Dan An, Zhenzhen Zhu, Chongjun Xu, Ao Chen, Ming Ni, Jian Liu…
    Citation: Clinical Epigenetics 2016 8:123
  3. A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational histone modifications, or chromatin structure. These changes of th...

    Authors: René A. M. Dirks, Hendrik G. Stunnenberg and Hendrik Marks
    Citation: Clinical Epigenetics 2016 8:122
  4. Authors: Magdalena Spólnicka, Renata Zbieć Piekarska, Emilia Jaskuła, Grzegorz W. Basak, Renata Jacewicz, Agnieszka Pięta, Żanetta Makowska, Maciej Jedrzejczyk, Agnieszka Wierzbowska, Agnieszka Pluta, Tadeusz Robak, Jarosław Berent, Wojciech Branicki, Wiesław Jędrzejczak, Andrzej Lange and Rafał Płoski
    Citation: Clinical Epigenetics 2016 8:121

    The original article was published in Clinical Epigenetics 2016 8:93

  5. Metastasis is a leading cause of death among cancer patients. In the tumor microenvironment, altered levels of extracellular matrix proteins, such as collagens, can facilitate the first steps of cancer cell me...

    Authors: Pulari U. Thangavelu, Tibor Krenács, Eloise Dray and Pascal H. G. Duijf
    Citation: Clinical Epigenetics 2016 8:120
  6. In the presence of different environmental cues that are able to trigger specific responses, a given genotype has the ability to originate a variety of different phenotypes. This property is defined as plastic...

    Authors: T. A. L. Brevini, G. Pennarossa, E. F. M. Manzoni, C. E. Gandolfi, A. Zenobi and F. Gandolfi
    Citation: Clinical Epigenetics 2016 8:119
  7. Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mec...

    Authors: Golareh Agha, Hanine Hajj, Sheryl L. Rifas-Shiman, Allan C. Just, Marie-France Hivert, Heather H. Burris, Xihong Lin, Augusto A. Litonjua, Emily Oken, Dawn L. DeMeo, Matthew W. Gillman and Andrea A. Baccarelli
    Citation: Clinical Epigenetics 2016 8:118
  8. Pancreatic cancer has a 5-year survival rate of only 5–7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. ...

    Authors: Stine Dam Henriksen, Poul Henning Madsen, Anders Christian Larsen, Martin Berg Johansen, Asbjørn Mohr Drewes, Inge Søkilde Pedersen, Henrik Krarup and Ole Thorlacius-Ussing
    Citation: Clinical Epigenetics 2016 8:117
  9. The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pr...

    Authors: Karin Boer, L. Elly A. de Wit, Fleur S. Peters, Dennis A. Hesselink, Leo J. Hofland, Michiel G. H. Betjes, Caspar W. N. Looman and Carla C. Baan
    Citation: Clinical Epigenetics 2016 8:116
  10. Evidence is accumulating that nutritional exposures in utero can influence health outcomes in later life. Animal studies and human epidemiological studies have implicated epigenetic modifications as playing a ...

    Authors: Susan J. van Dijk, Jing Zhou, Timothy J. Peters, Michael Buckley, Brodie Sutcliffe, Yalchin Oytam, Robert A. Gibson, Andrew McPhee, Lisa N. Yelland, Maria Makrides, Peter L. Molloy and Beverly S. Muhlhausler
    Citation: Clinical Epigenetics 2016 8:114
  11. Suicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk are essential for implementing prevention strategies, and the developmen...

    Authors: Makena L. Clive, Marco P. Boks, Christiaan H. Vinkers, Lauren M. Osborne, Jennifer L. Payne, Kerry J. Ressler, Alicia K. Smith, Holly C. Wilcox and Zachary Kaminsky
    Citation: Clinical Epigenetics 2016 8:113
  12. Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal lung developmental disorder caused by heterozygous point mutations or genomic deletions involving FOXF1 or its 60-kb tis...

    Authors: Przemyslaw Szafranski, Carmen Herrera, Lori A. Proe, Brittany Coffman, Debra L. Kearney, Edwina Popek and Paweł Stankiewicz
    Citation: Clinical Epigenetics 2016 8:112
  13. The risk of developing Barrett’s esophagus (BE) and/or esophageal adenocarcinoma (EAC) is associated with specific demographic and behavioral factors, including gender, obesity/elevated body mass index (BMI), ...

