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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells

Fig. 3

Visualisation of the consensus module created with the DMGs from the differential methylation comparison between the double-treated L.reuteri/ω-3 (Lω) and the double placebo (PP) group. Nodes represent genes and connecting lines represent protein–protein interactions (STRING combined score > 0.7) within the network. Red nodes illustrate hypermethylated genes, blue nodes indicate hypomethylated genes and both colours denote mixed methylation patterns. Black lines enclose biologically relevant clusters identified by bioinformatic pathway enrichment analyses. Nodes marked with * are also present in an independent allergy data set (described later in the paper). DMGs—differentially methylated genes, L—Lactobacillus reuteri, ω—ω-3 fatty acids, P—placebo

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