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  1. Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain...

    Authors: Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller and Alexander G Haslberger

    Citation: Clinical Epigenetics 2012 4:19

    Content type: Research

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  2. Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined t...

    Authors: Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Katharine Hammond and Kari Nadeau

    Citation: Clinical Epigenetics 2012 4:17

    Content type: Research

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  3. MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies t...

    Authors: Mansi A Parasramka, W Mohaiza Dashwood, Rong Wang, Hassaan H Saeed, David E Williams, Emily Ho and Roderick H Dashwood

    Citation: Clinical Epigenetics 2012 4:16

    Content type: Research

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  4. Silver-Russell syndrome (SRS) is characterized by severe intrauterine and postnatal growth failure and frequent body asymmetry. Half of the patients with SRS carry a DNA hypomethylation of the imprinting cente...

    Authors: Kai Kannenberg, Karin Weber, Cathrin Binder, Christina Urban, Hans-Joachim Kirschner and Gerhard Binder

    Citation: Clinical Epigenetics 2012 4:15

    Content type: Research

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  5. A wet nurse can be used if a baby’s natural mother is unable or chooses not to breastfeed her infant. The practice of using wet nurses is ancient and common to many cultures.

    Authors: Hasan Ozkan, Funda Tuzun, Abdullah Kumral and Nuray Duman

    Citation: Clinical Epigenetics 2012 4:14

    Content type: Hypothesis

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  6. Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigen...

    Authors: Karla Bennemann, Oliver Galm, Stefan Wilop, Claudia Schubert, Tim H Brümmendorf and Edgar Jost

    Citation: Clinical Epigenetics 2012 4:12

    Content type: Research

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  7. Epigenetic mechanisms may be involved in the regulation of genes found to be differentially expressed in the visceral adipose tissue (VAT) of severely obese subjects with (MetS+) versus without (MetS-) metabol...

    Authors: Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho and Marie-Claude Vohl

    Citation: Clinical Epigenetics 2012 4:10

    Content type: Research

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  8. It has been suggested that inactivation of p14ARF, a tumor suppressor central to regulating p53 protein stability through interaction with the MDM2 oncoprotein, abrogates p53 activity in human tumors retaining th...

    Authors: Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser and Karin Dahan

    Citation: Clinical Epigenetics 2012 4:9

    Content type: Research

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  9. Birth by cesarean delivery (CD) as opposed to vaginal delivery (VD) is associated with altered health outcomes later in life, including respiratory disorders, allergies and risk of developing type I diabetes. ...

    Authors: Shama Virani, Dana C Dolinoy, Sindhu Halubai, Tamara R Jones, Steve E Domino, Laura S Rozek, Muna S Nahar and Vasantha Padmanabhan

    Citation: Clinical Epigenetics 2012 4:8

    Content type: Research

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  10. Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. T...

    Authors: Christina Schleithoff, Susanne Voelter-Mahlknecht, Indra Navina Dahmke and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2012 4:7

    Content type: Review

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  11. The number of children ages 6 to 21 in the United States receiving special education services under the autism disability category increased 91% between 2005 to 2010 while the number of children receiving spec...

    Authors: Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga and Richard Deth

    Citation: Clinical Epigenetics 2012 4:6

    Content type: Review

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  12. The biological mechanisms responsible for the onset and exacerbation of asthma symptoms in children may involve the epigenetic regulation of inflammatory genes after environmental exposures. Using buccal cells...

    Authors: DZ Torrone, JS Kuriakose, K Moors, H Jiang, MM Niedzwiecki, FF Perera and RL Miller

    Citation: Clinical Epigenetics 2012 4:3

    Content type: Research

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  13. Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in whic...

    Authors: Daman Kumari and Karen Usdin

    Citation: Clinical Epigenetics 2012 4:2

    Content type: Review

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  14. Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins. Although environmental and gene...

    Authors: Takeo Kubota, Kunio Miyake and Takae Hirasawa

    Citation: Clinical Epigenetics 2012 4:1

    Content type: Review

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  15. The influence of epigenetics is evident in many fields of medicine today. This is also true in placentology, where versatile epigenetic mechanisms that regulate expression of genes have shown to have important...

    Authors: L Serman and D Dodig

    Citation: Clinical Epigenetics 2011 3:7

    Content type: Review

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  16. Adenomatous polyposis coli (APC) and Ataxia-telangiectasia-mutated (ATM) gene products have an important role in cell cycle control and maintenance of genomic stability. Our aim was to analyze ATM and APC methyla...

    Authors: Mohammad Ayub Rigi-Ladiz, Dor Mohammad Kordi-Tamandani and Adam Torkamanzehi

    Citation: Clinical Epigenetics 2011 3:6

    Content type: Research

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  17. Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effect...

