Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study

Clinical Epigenetics

Table 3 Cross-lagged association between lipid measures and DNA methylation

CpG	Gene	Lipid_baseline → Methylation_follow-up			Methylation_baseline → Lipid_follow-up			Model fit
CpG	Gene	β	SE	P_adj	β	SE	P_adj	SRMR	CFI
TG
cg27243685	ABCG1	0.3884	0.1426	0.0483	0.0264	0.0220	0.6682	< 0.001	1
cg05778424	AKAP1	0.5423	0.1660	0.0163	0.0147	0.0209	0.9468	< 0.001	1
HDL-C
cg06500161	ABCG1	− 0.5781	0.5812	0.3999	− 0.0320	0.0088	0.0014	< 0.001	1
cg11024682	SREBF1	− 1.4046	0.4655	0.0127	− 0.0193	0.0121	0.1837	< 0.001	1

Adjusted P-values less than 0.05 are in bold font
β, regression coefficient; SE, standard error; TG, triglyceride; HDL-C, high-density lipoprotein-cholesterol; SRMR, standardized root mean squared residual; CFI, comparative fit index

ISSN: 1868-7083