    Authors: Andrew M. Kaz, Chao-Jen Wong, Vinay Varadan, Joseph E. Willis, Amitabh Chak and William M. Grady
    Citation: Clinical Epigenetics 2016 8:111

    The Erratum to this article has been published in Clinical Epigenetics 2017 9:23

  14. Several studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well studied. The goals ...

    Authors: Kristina Gervin, Bettina Kulle Andreassen, Hanne Sagsveen Hjorthaug, Karin C. Lødrup Carlsen, Kai-Håkon Carlsen, Dag Erik Undlien, Robert Lyle and Monica Cheng Munthe-Kaas
    Citation: Clinical Epigenetics 2016 8:110
  15. Neural tube defects (NTDs) are severe congenital malformations that arise from failure of neurulation during early embryonic development. The molecular basis underlying most human NTDs still remains largely un...

    Authors: Anne Rochtus, Raf Winand, Griet Laenen, Elise Vangeel, Benedetta Izzi, Christine Wittevrongel, Yves Moreau, Carla Verpoorten, Katrien Jansen, Chris Van Geet and Kathleen Freson
    Citation: Clinical Epigenetics 2016 8:108
  16. Environmental perturbation of epigenetic mechanisms is linked to a growing number of diseases. Characterizing the role environmental factors play in modifying the epigenome is important for disease etiology. V...

    Authors: Jing Xue, Sarah A. Schoenrock, William Valdar, Lisa M. Tarantino and Folami Y. Ideraabdullah
    Citation: Clinical Epigenetics 2016 8:107
  17. Methyl-CpG-binding domain protein enriched genome-wide sequencing (MBD-Seq) is a robust and powerful method for analyzing methylated CpG-rich regions with complete genome-wide coverage. In chronic lymphocytic ...

    Authors: Santhilal Subhash, Per-Ola Andersson, Subazini Thankaswamy Kosalai, Chandrasekhar Kanduri and Meena Kanduri
    Citation: Clinical Epigenetics 2016 8:106
  18. Molecular biomarkers that might help to distinguish between more aggressive and clinically insignificant prostate cancers (PCa) are still urgently needed. Aberrant DNA methylation as a common molecular alterat...

    Authors: Emily Eva Holmes, Diane Goltz, Verena Sailer, Maria Jung, Sebastian Meller, Barbara Uhl, Jörn Dietrich, Magda Röhler, Jörg Ellinger, Glen Kristiansen and Dimo Dietrich
    Citation: Clinical Epigenetics 2016 8:104
  19. Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely under...

    Authors: Mi Kyeong Lee, Yoonki Hong, Sun-Young Kim, Stephanie J. London and Woo Jin Kim
    Citation: Clinical Epigenetics 2016 8:103
  20. SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nucle...

    Authors: Ciro Milite, Alessandra Feoli, Monica Viviano, Donatella Rescigno, Agostino Cianciulli, Amodio Luca Balzano, Antonello Mai, Sabrina Castellano and Gianluca Sbardella
    Citation: Clinical Epigenetics 2016 8:102
  21. Bisulfite (BS) conversion-based and methylation-sensitive restriction enzyme (MSRE)-based PCR methods have been the most commonly used techniques for locus-specific DNA methylation analysis. However, both meth...

    Authors: Ram Vinay Pandey, Walter Pulverer, Rainer Kallmeyer, Gabriel Beikircher, Stephan Pabinger, Albert Kriegner and Andreas Weinhäusel
    Citation: Clinical Epigenetics 2016 8:101
  22. Colorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinom...

    Authors: Alexander Semaan, Anne van Ellen, Sebastian Meller, Dominik Bergheim, Vittorio Branchi, Philipp Lingohr, Diane Goltz, Jörg C. Kalff, Glen Kristiansen, Hanno Matthaei, Dimitrios Pantelis and Dimo Dietrich
    Citation: Clinical Epigenetics 2016 8:100
  23. Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptible to infections, but the factors regulating neonatal-specific immune respon...

