Table 1 Effect of REs hypomethylation on tumours
From: Gene body methylation in cancer: molecular mechanisms and clinical applications
REs | Tumours | Effect | References |
|---|---|---|---|
LINE-1 | Lung cancer | Cancer stage and prognosis | [94] |
Alu | Thyroid cancer | Metastasis and prognosis | [95] |
LINE and Alu Yb8 | Bladder cancer | Cancer stage or disease outcome | [96] |
Sat2, Satα, and Alu | Liver cancer | Gain of chromosome 1q and diagnosis of cancer | |
Satα | Nephroblastoma | Loss of chromosome 16q Gain of chromosome 1q | [98] |
Sat2, Satα, LINE1 and Alu | Ovarian epithelial tumour | Prognosis and biomarkers | |
LINE-1and Alu | Breast cancer | Risk, progression, and type of cancer | |
LINE-1 and Alu | Gastrointestinal tumours | Cancer stage and prognosis |