Association of recurrent venous thromboembolism and circulating microRNAs

Clinical Epigenetics

Table 2 Differentially expressed miRNAs in cases and controls in recurrent VTE

miRNAs^a, ΔCt^b Median (IQR)	Cases (recurrent VTE) (n = 39)	Controls (non-recurrent VTE) (n = 39)	p value
miR-15b-5p	− 1.13 (0.49)	− 1.42 (0.53)	0.00005
miR-106a-5p	2.93 (0.30)	3.2 (0.37)	0.0006
miR-197-3p	− 1.62 (0.51)	− 1.30 (0.85)	0.0009
miR-652-3p	0.08 (0.62)	0.26 (0.63)	0.003
miR-361-5p	− 0.32 (0.56)	− 0.25 (0.37)	0.004
miR-222-3p	0.78 (0.45)	0.72 (0.50)	0.009
miR-26b-5p*	− 1.07 (0.44)	− 1.19 (0.47)	0.016
miR-532-5p	− 2.50 (0.66)	− 2.95 (1.04)	0.018
miR-27b-3p	1.49 (0.43)	1.72 (0.59)	0.019
miR-21-5p*	3.77 (0.34)	3.64 (0.29)	0.021
miR-103a-3p	2.72 (0.53)	2.85 (0.56)	0.022
miR-30c-5p*	− 0.43 (0.62)	− 0.47 (0.58)	0.023
miR-146b-5p	− 3.69 (1.02)	− 4.19 (0.90)	0.024
miR-22-3p	1.11 (0.40)	0.98 (0.42)	0.024

Abbreviations: IQR = interquartile range
^aAll miRNAs shown were significant after adjusting for the false discovery rate using the Benjamini-Hochberg correction. False discovery rate was chosen to 0.25 (25% false positives are allowed)
^bΔCt = Ct_{global mean} − Ct_{miR of interest}
*Paired t tests were used instead of Wilcoxon signed rank test

ISSN: 1868-7083