    Authors: Jennifer R. Bermick, Nathalie J. Lambrecht, Aaron D. denDekker, Steven L. Kunkel, Nicholas W. Lukacs, Cory M. Hogaboam and Matthew A. Schaller
    Citation: Clinical Epigenetics 2016 8:99
  24. Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of ...

    Authors: Inês Graça, Eva Pereira-Silva, Rui Henrique, Graham Packham, Simon J. Crabb and Carmen Jerónimo
    Citation: Clinical Epigenetics 2016 8:98
  25. Identifying the subset of patients with clinically localized prostate cancer (PCa) at the highest risk of recurrence remains challenging, and better prognostic markers are needed. Gleason score is the best pre...

    Authors: Milan S. Geybels, Jonathan L. Wright, Marina Bibikova, Brandy Klotzle, Jian-Bing Fan, Shanshan Zhao, Ziding Feng, Elaine A. Ostrander, Daniel W. Lin, Peter S. Nelson and Janet L. Stanford
    Citation: Clinical Epigenetics 2016 8:97
  26. The Pap smear has remained the foundation for cervical cancer screening for over 70 years. With advancements in molecular diagnostics, primary high-risk human papillomavirus (hrHPV) screening has recently beco...

    Authors: Jane Shen-Gunther, Chiou-Miin Wang, Graham M. Poage, Chun-Lin Lin, Luis Perez, Nancy A. Banks and Tim Hui-Ming Huang
    Citation: Clinical Epigenetics 2016 8:96
  27. The prognostic value of aberrant DNA methylation of cell-free circulating DNA in plasma has not previously been evaluated in diffuse large B cell lymphoma (DLBCL). The aim of this study was to investigate if a...

    Authors: Lasse Sommer Kristensen, Jakob Werner Hansen, Søren Sommer Kristensen, Dorte Tholstrup, Laurine Bente Schram Harsløf, Ole Birger Pedersen, Peter De Nully Brown and Kirsten Grønbæk
    Citation: Clinical Epigenetics 2016 8:95
  28. Epigenetic mechanisms are important for the regulation of gene expression and differentiation in the fetus and the newborn child. Symptoms of maternal depression and antidepressant use affects up to 20 % of pr...

    Authors: Anne-Cathrine F. Viuff, Lars Henning Pedersen, Kasper Kyng, Nicklas Heine Staunstrup, Anders Børglum and Tine Brink Henriksen
    Citation: Clinical Epigenetics 2016 8:94
  29. Our recent study demonstrated that DNA methylation status in a set of CpGs located in ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 can accurately predict calendar age in blood. In the present work, we used these mar...

    Authors: Magdalena Spólnicka, Renata Zbieć Piekarska, Emilia Jaskuła, Grzegorz W. Basak, Renata Jacewicz, Agnieszka Pięta, Żanetta Makowska, Maciej Jedrzejczyk, Agnieszka Wierzbowska, Agnieszka Pluta, Tadeusz Robak, Jarosław Berent, Wojciech Branicki, Wiesław Jędrzejczak, Andrzej Lange and Rafał Płoski
    Citation: Clinical Epigenetics 2016 8:93

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:121

  30. DNA methylation is an essential epigenetic mark, controlled by DNA methyltransferase (DNMT) proteins, which regulates chromatin structure and gene expression throughout the genome. In this study, we describe a...

    Authors: Kristin D. Kernohan, Laila Cigana Schenkel, Lijia Huang, Amanda Smith, Guillaume Pare, Peter Ainsworth, Kym M. Boycott, Jodi Warman-Chardon and Bekim Sadikovic
    Citation: Clinical Epigenetics 2016 8:91
  31. Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DN...

    Authors: Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J. Barton, Hazel Inskip, Nicholas C. Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson and Keith M. Godfrey
    Citation: Clinical Epigenetics 2016 8:90
  32. Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations b...

    Authors: Ailsa Maria Main, Linn Gillberg, Anna Louisa Jacobsen, Emma Nilsson, Anette Prior Gjesing, Torben Hansen, Oluf Pedersen, Rasmus Ribel-Madsen and Allan Vaag
    Citation: Clinical Epigenetics 2016 8:89
  33. Alterations in histone modifications are now well known to result in epigenetic heterogeneity in tumor tissues; however, their prognostic value and association with resection margins still remain poorly unders...

