Table 4 Epigenetics role in tumorigenesis and progression. Adapted from [247] with permission of the publisher (License ID 1165278-1, 01-Dec-2021)
From: Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
| Â | Â | Enzymes/readers | Mutation | Tumor |
|---|---|---|---|---|
Cancer mutations affecting epigenetic regulators of DNA methylation | Methyltransferase | DNMT3A | M, F,N,S | AML, MDS, MPD |
| Â | Hydroxymethylation and derivatives | TET1 | T | AML |
| Â | Hydroxymethylation and derivatives | TET2 | M, N, F | AML, MPD, MDS, CMML |