Prenatal epigenetics diets play protective roles against environmental pollution

Li, Shizhao; Chen, Min; Li, Yuanyuan; Tollefsbol, Trygve O.

doi:10.1186/s13148-019-0659-4

Clinical Epigenetics

Table 1 Summary of human studies reporting associations between prenatal exposure to air pollution and epigenetic alterations

From: Prenatal epigenetics diets play protective roles against environmental pollution

Pollution	Exposure stage	Epigenetic change	Ref.
Particulate matter	Prenatal	Altered DNA methylation at CpG sites	[65]
	First trimester	Positive correlation with placental global DNA methylation	[74]
	Second trimester	Lower placental leptin promoter methylation	[78]
	Early pregnancy	Associated with placental DNA methylation of LINE1 and HSD11B2	[75]
	Prenatal	Decreased expression of miR-21, miR-146a and miR-222; increased expression of miR-20a and miR-21	[80]
	Gestation	Increased mtDNA methylation levels and decreased LINE-1 methylation levels	[77]
	Prenatal	Decrease in global DNA methylation for whole pregnancy	[73]
	Prenatal	Increased DNA methylation in LINE1, OGG1, APEX and PARP1	[79]
Smoking	Prenatal	Nearly 3000 CpGs corresponding to genes differentially methylated in offspring	[85]
	Maternal	Altered DNA methylation levels at CpG sites of GFI1, AHRR and PRNP gene in male and female, differentially	[110]
	In utero	Impact key biological pathways through epigenetic modification	[84]
	Maternal	Differential methylation of MYO1G, CNTNAP2 and FRMD4A genes in children blood	[107]
	In utero	Global DNA hypomethylation; 31 CpG sites associated to 25 genes	[99]
	Prenatal	Altered methylation at 15 CpG sites	[100]
	Prenatal	Differential methylation at five CpGs in MYO1G and CNTNAP2; persist in exposed offspring for many years	[88]
	In utero	Increased CpG methylation in FRMD4A and Cllorf52; reproducible epigenetic changes persist into childhood	[87]
	In utero	Altered methylation at 185 CpGs of 110 gene regions in infants	[101]
	In utero	Hypomethylation of AHRR in the cord blood mononuclear cells, buccal epithelium and placenta tissue	[44]
	In utero	Altered methylation at TSLP promoter	[106]
	Maternal	Altered methylation patterns of a few loci within the RUNX3 gene	[102]
	In utero	Increased IGF2 DMR	[105]
	In utero	Altered LINE-1 and AluYb8 methylation levels	[83]
	Maternal	Differential DNA methylation at epigenome-wide for 26 CpGs mapped to 10 genes	[104]
	Maternal	Differential epigenome-wide placental DNA methylation	[82]
	Gestation	Decreased methylation of Sat2	[96]
	Maternal	Increased DNA methylation in the BNDF-6 exon	[108]
	Gestation	Downregulation of miR-16, miR-21 and miR-146a in placenta	[109]
	In utero	Global DNA methylation inversely correlates with cotinine levels in cord blood	[95]
	In utero	Decreased methylation at CYPIAI promoter in the placenta	[103]
	Prenatal	Lower methylation of AluYb8; differential methylation of LINE1; increased methylation of AXL and PTPRO	[98]
Polycyclic aromatic hydrocarbons	Prenatal	Inverse relationship with LINE1 DNA methylation in cord blood	[119]
	Prenatal	Decreased global methylation in umbilical cord white blood cells	[118]
	Prenatal	Altered methylation in 5′-CpG islands of ACSL3	[120]
NO₂	Prenatal	Related alteration of ADORA2B methylation	[65]
NO₂	Prenatal	Differential offspring DNA methylation in antioxidant and mitochondria-related genes	[122]

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ISSN: 1868-7083

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