    Authors: Shafqat Ali Khan, Ramchandra Amnekar, Bharat Khade, Savio George Barreto, Mukta Ramadwar, Shailesh V. Shrikhande and Sanjay Gupta
    Citation: Clinical Epigenetics 2016 8:88
  34. Immunoactivation is less evident in secondary progressive MS (SPMS) compared to relapsing-remitting disease. MicroRNA (miRNA) expression is integral to the regulation of gene expression; determining their impa...

    Authors: Katherine A. Sanders, Miles C. Benton, Rod A. Lea, Vicki E. Maltby, Susan Agland, Nathan Griffin, Rodney J. Scott, Lotti Tajouri and Jeannette Lechner-Scott
    Citation: Clinical Epigenetics 2016 8:87
  35. DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs...

    Authors: Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D’Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore and Roberto Berni Canani
    Citation: Clinical Epigenetics 2016 8:86
  36. Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation. Two prominent ANCA autoantigens are myeloperoxid...

    Authors: Jiajin Yang, Heng Ge, Caroline J. Poulton, Susan L. Hogan, Yichun Hu, Britta E. Jones, Candace D. Henderson, Elizabeth A. McInnis, William F. Pendergraft III, J. Charles Jennette, Ronald J. Falk and Dominic J. Ciavatta
    Citation: Clinical Epigenetics 2016 8:85
  37. Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association of tobacco smoking with epigenetic cha...

    Authors: Mario Bauer, Beate Fink, Loreen Thürmann, Markus Eszlinger, Gunda Herberth and Irina Lehmann
    Citation: Clinical Epigenetics 2016 8:83
  38. Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. It is known that GDM is associated with an altered placental function and changes in placental gene regulation. More recent st...

    Authors: C. Reichetzeder, S. E. Dwi Putra, T. Pfab, T. Slowinski, C. Neuber, B. Kleuser and B. Hocher
    Citation: Clinical Epigenetics 2016 8:82
  39. In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases potentially mediated through lasting effects on the epigenome. As the epigeno...

    Authors: Nicklas H. Staunstrup, Anna Starnawska, Mette Nyegaard, Lene Christiansen, Anders L. Nielsen, Anders Børglum and Ole Mors
    Citation: Clinical Epigenetics 2016 8:81
  40. Epigenetic events mediated by methylation and histone modifications have been associated with the development of metastasis in patients with uveal melanoma. The role of epigenetic events mediated by microRNA (...

    Authors: Pierre L. Triozzi, Susan Achberger, Wayne Aldrich, John W. Crabb, Yogen Saunthararajah and Arun D. Singh
    Citation: Clinical Epigenetics 2016 8:80
  41. Refractory and/or relapsed diffuse large B cell lymphoma (RR-DLBCL) patients are incurable with conventional chemotherapy due to the aggressiveness and the chemorefractory state of these tumors. DNA hypermethy...

    Authors: Benet Pera, Tiffany Tang, Rossella Marullo, Shao-Ning Yang, Haelee Ahn, Jayeshkumar Patel, Rebecca Elstrom, Jia Ruan, Richard Furman, John Leonard, Leandro Cerchietti and Peter Martin
    Citation: Clinical Epigenetics 2016 8:79
  42. Vascular malformations are developmental congenital abnormalities of the vascular system which may involve any segment of the vascular tree such as capillaries, veins, arteries, or lymphatics. Arteriovenous ma...

    Authors: Jaya Mary Thomas, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu and Chandrasekharan C. Kartha
    Citation: Clinical Epigenetics 2016 8:78

    The Correction to this article has been published in Clinical Epigenetics 2018 10:124

  43. Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skelet...

    Authors: Samantha E. Day, Richard L. Coletta, Joon Young Kim, Latoya E. Campbell, Tonya R. Benjamin, Lori R. Roust, Elena A. De Filippis, Valentin Dinu, Gabriel Q. Shaibi, Lawrence J. Mandarino and Dawn K. Coletta
    Citation: Clinical Epigenetics 2016 8:77
  44. DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be f...

    Authors: Annette M. Lim, Nicholas C. Wong, Ruth Pidsley, Elena Zotenko, June Corry, Alexander Dobrovic, Susan J. Clark, Danny Rischin and Benjamin Solomon
    Citation: Clinical Epigenetics 2016 8:74