Marijuana use and DNA methylation-based biological age in young adults

Clinical Epigenetics

Table 3 Analysis results for the association between recent marijuana use and EAA at examination years 15 and 20

	Year 15		Year 20		GEE
	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P
Recent marijuana use
IEAA	− 0.42 [− 1.24, 0.41]	0.322	− 0.40 [− 1.32, 0.53]	0.402	− 0.39 [− 1.05, 0.28]	0.253
EEAA	0.39 [− 0.59, 1.37]	0.438	0.10 [− 0.93, 1.13]	0.852	0.26 [− 0.56, 1.07]	0.536
PAA	0.23 [− 0.92, 1.37]	0.699	0.30 [− 0.98, 1.58]	0.642	0.28 [− 0.74, 1.29]	0.593
GAA	1.82 [1.16, 2.48]	< 0.001	1.50 [0.78, 2.21]	< 0.001	1.70 [1.04, 2.37]	< 0.001
Recent marijuana use quantity
IEAA	− 0.05 [− 0.11, 0.00]	0.050	− 0.02 [− 0.09, 0.04]	0.446	− 0.04 [− 0.08, 0.01]	0.097
EEAA	− 0.01 [− 0.07, 0.05]	0.752	− 0.02 [− 0.09, 0.05]	0.607	− 0.01 [− 0.07, 0.04]	0.667
PAA	− 0.04 [− 0.11, 0.04]	0.343	0.01 [− 0.08, 0.09]	0.865	− 0.02 [− 0.08, 0.05]	0.605
GAA	0.10 [0.05, 0.14]	< 0.001	0.10 [0.06, 0.15]	< 0.001	0.10 [0.06, 0.14]	< 0.001

Results are adjusted for sex, race, center, education, tobacco smoking status, cumulative packs of cigarettes, BMI, physical activity, and alcohol consumption
Beta coefficient for recent marijuana use represents gain in EAA for use in the last 30 days and beta coefficient for recent marijuana use quantity represents gain in EAA for each additional day within the last 30 days

ISSN: 1868-7083