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Correction to: Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth

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Clinical EpigeneticsThe official journal of the Clinical Epigenetics Society201810:36

Published: 14 March 2018

The original article was published in Clinical Epigenetics 2017 9:115


After publication of the original article [1], it came to the authors’ attention that a reference was omitted from the Background. The reference should have been inserted as [16] and is the following:

Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. Int J Cancer 2015, 136:844–853.

The last paragraph of the Background should have read as follows:

“Zinc finger protein 331 (ZNF331) was first identified from thyroid tumors [12]. It is also known as RITA (rearranged in thyroid adenoma), ZNF361, and ZNF463 [13]. The ZNF331 gene is located at chromosome 19q13.42, a region in which loss of heterozygosity (LOH) was detected in prostate cancer [14]. In our previous study, we found that the ZNF331 gene is frequently methylated in human esophageal squamous cell cancer (ESCC) and it serves as a tumor suppressor in ESCC [15]. It was reported that the high methylation frequency of ZNF331 was found in some types of gastrointestinal cancer including CRC [16]. But the function of ZNF331 in human CRC remains unclear. In this study, we analyzed the epigenetic regulation and the function of ZNF331 in human CRC.”



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Authors’ Affiliations

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China
Department of Geriatric Digestive System, Chinese PLA Navy General Hospital, Beijing, China
The Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, USA
Laboratory of Cancer Epigenetics, Free University of Brussels (U.L.B.), Brussels, Belgium
Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, China
Department of General Surgery, Chinese PLA General Hospital, Beijing, China
Medical College of NanKai University, Tianjin, China


  1. Wang, et al. Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth. Clin Epigenetics. 2017;9:115. ArticlePubMedPubMed CentralGoogle Scholar


© The Author(s). 2018