    Authors: Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood and Emily Ho

    Citation: Clinical Epigenetics 2011 3:3

    Content type: Research

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  18. In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship betwee...

    Authors: A Soubry, SK Murphy, Z Huang, A Murtha, JM Schildkraut, RL Jirtle, F Wang, J Kurtzberg, W Demark-Wahnefried, MR Forman and C Hoyo

    Citation: Clinical Epigenetics 2011 3:2

    Content type: Research

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  19. A sequence variant of histone H2A called H2AX is one of the key components of chromatin involved in DNA damage response induced by different genotoxic stresses. Phosphorylated H2AX (γH2AX) is rapidly concentra...

    Authors: Denis V. Firsanov, Liudmila V. Solovjeva and Maria P. Svetlova

    Citation: Clinical Epigenetics 2011 2:44

    Content type: Review

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  20. Epigenetic mechanisms such as DNA hypermethylation and modifications of histone amino acids are known to play an important role in the control of gene expression both in normal human development and tumorigene...

    Authors: Christoph Oing, Edgar Jost, Edgar Dahl, Stefan Wilop, Tim H. Brümmendorf and Oliver Galm

    Citation: Clinical Epigenetics 2011 2:43

    Content type: Original Article

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  21. Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be determined, it is evident that both genet...

    Authors: Suyin P. Chin, Joanne L. Dickinson and Adele F. Holloway

    Citation: Clinical Epigenetics 2011 2:41

    Content type: Review

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  22. DNA methylation plays an integral role in development and aging through epigenetic regulation of genome function. DNA methyltransferase 1 (Dnmt1) is the most prevalent DNA methyltransferase that maintains geno...

    Authors: Liang Liu, Thomas van Groen, Inga Kadish, Yuanyuan Li, Deli Wang, Smitha R. James, Adam R. Karpf and Trygve O. Tollefsbol

    Citation: Clinical Epigenetics 2011 2:42

    Content type: Original Article

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  23. Elevated activation of the platelet-derived growth factor (PDGF) pathway, apoptosis evasion phenotype, and global DNA hypomethylation are hallmarks frequently observed in cancers, such as in low-grade glioma (...

    Authors: Emilie Debien, Eric Hervouet, Fabien Gautier, Philippe Juin, Francois M. Vallette and Pierre-Francois Cartron

    Citation: Clinical Epigenetics 2011 2:35

    Content type: Original Article

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  24. Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pa...

    Authors: Jacob Peedicayil

    Citation: Clinical Epigenetics 2011 2:38

    Content type: Review

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  25. Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studi...

    Authors: Norishige Yamada, Sho Kitamoto, Seiya Yokoyama, Tomofumi Hamada, Masamichi Goto, Hideaki Tsutsumida, Michiyo Higashi and Suguru Yonezawa

    Citation: Clinical Epigenetics 2011 2:37

    Content type: Review

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  26. This review presents an epigenetic view on complex factors leading to development and perception of “genius.” There is increasing evidence which indicates that artistic creativity is influenced by epigenetic p...

    Authors: Heidrun Karlic and Pia Baurek

    Citation: Clinical Epigenetics 2011 2:33

    Content type: Review

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  27. Lymphocytes from the peripheral blood of patients with prostate cancer—the most frequent (noncutaneous) tumor in men—display epigenetic aberrations (altered modes of allelic replication) characteristic of the ...

    Authors: Samuel Cytron, Evgeni Stepnov, Igor Bounkin, Maya Mashevich, Aviva Dotan and Lydia Avivi

    Citation: Clinical Epigenetics 2011 2:29

    Content type: Original Article

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  28. About 15–20% of human cancers worldwide have viral etiology. Emerging data clearly indicate that several human DNA and RNA viruses, such as human papillomavirus, Epstein–Barr virus, Kaposi’s sarcoma-associated...

    Authors: Elzbieta Poreba, Justyna Karolina Broniarczyk and Anna Gozdzicka-Jozefiak

    Citation: Clinical Epigenetics 2011 2:26

    Content type: Review

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  29. S100 proteins are small, calcium-binding proteins whose genes are localized in a cluster on human chromosome 1. Through their ability to interact with various protein partners in a calcium-dependent manner, th...

    Authors: Wiesława Leśniak

    Citation: Clinical Epigenetics 2011 2:23

    Content type: Review

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  30. Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapi...

    Authors: Chris J. McNeil, John H. Beattie, M-J Gordon, Lynn P. Pirie and Susan J. Duthie

    Citation: Clinical Epigenetics 2011 2:22

    Content type: Original Article

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  31. Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasiv...

    Authors: Emily L. Putiri and Keith D. Robertson

    Citation: Clinical Epigenetics 2010 2:17

    Content type: Review

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