Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells

Table 2 Results from the differential methylation analyses, comparing the active treatments vs. the double placebo group

Intervention group	Lω vs. PP	LP vs. PP	Pω vs. PP
DMCs	1 659	1246	984
Hypomethylated CpGs	576 (35%)	380 (30%)	415 (42%)
Hypermethylated CpGs	1083 (65%)	866 (70%)	569 (58%)
DMGs	794	620	494
Hypomethylated genes	247 (31%)	204 (33%)	184 (37%)
Hypermethylated genes	524 (66%)	405 (65%)	295 (60%)
Mixed methylation genes	23 (3%)	11 (2%)	15 (3%)

Proportions of hypo- and hypermethylated CpGs and genes, from the differential DNA methylation analyses comparing the active treatment groups vs. the double placebo group, are presented as n (% of total). DMCs—differentially methylated CpGs, DMGs—differentially methylated genes, L—Lactobacillus reuteri, ω—ω-3 fatty acids, P—placebo

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