Table 2 Downstream targets of the microRNAs analyzed in tumor and non-tumor lungs of the study patients

PTEN, gene expression

82.4 (70.2)

0.26 (0.60)^{*, §§§}

MARCKs, gene expression

0.5 (0.5)

0.2 (0.1)^{*, §}

TPM-1, gene expression

5.8 (4.9)

1.8 (1.5)^§§

PDCD4, gene expression

4.0 (2.5)

1.4 (1.0)^§

SPRY-2, gene expression

3.4 (1.9)

1.2 (1.0)^§§§

ETS-1, gene expression

2.8 (2.5)

0.6 (0.3)^§

ZEB-2, gene expression

0.7 (0.2)^#

0.4 (0.3)^§§§

EGFL-7, gene expression

5.0 (5.0)

1 (0.7)

TOM-1, gene expression

1.3 (1.0)

0.8 (0.6)^§§§

CRK, gene expression

6.6 (5.8)

3.7 (3.5)^§§§

Ang-2, protein content

0.3 (0.07)

0.5 (0.2)^{*, §}

Fibulin-3, protein content

0.5 (0.2)

0.4 (0.2)

Fibulin-2, protein content

0.04 (0.02)

0.04 (0.03)

Fibulin-5, protein content

0.5 (0.1)^#

0.5 (0.1)

MIF, gene expression

1.3 (1.1)

0.3 (0.2) ^§§§

RAB-14, gene expression

1.5 (1.3) ^##

2.4 (2.1)

FGFRL-1, gene expression

4.1 (2.3)

1.3 (1.0)^{***, §}

EFNA-3, gene expression

0.2 (0.1)

0.1 (0.08)^§§

P-62, protein content

0.1 (0.02)

0.3 (0.1)^*

LC3II/LC3II, protein content

0.2 (0.1)

0.4 (0.1)^*

Beclin-1, protein content

0.2 (0.1)

0.3 (0.1)

BAX, protein content

0.2 (0.1)

0.3 (0.2)

BCL-2, protein content

0.1 (0.04)

0.2 (0.05)^**

miR-30a-30p

SNAIL-1, gene expression

2.8 (1.7)

0.6 (0.4)^{*, §§§}

P53, gene expression

0.5 (0.3)

0.3 (0.2)^§

CDKN2A, gene expression

9.8 (7.8)^#

19.4 (16.5)^§§§

P63, gene expression

0.8 (0.5)^###

0.4 (0.3)^*

CDKN1A, gene expression

13.5 (7.7)

6.4 (4.8)^**

Ki-67 positive cells, %

42.6 (19.0)

96.2 (4.7)^***

k-RAS, gene expression

2.7 (2.1)

1.1 (0.5)^{*, §}