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Table 1 Effect of REs hypomethylation on tumours

From: Gene body methylation in cancer: molecular mechanisms and clinical applications

REs

Tumours

Effect

References

LINE-1

Lung cancer

Cancer stage and prognosis

[94]

Alu

Thyroid cancer

Metastasis and prognosis

[95]

LINE and

Alu Yb8

Bladder cancer

Cancer stage or disease outcome

[96]

Sat2, Satα, and Alu

Liver cancer

Gain of chromosome 1q and diagnosis of cancer

[89, 97]

Satα

Nephroblastoma

Loss of chromosome 16q

Gain of chromosome 1q

[98]

Sat2, Satα,

LINE1 and Alu

Ovarian epithelial tumour

Prognosis and biomarkers

[99,100,101]

LINE-1and Alu

Breast cancer

Risk, progression, and type of cancer

[102, 103]

LINE-1 and Alu

Gastrointestinal tumours

Cancer stage and prognosis

[104,105,106]